Revista Espanola de Patologia最新文献

{"title":"Intimal sarcoma of the pulmonary vein with left atrial extension: a case report and diagnostic relevance of MDM2.","authors":"Gabriela Maria Sambuelli, Mariangela Bes, Patricia Calafat, Maria Kurpis","doi":"10.1016/j.patol.2026.100903","DOIUrl":"https://doi.org/10.1016/j.patol.2026.100903","url":null,"abstract":"<p><p>Intimal sarcoma is an uncommon, aggressive neoplasm originating in the tunica intima of large vessels. Although most cases arise in the pulmonary artery, primary involvement of the pulmonary veins is exceptional. We present the case of a 52-year-old woman who presented to the emergency department with acute heart failure and dyspnoea. Imaging studies initially suggested an atrial myxoma. Surgical resection of the lesion revealed a proliferation characterised by a relatively monotonous spindle-cell proliferation within the pulmonary vein and a separate zone showing greater pleomorphism, necrosis, and atypical mitoses within the left atrial cavity. Immunohistochemistry demonstrated nuclear positivity for MDM2, supporting the diagnosis. Pulmonary vein intimal sarcoma is an extremely rare entity that can be challenging to diagnose. Detection of MDM2 by immunohistochemistry is a key diagnostic tool.</p>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":" ","pages":"100903"},"PeriodicalIF":0.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade of dysplasia: Clinicopathological patterns and malignant transformation with Candida co-infection","authors":"Deepika Lakshmi Radhakrishnan,&nbsp;Suganya Panneer Selvam,&nbsp;Deepak Pandiar","doi":"10.1016/j.patol.2026.100898","DOIUrl":"10.1016/j.patol.2026.100898","url":null,"abstract":"<div><h3>Background</h3><div>Oral epithelial dysplasia (OED) is a key precursor to oral squamous cell carcinoma (OSCC); however, predicting its malignant transformation remains a clinical challenge due to its multifactorial aetiology and regional variations in risk-related habits. This study aimed to analyse the clinicopathological characteristics and malignant transformation potential of OED, including <em>Candida</em>-associated lesions, over a 10-year institutional period.</div></div><div><h3>Methods</h3><div>A 10-year retrospective analysis (2014–2025) was conducted on 305 histopathologically confirmed OED cases from the Department of Oral Pathology, Saveetha Dental College, Chennai. Demographic characteristics, lesion site, habits, dysplasia grade, oral submucous fibrosis (OSMF) stage, <em>Candida</em> colonisation, treatment modality, and progression to OSCC were recorded and analysed using SPSS v26.</div></div><div><h3>Results</h3><div>Middle-aged males predominated (87%), with the buccal mucosa being the most common site (52%). Pan chewing without tobacco was the leading habit (31%). OSMF was present in 41% of patients, most of whom had advanced-stage disease, and moderate dysplasia accounted for 43% of cases. <em>Candida</em> colonisation was identified in 2.3% of cases, with no statistically significant association with transformation (<em>p</em> <!-->&gt;<!--> <!-->0.05). Among the 58 patients with documented follow-up, 15 (25.9%) demonstrated progression to OSCC during the available 12-month follow-up period. Malignant transformation occurred in 15 patients (4.9% of the total cohort) during follow-up. Surgical excision was the most frequent management approach, although long-term follow-up adherence remained low (19%).</div></div><div><h3>Conclusion</h3><div>OED in this South-Indian cohort exhibited a distinct aetiological profile dominated by pan chewing and OSMF; however the limited duration of follow-up precluded reliable estimation of the long-term malignant transformation rate. <em>Candida</em> infection appeared to be a minor co-factor rather than a direct predictor of progression.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 4","pages":"Article 100898"},"PeriodicalIF":0.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic spectrum and developmental reactivation in adenomatoid odontogenic tumour: A 35-year retrospective study","authors":"Kochli Channappa Niranjan,&nbsp;Nitya Krishnasamy,&nbsp;Shriya Gaonkar,&nbsp;Sahana Santoshkumar Katti,&nbsp;Vani Hm","doi":"10.1016/j.patol.2026.100900","DOIUrl":"10.1016/j.patol.2026.100900","url":null,"abstract":"<div><h3>Background</h3><div>Adenomatoid odontogenic tumour (AOT) is an uncommon benign epithelial odontogenic tumour characterised by distinctive clinicopathological and histopathological features. This study evaluated the clinical, radiographic, and histopathological spectrum of AOT, compared intra-follicular (IF-AOT) and extra-follicular (EF-AOT) variants, and assessed the potential utility of machine learning for variant classification.