Results and Problems in Cell Differentiation最新文献_第3页

Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors. 利用外源转录因子将细胞重编程为 iPSCs 的分子基础。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_11

Hisato Kondoh

{"title":"Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors.","authors":"Hisato Kondoh","doi":"10.1007/978-3-031-39027-2_11","DOIUrl":"10.1007/978-3-031-39027-2_11","url":null,"abstract":"A striking discovery in recent decades concerning the transcription factor (TF)-dependent process was the production of induced pluripotent stem cell (iPSCs) from fibroblasts by the exogenous expression of the TF cocktail containing Oct3/4 (Pou5f1), Sox2, Klf4, and Myc, collectively called OSKM. How fibroblast cells can be remodeled into embryonic stem cell (ESC)-like iPSCs despite high epigenetic barriers has opened a new essential avenue to understanding the action of TFs in developmental regulation. Two forerunning investigations preceded the iPSC phenomenon: exogenous TF-mediated cell remodeling driven by the action of MyoD, and the \"pioneer TF\" action to preopen chromatin, allowing multiple TFs to access enhancer sequences. The process of remodeling somatic cells into iPSCs has been broken down into multiple subprocesses: the initial attack of OSKM on closed chromatin, sequential changes in cytosine modification, enhancer usage, and gene silencing and activation. Notably, the OSKM TFs change their genomic binding sites extensively. The analyses are still at the descriptive stage, but currently available information is discussed in this chapter.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"72 ","pages":"193-218"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Epiblast and Pluripotent Stem Cell Lines. 上胚层和多能干细胞系。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_1

Hisato Kondoh

引用次数: 0

Origin and Role of Testicular Macrophages in Testis Development, Steroidogenesis, and Spermatogenesis. 睾丸巨噬细胞在睾丸发育、类固醇生成和精子生成中的起源和作用

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_5

Rafal P Piprek, Malgorzata Kloc, Klaudia Porebska, Paulina C Mizia, Izabela Rams-Pociecha, Jacek Z Kubiak

引用次数: 0

Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair. 螺旋体感染中的单核细胞/巨噬细胞：宿主防御、炎症和组织修复中的关键角色。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_13

Anuradha Rajamanickam, Subash Babu

{"title":"Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair.","authors":"Anuradha Rajamanickam, Subash Babu","doi":"10.1007/978-3-031-65944-7_13","DOIUrl":"10.1007/978-3-031-65944-7_13","url":null,"abstract":"Monocytes/macrophages are pivotal in host defense, inflammation, and tissue repair. They are actively engaged during helminth infections, playing critical roles in trapping pathogens, eliminating them, repairing tissue damage, and mitigating type 2 inflammation. These cells are indispensable in preserving physiological equilibrium and overseeing pathogen resistance as well as metabolic processes. Furthermore, these immune cells are influenced by cellular metabolism, which adjusts in response to host-derived factors and environmental cues. They secrete effector molecules crucial for anti-helminthic immunity and healing tissues damaged by parasites. Helminth parasites manipulate the immune regulatory capabilities of monocytes/macrophages by secreting anti-inflammatory mediators to dodge host defenses. Infections, especially with helminths, induce metabolic adaptations involving monocytes/macrophages that can lead to enhanced insulin sensitivity. This review provides a synthesis of the activation and diversity of monocytes/macrophages, their involvement in inflammation, and the latest insights into the strategies of monocyte/macrophage-mediated host defense against helminth infections. It also sheds light on recent discoveries concerning the immune regulatory interactions between monocytes/macrophages and helminth parasites.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"74 ","pages":"315-340"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Intracellular Communication in Cancer and Pathogen Spreading. 癌症和病原体传播中的细胞内通讯机制。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_13

Silvana Valdebenito, David Ajasin, Karl Valerdi, Yue Ran Liu, Samvrit Rao, Eliseo A Eugenin

引用次数: 0

Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions. 卵母细胞的健康和质量：线粒体相关细胞器相互作用的影响

