Clinical Microbiology Newsletter最新文献_第4页

A Day in the Life of a Medical Microbiology Fellow: Four Perspectives 医学微生物学研究员的一天:四个视角

Clinical Microbiology Newsletter Pub Date : 2023-10-01 DOI: 10.1016/j.clinmicnews.2023.11.001

Jennifer D. Bowling Ph.D., MLS(ASCP)CM , Hannah K. Gray Ph.D., M(ASCP)CM , Esther Vaugon M.D. , Lucas J. Osborn Ph.D., MLS(ASCP)CM

{"title":"A Day in the Life of a Medical Microbiology Fellow: Four Perspectives","authors":"Jennifer D. Bowling Ph.D., MLS(ASCP)CM , Hannah K. Gray Ph.D., M(ASCP)CM , Esther Vaugon M.D. , Lucas J. Osborn Ph.D., MLS(ASCP)CM","doi":"10.1016/j.clinmicnews.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2023.11.001","url":null,"abstract":"<div>Medical microbiology is a dynamic science essential to the clinical diagnosis and management of infectious diseases. Medical microbiologists serve as content experts in bacteria, fungi, viruses, and parasites as they pertain to human infections. There are several different paths one may take to become the director of a medical microbiology laboratory, the most common of which are enrollment in an Accreditation Council for Graduate Medical Education (ACGME)-approved fellowship for applicants with medical degrees or an American Society for Microbiology (ASM) Subcommittee on Post-Graduate Education Programs (CPEP) fellowship for those with a Ph.D., M.D., Sc.D., D.O. and Dr. P.H. Upon completion of either track, fellows are eligible to sit for the American Board of Medical Microbiology (ABMM) examination. Additional eligibility tracks are available for equivalent training experiences in Canada and also through non-fellowship medical microbiology experience.A day in the life of a medical microbiology fellow can vary drastically but can typically be summarized by three primary responsibilities in descending order of effort: clinical service, research, and teaching. A medical microbiology fellowship represents an opportunity to acquire new knowledge, apply what you have learned, and develop the skills necessary to direct a laboratory. While all fellowship programs lead to eligibility for the ABMM examination, certain aspects are unique to the training experience at each program. Here, we present the distinct perspectives of four current medical microbiology fellows, highlighting the common themes and diversity of experiences leading up to and during fellowship.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 19","pages":"Pages 159-166"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echinococcus multilocularis and Alveolar Echinococcosis: Should We Be Concerned?

Clinical Microbiology Newsletter Pub Date : 2023-09-15 DOI: 10.1016/j.clinmicnews.2023.10.001

Kinga T. Kowalewska-Grochowska M.D., FRCP(C)

{"title":"Echinococcus multilocularis and Alveolar Echinococcosis: Should We Be Concerned?","authors":"Kinga T. Kowalewska-Grochowska M.D., FRCP(C)","doi":"10.1016/j.clinmicnews.2023.10.001","DOIUrl":"10.1016/j.clinmicnews.2023.10.001","url":null,"abstract":"<div><div>Alveolar echinococcosis (AE) is a life-threatening zoonotic infection caused by Echinococcus multilocularis, an intestinal cestode of carnivorous animals (mostly canids). Its life cycle includes an adult stage in the intestines of carnivores and a larval stage (metacestode) in tissues of herbivores or omnivores. Humans are accidental/aberrant hosts and harbor the metacestode only. The disease presents as a continuously growing tumor-like liver mass with local or metastatic spread to distant organs, with mortality approaching 90% if untreated or partially treated. Diagnosis is based on characteristic imaging, serology and histopathology, and confirmation by nucleic acid amplification test. The geographical distribution of E. multilocularis covers most of the northern hemisphere, with human cases in Europe, Japan, Central Asia, and now North America. The recent establishment of a new parasite strain that is pathogenic to humans in Canada and the United States poses an emerging medical and public health threat and warrants a reassessment of our approach to this parasite.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 18","pages":"Pages 151-156"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143212136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A Special Invitation to Authors

