Clinical Microbiology Newsletter最新文献_第3页

Microbe snapshots: Dengue virus 微生物快照：登革热病毒

Clinical Microbiology Newsletter Pub Date : 2024-11-26 DOI: 10.1016/j.clinmicnews.2024.11.002

Samuel M. Goodfellow , Esther Vaugon

引用次数: 0

Peritoneal Tuberculosis: Navigating diagnostic challenges 腹膜结核：导航诊断挑战

Clinical Microbiology Newsletter Pub Date : 2024-11-22 DOI: 10.1016/j.clinmicnews.2024.11.001

Reanay Berezovskiy , Meher Sultana , Jason Guyotte , Daria Yunina-Distefano , Niyati Goradia , Irene E. Rossmer

引用次数: 0

Bilateral otitis media as an initial manifestation of disseminated tuberculosis disease in a patient with late HIV infection diagnosis 双侧中耳炎是一名晚期艾滋病毒感染患者播散性结核病的初期表现

Clinical Microbiology Newsletter Pub Date : 2024-11-07 DOI: 10.1016/j.clinmicnews.2024.10.004

Victoria Lobo-Antuña , Marta Lobo-Antuña , Juan Martínez-Andrés , Cristina Rodríguez-Prado , María Remedios Guna-Serrano , Atilio Navarro-Gonzales , Magdalena García-Rodríguez , Carmen Ricart-Olmos

{"title":"Bilateral otitis media as an initial manifestation of disseminated tuberculosis disease in a patient with late HIV infection diagnosis","authors":"Victoria Lobo-Antuña , Marta Lobo-Antuña , Juan Martínez-Andrés , Cristina Rodríguez-Prado , María Remedios Guna-Serrano , Atilio Navarro-Gonzales , Magdalena García-Rodríguez , Carmen Ricart-Olmos","doi":"10.1016/j.clinmicnews.2024.10.004","DOIUrl":"10.1016/j.clinmicnews.2024.10.004","url":null,"abstract":"<div><div>Tuberculous otitis media is a rare form of extrapulmonary tuberculosis, often resulting in delayed diagnosis due to its nonspecific symptoms and low clinical suspicion. We present the case of a 29-year-old woman with initial symptoms of sudden speech impairment without other neurological manifestations. In the previous 3 months, the patient had consulted several times to the health care system due to bilateral otitis media, which did not improve with conventional treatments. Daily fever, diarrhea and weight loss were added to the picture. After admission to the Infectious Diseases department, she was diagnosed with advanced HIV infection and disseminated tuberculosis (TB) with pulmonary, intestinal, lymph node and otic involvement. This case underlines the complexity of diagnosing TB otitis media, especially in the context of HIV co-infection, and highlights the importance of routine HIV screening in patients with persistent, unexplained symptoms to facilitate early diagnosis and prevent complications.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"50 ","pages":"Pages 1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medically important alphaviruses in the United States and how to test for them 美国医学上重要的字母病毒及其检测方法

Clinical Microbiology Newsletter Pub Date : 2024-11-04 DOI: 10.1016/j.clinmicnews.2024.10.003

Allison R. Eberly

{"title":"Medically important alphaviruses in the United States and how to test for them","authors":"Allison R. Eberly","doi":"10.1016/j.clinmicnews.2024.10.003","DOIUrl":"10.1016/j.clinmicnews.2024.10.003","url":null,"abstract":"<div><div>Alphaviruses are arthropod-borne viruses (i.e. arboviruses) transmitted by mosquitos that are classically divided into two groups that infect humans: encephalitic and arthralgia-associated. While the encephalitic alphaviruses are primarily endemic in North and South America, alphaviruses associated with arthralgia are distributed globally. Given the overlapping clinical manifestations of alphaviruses with other arboviruses, diagnosis is dependent on both exposure history and laboratory testing. In the United States, diagnostic approaches largely rely on detection of host antibodies against these viruses via enzyme-linked immunosorbent assays (ELISAs) or indirect immunofluorescence assays (IFAs) in serum and/or cerebrospinal fluid. Positive results can be confirmed by plaque reduction neutralization testing (PRNT), which remains the reference standard method for anti-alphavirus antibody detection. Increasingly, select public health and reference laboratories are also offering molecular testing for certain alphaviruses, including chikungunya virus and Eastern equine encephalitis virus. Molecular testing, however, is most useful in acutely ill, viremic patients who present within the first week of symptom onset. There are no targeted antivirals for treatment, and prevention relies on protection from mosquito bites.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"49 ","pages":"Pages 28-36"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current scenario and future prospect of scabies treatment: A comprehensive review 疥疮治疗的现状与前景：全面回顾

