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Current scenario and future prospect of scabies treatment: A comprehensive review 疥疮治疗的现状与前景：全面回顾
Clinical Microbiology Newsletter Pub Date : 2024-10-16 DOI: 10.1016/j.clinmicnews.2024.10.002
Nishan Hazra , Soutik Sarkar , Srijita Chakrabarti
{"title":"Current scenario and future prospect of scabies treatment: A comprehensive review","authors":"Nishan Hazra ,&nbsp;Soutik Sarkar ,&nbsp;Srijita Chakrabarti","doi":"10.1016/j.clinmicnews.2024.10.002","DOIUrl":"10.1016/j.clinmicnews.2024.10.002","url":null,"abstract":"<div><div>Scabies is a common skin condition, cause by the mite known as <em>Sarcoptes Scabiei</em>. Every year, 150–200 million people worldwide suffer from scabies. Small children are most vulnerable to scabies, which is most prevalent in congested, unsanitary living environments. It can transfer both directly from person to person and indirectly through contact with contaminated things. Scabies results in a highly irritating host immunological reaction. Impetigo and other secondary bacterial skin infections might result from scratching the wounds. It was officially classified as a neglected tropical illness by the World Health Organization in 2017. This review gives an overview of all the available therapy to treat scabies, and recent advancements in the management of scabies treatment in preclinical as well as clinical trials.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Eye see worms on the down Loa”: A case study of microfilarial co-infection "眼见虫子下罗亚"：微丝蚴合并感染病例研究
Clinical Microbiology Newsletter Pub Date : 2024-10-10 DOI: 10.1016/j.clinmicnews.2024.10.001
Christopher George Kendra , Kevin Andrew Smith , Trina Trusty , Amber Ryan , Kenneth Gavina
{"title":"“Eye see worms on the down Loa”: A case study of microfilarial co-infection","authors":"Christopher George Kendra ,&nbsp;Kevin Andrew Smith ,&nbsp;Trina Trusty ,&nbsp;Amber Ryan ,&nbsp;Kenneth Gavina","doi":"10.1016/j.clinmicnews.2024.10.001","DOIUrl":"10.1016/j.clinmicnews.2024.10.001","url":null,"abstract":"<div><div><em>Loa loa</em> is an arthropod-transmitted filarial nematode, and one of four pathologically prevalent blood microfilaria associated with human infection. This case report describes an instance of a 41-year-old male diagnosed with <em>Loa loa</em> by peripheral blood smear and subsequently also diagnosed with <em>Onchocerca</em>. Here we describe the clinical course, diagnostic evaluation and treatment considerations when managing potential nematode co-infections. This case also highlights laboratory diagnosis strategies, treatment challenges, and emphasizes a differential diagnosis of chronic infections with neglected tropical infectious agents.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General perspectives on dengue fever 关于登革热的一般观点
Clinical Microbiology Newsletter Pub Date : 2024-09-24 DOI: 10.1016/j.clinmicnews.2024.09.002
Oluwabunmi Bola Olajide , Joshua Seun Olajide , Olusanya Olasehinde
{"title":"General perspectives on dengue fever","authors":"Oluwabunmi Bola Olajide ,&nbsp;Joshua Seun Olajide ,&nbsp;Olusanya Olasehinde","doi":"10.1016/j.clinmicnews.2024.09.002","DOIUrl":"10.1016/j.clinmicnews.2024.09.002","url":null,"abstract":"<div><div>Dengue is the leading arboviral disease of major public health importance across the globe. Severe dengue causes bleeding and shock, and can be life threatening, terminating in death. There has been considerable success in vector territorial mapping, disease transmission process, diagnosis and molecular characterization of the virus. However, continuous sporadic outbreaks and re-emergence of dengue infections are common in recent time. Also, limited treatment options, weak host immune response in sequential infection, inadequate preventive measures in some areas and continual territorial expansion of the vectors are factors sustaining dengue transmission. In this review, we present an overview of dengue virus, disease predisposing factors, surveillance tools and control measures. In addition, we offer suggestions on future research direction to deepen the control efforts. Nonetheless, continual re-emergence of dengue requires redirection from antibody-dependent enhancement and the use of insecticides into environmentally favourable bio-control and molecular surveillance of the vector until effective vaccines are readily available.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142426161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the new norm: The FDA's final rule on laboratory developed tests (LDTs) and its impact on clinical laboratory operations 驾驭新规范：美国食品和药物管理局关于实验室开发测试 (LDT) 的最终规定及其对临床实验室运作的影响
