Results and Problems in Cell Differentiation最新文献_第2页

Repurposing Histone Deacetylase Inhibitors for Management of Solid Organ Transplant Rejection. 重新利用组蛋白去乙酰化酶抑制剂治疗实体器官移植排斥反应。

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-91459-1_11

Marta Halasa, Anna Wawruszak, Malgorzata Kloc

引用次数: 0

Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals. 哺乳动物着床前胚胎发育过程中的可逆组蛋白乙酰化。

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-91459-1_6

Giulia Musmeci, Fernanda Fagali Franchi, Francesca Mossa, Alberto Maria Luciano, Valentina Lodde, Federica Franciosi

{"title":"Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals.","authors":"Giulia Musmeci, Fernanda Fagali Franchi, Francesca Mossa, Alberto Maria Luciano, Valentina Lodde, Federica Franciosi","doi":"10.1007/978-3-031-91459-1_6","DOIUrl":"https://doi.org/10.1007/978-3-031-91459-1_6","url":null,"abstract":"Histone acetylation is an epigenetic modification responsible for changes in chromatin architecture, accessibility, and ultimately gene expression. At the onset of a new life, when the fully differentiated parental genomes fuse together to generate a new totipotent cell, the gametes' epigenetic program must be erased, and new ones are progressively installed. Together with other epigenetic modifications, histone acetylation participates in the early events of embryogenesis, undergoing dynamic changes that involve several amino acid residues on different histone proteins. By analyzing studies that followed these changes during the preimplantation development in different mammals, we identified critical windows of acetylation/deacetylation in relation to the oocyte-to-zygote transition, the activation of the embryonic genome, and the specification of cell lineages, all crucial events for early embryo development, the establishment of pluripotent embryonic tissue, and ultimately of a multicellular organism.Finally, this survey points out the possibility that while contributing to the necessary plasticity of the embryonic stem cells, the reversibility of histone acetylation/deacetylation patterns renders this mechanism prone to be hijacked by environmental conditions, such as maternal diet or pollutants, leading to the alterations of epigenetic marks that can be potentially transmitted to the daughter cells and up to adulthood.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"75 ","pages":"165-188"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory Roles for SIRT1 in Aging and Immunosenescence. SIRT1在衰老和免疫衰老中的调节作用。

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-91459-1_10

Devonique Brissett-Lasalle, Zoya Syed, Yashitha Yarubandi, Jeff Leips, Erin Green

{"title":"Regulatory Roles for SIRT1 in Aging and Immunosenescence.","authors":"Devonique Brissett-Lasalle, Zoya Syed, Yashitha Yarubandi, Jeff Leips, Erin Green","doi":"10.1007/978-3-031-91459-1_10","DOIUrl":"https://doi.org/10.1007/978-3-031-91459-1_10","url":null,"abstract":"Silent information regulator 1 (SIRT1), a conserved lysine deacetylase, is an important contributor to the function of macrophages, which are the scavengers of the innate immune system. Macrophages are part of the first line of defense against infection and key players in immunity due to their ability to survey tissue for infections or damage, release inflammatory cytokines, and clear pathogens. Macrophage function deteriorates with age and is a common indicator of immunosenescence. SIRT1 is known to influence multiple aspects of macrophage physiology, particularly proliferation, self-renewal, migration, the regulation of macrophage polarization, and the ability of macrophages to clear pathogens via phagocytosis and inflammasome signaling. Furthermore, mammalian SIRT1 and orthologous Sir2 in other organisms have well-defined roles in aging. Therefore, in this chapter, we discuss evidence that links SIRT1 to macrophage behavior and function, explore its role in inflammatory pathways linked to aging, and highlight key research questions in immunosenescence and the implications for epigenetic and non-epigenetic roles of SIRT1.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"75 ","pages":"291-308"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bromodomain and PHD Finger-Containing Protein 1: From Functions to a Developmental Disorder, Cancer, and Therapeutics. 溴结构域和PHD含指蛋白1：从功能到发育障碍、癌症和治疗。

