Revista Espanola de Patologia最新文献

Ectopic thyroid tissue in the mandible: Case report 下颌骨甲状腺组织异位1例

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Revista Espanola de Patologia Pub Date : 2025-09-10 DOI: 10.1016/j.patol.2025.100842

Daniela Alejandra García Alonso , Moisés Salamanca García , María Edith Salgado Alday

引用次数: 0

Fine needle aspiration cytology of epithelioid sarcoma: A case series with histopathological correlation and literature review 上皮样肉瘤的细针抽吸细胞学：一个具有组织病理学相关性的病例系列和文献复习

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Revista Espanola de Patologia Pub Date : 2025-09-03 DOI: 10.1016/j.patol.2025.100831

Sagir Akhtar , Adil Aziz Khan , Geet Bhuyan , Sumanta Das

{"title":"Fine needle aspiration cytology of epithelioid sarcoma: A case series with histopathological correlation and literature review","authors":"Sagir Akhtar , Adil Aziz Khan , Geet Bhuyan , Sumanta Das","doi":"10.1016/j.patol.2025.100831","DOIUrl":"10.1016/j.patol.2025.100831","url":null,"abstract":"<div><h3>Introduction</h3><div>Epithelioid sarcoma (ES) is an uncommon malignant mesenchymal tumour that occurs in young adults and adolescents. Few documented series have elucidated the cytopathological features and immunostaining results of epithelioid sarcoma. Here, we present one of the largest series documenting 15 cases of ES.</div></div><div><h3>Method</h3><div>Archives of cytology and histopathology have been searched for data on epithelioid sarcoma from the past 10 years. Only cases with histopathological records and immunohistochemistry follow-up have been included.</div></div><div><h3>Result</h3><div>Out of the 27 cases of ES in our database, 15 had both cytology and corresponding histopathology. Of these 15 cases, Fine Needle Aspiration Cytology (FNAC) was indicated for primary diagnosis in 4 cases, for recurrent settings in 5 cases, and metastatic settings in 6 cases. Immunohistochemistry was correlated wherever available. In 8 cases, retrospective immunohistochemistry was performed for confirmation of epithelioid sarcoma.</div></div><div><h3>Conclusion</h3><div>FNAC is a valuable tool in the recurrent and metastatic settings of epithelioid sarcoma. However, for primary diagnosis, it is helpful but not diagnostic, as various morphologies can be observed and several differential diagnoses must be taken into account.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100831"},"PeriodicalIF":0.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of second opinions in pathology: Recommendations of the Spanish Society of Anatomical Pathology (SEAP). Second opinions in pathology 病理第二意见的管理：西班牙解剖病理学会（SEAP）的建议。病理第二意见

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Revista Espanola de Patologia Pub Date : 2025-09-03 DOI: 10.1016/j.patol.2025.100837

Francesc Tresserra , Isabel Colmenero , Mar Iglesias , Luis Ortega , Jordi Temprana-Salvador , Antonio Martínez Lorente , Carme Dinares , Empar Mayordomo , Maria Dolores Lozano , Xavier Matias Guiu , Santiago Ramon y Cajal