Clinical Microbiology Newsletter Pub Date : 2024-09-01 DOI: 10.1016/j.clinmicnews.2024.09.001
Rob E. Carpenter
{"title":"Navigating the new norm: The FDA's final rule on laboratory developed tests (LDTs) and its impact on clinical laboratory operations","authors":"Rob E. Carpenter","doi":"10.1016/j.clinmicnews.2024.09.001","DOIUrl":"10.1016/j.clinmicnews.2024.09.001","url":null,"abstract":"<div><div>On April 29, 2024, the U.S. Food and Drug Administration (FDA) issued a transformative final rule impacting the regulatory landscape for laboratory-developed tests (LDTs). This new regulation categorizes in vitro diagnostics (IVDs) used as LDTs under the same stringent oversight applied to other medical devices, thereby phasing out the agency's long-standing policy of enforcement discretion. This paper offers a concise historical overview and examines the FDA's revised regulatory framework scheduled for the next four years, examining its impact on laboratory operations in terms of safety, efficacy, and innovation. It explores how the new rule's increased compliance demands and economic implications impact laboratory operations, including economic stability, innovation, and patient safety. Also highlighted is how certain laboratories gain strategic advantages that could enhance their market stability and attract investors. The overall intent of this paper is not an in-depth analysis but instead it aims to inform stakeholders in health services about evolving laboratory standards. By doing so, it equips healthcare participants to strategically align with emerging regulatory demands, enhancing comprehension of how these changes influence healthcare delivery and laboratory procedures.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neisseria meningitidis pyelonephritis: A rare and unusual presentation of an established pathogen 脑膜炎奈瑟菌肾盂肾炎：一种既往病原体的罕见和不寻常表现形式
Clinical Microbiology Newsletter Pub Date : 2024-07-01 DOI: 10.1016/j.clinmicnews.2024.05.005
Hasan Hamze , Natasha Press , Aleksandra Stefanovic , Gordon Ritchie , Marc Romney
{"title":"Neisseria meningitidis pyelonephritis: A rare and unusual presentation of an established pathogen","authors":"Hasan Hamze ,&nbsp;Natasha Press ,&nbsp;Aleksandra Stefanovic ,&nbsp;Gordon Ritchie ,&nbsp;Marc Romney","doi":"10.1016/j.clinmicnews.2024.05.005","DOIUrl":"10.1016/j.clinmicnews.2024.05.005","url":null,"abstract":"<div><p><em>Neisseria meningitidis</em> is a gram-negative organism primarily associated with invasive meningococcal disease. This case report presents a rare occurrence of <em>Neisseria meningitidis</em> pyelonephritis in a 24-year-old male with congenital urological abnormalities. We describe the diagnostic challenges and management of this unique case. Ultimately, the patient completed IV then oral antibiotics and recovered with no complications. This case emphasizes the importance of considering atypical pathogens in urinary tract infections and contributes valuable insights to diagnostic microbiology and clinical practice.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196439924000217/pdfft?md5=445c7e573de940cb7ddb10e692379e0b&pid=1-s2.0-S0196439924000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The contamination monitoring toolbox: Best practices for molecular microbiology testing 污染监测工具箱：分子微生物学测试的最佳实践
Clinical Microbiology Newsletter Pub Date : 2024-07-01 DOI: 10.1016/j.clinmicnews.2024.07.001
Meghan W. Starolis
{"title":"The contamination monitoring toolbox: Best practices for molecular microbiology testing","authors":"Meghan W. Starolis","doi":"10.1016/j.clinmicnews.2024.07.001","DOIUrl":"10.1016/j.clinmicnews.2024.07.001","url":null,"abstract":"<div><p>Assays that utilize nucleic acid amplification are prone to contamination from a variety of sources, including both target organisms and amplicon. Implementing effective systems for contamination monitoring as well as laboratory best practices are essential to any quality management system for molecular microbiology testing. A comprehensive contamination monitoring toolbox will be introduced here that includes guidance for environment swabbing, positivity rate monitoring, use of process controls, and monitoring complaints. As prevention of contamination is preferable, best practices for laboratory design, workflow, and personnel training will also be discussed. Lastly, a suggested plan for managing a contamination event will be proposed. The laboratory director should carefully assess the specific risks associated with testing performed in the laboratory and create a written plan for contamination monitoring, prevention, and management of contamination events.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Day in the life of a medical microbiology director: Navigating the diverse duties as a clinical conductor 医学微生物学主任的一天：作为临床指挥员，履行各种职责