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis of 29 histopathologically confirmed intraosseous AOTs diagnosed over a 35-year period (1989–2024) was performed. Demographic, clinical, radiographic, histopathological, treatment, and follow-up data were evaluated. Cases were classified as IF-AOT or EF-AOT based on their relationship with impacted teeth. Associations between variant type and clinical characteristics were assessed using Fisher's exact test. A decision-tree model incorporating clinical variables was used to classify AOT variants.</div></div><div><h3>Results</h3><div>The mean age at diagnosis was 19.07 years, with a female-to-male ratio of 3:1. The maxilla was affected in 58.6% of cases, with a predominance of lesions in the anterior region. IF-AOT accounted for 69.0% of cases and EF-AOT for 31.0%. Histopathological examination demonstrated duct-like structures, whorled epithelial nests, sheet-like and rosette-like arrangements, together with less common findings, including CEOT-like calcifications, stellate reticulum-like cells, squamous metaplasia, and dentigerous cyst-associated changes. No statistically significant associations were identified between AOT variant and the clinical features evaluated (<em>p</em> <!-->&gt;<!--> <!-->0.05). The decision-tree model achieved an overall classification accuracy of 88.9%. Postoperative follow-up ranged from 6 months to 2 years, with no recurrences documented during the follow-up period.</div></div><div><h3>Conclusion</h3><div>AOT demonstrates considerable clinicopathological and histopathological diversity while retaining its characteristically favourable biological behaviour. Integration of clinical, radiographic, and histopathological findings facilitates accurate recognition of its variants and uncommon morphological presentations. Machine learning may provide an adjunctive approach to variant classification; however, validation in larger datasets is required.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 4","pages":"Article 100900"},"PeriodicalIF":0.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant cell interstitial pneumonia associated with occupational iron exposure: An exceptional case report","authors":"Clara González Rodríguez,&nbsp;María de la Paz González Gutiérrez,&nbsp;Cristina Fuente Díaz,&nbsp;Héctor-Enrique Torres-Rivas","doi":"10.1016/j.patol.2026.100897","DOIUrl":"10.1016/j.patol.2026.100897","url":null,"abstract":"<div><div>Multinucleated giant cell pneumonia associated with heavy metals (GIP) is a rare disease of the pulmonary parenchyma, with just over one hundred cases reported in the scientific literature. It has been associated almost exclusively with occupational exposure to tungsten and cobalt. Although its pathogenesis is not fully understood, it has been proposed that exposure to an aetiological agent, together with an immune imbalance, underlies the pathophysiology of the characteristic microscopic findings, including fibrosis, multinucleated foreign-body giant cells and cannibalism. To date, iron has not been described as one of the causative agents. We present the case of a 41-year-old patient with documented occupational exposure to iron who developed respiratory failure. For the first time, findings consistent with GIP were demonstrated in the pulmonary parenchyma, with microscopic features that we consider specific.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 4","pages":"Article 100897"},"PeriodicalIF":0.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoid ameloblastomas: Expanding the clinicopathological spectrum with five new cases","authors":"Kiran Jot,&nbsp;Vivek Nayyar,&nbsp;Naina Sivakumar,&nbsp;Varun Surya,&nbsp;Deepika Mishra,&nbsp;Anand Ramanathan,&nbsp;Akhilanand Chaurasia","doi":"10.1016/j.patol.2026.100901","DOIUrl":"10.1016/j.patol.2026.100901","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the clinicopathological and immunohistochemical characteristics of adenoid ameloblastoma (AdAM), a rare odontogenic neoplasm recognised as a distinct entity in the 2022 WHO classification, and to highlight the diagnostic challenges associated with its overlapping features.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on five cases of AdAM diagnosed between 2021 and 2023 at a tertiary care institution. Clinical presentation, radiographic findings, histopathological features, and immunohistochemical profiles were reviewed and systematically analysed.</div></div><div><h3>Results</h3><div>All patients presented with painless jaw swelling, with a mean age of 40.8 years and a female-to-male ratio of 4:1. Three lesions involved the posterior mandible and two involved the maxilla. Radiographically, four tumours were radiolucent, whereas one exhibited mixed radiolucent–radiopaque features. Histologically, all cases demonstrated characteristic pseudoductal and cribriform patterns with whorled epithelial formations. Additional findings included clear cells, dentinoid deposition, spindle cell areas, ghost cells, and keratin pearl formation. Immunohistochemically, al tumours were positive for AE1/AE3, CK5/6, CK14, and CK19 and negative for CK7. The Ki-67 proliferation index ranged from 2% to 30%, with low-level p53 expression in all cases. One tumour showed BRAF V600E positivity.