Results and Problems in Cell Differentiation最新文献

The Myeloid-T Lymphocyte Axis in Chronic Lung Allograft Rejection: Emerging Insights into the Immune Circuitry Driving Fibrosis. 慢性肺同种异体移植排斥反应中的骨髓- t淋巴细胞轴：免疫回路驱动纤维化的新见解。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_9

Sajad Moshkelgosha, Sumiha Ramendra, Ke Fan Bei, Stephen Juvet

引用次数: 0

PIEZO1 in Immune Cells: From Force to Function. 免疫细胞中的PIEZO1：从力到功能。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_3

Dipanwita Ghosh, Dipyaman Ganguly

引用次数: 0

Setting Up to Divide: Nuclear Mechanotransduction in the Regulation of Mitosis. 建立分裂：核机械转导在有丝分裂调控中的作用。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_9

Jorge G Ferreira

引用次数: 0

Influence of Magneto-Mechanical Stress on Cellular Membranes, Ion Channel Activity, and Gene Expression Dynamics. 磁机械应力对细胞膜、离子通道活性和基因表达动力学的影响。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_8

Vitalii Zablotskii, Tatyana Polyakova

{"title":"Influence of Magneto-Mechanical Stress on Cellular Membranes, Ion Channel Activity, and Gene Expression Dynamics.","authors":"Vitalii Zablotskii, Tatyana Polyakova","doi":"10.1007/978-3-032-19509-8_8","DOIUrl":"10.1007/978-3-032-19509-8_8","url":null,"abstract":"This chapter elucidates the fundamental role of magneto-mechanical stresses as a primary mechanism through which static and low-frequency magnetic fields influence cellular processes. We demonstrate that magnetic forces, particularly when amplified by magnetic nanoparticles (MNPs), exert precise control over cellular mechanics. At the membrane level, these forces induce subtle deformations that directly modulate the gating of mechanosensitive ion channels, such as Piezo1, thereby regulating Ca2+ and K+ fluxes and initiating downstream signaling cascades that govern gene expression, metabolism, and cytoskeletal remodeling. At higher force thresholds, magneto-mechanical stress triggers significant structural alterations, including membrane blebbing due to cortical detachment, which can act as a precursor to apoptosis-an effect with pronounced implications for cancer therapeutics. Furthermore, these magnetic stresses are transmitted through the cytoskeletal network, altering the tension in F-actin, microtubules, and intermediate filaments to remodel cell shape, motility, and adhesion, thereby influencing critical processes like cell migration and differentiation. We demonstrate that the noninvasive and selective nature of this magneto-mechanical approach offers a highly versatile and potent strategy for biomedical applications.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"78 ","pages":"167-197"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions. 慢性同种异体肝移植排斥反应：组织病理学观察和未来方向。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_12

Samar Seeman, Joshua Wong, Adib Edilbi, Ashton A Connor, John M Vierling, Mary R Schwartz, Sadhna Dhingra

{"title":"Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions.","authors":"Samar Seeman, Joshua Wong, Adib Edilbi, Ashton A Connor, John M Vierling, Mary R Schwartz, Sadhna Dhingra","doi":"10.1007/978-3-032-07686-1_12","DOIUrl":"https://doi.org/10.1007/978-3-032-07686-1_12","url":null,"abstract":"Chronic liver allograft rejection (CR) remains a significant cause of late graft dysfunction and failure despite advances in surgical techniques and immunosuppression. This chapter reviews the current understanding of CR, integrating diagnostic histopathological findings, atypical histological patterns of late rejection that are frequently associated with CR, and emerging diagnostic tools. CR is driven by overlapping T cell-mediated and antibody-mediated mechanisms, leading to progressive bile duct loss, vascular injury, and structural alterations. Diagnostic histopathological criteria include interlobular bile duct atrophy or loss, foam cell obliterative arteriopathy, and portal/periportal, perisinusoidal, and perivenular fibrosis. Chronic antibody-mediated rejection (cAMR) and mixed phenotypes exhibit additional vascular and sinusoidal injury, often with subtle biochemical changes. Structural sequelae such as nodular regenerative hyperplasia and variable parenchymal fibrosis underscore the heterogeneity of late graft injury. This chapter also examines late-onset rejection phenotypes, i.e., plasma cell-rich rejection, idiopathic post-transplant hepatitis, and isolated central perivenulitis and their potential to progress to chronic rejection. Future directions emphasize the integration of molecular diagnostics, digital pathology, and noninvasive biomarkers, such as donor-specific antibodies, liver stiffness measurement, and donor-derived cell-free DNA (dd-cfDNA), to complement or replace protocol biopsies, to guide personalized immunosuppression, and to enable earlier intervention. Advances in regenerative medicine and antifibrotic therapies have the potential to alter the natural history of CR, shifting toward precision medicine approaches that may extend long-term graft survival after liver transplantation.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"251-273"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving Therapeutic Approaches for Treatment of Antibody-Mediated Rejection in Renal Allograft Recipients. 治疗同种异体肾移植受者抗体介导的排斥反应的新方法。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_11

