Revista Espanola de Patologia最新文献

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Diagnóstico clínico-patológico de la neoplasia de células dendríticas plasmocitoides blásticas: reporte de 3 casos 大疱性浆细胞树突状细胞瘤的临床病理诊断:3 个病例的报告。
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.04.003
Iván Rienda , Vicent Martínez-Cózar , Ignacio Torres-Navarro , Margarita Llavador
{"title":"Diagnóstico clínico-patológico de la neoplasia de células dendríticas plasmocitoides blásticas: reporte de 3 casos","authors":"Iván Rienda ,&nbsp;Vicent Martínez-Cózar ,&nbsp;Ignacio Torres-Navarro ,&nbsp;Margarita Llavador","doi":"10.1016/j.patol.2023.04.003","DOIUrl":"10.1016/j.patol.2023.04.003","url":null,"abstract":"<div><p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease with a poor prognosis. It frequently affects the skin; indeed, dermal lesions may be the first clinical manifestation.</p><p>We report three cases of BPDCN where the patients presented with skin lesions and describe the clinical, histopathological and immunohistochemical findings, its molecular characteristics and metastatic work-up.</p><p>One of the patients remains in a clinical trial with IMGN632, a molecule directed against CD123, while the other two patients died after different therapeutic regimens.</p><p>BPDCN is a complex diagnostic challenge which, together with its poor prognosis, requires close clinical-pathological cooperation in order to accelerate its diagnosis and offer early therapeutic alternatives with drugs directed against specific molecular targets.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant “triton” tumor of the lower extremity with a history of fracture 有骨折史的下肢恶性 "三叉 "肿瘤
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.06.004
Diogo Nóbrega Catelas , Sérgio Pita , André Coelho , Vânia Oliveira , Pedro Cardoso
{"title":"Malignant “triton” tumor of the lower extremity with a history of fracture","authors":"Diogo Nóbrega Catelas ,&nbsp;Sérgio Pita ,&nbsp;André Coelho ,&nbsp;Vânia Oliveira ,&nbsp;Pedro Cardoso","doi":"10.1016/j.patol.2023.06.004","DOIUrl":"10.1016/j.patol.2023.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Malignant triton tumor (MTT) is a rare and aggressive subtype of malignant peripheral nerve sheath tumor consisting of a neurogenic tumor with rhabdomyoblastic differentiation. Only 170 cases have been reported to date, two-thirds occurring in young patients with neurofibromatosis type 1 and the remaining third presenting as a sporadic tumor.</p></div><div><h3>Case presentation</h3><p>We present the case of a 49-year-old man with a sporadic grade 2 MTT of the lower limb which had had a previous tibial fracture. The patient underwent an above-knee amputation. Five months post-operatively metastases were present in the liver and vertebral column causing compression of the spinal cord, so decompressive radiotherapy and palliative chemotherapy were initiated.</p></div><div><h3>Conclusion</h3><p>Due to the precocious spread of the disease, we would suggest that adjuvant chemotherapy be considered for the eradication of micrometastases. To our knowledge, this is only the second reported case of an MTT arising in a site with a history of previous severe trauma.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135249002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of phosphatase and tensin homologue (PTEN) expression in gastric cancer and its relationship with histopathological findings 评估胃癌中磷酸酶和天丝同源物 (PTEN) 的表达及其与组织病理学结果的关系
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.11.001
Seyed Amir Miratashi Yazdi , Fatemeh Hoseini , Arezoo Eftekhar Javadi , Elham Nazar
{"title":"Evaluation of phosphatase and tensin homologue (PTEN) expression in gastric cancer and its relationship with histopathological findings","authors":"Seyed Amir Miratashi Yazdi ,&nbsp;Fatemeh Hoseini ,&nbsp;Arezoo Eftekhar Javadi ,&nbsp;Elham Nazar","doi":"10.1016/j.patol.2023.11.001","DOIUrl":"10.1016/j.patol.2023.11.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Phosphatase and tensin homologue (PTEN) is an important tumour suppressor in multi-step tumorigenesis. To establish the role of PTEN in gastric cancer progression, we examined the PTEN expression degree in gastric cancer tissues. We also explained the connection between PTEN expression and histopathological findings.</p></div><div><h3>Materials and methods</h3><p>Our study was cross-sectional and made up of 50 patients with known gastric cancer. Immunohistochemical staining for PTEN was done on gastric cancer tissues. Tumour behaviour was estimated by histopathological assessments.</p></div><div><h3>Results</h3><p>Twenty-seven (54%) of the 50 patients had PTEN staining. The evaluation of the connection between PTEN expression and demographic data and tumour behaviours revealed no meaningful relationship between PTEN expression and patients’ age, gender, tumour site and size, tumour type, tumour grade and stage, neural, and lymphovascular invasion (<em>P</em>-value<!--> <!-->&gt;<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>PTEN expression level is expected to be a significant molecular event in the progression of gastric cancer and may be a predictive marker for gastric cancer behaviours dependent on society.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principales tipos de quistes en dermatopatología: parte 1 皮肤病理学中囊肿的主要类型:第一部分