Clinical Microbiology Newsletter Pub Date : 2023-09-15 DOI: 10.1016/j.clinmicnews.2023.10.002

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Chagas Disease: a Review and Perspective on Laboratory Diagnostics in the United States 查加斯病：美国实验室诊断的回顾与展望

Clinical Microbiology Newsletter Pub Date : 2023-09-01 DOI: 10.1016/j.clinmicnews.2023.09.001

Jeffrey D. Whitman

{"title":"Chagas Disease: a Review and Perspective on Laboratory Diagnostics in the United States","authors":"Jeffrey D. Whitman","doi":"10.1016/j.clinmicnews.2023.09.001","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2023.09.001","url":null,"abstract":"<div>Chagas disease is a chronic infection by the protozoan parasite Trypanosoma cruzi. The epidemiology of the disease results from the distribution of its arthropod vector, the triatomine bug, throughout Latin America and the southern United States, as well as migration of chronically infected individuals worldwide. In mammals, the parasite cycles through an extracellular infective form and an intracellular replicative form with tropism for cardiac and gastrointestinal (GI) tissues. Over decades, the low-grade inflammatory response can lead to cardiomyopathy and GI dysmotility disorders. This natural history necessitates presentation-dependent diagnostic approaches for clinical workup and risk-based screening, as well as blood donor and organ transplant screening. Implementing effective Chagas disease testing in the U.S. is an increasing topic of interest but is hindered by low provider awareness, few FDA-cleared assays, and limited laboratory capacity for multi-step confirmatory testing. This article provides a clinically focused review of Chagas disease, outlines the current status of clinical testing in the U.S., and reports on new innovations in diagnostics and research that may impact the field.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 17","pages":"Pages 141-149"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49750033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2023-09-01 DOI: 10.1016/j.clinmicnews.2023.09.002

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A Brief Summary of the Current Role of Human Papillomavirus Testing in Cervical Cancer Screening 人类乳头瘤病毒检测在宫颈癌症筛查中的作用综述

Clinical Microbiology Newsletter Pub Date : 2023-08-15 DOI: 10.1016/j.clinmicnews.2023.08.002

Tam T. Van Ph.D., D(ABMM)

引用次数: 0

An Update on Schistosomiasis 血吸虫病研究进展

Clinical Microbiology Newsletter Pub Date : 2023-08-01 DOI: 10.1016/j.clinmicnews.2023.08.001

L. Payne , P.L. Chiodini , A.L. Bustinduy

{"title":"An Update on Schistosomiasis","authors":"L. Payne , P.L. Chiodini , A.L. Bustinduy","doi":"10.1016/j.clinmicnews.2023.08.001","DOIUrl":"10.1016/j.clinmicnews.2023.08.001","url":null,"abstract":"<div>Human schistosomiasis is caused by trematode parasites of the genus Schistosoma. Four species and two distinct clinical syndromes are relevant to humans, including S. haematobium, which is associated with urogenital schistosomiasis, whereas S. mansoni, S. mekongi, and S. japonicum are responsible for intestinal schistosomiasis. These flukes reside in the venous plexus of the human bladder and in mesenteric veins and release eggs that, when trapped in tissues, cause inflammation and fibrosis. More specifically, S. mansoni, S. mekongi, and S. japonicum can cause intestinal inflammation, hepatosplenic periportal fibrosis, portal hypertension, and esophageal varices that can bleed and cause death. In contrast, S. haematobium, a recognized carcinogenic organism, can drive bladder carcinoma and contribute to infertility and cervical cancer. Additionally, schistosomiasis can cause general anaemia, stunted growth, and cognitive impairment.Despite the chronic complications associated with schistosomiasis, public awareness in areas of non-endemicity is limited, and travelers rarely consider risk of infection. We describe the diagnostics available in areas of endemicity, as well as in reference laboratories, to diagnose schistosomiasis in returning travelers or migrants to resource-rich locations.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 15","pages":"Pages 125-132"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47232788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A special invitation to authors 对作者的特别邀请

Clinical Microbiology Newsletter Pub Date : 2023-07-15 DOI: 10.1016/j.clinmicnews.2023.07.004

