Bradley J Edelman, Shuailei Zhang, Gerwin Schalk, Peter Brunner, Gernot Muller-Putz, Cuntai Guan, Bin He
{"title":"Non-invasive Brain-Computer Interfaces: State of the Art and Trends.","authors":"Bradley J Edelman, Shuailei Zhang, Gerwin Schalk, Peter Brunner, Gernot Muller-Putz, Cuntai Guan, Bin He","doi":"10.1109/RBME.2024.3449790","DOIUrl":"https://doi.org/10.1109/RBME.2024.3449790","url":null,"abstract":"<p><p>Brain-computer interface (BCI) is a rapidly evolving technology that has the potential to widely influence research, clinical and recreational use. Non-invasive BCI approaches are particularly common as they can impact a large number of participants safely and at a relatively low cost. Where traditional non-invasive BCIs were used for simple computer cursor tasks, it is now increasingly common for these systems to control robotic devices for complex tasks that may be useful in daily life. In this review, we provide an overview of the general BCI framework as well as the various methods that can be used to record neural activity, extract signals of interest, and decode brain states. In this context, we summarize the current state-of-the-art of non-invasive BCI research, focusing on trends in both the application of BCIs for controlling external devices and algorithm development to optimize their use. We also discuss various open-source BCI toolboxes and software, and describe their impact on the field at large.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isaiah Lahr, Saghir Alfasly, Peyman Nejat, Jibran Khan, Luke Kottom, Vaishnavi Kumbhar, Areej Alsaafin, Abubakr Shafique, Sobhan Hemati, Ghazal Alabtah, Nneka Comfere, Dennis Murphree, Aaron Mangold, Saba Yasir, Chady Meroueh, Lisa Boardman, Vijay H Shah, Joaquin J Garcia, H R Tizhoosh
{"title":"Analysis and Validation of Image Search Engines in Histopathology.","authors":"Isaiah Lahr, Saghir Alfasly, Peyman Nejat, Jibran Khan, Luke Kottom, Vaishnavi Kumbhar, Areej Alsaafin, Abubakr Shafique, Sobhan Hemati, Ghazal Alabtah, Nneka Comfere, Dennis Murphree, Aaron Mangold, Saba Yasir, Chady Meroueh, Lisa Boardman, Vijay H Shah, Joaquin J Garcia, H R Tizhoosh","doi":"10.1109/RBME.2024.3425769","DOIUrl":"https://doi.org/10.1109/RBME.2024.3425769","url":null,"abstract":"<p><p>Searching for similar images in archives of histology and histopathology images is a crucial task that may aid in patient tissue comparison for various purposes, ranging from triaging and diagnosis to prognosis and prediction. Whole slide images (WSIs) are highly detailed digital representations of tissue specimens mounted on glass slides. Matching WSI to WSI can serve as the critical method for patient tissue comparison. In this paper, we report extensive analysis and validation of four search methods bag of visual words (BoVW), Yottixel, SISH, RetCCL, and some of their potential variants. We analyze their algorithms and structures and assess their performance. For this evaluation, we utilized four internal datasets (1269 patients) and three public datasets (1207 patients), totaling more than 200, 000 patches from 38 different classes/subtypes across five primary sites. Certain search engines, for example, BoVW, exhibit notable efficiency and speed but suffer from low accuracy. Conversely, search engines like Yottixel demonstrate efficiency and speed, providing moderately accurate results. Recent proposals, including SISH, display inefficiency and yield inconsistent outcomes, while alternatives like RetCCL prove inadequate in both accuracy and efficiency. Further research is imperative to address the dual aspects of accuracy and minimal storage requirements in histopathological image search.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnaBelen Amado-Rey, AnaCarolina GoncalvesSeabra, Thomas Stieglitz
{"title":"Towards ultrasound wearable technology for cardiovascular monitoring: from device development to clinical validation.","authors":"AnaBelen Amado-Rey, AnaCarolina GoncalvesSeabra, Thomas Stieglitz","doi":"10.1109/RBME.2024.3410399","DOIUrl":"10.1109/RBME.2024.3410399","url":null,"abstract":"<p><p>The advent of flexible, compact, energy-efficient, robust, and user-friendly wearables has significantly impacted the market growth, with an estimated value of 61.30 billion USD in 2022. Wearable sensors have revolutionized in-home health monitoring by warranting continuous measurements of vital parameters. Ultrasound is used to non-invasively, safely, and continuously record vital parameters. The next generation of smart ultrasonic devices for healthcare integrates microelectronics with flexible, stretchable patches and body-conformable devices. They offer not only wearability, and user comfort, but