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.11.006
María Teresa Fernández Figueras , Jacques Alzoghby-Abi Chaker , Miriam Fernandez-Parrado , Adriana García Herrera , María Garrido , Miguel Ángel Idoate Gastearena , Mar Llamas-Velasco , Carlos Monteagudo , José Onrubia , Noelia Pérez Muñoz , Juan José Ríos-Martín , José Luis Rodríguez Peralto , Eduardo Rozas Muñoz , Onofre Sanmartín , Ángel Santos-Briz , Carles Saus , José Manuel Suárez Peñaranda , Verónica Velasco Benito , María José Beato Merino , Ángel Fernandez-Flores
{"title":"Principales tipos de quistes en dermatopatología: parte 1","authors":"María Teresa Fernández Figueras ,&nbsp;Jacques Alzoghby-Abi Chaker ,&nbsp;Miriam Fernandez-Parrado ,&nbsp;Adriana García Herrera ,&nbsp;María Garrido ,&nbsp;Miguel Ángel Idoate Gastearena ,&nbsp;Mar Llamas-Velasco ,&nbsp;Carlos Monteagudo ,&nbsp;José Onrubia ,&nbsp;Noelia Pérez Muñoz ,&nbsp;Juan José Ríos-Martín ,&nbsp;José Luis Rodríguez Peralto ,&nbsp;Eduardo Rozas Muñoz ,&nbsp;Onofre Sanmartín ,&nbsp;Ángel Santos-Briz ,&nbsp;Carles Saus ,&nbsp;José Manuel Suárez Peñaranda ,&nbsp;Verónica Velasco Benito ,&nbsp;María José Beato Merino ,&nbsp;Ángel Fernandez-Flores","doi":"10.1016/j.patol.2023.11.006","DOIUrl":"10.1016/j.patol.2023.11.006","url":null,"abstract":"<div><p>Cystic structures represent one of the most common findings in dermatopathology. These encompass both cystic tumors and pseudocysts resulting from the accumulation of certain substances, such as mucin. In a two-part series (of which this is the first part), we have reviewed the principal types of cysts and pseudocysts that may be observed in cutaneous biopsies, examining their histopathological features and primary differential diagnoses. This first part encompasses infundibular cysts, eruptive dermoid cysts, pigmented follicular cysts, pilonidal cysts, tricholemmal cysts, milium cysts, hybrid cysts, bronchogenic cysts, as well as steatocystoma, hydrocystoma, and comedones.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones 关于一例弗雷泽综合征。对一名妊娠 37 周的多发畸形胎儿进行尸检。
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.07.002
Laura Sánchez Godoy, José Emilio Hernández Barceló
{"title":"A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones","authors":"Laura Sánchez Godoy,&nbsp;José Emilio Hernández Barceló","doi":"10.1016/j.patol.2023.07.002","DOIUrl":"10.1016/j.patol.2023.07.002","url":null,"abstract":"<div><p>Fraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways).</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocitoma de bajo grado en un teratoma retroperitoneal: reporte de caso 腹膜后畸胎瘤中的低级别星形细胞瘤:病例报告
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.08.003
Eduardo Alfredo González Murillo, Eduardo Benavides Salas, María Margarita Vizcaino Lozano
{"title":"Astrocitoma de bajo grado en un teratoma retroperitoneal: reporte de caso","authors":"Eduardo Alfredo González Murillo,&nbsp;Eduardo Benavides Salas,&nbsp;María Margarita Vizcaino Lozano","doi":"10.1016/j.patol.2023.08.003","DOIUrl":"10.1016/j.patol.2023.08.003","url":null,"abstract":"<div><p>Teratomas are neoplasms originate from germ cells and can undergo malignant transformation, the World Health Organization (WHO) classified them as teratoma with somatic-type malignancy which is uncommon and sarcomas are the histological type with the highest incidence. It is important to identify this type of tumors because influences the prognosis and survival of the patient.</p><p>We present the case of a 5-month-old male, who began his condition at one month-old with constipation and increase of the abdominal circumference, imaging studies revealed an abdominal lesion, he was treated with chemotherapy and surgery. The histopathological report was immature teratoma, grade 1, with a focus of nervous tissue showing characteristics of low-grade astrocytoma.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135848698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumores de colisión en la piel: un hallazgo incidental en la mayoría de los casos. Estudio retrospectivo y revisión de la literatura 皮肤碰撞瘤:大多数病例中的偶然发现。回顾性研究和文献综述
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.11.004
Sonia García-Fuertes , Lucía Prieto-Torres , Mar García-García
