Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity.

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2025-01-01 DOI:10.1007/978-3-031-91459-1_8

Alessandra Dominicis, Tommaso Fabiano, Simone Peria, Aland Ibrahim Ahmed Al Jaf, Antonella Ragnini-Wilson

{"title":"Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity.","authors":"Alessandra Dominicis, Tommaso Fabiano, Simone Peria, Aland Ibrahim Ahmed Al Jaf, Antonella Ragnini-Wilson","doi":"10.1007/978-3-031-91459-1_8","DOIUrl":null,"url":null,"abstract":"<p><p>Myelin plasticity is a key process for acquiring new motor skills and preventing neurodegeneration during ageing. Neural precursor cells (NPCs) and parenchymal oligodendrocyte precursor cells (OPCs) play a key role in myelin plasticity in the central nervous system (CNS), being specialized in reconstituting the myelin sheath upon damage. Reversible acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) activity, controls these stem cells' differentiation in myelinating oligodendrocytes (mOLs) during their proliferation and remyelination processes. By modulating cytosolic protein activity and precisely orchestrating the spatial and timely regulated activity of the transcription factors participating in the NPC and OPC differentiation process, these enzymes play a vital role in preserving the adult brain's cognitive capacity during ageing. This review highlights the role of reversible acetylation in the regulation of stem cell differentiation during remyelination, as disruptions in this process contribute to severe neurodegenerative impairments and accelerated ageing.</p>","PeriodicalId":39320,"journal":{"name":"Results and Problems in Cell Differentiation","volume":"75 ","pages":"213-246"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results and Problems in Cell Differentiation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-031-91459-1_8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

Abstract

Myelin plasticity is a key process for acquiring new motor skills and preventing neurodegeneration during ageing. Neural precursor cells (NPCs) and parenchymal oligodendrocyte precursor cells (OPCs) play a key role in myelin plasticity in the central nervous system (CNS), being specialized in reconstituting the myelin sheath upon damage. Reversible acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) activity, controls these stem cells' differentiation in myelinating oligodendrocytes (mOLs) during their proliferation and remyelination processes. By modulating cytosolic protein activity and precisely orchestrating the spatial and timely regulated activity of the transcription factors participating in the NPC and OPC differentiation process, these enzymes play a vital role in preserving the adult brain's cognitive capacity during ageing. This review highlights the role of reversible acetylation in the regulation of stem cell differentiation during remyelination, as disruptions in this process contribute to severe neurodegenerative impairments and accelerated ageing.

查看原文本刊更多论文

组蛋白乙酰转移酶和组蛋白去乙酰化酶对成人脑髓磷脂可塑性的影响。

髓磷脂可塑性是在衰老过程中获得新的运动技能和防止神经退行性变的关键过程。神经前体细胞（Neural precursor cells, npc）和实质少突胶质前体细胞（parenchymal oligodendrocytes precursor cells, OPCs）在中枢神经系统（central nervous system， CNS）髓磷脂可塑性中起着关键作用，它们专门负责髓鞘损伤后的重建。可逆乙酰化由组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（hdac）活性调控，在髓鞘少突胶质细胞（mOLs）增殖和再髓鞘形成过程中控制着干细胞的分化。这些酶通过调节胞质蛋白活性，精确地协调参与NPC和OPC分化过程的转录因子的空间和及时调节活性，在保持衰老过程中成人大脑的认知能力方面发挥重要作用。这篇综述强调了可逆乙酰化在髓鞘再生过程中干细胞分化调控中的作用，因为这一过程的破坏会导致严重的神经退行性损伤和加速衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.