Clinical Microbiology Newsletter Pub Date : 2024-10-16 DOI: 10.1016/j.clinmicnews.2024.10.002

Nishan Hazra , Soutik Sarkar , Srijita Chakrabarti

引用次数: 0

“Eye see worms on the down Loa”: A case study of microfilarial co-infection "眼见虫子下罗亚"：微丝蚴合并感染病例研究

Clinical Microbiology Newsletter Pub Date : 2024-10-10 DOI: 10.1016/j.clinmicnews.2024.10.001

Christopher George Kendra , Kevin Andrew Smith , Trina Trusty , Amber Ryan , Kenneth Gavina

引用次数: 0

General perspectives on dengue fever 关于登革热的一般观点

Clinical Microbiology Newsletter Pub Date : 2024-09-24 DOI: 10.1016/j.clinmicnews.2024.09.002

Oluwabunmi Bola Olajide , Joshua Seun Olajide , Olusanya Olasehinde

{"title":"General perspectives on dengue fever","authors":"Oluwabunmi Bola Olajide , Joshua Seun Olajide , Olusanya Olasehinde","doi":"10.1016/j.clinmicnews.2024.09.002","DOIUrl":"10.1016/j.clinmicnews.2024.09.002","url":null,"abstract":"<div><div>Dengue is the leading arboviral disease of major public health importance across the globe. Severe dengue causes bleeding and shock, and can be life threatening, terminating in death. There has been considerable success in vector territorial mapping, disease transmission process, diagnosis and molecular characterization of the virus. However, continuous sporadic outbreaks and re-emergence of dengue infections are common in recent time. Also, limited treatment options, weak host immune response in sequential infection, inadequate preventive measures in some areas and continual territorial expansion of the vectors are factors sustaining dengue transmission. In this review, we present an overview of dengue virus, disease predisposing factors, surveillance tools and control measures. In addition, we offer suggestions on future research direction to deepen the control efforts. Nonetheless, continual re-emergence of dengue requires redirection from antibody-dependent enhancement and the use of insecticides into environmentally favourable bio-control and molecular surveillance of the vector until effective vaccines are readily available.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"49 ","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142426161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the new norm: The FDA's final rule on laboratory developed tests (LDTs) and its impact on clinical laboratory operations 驾驭新规范：美国食品和药物管理局关于实验室开发测试 (LDT) 的最终规定及其对临床实验室运作的影响

Clinical Microbiology Newsletter Pub Date : 2024-09-01 DOI: 10.1016/j.clinmicnews.2024.09.001

Rob E. Carpenter

{"title":"Navigating the new norm: The FDA's final rule on laboratory developed tests (LDTs) and its impact on clinical laboratory operations","authors":"Rob E. Carpenter","doi":"10.1016/j.clinmicnews.2024.09.001","DOIUrl":"10.1016/j.clinmicnews.2024.09.001","url":null,"abstract":"<div><div>On April 29, 2024, the U.S. Food and Drug Administration (FDA) issued a transformative final rule impacting the regulatory landscape for laboratory-developed tests (LDTs). This new regulation categorizes in vitro diagnostics (IVDs) used as LDTs under the same stringent oversight applied to other medical devices, thereby phasing out the agency's long-standing policy of enforcement discretion. This paper offers a concise historical overview and examines the FDA's revised regulatory framework scheduled for the next four years, examining its impact on laboratory operations in terms of safety, efficacy, and innovation. It explores how the new rule's increased compliance demands and economic implications impact laboratory operations, including economic stability, innovation, and patient safety. Also highlighted is how certain laboratories gain strategic advantages that could enhance their market stability and attract investors. The overall intent of this paper is not an in-depth analysis but instead it aims to inform stakeholders in health services about evolving laboratory standards. By doing so, it equips healthcare participants to strategically align with emerging regulatory demands, enhancing comprehension of how these changes influence healthcare delivery and laboratory procedures.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"48 ","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neisseria meningitidis pyelonephritis: A rare and unusual presentation of an established pathogen 脑膜炎奈瑟菌肾盂肾炎：一种既往病原体的罕见和不寻常表现形式

Clinical Microbiology Newsletter Pub Date : 2024-07-01 DOI: 10.1016/j.clinmicnews.2024.05.005

Hasan Hamze , Natasha Press , Aleksandra Stefanovic , Gordon Ritchie , Marc Romney

引用次数: 0

The contamination monitoring toolbox: Best practices for molecular microbiology testing 污染监测工具箱：分子微生物学测试的最佳实践

Clinical Microbiology Newsletter Pub Date : 2024-07-01 DOI: 10.1016/j.clinmicnews.2024.07.001

Meghan W. Starolis

引用次数: 0