Clinical Microbiology Newsletter最新文献

Microbe snapshot—Mycoplasma pneumoniae 微生物快照-肺炎支原体

Clinical Microbiology Newsletter Pub Date : 2025-07-06 DOI: 10.1016/j.clinmicnews.2025.07.001

Bradley Conlin

引用次数: 0

Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 3*: Molecular diagnostics, environmental testing, and notifiable conditions 非结核分枝杆菌的实验室诊断-更新-第3部分*：分子诊断、环境检测和应通报的条件

Clinical Microbiology Newsletter Pub Date : 2025-06-25 DOI: 10.1016/j.clinmicnews.2025.06.008

Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny

{"title":"Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 3*: Molecular diagnostics, environmental testing, and notifiable conditions","authors":"Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny","doi":"10.1016/j.clinmicnews.2025.06.008","DOIUrl":"10.1016/j.clinmicnews.2025.06.008","url":null,"abstract":"<div><div>The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20-30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 50-60"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholangitis caused by Streptococcus gordonii: A case report and review of the literature 戈多氏链球菌所致胆管炎1例报告及文献复习

Clinical Microbiology Newsletter Pub Date : 2025-06-18 DOI: 10.1016/j.clinmicnews.2025.06.007

Kaoutar Jamal , Said Ezrari , Abderrazak Saddari , Sabah Mokhtari , Zahi Ismaili , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb

{"title":"Cholangitis caused by Streptococcus gordonii: A case report and review of the literature","authors":"Kaoutar Jamal , Said Ezrari , Abderrazak Saddari , Sabah Mokhtari , Zahi Ismaili , Elmostapha Benaissa , Yassine Ben Lahlou , Mostafa Elouennass , Adil Maleb","doi":"10.1016/j.clinmicnews.2025.06.007","DOIUrl":"10.1016/j.clinmicnews.2025.06.007","url":null,"abstract":"<div><div><em>Streptococcus gordonii</em> is a commensal bacterium rarely described in human infections. Herein, we describe a case of cholangitis due to <em>Streptococcus gordonii</em>. A 62-year-old woman, known to have had cholelithiasis, with history of gastroesophageal reflux and a brother who died of nasopharyngeal carcinoma, was admitted due to abdominal pain, fever, and jaundice. Abdominal computed tomography showed moderate dilation of the common and intrahepatic bile duct upstream of stones the distal ampullary portion, and cholelithiasis. The patient underwent endoscopic retrograde cholangiopancreatography and intraoperative sampling of bile fluid. The patient received empiric antibiotic therapy based on parenteral ceftriaxone and metronidazole. The microbiological analysis revealed the exclusive presence of <em>Streptococcus gordonii</em>. The initial treatment was maintained for 5 days and then replaced by oral amoxicillin-clavulanate and metronidazole. The clinical evolution was favorable. We present here a case of cholangitis caused by <em>Streptococcus gordonii</em> and a literature review.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 24-30"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 1★: Epidemiology, environment sources, and guidance for the provider 非结核分枝杆菌的实验室诊断-更新-第1部分★：流行病学、环境来源和对提供者的指导

Clinical Microbiology Newsletter Pub Date : 2025-06-17 DOI: 10.1016/j.clinmicnews.2025.06.006

Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny

{"title":"Laboratory diagnosis of nontuberculous mycobacteria – an update – Part 1★: Epidemiology, environment sources, and guidance for the provider","authors":"Barbara A. Brown-Elliott , Joseph O. Falkinham 3rd , Jennifer L. Furlong , David E. Griffith , Kimberlee A. Musser , Nicole M. Parrish , Max Salfinger , Janet E. Stout , Nancy L. Wengenack , Adrian M. Zelazny","doi":"10.1016/j.clinmicnews.2025.06.006","DOIUrl":"10.1016/j.clinmicnews.2025.06.006","url":null,"abstract":"<div><div>The nontuberculous mycobacteria (NTM) are now more frequently encountered in the laboratory compared to 20–30 years ago. New media and molecular assays have been introduced for the accurate detection and identification of an increased number of new NTM species. Furthermore, antimicrobial drug resistance genes have been characterized for the detection of macrolide and aminoglycoside resistance. NTM are often involved in nosocomial outbreaks where water sources are often the culprit. The authors of this 3-part publication aimed to provide an update on current clinical diagnostics for NTM as well as information about testing water or environmental samples for NTM, since this is often requested of the clinical laboratory. For an NTM disease to develop, a trifecta of elements/forces are in play: host characteristics, the NTM, and the environment.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 31-43"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clostridium botulinum disorders associated with speech processes and verbal communication: a comprehensive and documented review 肉毒杆菌疾病与语言过程和语言交流相关：一项全面的文献综述