Stanley C Jordan, Noriko Ammerman, Edmund Huang, Ashley Vo

引用次数: 0

Macrophage Actin Cytoskeleton in Chronic Rejection. 慢性排斥反应中的巨噬细胞肌动蛋白骨架。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_6

Malgorzata Kloc, Marta Halasa, Souhail A Thabet, Jarek Wosik, Ahmed Uosef, Arijita Subuddhi, Rafik Mark Ghobrial

引用次数: 0

Oogenesis of the German Cockroach: From Morphology to Regulation. 德国蟑螂的卵发生：从形态学到调控。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_8

Maria-Dolors Piulachs

{"title":"Oogenesis of the German Cockroach: From Morphology to Regulation.","authors":"Maria-Dolors Piulachs","doi":"10.1007/978-3-032-06766-1_8","DOIUrl":"10.1007/978-3-032-06766-1_8","url":null,"abstract":"The German cockroach, Blattella germanica, has emerged as an important model organism for studying oogenesis, embryonic and postembryonic development, as well as morphogenesis. As an insect with panoistic ovaries, it provides unique insights into reproductive and developmental processes that differ significantly from those operating in holometabolous insects (including the model species Drosophila melanogaster), characterized by meroistic ovaries, i.e., the presence of specialized germline cells, termed the nurse cells. In panoistic ovaries, the nurse cells are absent; instead, both the oocyte and its nucleus, the germinal vesicle, are metabolically and synthetically active, relying on nutrients obtained directly from the hemolymph. A distinctive feature of B. germanica oogenesis is that during each gonadotrophic cycle, only the basal (terminal) ovarian follicle in each ovariole develops, while the others remain inactive until the basal one is oviposited.B. germanica is particularly advantageous as a model organism due to its relatively short reproductive cycle, ease of laboratory maintenance, and well-studied hormonal regulation. Its sensitivity to RNA interference (RNAi) and the potential for genome editing using DIPA (direct parental)-CRISPR further enhance its value for functional genomics and evo-devo studies.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"76 ","pages":"151-166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Touch Triggers Mechanotransduction in Cutaneous Mechanoreceptors. 触摸如何触发皮肤机械感受器的机械传导。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_2

Alexandre Bergheau, Ombeline Parbaud, Gabriel Cazorla, Youcef Ben-Khalifa, Hassan Zahouani

{"title":"How Touch Triggers Mechanotransduction in Cutaneous Mechanoreceptors.","authors":"Alexandre Bergheau, Ombeline Parbaud, Gabriel Cazorla, Youcef Ben-Khalifa, Hassan Zahouani","doi":"10.1007/978-3-032-19509-8_2","DOIUrl":"10.1007/978-3-032-19509-8_2","url":null,"abstract":"Understanding the mechanotransduction mechanisms underlying the tactile dimension of skin aging remains an underexplored aspect of dermatological and neurosciences. This investigation introduces a novel mechanosensory responsiveness index, tactile acuity index (TAI), derived from a time-frequency analysis of friction-induced vibrations recorded during controlled touch interactions utilizing the wearable tactile acquisition device (WTAD). By decomposing tactile signals across frequency bands specific to Merkel, Meissner, Ruffini, and Pacinian mechanoreceptors, TAI quantifies both the amplitude and spectral organization of vibrational energy transmitted through the skin.In a first experimental phase, TAI exhibited a clear monotonic decline across seven grades of paper textures, confirming that smoother surfaces produce weaker and spectrally narrower mechanical stimulation, thereby reducing mechanoreceptor recruitment. The strongest correlations were observed for Ruffini (R2 = 0.89) and Pacinian (R2 = 0.95) receptors, reflecting their sensitivity to macroscopic strain and high-frequency vibration. In an ensuing aging study involving 40 women aged 20-65, TAI revealed a pronounced reduction in mechanosensory activity across all receptor types, with the largest declines in deep mechanotransductive pathways. The associated time-frequency spectrograms further highlighted shorter, lower-amplitude bursts and restricted spectral bandwidths in older skin, indicating a progressive simplification of tactile encoding with age.Together, these findings validate TAI as a quantitative biomarker of tactile vitality, capable of distinguishing between textural and biological sources of sensory decline. By providing receptor-specific insights into mechanotransduction efficiency, this approach establishes a novel framework for diagnosing, monitoring, and potentially restoring tactile function through targeted cosmetic or therapeutic interventions.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"78 ","pages":"27-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Models of Cellular Mechanosensation. 细胞机械感觉模型。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_5

David Dolgitzer, Pablo A Iglesias

引用次数: 0