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Pharmacokinetic-Pharmacodynamic and Clinical Considerations for Extended- and Continuous-Infusion Antibiotics 长期和连续输注抗生素的药代动力学、药效学和临床考虑

Clinical Microbiology Newsletter Pub Date : 2023-07-15 DOI: 10.1016/j.clinmicnews.2023.07.003

Anne M. Masich Pharm. D., BCPS, Nicole E. Omecene Pharm. D., BCPPS, Jessica Lai Pharm. D. Candidate 2024, Ryan Ong Pharm. D. Candidate 2024, Leigh Anne Hylton Gravatt Pharm. D., BCPS, Rachel W. Khan Pharm. D., BCPS

{"title":"Pharmacokinetic-Pharmacodynamic and Clinical Considerations for Extended- and Continuous-Infusion Antibiotics","authors":"Anne M. Masich Pharm. D., BCPS, Nicole E. Omecene Pharm. D., BCPPS, Jessica Lai Pharm. D. Candidate 2024, Ryan Ong Pharm. D. Candidate 2024, Leigh Anne Hylton Gravatt Pharm. D., BCPS, Rachel W. Khan Pharm. D., BCPS","doi":"10.1016/j.clinmicnews.2023.07.003","DOIUrl":"10.1016/j.clinmicnews.2023.07.003","url":null,"abstract":"<div>Antibiotics are the most widely used treatment for infections yet there has been minimal antibiotic discovery in recent years despite rising drug resistance and treatment failures. A better understanding of antibiotic pharmacokinetics (PK) and pharmacodynamics (PD), along with the development of novel dosing strategies, such as extended (EI) and continuous infusions (CI), has helped to overcome these barriers. Studies have consistently demonstrated that EI/CI administration of beta-lactams and vancomycin in particular, improves PK-PD target attainment compared to intermittent infusions. However, the effects of EI/CI on clinical outcomes, including efficacy and safety, remain controversial. Emerging data focus on patient populations with altered PK that may benefit from EI/CI beta-lactams or vancomycin (e.g., critically ill, cystic fibrosis, or outpatient parenteral antibiotic therapy). Logistical barriers limit EI/CI use in practice, including intravenous access, drug stability and drug incompatibility. This review highlights beta-lactam and vancomycin PK-PD, EI/CI dosing strategies and relevant evidence for practice.</div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"45 14","pages":"Pages 115-123"},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48920380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Microbiology Newsletter Pub Date : 2023-07-14 eCollection Date: 2023-01-01 DOI: 10.5334/cie.58

Livia Buratta, Elisa Delvecchio, Michele Capurso, Claudia Mazzeschi

{"title":"Health-Related Quality of Life in Children with Overweight and Obesity: An Explorative Study Focused on School Functioning and Well-being.","authors":"Livia Buratta, Elisa Delvecchio, Michele Capurso, Claudia Mazzeschi","doi":"10.5334/cie.58","DOIUrl":"10.5334/cie.58","url":null,"abstract":"Overweight and obesity in childhood has reached epidemic levels, and their roles in physical and psychological health are now recognized. Recently, researchers have focused on the impact of these weight problems in health-related quality of life (HRQoL) domains, which are less investigated in children. This exploratory study examined the differences in HRQoL domains between a clinical group who were overweight/obesity treatment-seeking (n = 58) and a normal-weight group (n = 44) in a sample of 102 children, with a specific focus on school functioning and well-being. The second aim explored the link between our findings and other HRQoL dimensions. After controlling for sex and age, a multivariate analysis of variance showed lower levels in school functioning and well-being dimensions between overweight/obesity than normal-weight (F = 4.72; p < 0.05). Correlation analyses highlighted positive links between lower school functioning and well-being and lower levels of self-esteem (r = 0.308; p < 0.01) and social domains in terms of friendships (r = 0.522 ; p < 0.001) and family relationships (r = 0.561; p < 0.001) in children who were with overweight and obesity. This study discusses the implications of these findings in educational research and practices.","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"24 1","pages":"96-104"},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78450189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0