Clinical Microbiology Newsletter Pub Date : 2025-06-16 DOI: 10.1016/j.clinmicnews.2025.06.005

Parham Salmani , Masoud Keikha , Mohsen Karbalaei

{"title":"Clostridium botulinum disorders associated with speech processes and verbal communication: a comprehensive and documented review","authors":"Parham Salmani , Masoud Keikha , Mohsen Karbalaei","doi":"10.1016/j.clinmicnews.2025.06.005","DOIUrl":"10.1016/j.clinmicnews.2025.06.005","url":null,"abstract":"<div><div><em>Clostridium botulinum</em> is an anaerobic, spore-forming bacterium which produces eight different antigenic exotoxins (A, B, C1, C2, D, E, F, and G) and among them A, B, E and F are special for humans. This toxin has heavy (H) and light (L) chains, the light chain acts on Snap-25 protein in neuromuscular junction and cause paralysis in skeletal muscles by disabling SNARE proteins and then inhibiting the release of acetylcholine, then, causing diplopia, dysarthria, dysphagia. Among all clinical signs, dysarthria is characterized by difficulty in speech which is caused by paralysis of muscles of larynx, pharynx and oral cavity which are related to phonation and then speech. Dysarthria is a sign of botulism that appears in different kinds of botulism, but especially in wound botulism. Early administration of antitoxin play a vital role in the treatment, but the efficacy of antibiotic therapy has not been completely understood, because it can either improve or worsen the situation, also supportive treatments such as mechanical ventilation, physiotherapy and gastric lavage may help to reduce the incubation period.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 44-49"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbe snapshot: Avian influenza A H5N1 微生物快照：甲型H5N1禽流感

Clinical Microbiology Newsletter Pub Date : 2025-06-16 DOI: 10.1016/j.clinmicnews.2025.06.003

Emily Puumala

引用次数: 0

Vibrio cholerae cystitis following geothermal hot springs exposure in California 加州地热温泉暴露后的霍乱弧菌膀胱炎

Clinical Microbiology Newsletter Pub Date : 2025-06-16 DOI: 10.1016/j.clinmicnews.2025.06.004

Geneviève Amaral , Christopher F. Lowe , Gordon Ritchie , Conor Broderick , Michael Payne , Aleksandra Stefanovic , Nancy Matic , Nick P.G. Gauthier , Samuel D. Chorlton , Patrick Tang , Marc G. Romney

引用次数: 0

Microbe snapshots: Measles virus 微生物快照：麻疹病毒

Clinical Microbiology Newsletter Pub Date : 2025-06-10 DOI: 10.1016/j.clinmicnews.2025.06.002

Kevin Fonseca

引用次数: 0

Trueperella pyogenes bacteremia in a patient with nasal NK/T-cell lymphoma: A case report 鼻部NK/ t细胞淋巴瘤患者发生化脓性真芽孢菌血症1例

Clinical Microbiology Newsletter Pub Date : 2025-06-09 DOI: 10.1016/j.clinmicnews.2025.06.001

Sinem Özdemir , Okan Aydoğan , Umut Yılmaz , Ahmet Emre Eşkazan , Fatma Köksal Çakırlar