also higher tracking accuracy of immediate changes of cardiovascular parameters. Moreover, due to the fixed adhesion to the skin, errors derived from probe placement or patient movement are mitigated, even though placement at the correct anatomical location is still critical and requires a user's skill and knowledge. In this review, the steps required to bring wearable ultrasonic systems into the medical market (technologies, device development, signal-processing, in-lab validation, and, finally, clinical validation) are discussed. The next generation of vascular ultrasound and its future research directions offer many possibilities for modernizing vascular health assessment and the quality of personalized care for home and clinical monitoring.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phillip Sloan, Philip Clatworthy, Edwin Simpson, Majid Mirmehdi
{"title":"Automated Radiology Report Generation: A Review of Recent Advances.","authors":"Phillip Sloan, Philip Clatworthy, Edwin Simpson, Majid Mirmehdi","doi":"10.1109/RBME.2024.3408456","DOIUrl":"https://doi.org/10.1109/RBME.2024.3408456","url":null,"abstract":"<p><p>Increasing demands on medical imaging departments are taking a toll on the radiologist's ability to deliver timely and accurate reports. Recent technological advances in artificial intelligence have demonstrated great potential for automatic radiology report generation (ARRG), sparking an explosion of research. This survey paper conducts a methodological review of contemporary ARRG approaches by way of (i) assessing datasets based on characteristics, such as availability, size, and adoption rate, (ii) examining deep learning training methods, such as contrastive learning and reinforcement learning, (iii) exploring state-of-the-art model architectures, including variations of CNN and transformer models, (iv) outlining techniques integrating clinical knowledge through multimodal inputs and knowledge graphs, and (v) scrutinising current model evaluation techniques, including commonly applied NLP metrics and qualitative clinical reviews. Furthermore, the quantitative results of the reviewed models are analysed, where the top performing models are examined to seek further insights. Finally, potential new directions are highlighted, with the adoption of additional datasets from other radiological modalities and improved evaluation methods predicted as important areas of future development.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia.","authors":"Fahimeh Marvi, Yun-Hsuan Chen, Mohamad Sawan","doi":"10.1109/RBME.2024.3376835","DOIUrl":"https://doi.org/10.1109/RBME.2024.3376835","url":null,"abstract":"<p><p>Alzheimer's disease (AD) progressively impairs the memory and thinking skills of patients, resulting in a significant global economic and social burden each year. However, diagnosis of this neurodegenerative disorder can be challenging, particularly in the early stages of developing cognitive decline. Current clinical techniques are expensive, laborious, and invasive, which hinders comprehensive studies on Alzheimer's biomarkers and the development of efficient devices for Point-of-Care testing (POCT) applications. To address these limitations, researchers have been investigating various biosensing techniques. Unfortunately, these methods have not been commercialized due to several drawbacks, such as low efficiency, reproducibility, and the lack of accurate identification of AD markers. In this review, we present diverse promising hallmarks of Alzheimer's disease identified in various biofluids and body behaviors. Additionally, we thoroughly discuss different biosensing mechanisms and the associated challenges in disease diagnosis. In each context, we highlight the potential of realizing new biosensors to study various features of the disease, facilitating its early diagnosis in POCT. This comprehensive study, focusing on recent efforts for different aspects of the disease and representing promising opportunities, aims to conduct the future trend toward developing a new generation of compact multipurpose devices that can address the challenges in the early detection of AD.