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-91459-1_15

Arezousadat Razavi, Paulina Varela-Castillo, Xiang-Jiao Yang

{"title":"Bromodomain and PHD Finger-Containing Protein 1: From Functions to a Developmental Disorder, Cancer, and Therapeutics.","authors":"Arezousadat Razavi, Paulina Varela-Castillo, Xiang-Jiao Yang","doi":"10.1007/978-3-031-91459-1_15","DOIUrl":"https://doi.org/10.1007/978-3-031-91459-1_15","url":null,"abstract":"Bromodomain and PHD finger-containing protein 1 (BRPF1) is an essential epigenetic regulator and plays a key role in post-translational modification of histones. It is a chromatin reader that recognizes acetylated histones and interacts with the paralogous lysine acetyltransferases KAT6A and KAT6B to promote histone acetylation and related acylations, such as propionylation, at lysine 23 of histone H3, thereby influencing gene expression and regulating developmental programs. BRPF1 contributes to a variety of cellular processes such as cell cycle progression, cell proliferation, cell differentiation, and responses to cellular stresses, including DNA damage. Moreover, BRPF1 is implicated in hematopoiesis, embryonic development, skeletal development, neurodevelopment, neurogenesis, learning, and memory. BRPF1 gene knockout in mice leads to severe bone marrow failure, anemia, and eventual death in a few weeks after birth. This review provides a brief overview of BRPF1 and its contribution to the molecular structure and biological functions of KAT6A and KAT6B complexes. We will explore the emerging evidence linking BRPF1 dysfunction to human diseases, particularly cancer and abnormal neurodevelopment, to highlight promising therapeutic opportunities for treating associated pathology.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"75 ","pages":"411-434"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer. 赖氨酸乙酰转移酶6复合物在神经发育障碍和不同类型癌症中的作用。

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-91459-1_14

Negar Mousavi, Xiang-Jiao Yang

引用次数: 0

Airineme-Mediated Intercellular Communication. 以空气介质为媒介的细胞间通信

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_7

Dae Seok Eom

引用次数: 0

Orchestrating Blood Flow in the Retina: Interpericyte Tunnelling Nanotube Communication. 协调视网膜中的血流：膜间隧道纳米管通信

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_11

Hannah McDonald, Jesse Gardner-Russell, Luis Alarcon-Martinez

{"title":"Orchestrating Blood Flow in the Retina: Interpericyte Tunnelling Nanotube Communication.","authors":"Hannah McDonald, Jesse Gardner-Russell, Luis Alarcon-Martinez","doi":"10.1007/978-3-031-62036-2_11","DOIUrl":"10.1007/978-3-031-62036-2_11","url":null,"abstract":"The retina transforms light into electrical signals, which are sent to the brain via the optic nerve to form our visual perception. This complex signal processing is performed by the retinal neuron and requires a significant amount of energy. Since neurons are unable to store energy, they must obtain glucose and oxygen from the bloodstream to produce energy to match metabolic needs. This process is called neurovascular coupling (NVC), and it is based on a precise mechanism that is not totally understood. The discovery of fine tubular processes termed tunnelling nanotubes (TNTs) set a new type of cell-to-cell communication. TNTs are extensions of the cellular membrane that allow the transfer of material between connected cells. Recently, they have been reported in the brain and retina of living mice, where they connect pericytes, which are vascular mural cells that regulate vessel diameter. Accordingly, these TNTs were termed interpericyte tunnelling nanotubes (IPTNTs), which showed a vital role in blood delivery and NVC. In this chapter, we review the involvement of TNTs in NVC and discuss their implications in retinal neurodegeneration.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"73 ","pages":"229-247"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial Extracellular Vesicles in Host-Microbiota Interactions. 宿主与微生物群互动中的微生物胞外囊泡

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_19

Sarah Abubaker, Saba Miri, Walid Mottawea, Riadh Hammami

引用次数: 0

Tunneling Nanotubes in the Brain. 大脑中的隧道纳米管

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_10

Dimitri Budinger, Vivian Baker, Michael T Heneka

引用次数: 0

Enhancer Activation by Transcription Factors and Underlying Mechanisms. 转录因子对增强子的激活作用及其内在机制

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_10

Hisato Kondoh

{"title":"Enhancer Activation by Transcription Factors and Underlying Mechanisms.","authors":"Hisato Kondoh","doi":"10.1007/978-3-031-39027-2_10","DOIUrl":"10.1007/978-3-031-39027-2_10","url":null,"abstract":"Enhancers are classified into two classes based on various criteria. Class I enhancers participate primarily in finely tuned cell-specific regulation, as exemplified by the neural enhancers discussed in Chap. 9 . They are activated by simultaneous binding of transcription factors (TFs) to adjacent sites in the core sequence and are marked by moderate levels of H3K27ac modification. Class II enhancers are activated by the reiterated binding of the same TFs at multiple sites and are marked by high levels of H3K27ac modification. Class II enhancers are exemplified by enhancers in the SCR downstream of the Sox2 gene, as also discussed in Chap. 9 . Both classes of enhancers activate transcription similarly with low selectivity toward the promoters.The genomic loci broadly covered by high-level H3K27ac modification were once dubbed \"Super-enhancers,\" implying that they are densely packed enhancers with superpowers in gene regulation. However, marking with H3K27ac modification does not predict the enhancer activity of a sequence; a \"Super enhancer\" region includes a few ordinary Class II enhancers. Currently, the most reliable criterion for enhancer prediction is cross-species sequence conservation.The mechanism by which transcription factors find and stay on the target enhancer site remains elusive. Results from two approaches, single-molecule live imaging and kinetic analysis using FRAP, are discussed.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"72 ","pages":"167-191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0