{"title":"Trueperella pyogenes bacteremia in a patient with nasal NK/T-cell lymphoma: A case report","authors":"Sinem Özdemir , Okan Aydoğan , Umut Yılmaz , Ahmet Emre Eşkazan , Fatma Köksal Çakırlar","doi":"10.1016/j.clinmicnews.2025.06.001","DOIUrl":"10.1016/j.clinmicnews.2025.06.001","url":null,"abstract":"<div><div><em>Trueperella pyogenes</em> is a well-known pathogen that causes opportunistic infections in farm animals, especially cattle and pigs. However, human infections are extremely rare and typically linked to occupational exposure. In this report, we present a case of sepsis due to <em>T. pyogenes</em> in an immunocompromised patient. A 75-year-old male patient, with a background of chronic obstructive pulmonary disease and a history of livestock farming, was admitted with headache, nasal congestion, dyspnea, and hypotension. He was hypoxic, pancytopenic, and severely hyponatremic, with elevated inflammatory markers. A biopsy from a maxillary sinus mass revealed nasal-type NK/T-cell lymphoma. Two sets of blood cultures (each consisting of two aerobic and one anaerobic bottle) were collected from separate venipuncture sites 24 h apart. A growth signal was detected on day two, and <em>T. pyogenes</em> was isolated from all bottles across both sets. Beta-hemolytic colonies grew on sheep blood agar; Gram staining revealed pleomorphic Gram-positive rods. The isolate was catalase and oxidase negative and identified as <em>T. pyogenes</em> via VITEK-MS. Susceptibility testing showed resistance to trimethoprim-sulfamethoxazole and susceptibility to penicillin, tetracycline, clindamycin, rifampin, linezolid, and vancomycin. Empirical treatment with meropenem, vancomycin, and levofloxacin was initiated; dexamethasone was added due to suspected lymphoma infiltration. By the fifth day, respiratory symptoms and fever had resolved, and inflammatory markers normalized. The patient was discharged with oral methylprednisolone for lymphoma and levofloxacin for antimicrobial therapy. This case highlights the importance of recognizing <em>T. pyogenes</em> as a rare but significant human pathogen, especially in immunocompromised individuals with animal exposure, and underlines the need for advanced identification methods in clinical microbiology.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 10-13"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal tuberculosis diagnosed by clinical presentation, imaging, and endoscopy, associated with pulmonary tuberculosis: A case report and narrative literature review 经临床表现、影像学及内窥镜诊断的肠结核合并肺结核：1例报告及文献综述

Clinical Microbiology Newsletter Pub Date : 2025-05-26 DOI: 10.1016/j.clinmicnews.2025.05.003

Dínimo Bolivar-Saénz , Nohora Patricia Bonilla Solano , Georgina González Tarazona , José Antonio Villamizar Silva , Yohana Alfonso Guerra , Juan Camilo Arango Brand , Andrea Torres Contreras

{"title":"Intestinal tuberculosis diagnosed by clinical presentation, imaging, and endoscopy, associated with pulmonary tuberculosis: A case report and narrative literature review","authors":"Dínimo Bolivar-Saénz , Nohora Patricia Bonilla Solano , Georgina González Tarazona , José Antonio Villamizar Silva , Yohana Alfonso Guerra , Juan Camilo Arango Brand , Andrea Torres Contreras","doi":"10.1016/j.clinmicnews.2025.05.003","DOIUrl":"10.1016/j.clinmicnews.2025.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>Intestinal tuberculosis (ITB) represents an atypical clinical manifestation of tuberculosis, constituting a significant proportion of extrapulmonary cases. This study, combining a case report and a narrative literature review, aims to deepen the understanding of ITB and its clinical characteristics.</div></div><div><h3>Case presentation</h3><div>We present a clinical case of a young patient with concomitant pulmonary tuberculosis and chronic gastrointestinal symptoms. Imaging studies revealed intestinal wall thickening in the ileum and cecum, findings corroborated by colonoscopy, which showed multiple ulcers and an inflammatory response on biopsy, albeit without direct identification of the bacillus. The patient responded favorably to standard anti-tuberculosis treatment.</div></div><div><h3>Discussion</h3><div>Our findings, coupled with the literature review, suggest that ITB can present with nonspecific clinical features, hindering early diagnosis. Coexistence with pulmonary tuberculosis is common, and complications such as intestinal obstruction may necessitate surgical intervention.</div></div><div><h3>Conclusion</h3><div>Intestinal tuberculosis poses a diagnostic challenge due to the variability of its clinical manifestations and the lack of specific diagnostic tests. A high index of clinical suspicion, particularly in patients with pulmonary tuberculosis or risk factors, is crucial for early diagnosis, appropriate management, and consequently enhance the prognosis of the disease.</div></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":"52 ","pages":"Pages 4-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0