{"title":"Management of second opinions in pathology: Recommendations of the Spanish Society of Anatomical Pathology (SEAP). Second opinions in pathology","authors":"Francesc Tresserra , Isabel Colmenero , Mar Iglesias , Luis Ortega , Jordi Temprana-Salvador , Antonio Martínez Lorente , Carme Dinares , Empar Mayordomo , Maria Dolores Lozano , Xavier Matias Guiu , Santiago Ramon y Cajal","doi":"10.1016/j.patol.2025.100837","DOIUrl":"10.1016/j.patol.2025.100837","url":null,"abstract":"<div><h3>Introduction</h3><div>As diagnostic complexity in pathology increases, mainly in cancer diagnoses, the demand for second opinions from specialized and highly qualified centres also increases. There is a certain lack of uniformity in the criteria for carrying out these consultations, managing the material under review, and the responses from the consultant centre.</div></div><div><h3>Material and methods</h3><div>In order to establish recommendations on the aspects to be considered both by the pathologist or referring centre and by the pathologist or consultant centre, a group of experts from the Spanish Society of Anatomical Pathology conducted a literature review of guidelines and recommendations from other societies and relevant published articles. Based on this review, consensus criteria have been established.</div></div><div><h3>Results</h3><div>Recommendations are provided on how second opinions in pathology should be managed by both the referring and consultant pathologists, including aspects of material submission and funding.</div></div><div><h3>Conclusion</h3><div>Second opinions should be carried out following standardized guidelines for both the referring and consultant pathologists, covering referral, management of discrepancies, and funding to ensure a consistent system.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100837"},"PeriodicalIF":0.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic melanoma mimicking an angiomatoid fibrous histiocytoma 类似血管瘤样纤维组织细胞瘤的转移性黑色素瘤

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Revista Espanola de Patologia Pub Date : 2025-09-02 DOI: 10.1016/j.patol.2025.100841

Caterina Fumagalli, Anna Mozos, Justyna Szafranska, Ruth Orellana

{"title":"Metastatic melanoma mimicking an angiomatoid fibrous histiocytoma","authors":"Caterina Fumagalli, Anna Mozos, Justyna Szafranska, Ruth Orellana","doi":"10.1016/j.patol.2025.100841","DOIUrl":"10.1016/j.patol.2025.100841","url":null,"abstract":"<div><div>Melanoma is known for its remarkable histopathological heterogeneity, capable of mimicking both epithelial and mesenchymal neoplasms. We report the case of a 46-year-old male who was externally diagnosed with sarcoma and presented with a subcutaneous pre-sternal mass comprising a proliferation of epithelioid–histiocytoid cells, hemosiderin deposition, and chronic inflammation, closely resembling an angiomatoid fibrous histiocytoma (AFH). A peripheral pseudo-capsule and a pericapsular lymphocytic cuff were also observed. Immunohistochemically, the tumour cells were focally positive for desmin and S100 protein, but negative for EMA, CD99 and CD68. Further studies demonstrated SOX10 positivity and identified a <em>BRAF</em> p.V600E mutation, findings consistent with melanoma. Review of the external clinical history confirmed that the patient had undergone surgery for a melanoma near the current lesion site three years earlier. In conclusion, the integration of histology, immunohistochemistry, molecular studies and clinical history is essential for the accurate diagnosis of melanoma and for avoiding misdiagnosis.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100841"},"PeriodicalIF":0.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The implications of COX-2 and HER2 protein expression for the prognosis of colorectal cancer patients: An exploratory study from the North African region COX-2和HER2蛋白表达对结直肠癌患者预后的影响：来自北非地区的一项探索性研究

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Revista Espanola de Patologia Pub Date : 2025-09-01 DOI: 10.1016/j.patol.2025.100840

Fatima El Agy , Sara Bahja , Mohammed El Abkari , Sidi Adil Ibrahimi , Karima El Rhazi , Laila Chbani , Nada Lahmidani

