Results and Problems in Cell Differentiation最新文献_第4页

Correction to: Tunneling Nanotubes: The Cables for Viral Spread and Beyond. 更正：隧道纳米管：病毒传播的电缆及其他。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_23

Divya Kapoor, Pankaj Sharma, Akash Saini, Eisa Azhar, James Elste, Ellen K Kohlmeir, Deepak Shukla, Vaibhav Tiwari

引用次数: 0

Theranostic Diagnostics. Theranostic Diagnostics.

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_22

Mohammad Uzair Ali, Bharat N Chaudhary, Sudipta Panja, Howard E Gendelman

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Organelle Communication with the Nucleus. 细胞器与细胞核的交流

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_1

Sourabh Sengupta, Daniel L Levy

{"title":"Organelle Communication with the Nucleus.","authors":"Sourabh Sengupta, Daniel L Levy","doi":"10.1007/978-3-031-62036-2_1","DOIUrl":"10.1007/978-3-031-62036-2_1","url":null,"abstract":"Compartmentalization of cellular components is critical to the spatiotemporal and environmental regulation of biochemical activities inside a cell, ensures the proper division of cellular labor and resources, and increases the efficiency of metabolic processes. However, compartmentalization also poses a challenge as organelles often need to communicate across these compartments to complete reaction pathways. These communication signals are often critical aspects of the cellular response to changing environmental conditions. A central signaling hub in the cell, the nucleus communicates with mitochondria, lysosomes, the endoplasmic reticulum, and the Golgi body to ensure optimal organellar and cellular performance. Here we review different mechanisms by which these organelles communicate with the nucleus, focusing on anterograde and retrograde signaling of mitochondria, localization-based signaling of lysosomes, the unfolded protein response of the endoplasmic reticulum, and evidence for nucleus-Golgi signaling. We also include a brief overview of some less well-characterized mechanisms of communication between non-nuclear organelles.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"73 ","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Biological Significance of Trogocytosis. 逆行吞噬的生物学意义。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_5

Deborah Agbakwuru, Scott A Wetzel

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Liver Macrophage Diversity in Health and Disease. 健康与疾病中的肝脏巨噬细胞多样性

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_7

Paul Horn, Frank Tacke

{"title":"Liver Macrophage Diversity in Health and Disease.","authors":"Paul Horn, Frank Tacke","doi":"10.1007/978-3-031-65944-7_7","DOIUrl":"https://doi.org/10.1007/978-3-031-65944-7_7","url":null,"abstract":"The liver fulfils a plethora of metabolic and immunological functions. Liver macrophages are a heterogeneous immune cell population with high plasticity and are important for maintaining normal liver function but are also critically involved in disease processes. In this chapter, we review the heterogeneity and multifaceted functions of hepatic macrophages in liver health and in disease conditions, including acute liver injury, chronic liver diseases, and hepatocellular carcinoma. Under homeostatic conditions, the tissue resident Kupffer cells are phagocytic cells that have important functions in immune surveillance, antigen presentation, and metabolic regulation while the roles of other populations such as capsular, peritoneal, or monocyte-derived macrophages in liver health are less clearly defined. Upon liver injury, Kupffer cell numbers are markedly reduced while monocyte-derived macrophages significantly expand and take critical roles in driving and resolving liver injury, including important pathogenic involvements in inflammation, fibrosis, and regeneration. They also create and maintain an immunosuppressive and immune-excluded microenvironment in hepatocellular carcinoma. Single-cell and spatial omics technologies are significantly expanding our understanding of the diversity and plasticity of macrophage populations under different conditions and enable the reliable identification of specific hepatic macrophage subsets. This knowledge can now be applied to dissect the exact contributions of distinct macrophage populations to disease processes and hopefully will pave the way for new therapeutic interventions.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"74 ","pages":"175-209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular Communication Through Microtubular Highways. 通过微管高速公路进行细胞间通信

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_8

Lorél Y Medina, Rita E Serda

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Reciprocal Interactions Between the Epithelium and Mesenchyme in Organogenesis. 器官形成过程中上皮细胞和间充质之间的相互影响

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_7

Hisato Kondoh

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Intercellular Highways in Transport Processes. 运输过程中的细胞间通道。

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62036-2_9

Edina Szabó-Meleg

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Macrophage Cell Cycle. 巨噬细胞的细胞周期

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-65944-7_4

Louis Dillac, Leon El Dika, Rahim Ullah, Jacek Z Kubiak, Malgorzata Kloc

引用次数: 0

Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm. 调控发育基因的增强子阵列：以 Sox2 增强子为范例

Results and Problems in Cell Differentiation Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-39027-2_9

Hisato Kondoh

{"title":"Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm.","authors":"Hisato Kondoh","doi":"10.1007/978-3-031-39027-2_9","DOIUrl":"10.1007/978-3-031-39027-2_9","url":null,"abstract":"Enhancers are the primary regulatory DNA sequences in eukaryotes and are mostly located in the non-coding sequences of genes, namely, intergenic regions and introns. The essential characteristic of an enhancer is the ability to activate proximal genes, e.g., a reporter gene in a reporter assay, regardless of orientation, relative position, and distance from the gene. These characteristics are ascribed to the interaction (spatial proximity) of the enhancer sequence and the gene promoter via DNA looping, discussed in the latter part of this chapter.Developmentally regulated genes are associated with multiple enhancers carrying distinct cell and developmental stage specificities, which form arrays on the genome. We discuss the array of enhancers regulating the Sox2 gene as a paradigm. Sox2 enhancers are the best studied enhancers of a single gene in developmental regulation. In addition, the Sox2 gene is located in a genomic region with a very sparse gene distribution (no other protein-coding genes in ~1.6 Mb in the mouse genome), termed a \"gene desert,\" which means that most identified enhancers in the region are associated with Sox2 regulation. Furthermore, the importance of the Sox2 gene in stem cell regulation and neural development justifies focusing on Sox2-associated enhancers.","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"72 ","pages":"145-166"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0