Results and Problems in Cell Differentiation最新文献_第2页

Oogenesis of the German Cockroach: From Morphology to Regulation. 德国蟑螂的卵发生：从形态学到调控。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_8

Maria-Dolors Piulachs

{"title":"Oogenesis of the German Cockroach: From Morphology to Regulation.","authors":"Maria-Dolors Piulachs","doi":"10.1007/978-3-032-06766-1_8","DOIUrl":"10.1007/978-3-032-06766-1_8","url":null,"abstract":"The German cockroach, Blattella germanica, has emerged as an important model organism for studying oogenesis, embryonic and postembryonic development, as well as morphogenesis. As an insect with panoistic ovaries, it provides unique insights into reproductive and developmental processes that differ significantly from those operating in holometabolous insects (including the model species Drosophila melanogaster), characterized by meroistic ovaries, i.e., the presence of specialized germline cells, termed the nurse cells. In panoistic ovaries, the nurse cells are absent; instead, both the oocyte and its nucleus, the germinal vesicle, are metabolically and synthetically active, relying on nutrients obtained directly from the hemolymph. A distinctive feature of B. germanica oogenesis is that during each gonadotrophic cycle, only the basal (terminal) ovarian follicle in each ovariole develops, while the others remain inactive until the basal one is oviposited.B. germanica is particularly advantageous as a model organism due to its relatively short reproductive cycle, ease of laboratory maintenance, and well-studied hormonal regulation. Its sensitivity to RNA interference (RNAi) and the potential for genome editing using DIPA (direct parental)-CRISPR further enhance its value for functional genomics and evo-devo studies.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"76 ","pages":"151-166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflections on Model Species in Evolutionary Developmental Biology. 进化发育生物学中模式物种的思考。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_1

Alan C Love, Yoshinari Yoshida

引用次数: 0

Evolution and Development of Insect Metamorphosis: A Case of Genetic Accommodation? 昆虫变态的进化与发展：一个遗传调节的案例？

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_7

Hana Nagata, Kohtaro Tanaka, Yuichiro Suzuki

引用次数: 0

Models in Evo-Devo: An Evolving Niche. Evo-Devo中的模型：一个不断发展的利基。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_2

Jessica A Bolker

引用次数: 0

Carnivorous Plants as Model Species for Recent and Further Studies. 食肉植物作为模式物种的研究进展。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-06766-1_13

Bartosz J Płachno, Marcin Feldo, Piotr Stolarczyk, Irene Lichtscheidl

{"title":"Carnivorous Plants as Model Species for Recent and Further Studies.","authors":"Bartosz J Płachno, Marcin Feldo, Piotr Stolarczyk, Irene Lichtscheidl","doi":"10.1007/978-3-032-06766-1_13","DOIUrl":"10.1007/978-3-032-06766-1_13","url":null,"abstract":"Carnivorous plants (commonly known as insectivorous plants) are autotrophic organisms that perform photosynthesis but also consume nutrients, mainly the minerals N and P and some organic compounds, from other organisms (animals, protozoa, and even plants) in order to increase growth and reproduction rates (\"mixotrophs\"). For this aim, they have developed specialized traps. The evolution of carnivory was determined by changes in the genome (e.g., loss of some genes, whole-genome and tandem gene duplications, or miniaturization of genomes), and also by physiological and anatomical modifications. Knowledge gained from the study of carnivorous plants promotes the general understanding of plants and makes them important research models for traditional plant species. Studies of carnivorous plants as a source of active biological compounds that can be used in pharmacy and medicine, as well as against bacteria and fungi, are also currently widespread. Finally, traps of carnivorous plants are an inspiration for the invention of new materials (bioinspired surfaces) that will have potential applications in the fields of microfluidic devices, mechanical engineering, and biomedicine.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"76 ","pages":"291-309"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Endothelium as a Key Regulator of Chronic Transplant Rejection. 内皮在慢性移植排斥反应中的关键调节作用。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_4

Wolfgang Jungraithmayr, Birte Ohm, Shampa Chatterjee

引用次数: 0

Network-Associated Mechanotransduction in Health and Disease. 健康和疾病中的网络相关机械转导。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_7