{"title":"The implications of COX-2 and HER2 protein expression for the prognosis of colorectal cancer patients: An exploratory study from the North African region","authors":"Fatima El Agy , Sara Bahja , Mohammed El Abkari , Sidi Adil Ibrahimi , Karima El Rhazi , Laila Chbani , Nada Lahmidani","doi":"10.1016/j.patol.2025.100840","DOIUrl":"10.1016/j.patol.2025.100840","url":null,"abstract":"<div><h3>Background</h3><div>The prognostic value of COX-2 and HER2 protein overexpression in colorectal cancer remains controversial and has not previously been evaluated in North Africa. In this study, we investigated the association between COX-2 and HER2 overexpression, clinicopathological features and patient survival.</div></div><div><h3>Methods</h3><div>Seventy patients with stage I–IV colon adenocarcinoma were prospectively and retrospectively included in this study between 2016 and 2021. The expression of COX-2 and HER2 proteins was evaluated using tissue microarrays (4μm). Overall survival (OS) and recurrence-free survival (RFS) outcomes were compared according to COX-2 and HER2 expression status using the Kaplan–Meier method.</div></div><div><h3>Results</h3><div>Positive expression of COX-2 and HER2 proteins was observed in 58 (82.9%) and 2 (2.9%) cases, respectively. COX-2 expression was associated with female sex, vascular invasion, lymph node metastasis, distant metastasis, TNM stage, and poor overall survival. HER2 expression was mainly associated with younger age, presence of positive LN and LN ratios, increased recurrence, and lower recurrence-free survival rate.</div></div><div><h3>Conclusion</h3><div>This study highlights the prognostic impact of COX-2 and HER2 expression in patients with colorectal cancer. The association of clinicopathological features with COX-2 and HER2 expression suggests the need to incorporate these two biomarkers into the pathomolecular classification of colorectal cancer. Based on survival analysis, COX-2 and HER2 expression were associated with shorter overall survival and recurrence-free survival in patients with colorectal cancer.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100840"},"PeriodicalIF":0.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-meningothelial mesenchymal tumours of the CNS in the diagnostic practice of the pathologist 病理医师对中枢神经系统非脑膜上皮间质肿瘤的诊断实践

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Revista Espanola de Patologia Pub Date : 2025-08-30 DOI: 10.1016/j.patol.2025.100839

Karen Rocío Latorre Rodríguez , Ana Laura Calderón-Garcidueñas

{"title":"Non-meningothelial mesenchymal tumours of the CNS in the diagnostic practice of the pathologist","authors":"Karen Rocío Latorre Rodríguez , Ana Laura Calderón-Garcidueñas","doi":"10.1016/j.patol.2025.100839","DOIUrl":"10.1016/j.patol.2025.100839","url":null,"abstract":"<div><h3>Introduction</h3><div>Primary mesenchymal tumours of the central nervous system with uncertain differentiation are rare. The 5th edition of the WHO classification groups three of these entities according to their molecular profiles into: intracranial mesenchymal tumours with FET-CREB fusion, sarcomas with CIC rearrangement, and primary intracranial sarcomas with DICER1 mutations. The objectives of this study were to carry out a systematic review of the literature and to determine whether a specific morphology predominates in relation to the proposed molecular types.</div></div><div><h3>Materials and methods</h3><div>A systematic review was performed using the PubMed database, with the search terms: “(sarcomas) and (central nervous system)”. Studies were included if they reported cases of patients with a diagnosis of primary sarcoma in the central nervous system (CNS) and provided information on both the molecular profile and histopathological characteristics.</div></div><div><h3>Results</h3><div>Of the 173 articles identified, eight were ultimately selected for analysis.</div></div><div><h3>Conclusions</h3><div>Histopathological differences were observed that may assist in diagnosis in the absence of molecular testing; however, follow-up data are required to evaluate the benefits of this classification in clinical practice.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100839"},"PeriodicalIF":0.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pott's puffy tumour: A report of 2 cases highlighting tuberculosis as a microbiological cause 波特氏浮肿瘤：附2例报告，强调结核是微生物病因

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Revista Espanola de Patologia Pub Date : 2025-08-30 DOI: 10.1016/j.patol.2025.100843