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucose Fuel Cells: Electricity from Blood Sugar.","authors":"Robert G Gloeb-McDonald, Gene Fridman","doi":"10.1109/RBME.2024.3368662","DOIUrl":"https://doi.org/10.1109/RBME.2024.3368662","url":null,"abstract":"<p><p>Harvesting energy from the human body is an area of growing interest. While several techniques have been explored, the focus in the field is converging on using Glucose Fuel Cells (GFCs) that use glucose oxidation reactions at an anode and oxygen reduction reactions (ORRs) at a cathode to create a voltage gradient that can be stored as power. To facilitate these reactions, catalysts are immobilized at an anode and cathode that result in electrochemistry that typically produces two electrons, a water molecule, and gluconic acid. There are two competing classes of these catalysts: enzymes, which use organic proteins, and abiotic options, which use reactive metals. Enzymatic catalysts show better specificity towards glucose, whereas abiotic options show superior operational stability. The most advanced enzymatic test showed a maximum power density of 119 μW/cm<sup>2</sup> and an efficiency loss of 4% over 15 hours of operation. The best abiotic experiment resulted in 43 μW/cm<sup>2</sup> and exhibited no signs of performance loss after 140 hours. Given the range of existing implantable devices' power budget from 10μW to 100mW and expected operational duration of 10 years or more, GFCs hold promise, but considerable advances need to be made to translate this technology to practical applications.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luyang Luo, Xi Wang, Yi Lin, Xiaoqi Ma, Andong Tan, Ronald Chan, Varut Vardhanabhuti, Winnie Cw Chu, Kwang-Ting Cheng, Hao Chen
{"title":"Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions.","authors":"Luyang Luo, Xi Wang, Yi Lin, Xiaoqi Ma, Andong Tan, Ronald Chan, Varut Vardhanabhuti, Winnie Cw Chu, Kwang-Ting Cheng, Hao Chen","doi":"10.1109/RBME.2024.3357877","DOIUrl":"10.1109/RBME.2024.3357877","url":null,"abstract":"<p><p>Breast cancer has reached the highest incidence rate worldwide among all malignancies since 2020. Breast imaging plays a significant role in early diagnosis and intervention to improve the outcome of breast cancer patients. In the past decade, deep learning has shown remarkable progress in breast cancer imaging analysis, holding great promise in interpreting the rich information and complex context of breast imaging modalities. Considering the rapid improvement in deep learning technology and the increasing severity of breast cancer, it is critical to summarize past progress and identify future challenges to be addressed. This paper provides an extensive review of deep learning-based breast cancer imaging research, covering studies on mammograms, ultrasound, magnetic resonance imaging, and digital pathology images over the past decade. The major deep learning methods and applications on imaging-based screening, diagnosis, treatment response prediction, and prognosis are elaborated and discussed. Drawn from the findings of this survey, we present a comprehensive discussion of the challenges and potential avenues for future research in deep learning-based breast cancer imaging.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neil Upreti, Geonsoo Jin, Joseph Rich, Ruoyu Zhong, John Mai, Chenglong Zhao, Tony Jun Huang
{"title":"Advances in Microsphere-based Super-resolution Imaging.","authors":"Neil Upreti, Geonsoo Jin, Joseph Rich, Ruoyu Zhong, John Mai, Chenglong Zhao, Tony Jun Huang","doi":"10.1109/RBME.2024.3355875","DOIUrl":"10.1109/RBME.2024.3355875","url":null,"abstract":"<p><p>Techniques to resolve images beyond the diffraction limit of light with a large field of view (FOV) are necessary to foster progress in various fields such as cell and molecular biology, biophysics, and nanotechnology, where nanoscale resolution is crucial for understanding the intricate details of large-scale molecular interactions. Although several means of achieving super-resolutions exist, they are often hindered by factors such as high costs, significant complexity, lengthy processing times, and the classical tradeoff between image resolution and FOV. Microsphere-based super-resolution imaging has emerged as a promising approach to address these limitations. In this review, we delve into the theoretical underpinnings of microsphere-based imaging and the associated photonic nanojet. This is followed by a comprehensive exploration of various microsphere-based imaging techniques, encompassing static imaging, mechanical scanning, optical scanning, and acoustofluidic scanning methodologies. This review concludes with a forward-looking perspective on the potential applications and future scientific directions of this innovative technology.</p>","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Engineering in Medicine and Biology Society Information","authors":"","doi":"10.1109/RBME.2023.3333510","DOIUrl":"https://doi.org/10.1109/RBME.2023.3333510","url":null,"abstract":"","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":17.6,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10398579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}