Clinical Microbiology Newsletter Pub Date : 2024-07-01 DOI: 10.1016/j.clinmicnews.2024.06.001
Karissa Culbreath , Peera Hemarajata , Richard B. Thomson Jr. , Rebecca Yee
{"title":"A Day in the life of a medical microbiology director: Navigating the diverse duties as a clinical conductor","authors":"Karissa Culbreath ,&nbsp;Peera Hemarajata ,&nbsp;Richard B. Thomson Jr. ,&nbsp;Rebecca Yee","doi":"10.1016/j.clinmicnews.2024.06.001","DOIUrl":"10.1016/j.clinmicnews.2024.06.001","url":null,"abstract":"<div><p>Clinical microbiology laboratories support a range of services such as infectious disease diagnosis, infection prevention, and antimicrobial stewardship. The role of the clinical microbiology laboratory is more pivotal than ever as we face emerging pathogens, increases in healthcare-associated infections, antibiotic-resistant organisms, and rapidly advancing technologies. In the wake of these challenges, it is crucial for a clinical microbiology laboratory to be directed by medical microbiologists (i.e. laboratory directors) as they can provide accurate laboratory oversight and professional competence. Medical microbiologists can be found pursuing leadership roles in academic medical centers, diagnostic reference laboratories, public health institutions, and commercial entities such as diagnostic and pharmaceutical companies. Given the diverse career trajectories that medical microbiologists can have, the perspectives of these laboratory directors may be different even though they all strive to meet the common goal of providing diagnosis and management of infectious diseases.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on common Bartonella infections 常见巴顿氏菌感染的最新情况
Clinical Microbiology Newsletter Pub Date : 2024-05-26 DOI: 10.1016/j.clinmicnews.2024.05.002
Portia Mira, Elitza S. Theel
{"title":"Update on common Bartonella infections","authors":"Portia Mira,&nbsp;Elitza S. Theel","doi":"10.1016/j.clinmicnews.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2024.05.002","url":null,"abstract":"<div><p>This comprehensive review provides updates on the epidemiology, clinical presentations, and diagnostic methods for the most common <em>Bartonella</em> species causing human disease, including <em>B. henselae, B. quintana,</em> and <em>B. bacilliformis.</em> We highlight the distinctive transmission dynamics and clinical manifestations associated with each species, such as cat-scratch disease, trench fever, and Carrion's disease. The review also evaluates the advantages and limitations of serological and molecular diagnostic techniques, emphasizing the importance of integrating clinical evaluation with laboratory testing for accurate diagnosis and effective management of <em>Bartonella</em> infections.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aminoglycoside antibiotics: Trying to find a place in this world 氨基糖苷类抗生素：试图在这个世界上找到一席之地
Clinical Microbiology Newsletter Pub Date : 2024-04-01 DOI: 10.1016/j.clinmicnews.2024.03.002
Erin N. Deja
{"title":"Aminoglycoside antibiotics: Trying to find a place in this world","authors":"Erin N. Deja","doi":"10.1016/j.clinmicnews.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2024.03.002","url":null,"abstract":"<div><p>Aminoglycoside antibiotics were historically a cornerstone of antimicrobial therapy for many bacterial infections but as the threat of antimicrobial resistance continues to rise, the once broad-spectrum activity of these agents grows smaller. They are also plagued with the potential for severe adverse events such as nephrotoxicity and ototoxicity, and emerging evidence suggests that these risks may outweigh their benefit in many cases. With the recent introduction of newer and likely safer broad-spectrum antibiotics, do aminoglycosides still have a place in therapy in modern medicine?</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196439924000126/pdfft?md5=84be899ff85f0c15b13019ab54bad65b&pid=1-s2.0-S0196439924000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum regarding previously published articles 关于以前发表的文章的勘误
Clinical Microbiology Newsletter Pub Date : 2024-04-01 DOI: 10.1016/j.clinmicnews.2024.05.003
{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.clinmicnews.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.clinmicnews.2024.05.003","url":null,"abstract":"","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196439924000187/pdfft?md5=a107e4f6fe580ee570d1637830d3bd08&pid=1-s2.0-S0196439924000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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