Revista Espanola de Patologia最新文献_第10页

Osteoclast-rich undifferentiated carcinoma of the bladder and the diagnostic usefulness of immunohistochemistry. A case report 富破骨细胞的膀胱癌及免疫组织化学的诊断价值。病例报告

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.01.002

Guillermo García-Porrero, José Joaquín Paricio Martínez, Laura Álvarez Gigli, Marta Abengózar Muela

引用次数: 0

Effect of non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP) terminology on surgical management concepts 具有乳头状特征的非侵袭性滤泡性甲状腺肿瘤(NIFTP)术语对手术管理概念的影响

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.11.001

Khaled Abdelwahab , Ahmed Abdallah , Islam H. Metwally , Shadi Awny , Omar Hamdy , Khadiga M. Ali , Mohammad Zuhdy

{"title":"Effect of non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP) terminology on surgical management concepts","authors":"Khaled Abdelwahab , Ahmed Abdallah , Islam H. Metwally , Shadi Awny , Omar Hamdy , Khadiga M. Ali , Mohammad Zuhdy","doi":"10.1016/j.patol.2022.11.001","DOIUrl":"10.1016/j.patol.2022.11.001","url":null,"abstract":"<div><h3>Background</h3><p>Despite the strict diagnostic criteria recently proposed for non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP), its incidence is still unknown. Employing a retrospective analysis of the follicular variant of papillary thyroid carcinoma (FVPTC), we investigated the diagnosis, prevalence and postoperative course of NIFTP.</p></div><div><h3>Methods</h3><p>We examined retrospectively the records of 112 patients who had undergone thyroid surgery and had a postoperative diagnosis of FVPTC at our hospital from 2010 to 2021. All clinical, radiologic, and pathologic features were evaluated.</p></div><div><h3>Results</h3><p>Only 34 (27.9%) patients met the strict pathologic criteria for NIFTP; 11 cases having been diagnosed as NIFTP initially and 23 after re-evaluation of histopathologic slides. None of the 11 NIFTP patients underwent a 2-stage operation, in contrast to 10 (29.4%) patients initially diagnosed as FVPTC who had a completion thyroidectomy after the initial hemithyroidectomy. The median follow-up was 14.5 (ranging from 0 to 78) months. None of the cases developed a recurrence.</p></div><div><h3>Conclusion</h3><p>To avoid unnecessary treatment or the follow-up advised for papillary thyroid carcinoma, clinicians and pathologists should be familiar with the terminology and the corresponding diagnostic criteria for NIFTP and their impact on management.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"56 2","pages":"Pages 82-87"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9333866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hybrid neurofibroma/schwannoma of the orbit 眼眶混合型神经纤维瘤/神经鞘瘤

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.03.002

Lourdes Salazar-Huayna , Lourdes Naranjo , Cleofé Romagosa , Miguel Ángel Arcediano , Sahyly Siurana , Santiago Ramón y Cajal , Carme Dinarès

引用次数: 0

Intestinal infantile fibrosarcoma with translocation of NTRK. A case report and review of the literature NTRK易位的肠婴儿纤维肉瘤。病例报告及文献回顾

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.09.004

Paula Martín Soler, María Soledad Rodríguez Duque, Germán Moreno De Juan, Adriana Katherine Calapaqui Terán, Ana Rosa Tabardilla Calvo, María Luisa Cagigal Cobo

