非组蛋白在人类癌症中的可逆乙酰化。

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI:10.1007/978-3-031-91459-1_13

Chunran Feng, Yiqun Zeng, Edward V Prochownik, Congqin Jiang, Youjun Li

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引用次数: 0

摘要

在过去的三十年中，我们在揭示非组蛋白可逆乙酰化的范围以及了解其机制和功能后果方面取得了巨大进展。本文综述了组蛋白乙酰转移酶(HATs)/去乙酰化酶（HDAC）及其抑制剂的研究进展，重点介绍了非组蛋白可逆乙酰化修饰在肿瘤发展中的作用，并探讨了HAT和HDAC抑制剂在肿瘤治疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reversible Acetylation of Non-histone Proteins in Human Cancers.

Over the last three decades, we have witnessed great progress in uncovering the scope of reversible acetylation of non-histone proteins and understanding its mechanisms and functional consequences. In this review, we summarize the histone acetyltransferases (HATs)/deacetylases (HDACs) and their inhibitors, focusing on the role of reversible acetylation modification of non-histone proteins in tumor development while also exploring the application of HAT and HDAC inhibitors in cancer therapy.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.