组蛋白和非组蛋白可逆乙酰化在发育、衰老和疾病中的作用。

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI:10.1007/978-3-031-91459-1_1

Sezgin Gunes, Neslihan Hekim, Sercan Ergun, Elzem Nisa Alkan, Cansu Can

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引用次数: 0

摘要

翻译后修饰（PTM）涉及组蛋白和非组蛋白中氨基酸残基的化学修饰，其化学性质多种多样。PTM在细胞核染色质结构调控中起着至关重要的作用，从而调控基因。在各种PTM中，组蛋白非组蛋白的可逆乙酰化在各种细胞过程中具有基本功能。在所有生物体中，赖氨酸残基的组蛋白乙酰化与转录激活有关。乙酰转移酶和去乙酰化酶是众所周知的组蛋白和非组蛋白乙酰化酶。本章将综述组蛋白和非组蛋白可逆乙酰化表观遗传改变及其机制的最新进展，并总结它们如何影响发育、衰老和疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Histone and Non-histone Reversible Acetylation in Development, Aging, and Disease.

Post-translational modifications (PTM) involve chemical modifications of amino acid residues within histone and non-histone proteins and are chemically diverse. PTM plays a vital role in regulating the chromatin structure in the nucleus, thus gene regulation. Among the various PTM, reversible acetylation of histone non-histone proteins has fundamental functions in various cellular processes. In all organisms, histone acetylation of lysine residues is connected with transcription activation. Acetyltransferases and deacetylases are well-known enzymes in the acetylation of the histone and non-histone proteins. This chapter will review the latest progress in histone and non-histone reversible acetylation epigenetic alterations and mechanisms and summarize how they affect development, aging, and diseases.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.