{"title":"Tumores de colisión en la piel: un hallazgo incidental en la mayoría de los casos. Estudio retrospectivo y revisión de la literatura","authors":"Sonia García-Fuertes ,&nbsp;Lucía Prieto-Torres ,&nbsp;Mar García-García","doi":"10.1016/j.patol.2023.11.004","DOIUrl":"https://doi.org/10.1016/j.patol.2023.11.004","url":null,"abstract":"<div><p>A collision tumour (CT) is a neoplastic lesion comprised of two or more distinct cell populations that maintain distinct borders. Mostly, these are incidental findings in skin biopsies, whose pathologic mechanism and prevalence remain unknown, with few references among literature. Here, we present a retrospective study of CT, diagnosed by a dermatopathologist in our hospital between 2019-2022. Lesions have been defined individually and organized into three categories: benign-benign (BB), benign-malignant (BM) and malignant-malignant (MM). A total of 108 CT were diagnosed (1,4% of the biopsies from the dermatopathologist during this period), from which BM was the most frequent collision (48,5%). Globally, basal cell carcinoma (BCC) was the main malignant lesion and melanocytic nevus (MN) the main benign lesion. We have used the software Stata 14.2 in order to analyse results, and we have detected a statistically significant difference between age and collision type.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers 鼻窦乳头状非角化鳞状细胞癌与 DEK::AFF2 融合和模拟物的诊断算法
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.08.002
Juan B. Laforga , Bacem K. Othman
{"title":"A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers","authors":"Juan B. Laforga ,&nbsp;Bacem K. Othman","doi":"10.1016/j.patol.2023.08.002","DOIUrl":"10.1016/j.patol.2023.08.002","url":null,"abstract":"<div><p>Sinonasal carcinomas represent a rare and diverse group of tumors, presenting diagnostic complexities due to their varied histological and molecular features. To ensure accurate differentiation among these malignancies, a systematic and stepwise approach is paramount. Even with the morphological similarities between poorly differentiated (non) keratinizing sinonasal squamous cell carcinoma (SNSCC) and <em>DEK::AFF2</em> SNSCC, the two lesions are distinguishable using the surrogate immunohistochemical marker AFF2 or molecular testing for <em>DEK::AFF2</em> mutation. We report a rare case of SMARCB1-retained <em>DEK::AFF2</em> papillary non-keratinizing SNSCC in a 53-year-old female, who presented with a polypoid mass corresponding to the left middle turbinate. Following the surgical resection of the tumor and locoregional lymph nodes, adjuvant radiotherapy was administered to eradicate any residual cancer cells that may have remained after surgery.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136160543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fe de errores sobre artículos publicados en la Revista Española de Patología 对发表在《西班牙病理学杂志》上的文章的更正
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.10.001
{"title":"Fe de errores sobre artículos publicados en la Revista Española de Patología","authors":"","doi":"10.1016/j.patol.2023.10.001","DOIUrl":"10.1016/j.patol.2023.10.001","url":null,"abstract":"","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1699885523000673/pdfft?md5=1bb55b000f86cb0ace1e885b39688f5b&pid=1-s2.0-S1699885523000673-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135454764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kikuchi–Fujimoto disease type lymph node reaction with increased plasmacytoid dendritic cells may appear as a side effect following COVID-19 vaccination: Report of a case and literature review 接种 COVID-19 疫苗后可能会出现副作用,即出现质体树突状细胞增多的菊池-藤本氏病类型淋巴结反应:病例报告和文献综述
Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.01.002
Germán Moreno de Juan , Amaia Pérez Del Barrio , Eduardo Germán Herrera Romero , Mario González Ruiz , Santiago Montes Moreno
{"title":"Kikuchi–Fujimoto disease type lymph node reaction with increased plasmacytoid dendritic cells may appear as a side effect following COVID-19 vaccination: Report of a case and literature review","authors":"Germán Moreno de Juan ,&nbsp;Amaia Pérez Del Barrio ,&nbsp;Eduardo Germán Herrera Romero ,&nbsp;Mario González Ruiz ,&nbsp;Santiago Montes Moreno","doi":"10.1016/j.patol.2023.01.002","DOIUrl":"10.1016/j.patol.2023.01.002","url":null,"abstract":"<div><p>Subsequent to mass vaccination programs against COVID-19, diverse side effects have been described, both at the injection site, such as pain, redness and swelling, and systemic effects such as fatigue, headache, muscle or joint pain. On rare occasions, a lymphadenopathic syndrome may develop, raising the clinical suspicion of a lymphoproliferative disorder. We present the case of a 30-year-old woman who developed self-limiting left axillary lymphadenopathy following COVID-19 vaccination. To date, only seven similar cases with a complete clinicopathological description have been published, and fourteen cases have been notified to the European adverse events databases (Eudravigilance) in relationship with vaccination against COVID-19.</p><p>It is important to be aware of this potential complication when a lymphadenopathic syndrome develops following vaccination, to avoid unnecessary treatment.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1699885523000065/pdfft?md5=51c850a7d3fd67d014a91968499c191c&pid=1-s2.0-S1699885523000065-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77132909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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