</div></div><div><h3>Conclusions</h3><div>AdAM represents a distinct but diagnostically challenging odontogenic tumour with locally aggressive behaviour and potential for recurrence. Recognition of its characteristic histopathological patterns, supported by immunohistochemical findings, is critical for accurate diagnosis and appropriate therapeutic management.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 4","pages":"Article 100901"},"PeriodicalIF":0.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of the optimal thickness of sections for adipose tissue, salivary glands and skeletal muscle during intraoperative frozen sections.","authors":"Abraham Sabu, Deepak Pandiar, Reshma Poothakulath Krishnan","doi":"10.1016/j.patol.2026.100902","DOIUrl":"https://doi.org/10.1016/j.patol.2026.100902","url":null,"abstract":"<p><strong>Aim: </strong>To estimate and evaluate the optimal thickness section tissue for adipose tissue, salivary glands and skeletal muscle during intraoperative frozen sectioning.</p><p><strong>Methodology: </strong>This prospective study was conducted in our oral oncology department after obtaining approval from the institutional ethics committee. For each tissue type, 143 sections were analysed at each of three thicknesses (5, 7, and 11 µm) using a two-step embedding technique, resulting in a total of 1287 sections. The sections were semi-qualitatively scored as acceptable or unacceptable based on the presence of artefacts, staining characteristics, cellular morphology, and cellular and nuclear outline. The data were analysed using SPSS software, version 26.</p><p><strong>Results: </strong>The adipose tissue, salivary glands and skeletal muscle were analysed at three different thicknesses, 5 µm (Group I), 7 µm (Group II) and 11 µm (Group III). A statistically significant difference was found between the three groups (p <0.001). Adipose tissue sections of 11 µm showed the highest percentage of acceptable sections (80.42%), with minimal artefacts compared with Groups I and II. However, salivary gland tissue showed higher percentages of satisfactory sections at 5 µm (84.61%) and 7 µm (81.81%). Similar results were obtained for skeletal muscle.</p><p><strong>Conclusion: </strong>Among the section thicknesses evaluated, adipose tissue showed the highest percentage of acceptable sections at 11 µm, whereas salivary gland tissue and skeletal muscle showed better section quality at 5-7 µm. Further studies in oncology centres are needed to validate these findings.</p>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":" ","pages":"100902"},"PeriodicalIF":0.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pathological significance of DNA damage-inducible transcript 3 immunohistochemistry in the diagnosis of myxoid liposarcoma.","authors":"Manar Moustafa, Fifi Mostafa El Sayed, Mohammed I Abdelhamid, Hanim M Abdelnour, Heba Mahmoud Abdelgeleel","doi":"10.1016/j.patol.2026.100899","DOIUrl":"https://doi.org/10.1016/j.patol.2026.100899","url":null,"abstract":"<p><strong>Background: </strong>Myxoid liposarcoma (MLS) is a distinct subtype of liposarcoma characterised by recurrent FUS-DDIT3 or EWSR1-DDIT3 gene fusions and distinctive histological features. DNA damage-inducible transcript 3 (DDIT3) is a key downstream mediator of these fusions and contributes to sarcoma development by disrupting adipocytic differentiation. In this study, we assessed the diagnostic value and biological relevance of DDIT3 by combining immunohistochemistry (IHC) with quantitative real-time polymerase chain reaction (qRT-PCR).</p><p><strong>Methods: </strong>The study included 128 soft tissue tumours, comprising 45 cases of MLS and 83 histological mimics. DDIT3 expression was evaluated by IHC, and transcript-level expression was analysed using qRT-PCR. FUS-DDIT3 fusion transcripts were assessed and associations with clinicopathological features and FNCLCC tumour grade were analysed.</p><p><strong>Results: </strong>DDIT3 IHC was positive in 42/45 (93.3%) MLS cases and 3/83 (3.6%) histological mimics (P < 0.001), yielding a sensitivity of 93.3%, specificity of 96.4%, positive predictive value of 93.3%, and negative predictive value of 96.4%. All cases with classic MLS morphology showed positive nuclear DDIT3 staining, whereas the three non-positive MLS cases occurred within the high-grade/round-cell subgroup. Among the mimics, DDIT3 positivity was observed only in 3 of 5 Ewing sarcoma cases. qRT-PCR demonstrated variation in FUS: DDIT3 transcript expression among the analysed cases; however, transcript-level expression did not uniformly parallel immunohistochemical protein detection.</p><p><strong>Conclusions: </strong>DDIT3 is a highly sensitive and specific marker for the diagnosis of MLS. The concordance between protein and transcript expression highlights the biological relevance of DDIT3 and supports its use as a practical, cost-effective adjunct to molecular testing in routine diagnostic practice.