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_2

Osamu Udagawa

引用次数: 0

Tunneling Nanotubes: The Cables for Viral Spread and Beyond. 隧道纳米管：病毒传播的电缆及其他

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_16

Divya Kapoor, Pankaj Sharma, Akash Saini, Eisa Azhar, James Elste, Ellen K Kohlmeir, Deepak Shukla, Vaibhav Tiwari

{"title":"Tunneling Nanotubes: The Cables for Viral Spread and Beyond.","authors":"Divya Kapoor, Pankaj Sharma, Akash Saini, Eisa Azhar, James Elste, Ellen K Kohlmeir, Deepak Shukla, Vaibhav Tiwari","doi":"10.1007/978-3-031-62036-2_16","DOIUrl":"10.1007/978-3-031-62036-2_16","url":null,"abstract":"Multicellular organisms require cell-to-cell communication to maintain homeostasis and thrive. For cells to communicate, a network of filamentous, actin-rich tunneling nanotubes (TNTs) plays a pivotal role in facilitating efficient cell-to-cell communication by connecting the cytoplasm of adjacent or distant cells. Substantial documentation indicates that diverse cell types employ TNTs in a sophisticated and intricately organized fashion for both long and short-distance communication. Paradoxically, several pathogens, including viruses, exploit the structural integrity of TNTs to facilitate viral entry and rapid cell-to-cell spread. These pathogens utilize a \"surfing\" mechanism or intracellular transport along TNTs to bypass high-traffic cellular regions and evade immune surveillance and neutralization. Although TNTs are present across various cell types in healthy tissue, their magnitude is increased in the presence of viruses. This heightened induction significantly amplifies the role of TNTs in exacerbating disease manifestations, severity, and subsequent complications. Despite significant advancements in TNT research within the realm of infectious diseases, further studies are imperative to gain a precise understanding of TNTs' roles in diverse pathological conditions. Such investigations are essential for the development of novel therapeutic strategies aimed at leveraging TNT-associated mechanisms for clinical applications. In this chapter, we emphasize the significance of TNTs in the life cycle of viruses, showcasing the potential for a targeted approach to impede virus-host cell interactions during the initial stages of viral infections. This approach holds promise for intervention and prevention strategies.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"73 ","pages":"375-417"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline and Somatic Cell Syncytia in Insects. 昆虫的生殖系和体细胞合胞体。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-37936-9_3

Malgorzata Kloc, Wacław Tworzydło, Teresa Szklarzewicz

{"title":"Germline and Somatic Cell Syncytia in Insects.","authors":"Malgorzata Kloc, Wacław Tworzydło, Teresa Szklarzewicz","doi":"10.1007/978-3-031-37936-9_3","DOIUrl":"10.1007/978-3-031-37936-9_3","url":null,"abstract":"Syncytia are common in the animal and plant kingdoms both under normal and pathological conditions. They form through cell fusion or division of a founder cell without cytokinesis. A particular type of syncytia occurs in invertebrate and vertebrate gametogenesis when the founder cell divides several times with partial cytokinesis producing a cyst (nest) of germ line cells connected by cytoplasmic bridges. The ultimate destiny of the cyst's cells differs between animal groups. Either all cells of the cyst become the gametes or some cells endoreplicate or polyploidize to become the nurse cells (trophocytes). Although many types of syncytia are permanent, the germ cell syncytium is temporary, and eventually, it separates into individual gametes. In this chapter, we give an overview of syncytium types and focus on the germline and somatic cell syncytia in various groups of insects. We also describe the multinuclear giant cells, which form through repetitive nuclear divisions and cytoplasm hypertrophy, but without cell fusion, and the accessory nuclei, which bud off the oocyte nucleus, migrate to its cortex and become included in the early embryonic syncytium.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"71 ","pages":"47-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138300240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages. 免疫代谢重新布线：宏量营养素与巨噬细胞的故事

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_3

Gerasimos Anagnostopoulos, Camille Blériot, Nicolas Venteclef, Florent Ginhoux

引用次数: 0

Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors. 巨噬细胞与乳腺癌细胞之间的相互影响：肿瘤内部的网络

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_8

Pooja Kamal Melwani, Rahul Checker, Murali Mohan Sagar Balla, Badri Narain Pandey

引用次数: 0