Sana Ahuja , Dipanker Singh Mankotia , Sufian Zaheer

{"title":"Pott's puffy tumour: A report of 2 cases highlighting tuberculosis as a microbiological cause","authors":"Sana Ahuja , Dipanker Singh Mankotia , Sufian Zaheer","doi":"10.1016/j.patol.2025.100843","DOIUrl":"10.1016/j.patol.2025.100843","url":null,"abstract":"<div><div>Pott's puffy tumour (PPT), characterized by subperiosteal abscess formation secondary to frontal bone osteomyelitis, is a rare clinical entity. This case series highlights tuberculosis as an unexpected cause of PPT. Two cases of PPT, diagnosed histologically and surgically managed within a one-year period, were retrospectively analyzed. Clinical, radiological, operative, and histopathological findings were evaluated. Both cases, aged 12 and 26 years respectively, presented with forehead swelling, headache, and low-grade fever. Imaging revealed subperiosteal abscesses involving the frontal bone. Surgical exploration and drainage confirmed PPT, with unexpected histopathological findings of tuberculosis. Anti-tubercular therapy led to symptom resolution and lesion regression. These cases underscore the need to consider tuberculosis as a differential diagnosis in PPT. Timely diagnosis and appropriate anti-tubercular therapy are critical for successful management and prevention of complications. Awareness of tuberculosis as a possible aetiological factor is particularly important in regions with a high disease burden.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100843"},"PeriodicalIF":0.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Granular cell tumour of the breast: An uncommon benign lesion with suspicious radiological features. Case report and literature review 乳腺颗粒细胞瘤：一种少见的良性病变，影像学特征可疑。病例报告及文献复习

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Revista Espanola de Patologia Pub Date : 2025-08-30 DOI: 10.1016/j.patol.2025.100838

Sonia García-Fuertes , José Ignacio Franco-Rubio

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Importance of the pathologist in sample management at the sampling site in an interventional pulmonology unit: ROSE, EBUS-TBNA and EBUS-TBLNC 介入肺科科室病理学家在采样点样本管理中的重要性：ROSE、EBUS-TBNA和EBUS-TBLNC

Revista Espanola de Patologia Pub Date : 2025-07-07 DOI: 10.1016/j.patol.2025.100833

Beatriz Agredano-Ávila , Francisco Javier Velasco-Albendea , María Jesús Gil-Belmonte , Juan José Cruz-Rueda , Andrés López-Pardo

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Metastatic cellular neurothekeoma arising over a vaccination scar: A case report and literature review 转移性细胞神经瘤发生在疫苗接种疤痕：一个病例报告和文献复习

Revista Espanola de Patologia Pub Date : 2025-07-07 DOI: 10.1016/j.patol.2025.100832

Jairo Fuentes-Carrascal , Beatriz Orozco-Sebá , Esperanza Meléndez-Ramírez , Claudia Montoya-Maya , José Tovar-Berardinelli , Juan Marchán-Cárdenas , Jesús Pérez-García

{"title":"Metastatic cellular neurothekeoma arising over a vaccination scar: A case report and literature review","authors":"Jairo Fuentes-Carrascal , Beatriz Orozco-Sebá , Esperanza Meléndez-Ramírez , Claudia Montoya-Maya , José Tovar-Berardinelli , Juan Marchán-Cárdenas , Jesús Pérez-García","doi":"10.1016/j.patol.2025.100832","DOIUrl":"10.1016/j.patol.2025.100832","url":null,"abstract":"<div><div>Cellular neurothekeoma is a rare non-melanocytic skin neoplasm, considered benign and more common in children and young adults, primarily affecting the healthy skin of the head, neck, and scapular region. Based on the morphological findings of the initially reported cases, it was thought to originate from neural sheath cells. Clinical, morphological, and immunohistochemical correlation studies have demonstrated its dermal origin and the absence of neural markers, suggesting a fibrohistiocytic origin, though its histogenesis remains uncertain. They present as slow-growing, self-limiting dermal nodules with exceptional recurrence and very low metastatic potential.</div><div>We present the case of a child with a reddish, firm, asymptomatic nodule on a vaccination scar on the right shoulder, which was excised, after which an ipsilateral axillary mass developed. The histopathological examination of both lesions revealed a neoplasm with morphological and immunohistochemical characteristics consistent with metastatic cutaneous cellular neurothekeoma in a regional lymph node.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100832"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0