</p>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":" ","pages":"100899"},"PeriodicalIF":0.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant intra-axial calcifying pseudoneoplasm of the neuraxis mimicking a high-grade glioma: A case report","authors":"William David Cardales Arizal,&nbsp;Brandon Steve Gómez Gil,&nbsp;Nancy Mejía Vargas","doi":"10.1016/j.patol.2026.100887","DOIUrl":"10.1016/j.patol.2026.100887","url":null,"abstract":"<div><h3>Introduction</h3><div>Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare benign lesion that can mimic malignant neoplasms.</div></div><div><h3>Case presentation</h3><div>A 19-year-old woman presented with long-standing seizures and severe headache. Magnetic resonance imaging revealed a giant intra-axial mass (8.3<!--> <!-->cm) in the right hemisphere with calcifications and mass effect, suggestive of a high-grade glioma. Complete surgical resection was performed. Histopathological examination showed a fibrillary stroma with abundant dystrophic calcifications, without atypia or mitotic figures. Immunohistochemistry demonstrated positivity for GFAP and S100 and negativity for EMA in the lesion, with a low proliferative index (Ki-67 &lt;1%), confirming CAPNON.</div></div><div><h3>Conclusion</h3><div>CAPNON is an important differential diagnosis of calcified lesions. Although its radiological appearance may be aggressive, it is a benign lesion, and complete surgical resection is usually curative.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 3","pages":"Article 100887"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposarcoma desdiferenciado con reordenamiento en HMGA2::KERA: reporte de un caso y revisión de la literatura","authors":"Ana Rosa Parra-Tercero,&nbsp;María Recuero-Pradillo,&nbsp;Bárbara Meléndez,&nbsp;Irene Manzano-Benito,&nbsp;Inés Bartolomé-Asensio,&nbsp;Juan Ruiz-Martín","doi":"10.1016/j.patol.2026.100884","DOIUrl":"10.1016/j.patol.2026.100884","url":null,"abstract":"<div><div>We report a case of retroperitoneal dedifferentiated liposarcoma in a 57-year-old woman, in which a rearrangement involving the <em>HMGA2</em> (12q14.3) and <em>KERA</em> (12q21.33) genes was detected by next-generation sequencing (NGS), a previously unreported rearrangement.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 3","pages":"Article 100884"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study to estimate the workload of high-level technicians in anatomical pathology and cytodiagnosis (technical time): Document produced by the working groups of Anatomic Pathology and Cytodiagnostics Higher Technician and on Applied Management and Quality of the Spanish Society of Anatomical Pathology (SEAP)","authors":"Francesc Tresserra Casas ,&nbsp;Candelaria Barberá Sánchez ,&nbsp;Ángeles García Sánchez ,&nbsp;Ana Calatrava Fons ,&nbsp;Diego García Fresnadillo ,&nbsp;Marco Antonio Fernández Miquel ,&nbsp;Silvia de la Horra Iglesias ,&nbsp;Sonia García del Busto Ruiz ,&nbsp;Rocío González Rodríguez ,&nbsp;Diana Izquierdo Moreno ,&nbsp;Begoña Jiménez Galván ,&nbsp;Violeta Marqués Larraz ,&nbsp;Amparo Morrió Mondéjar ,&nbsp;Rosario Pérez Díaz ,&nbsp;Alfredo Ramos Pastor ,&nbsp;Mª Cruz Sánchez Velasco ,&nbsp;Eva Sebastià Martínez ,&nbsp;Ana Villalba Fernández ,&nbsp;Santiago Fernando Yaguana Valencia ,&nbsp;Ana Isabel Goitia Viaña ,&nbsp;Antonio Martínez Lorente","doi":"10.1016/j.patol.2026.100882","DOIUrl":"10.1016/j.patol.2026.100882","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the time spent by technical staff in the anatomical pathology department on each of the processes in which they were involved, and to define a workload unit.</div></div><div><h3>Methods</h3><div>The time required for technical procedures was measured over 5 days in 10 hospitals. The median time for each process was calculated.</div></div><div><h3>Results</h3><div>The time required for registration was 3.92<!--> <!-->min/specimen; for embedding of small specimens, 1.96<!--> <!-->min/specimen; for embedding of large specimens 10.91<!--> <!-->min/specimen; for microtomy, 1.01<!--> <!-->min/specimen; for immunohistochemistry, 2.13<!--> <!-->min/specimen; for liquid-based cytology, 4.02<!--> <!-->min/specimen; and for archiving, 0.49<!--> <!-->min/specimen.</div></div><div><h3>Conclusions</h3><div>The technical workload unit (TWU) is set at 11<!--> <!-->min, corresponding to the rounding of 10.91<!--> <!-->min/specimen for large-specimen embedding, as this is the most time-consuming task. Thus, TWU values range from 0.09<!--> <!-->TWU/specimen for block preparation and sectioning to 1<!--> <!-->TWU/specimen for large-specimen embedding.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 3","pages":"Article 100882"},"PeriodicalIF":0.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}