Results and Problems in Cell Differentiation最新文献

The Myeloid-T Lymphocyte Axis in Chronic Lung Allograft Rejection: Emerging Insights into the Immune Circuitry Driving Fibrosis. 慢性肺同种异体移植排斥反应中的骨髓- t淋巴细胞轴：免疫回路驱动纤维化的新见解。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_9

Sajad Moshkelgosha, Sumiha Ramendra, Ke Fan Bei, Stephen Juvet

引用次数: 0

Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions. 慢性同种异体肝移植排斥反应：组织病理学观察和未来方向。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_12

Samar Seeman, Joshua Wong, Adib Edilbi, Ashton A Connor, John M Vierling, Mary R Schwartz, Sadhna Dhingra

{"title":"Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions.","authors":"Samar Seeman, Joshua Wong, Adib Edilbi, Ashton A Connor, John M Vierling, Mary R Schwartz, Sadhna Dhingra","doi":"10.1007/978-3-032-07686-1_12","DOIUrl":"https://doi.org/10.1007/978-3-032-07686-1_12","url":null,"abstract":"Chronic liver allograft rejection (CR) remains a significant cause of late graft dysfunction and failure despite advances in surgical techniques and immunosuppression. This chapter reviews the current understanding of CR, integrating diagnostic histopathological findings, atypical histological patterns of late rejection that are frequently associated with CR, and emerging diagnostic tools. CR is driven by overlapping T cell-mediated and antibody-mediated mechanisms, leading to progressive bile duct loss, vascular injury, and structural alterations. Diagnostic histopathological criteria include interlobular bile duct atrophy or loss, foam cell obliterative arteriopathy, and portal/periportal, perisinusoidal, and perivenular fibrosis. Chronic antibody-mediated rejection (cAMR) and mixed phenotypes exhibit additional vascular and sinusoidal injury, often with subtle biochemical changes. Structural sequelae such as nodular regenerative hyperplasia and variable parenchymal fibrosis underscore the heterogeneity of late graft injury. This chapter also examines late-onset rejection phenotypes, i.e., plasma cell-rich rejection, idiopathic post-transplant hepatitis, and isolated central perivenulitis and their potential to progress to chronic rejection. Future directions emphasize the integration of molecular diagnostics, digital pathology, and noninvasive biomarkers, such as donor-specific antibodies, liver stiffness measurement, and donor-derived cell-free DNA (dd-cfDNA), to complement or replace protocol biopsies, to guide personalized immunosuppression, and to enable earlier intervention. Advances in regenerative medicine and antifibrotic therapies have the potential to alter the natural history of CR, shifting toward precision medicine approaches that may extend long-term graft survival after liver transplantation.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"251-273"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving Therapeutic Approaches for Treatment of Antibody-Mediated Rejection in Renal Allograft Recipients. 治疗同种异体肾移植受者抗体介导的排斥反应的新方法。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_11

Stanley C Jordan, Noriko Ammerman, Edmund Huang, Ashley Vo

引用次数: 0

Macrophage Actin Cytoskeleton in Chronic Rejection. 慢性排斥反应中的巨噬细胞肌动蛋白骨架。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_6

Malgorzata Kloc, Marta Halasa, Souhail A Thabet, Jarek Wosik, Ahmed Uosef, Arijita Subuddhi, Rafik Mark Ghobrial

引用次数: 0

The Role of the Endothelium as a Key Regulator of Chronic Transplant Rejection. 内皮在慢性移植排斥反应中的关键调节作用。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_4

Wolfgang Jungraithmayr, Birte Ohm, Shampa Chatterjee

引用次数: 0

Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy. 慢性排斥反应的发病机制：移植物内皮细胞IL-15的递呈连接同种异体血管病变中同种抗体和细胞介导的步骤。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_5

Clancy W Mullan, Jordan S Pober

{"title":"Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy.","authors":"Clancy W Mullan, Jordan S Pober","doi":"10.1007/978-3-032-07686-1_5","DOIUrl":"10.1007/978-3-032-07686-1_5","url":null,"abstract":"Chronic rejection of allografts appears mechanistically distinct from acute antibody-mediated and or acute cell-mediated rejection. Histological features point to roles for alloantibody and lymphocytic infiltrates, and allograft vasculopathy is a common feature in chronic rejection of several different solid organs. Vasculopathy, in turn, can cause late graft failure due to chronic ischemia, parenchymal cell loss, and replacement fibrosis. Molecular analyses implicate graft vascular endothelial cells in this process. Here, we review evidence favoring a hypothesis linking alloantibody and complement to induction of endothelial cell surface expression and trans-presentation of IL-15 as a critical signal that enhances lymphocyte activation during antigen-mediated recruitment of alloreactive T cells. These T cells trans-migrate into the intima and secrete interferon-γ, which acts both on vascular smooth muscle cells within the arterial wall to stimulate their proliferation, resulting in vasculopathy, and back on the endothelial cells to provide positive feedback for this sequence of events.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"113-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Chronic Rejection in Organ Transplantation Through Computational Modeling. 通过计算模型探讨器官移植中的慢性排斥反应。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_3