Béla Suki, Joseph K Hall, Erzsébet Bartolák-Suki

{"title":"Network-Associated Mechanotransduction in Health and Disease.","authors":"Béla Suki, Joseph K Hall, Erzsébet Bartolák-Suki","doi":"10.1007/978-3-032-19509-8_7","DOIUrl":"10.1007/978-3-032-19509-8_7","url":null,"abstract":"Mechanical forces are known to influence many cellular and extracellular processes in the body via mechanical signal transduction pathways, collectively called mechanotransduction. The corresponding mechanical information transmission is a multiscale process: starting at the nanoscale level of motor proteins, mechanical forces percolate through the cytoskeleton of the cell to create contractile forces in the extracellular matrix, where they are further transmitted to reach the tissue and organ levels. This force transmission is supported by various networks of simpler elements, such as collagen and elastin molecules that form fibrils, fibers, and fiber networks. The efficiency of force transmission, including the magnitude and direction of the force, heavily depends on the organization of the network structure. In the limit, when the transmission pathway through a network is broken, the force signal does not reach its target, and no response can happen. Thus, mechanical force and stress transmission require a connected or percolating network. This chapter reviews how emergent network phenomena contribute to mechanotransduction at various length scales. Sufficiently realistic intra- and extracellular network models should eventually be able to help understand disease pathogenesis and progression, as well as drug effects, with potential for guiding clinical treatments.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"78 ","pages":"151-166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Podosomes and Mechanical Force. 波多体与机械力。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-19509-8_4

Malgorzata Kloc, Souhail A Thabet, Samruddhi Ranmale, Jarek Wosik

引用次数: 0

Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy. 慢性排斥反应的发病机制：移植物内皮细胞IL-15的递呈连接同种异体血管病变中同种抗体和细胞介导的步骤。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_5

Clancy W Mullan, Jordan S Pober

{"title":"Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy.","authors":"Clancy W Mullan, Jordan S Pober","doi":"10.1007/978-3-032-07686-1_5","DOIUrl":"10.1007/978-3-032-07686-1_5","url":null,"abstract":"Chronic rejection of allografts appears mechanistically distinct from acute antibody-mediated and or acute cell-mediated rejection. Histological features point to roles for alloantibody and lymphocytic infiltrates, and allograft vasculopathy is a common feature in chronic rejection of several different solid organs. Vasculopathy, in turn, can cause late graft failure due to chronic ischemia, parenchymal cell loss, and replacement fibrosis. Molecular analyses implicate graft vascular endothelial cells in this process. Here, we review evidence favoring a hypothesis linking alloantibody and complement to induction of endothelial cell surface expression and trans-presentation of IL-15 as a critical signal that enhances lymphocyte activation during antigen-mediated recruitment of alloreactive T cells. These T cells trans-migrate into the intima and secrete interferon-γ, which acts both on vascular smooth muscle cells within the arterial wall to stimulate their proliferation, resulting in vasculopathy, and back on the endothelial cells to provide positive feedback for this sequence of events.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"113-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Chronic Rejection in Organ Transplantation Through Computational Modeling. 通过计算模型探讨器官移植中的慢性排斥反应。

Results and Problems in Cell Differentiation Pub Date : 2026-01-01 DOI: 10.1007/978-3-032-07686-1_3

Stefano Casarin, Elisa Serafini

{"title":"Exploring Chronic Rejection in Organ Transplantation Through Computational Modeling.","authors":"Stefano Casarin, Elisa Serafini","doi":"10.1007/978-3-032-07686-1_3","DOIUrl":"https://doi.org/10.1007/978-3-032-07686-1_3","url":null,"abstract":"Chronic rejection remains a significant challenge in solid organ transplantation, contributing to graft dysfunction and eventual failure despite advances in immunosuppressive therapies. Computational modeling has emerged as a powerful tool for understanding chronic rejection mechanisms, enhancing diagnostic precision, and identifying novel therapeutic targets. This chapter explores various computational approaches, including artificial intelligence, machine learning, ordinary differential equations, partial differential equations, agent-based models, and gene network analysis applied to solid organ transplantation: kidney, liver, heart, and lung. While computational models offer numerous advantages, including cost-effectiveness and the ability to integrate multi-omics data, challenges remain in terms of data quality, standardization, and clinical validation. Bridging these gaps will require comprehensive longitudinal studies and the development of hybrid models that combine diverse computational techniques. Emerging technologies such as single-cell transcriptomics and spatial genomics hold promise for enhancing predictive accuracy and understanding cellular heterogeneity. As computational methods evolve, their integration with experimental research will be essential for developing precision medicine strategies to improve long-term graft survival.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"77 ","pages":"71-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0