Stefano Casarin, Elisa Serafini

{"title":"Exploring Chronic Rejection in Organ Transplantation Through Computational Modeling.","authors":"Stefano Casarin, Elisa Serafini","doi":"10.1007/978-3-032-07686-1_3","DOIUrl":"https://doi.org/10.1007/978-3-032-07686-1_3","url":null,"abstract":"Chronic rejection remains a significant challenge in solid organ transplantation, contributing to graft dysfunction and eventual failure despite advances in immunosuppressive therapies. Computational modeling has emerged as a powerful tool for understanding chronic rejection mechanisms, enhancing diagnostic precision, and identifying novel therapeutic targets. This chapter explores various computational approaches, including artificial intelligence, machine learning, ordinary differential equations, partial differential equations, agent-based models, and gene network analysis applied to solid organ transplantation: kidney, liver, heart, and lung. While computational models offer numerous advantages, including cost-effectiveness and the ability to integrate multi-omics data, challenges remain in terms of data quality, standardization, and clinical validation. Bridging these gaps will require comprehensive longitudinal studies and the development of hybrid models that combine diverse computational techniques. Emerging technologies such as single-cell transcriptomics and spatial genomics hold promise for enhancing predictive accuracy and understanding cellular heterogeneity. As computational methods evolve, their integration with experimental research will be essential for developing precision medicine strategies to improve long-term graft survival.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"71-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Everlasting Ovary: Decoding the Mechanisms of Lifelong Oogenesis in the Naked Mole-Rat. 永久的卵巢：解码裸鼹鼠终身卵子发生的机制。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_4

Odei Barreñada, Andrew C Pearson, Miguel A Brieño-Enríquez

{"title":"The Everlasting Ovary: Decoding the Mechanisms of Lifelong Oogenesis in the Naked Mole-Rat.","authors":"Odei Barreñada, Andrew C Pearson, Miguel A Brieño-Enríquez","doi":"10.1007/978-3-032-06766-1_4","DOIUrl":"10.1007/978-3-032-06766-1_4","url":null,"abstract":"The naked mole-rat (Heterocephalus glaber) is a fascinating model organism which challenges conventional paradigms in evolutionary developmental biology. As one of the two known eusocial mammals with a reproductive hierarchy akin to social insects, the naked mole-rat presents an exceptional system for studying the interplay between social structure, environmental adaptation, and developmental plasticity. This chapter explores how the species' unique reproductive strategies-including lifelong fertility, postnatal oogenesis, and social suppression of reproduction-reshape our understanding of mammalian reproductive aging. The queen, the sole breeding female within a colony, maintains an exceptionally large ovarian reserve throughout life, defying the prevailing dogma of a fixed oocyte pool and progressive depletion. Unlike other mammals, germ cells in the naked mole-rat continue to proliferate postnatally, offering unprecedented insights into the regulation of ovarian function and reproductive longevity. Additionally, the integration of genomic, epigenetic, and neuroendocrine mechanisms underlying eusociality provides a rare perspective on how developmental processes can be shaped by cooperative behaviors and environmental constraints. By situating these traits within an evo-devo framework, this chapter underscores the naked mole-rat's potential to advance research in several fields such as aging, reproductive biology, and the evolution of complex social systems.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"76 ","pages":"47-63"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-Derived Cell-Free DNA in Acute and Chronic Rejection of Solid Allograft Transplantation. 同种异体实体移植急性和慢性排斥反应中的供体来源无细胞DNA。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_7

Javier Muro-Perez, Manuel Muro-Perez, Jose Antonio Galian, Noelia Pérez-López, Isabel Legaz, Manuel Muro

{"title":"Donor-Derived Cell-Free DNA in Acute and Chronic Rejection of Solid Allograft Transplantation.","authors":"Javier Muro-Perez, Manuel Muro-Perez, Jose Antonio Galian, Noelia Pérez-López, Isabel Legaz, Manuel Muro","doi":"10.1007/978-3-032-07686-1_7","DOIUrl":"https://doi.org/10.1007/978-3-032-07686-1_7","url":null,"abstract":"Today, there have been spectacular advances in surgical techniques, organ preservation for transplantation, optimal and efficient donor and recipient selection, more efficient diagnosis of transplant complications, and major progress in pharmacological immunosuppression procedures. In this regard, survival rates after transplantation of various organs have been gaining ground, particularly in the case of lung transplants, whose average survival rate is lower than other types of transplants. In this regard, it is important to detect acute and subclinical clinical rejection, as well as chronic allograft rejection. This is especially important in heart and lung transplants. In the latter type of transplant, and due to the chronic dysfunction of the lung allograft, it is key to detect rejection early and promptly, as it can affect up to half of the transplant patient population. Therefore, effective diagnostic tools are needed to visualize the level of allograft damage using genomic methods such as those that measure donor-derived cell-free DNA (dd-cfDNA). The plasma concentration of dd-cfDNA increases after graft injury or infection. Our team has experience quantifying this parameter in allograft injury progression, and our experience and comparison with the published literature will be presented in the following sections, discussing validated and non-validated results.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"151-164"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular Remodeling in Chronic Rejection: Insights into Transplant Vasculopathy Across Solid Organ Allografts. 慢性排斥反应中的血管重构：对同种异体实体器官移植血管病变的认识。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_8

Samantha L Nelson, Sariah Hyacinth, Basmala Aldamak, Benjamin J Kopecky

引用次数: 0