{"title":"Intestinal infantile fibrosarcoma with translocation of NTRK. A case report and review of the literature","authors":"Paula Martín Soler, María Soledad Rodríguez Duque, Germán Moreno De Juan, Adriana Katherine Calapaqui Terán, Ana Rosa Tabardilla Calvo, María Luisa Cagigal Cobo","doi":"10.1016/j.patol.2022.09.004","DOIUrl":"10.1016/j.patol.2022.09.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Infantile fibrosarcoma is a rare non-rhabdomyosarcomatous soft tissue tumor (0.0005%) of which only 10% occur in the abdomen where they rarely affect the gastrointestinal tract. The median age at diagnosis is 3 months although 40% of them are present at birth.</p></div><div><h3>Material and methods</h3><p>When infantile fibrosarcoma is diagnosed in our center, a clinical–pathological description is made together with a bibliographic review.</p></div><div><h3>Results</h3><p>We present the case of a 6-day-old girl who presented with irritability and rejection of food. She was diagnosed with acute abdomen due to perforation and underwent surgery where a mass on the ascending colon was removed. Histopathology revealed a proliferation of spindle cells consisting of intertwined fascicles, infiltrating the adjacent tissues. Nuclear pleomorphism, few mitoses, foci of necrosis and hemorrhage are seen. Immunohistochemistry showed positivity for Pan-TRK and the NGS panel (Archer DX) demonstrated the TPR::NTRK1 fusion.</p><p>No case with these characteristics, location or TPR::NTRK1 fusion were found in the literature.</p></div><div><h3>Conclusions</h3><p>Infantile fibrosarcoma is a very infrequent tumor which is exceptionally rare in the intestine. It is important to look for the characteristic genetic rearrangement of these tumors both to confirm the diagnosis and differentiate them from other pediatric spindle cell tumors and determine the correct targeted treatment. Selective TRK inhibitors have shown a 75% response rate in children and adults with tumors that exhibit TRK fusion. It was possible to find fusions with the <em>Archer DX</em> panel that the <em>Oncomine panel</em> did not detect.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"56 2","pages":"Pages 76-81"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9333869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic intraductal papillary mucinous neoplasm with sarcomatous transformation. A case report 胰腺导管内乳头状粘液瘤伴肉瘤转化。病例报告

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2021.05.004

Álvaro López-Janeiro , Ana Margarita Rodriguez , Marta Mendiola , Rula Nasimi Sabbagh , Jaime Feliu , Arantxa Villadóniga , Maria del Carmen Mendez

引用次数: 0

La Patología ante un gran desafío: el impacto de las nuevas clasificaciones de las neoplasias 病理学面临巨大挑战：肿瘤新分类的影响

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2023.03.001

Miguel A. Idoate Gastearena

引用次数: 0

Tumor de células gigantes óseo en arco costal, tratado con denosumab. Reporte de un caso 肋弓骨巨细胞瘤，用Denosumab治疗。病例报告

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2021.04.002

Paula Serret Miralles, Ruth Orellana Fernández, Tamara Parra Parente, Rosa Belén García-Chamón Brígido, Rubén Carrera Salas

引用次数: 0

Pediatric patients with lysosomal acid lipase deficiency 溶酶体酸性脂肪酶缺乏症患儿

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2021.03.005

David A. Suarez-Zamora , Maria M. Rojas-Rojas , Felipe Ordoñez-Guerrero , Jacqueline Mugnier-Quijano , Rocio Lopez-Panqueva

{"title":"Pediatric patients with lysosomal acid lipase deficiency","authors":"David A. Suarez-Zamora , Maria M. Rojas-Rojas , Felipe Ordoñez-Guerrero , Jacqueline Mugnier-Quijano , Rocio Lopez-Panqueva","doi":"10.1016/j.patol.2021.03.005","DOIUrl":"10.1016/j.patol.2021.03.005","url":null,"abstract":"<div><p><span>Lysosomal acid lipase (LAL) deficiency is a rare, autosomal recessive disease caused by mutations in the LIPA gene, which produces cholesteryl ester and triglyceride accumulation predominantly in hepatocytes, adrenal glands, and gastrointestinal tract. We describe two new cases occurring in siblings, aged 5 and 7 years, who presented with hepatomegaly, dyslipidemia, and abnormal liver function. Percutaneous liver biopsy revealed portal inflammation, hypertrophic Kupffer cells with a foamy appearance and microvesicular steatosis with fibrosis. Immunostaining for lysosomal markers, cathepsin D and LAMP1 reflected the lysosomal nature of the lipid vacuoles. After enzymatic confirmation, enzyme replacement therapy was initiated for both siblings. Follow-up transaminase levels and lipid profiles showed a notable decrease in AST and ALT and a slight increase in </span>HDL<span> cholesterol. It is crucial to increase awareness of this rare condition among clinicians and pathologists. The expression of lysosomal markers around the lipid vacuoles might help diagnose LAL deficiency in pediatric patients.</span></p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"56 2","pages":"Pages 113-118"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9333865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Villitis crónica granulomatosa asociada a citomegalovirus. Un hallazgo inusual que induce a confusión. A propósito de un caso 与巨细胞病毒相关的慢性肉芽肿性绒毛膜炎。引起混乱的不寻常发现。关于一个案件

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2021.10.001

Marta Segado Martínez, María Isabel Oviedo Ramírez

引用次数: 0

Mesotelioma papilar bien diferenciado: descripción de tres casos y revisión bibliográfica 分化良好的乳头状间皮瘤3例报告并文献复习

Revista Espanola de Patologia Pub Date : 2023-01-01 DOI: 10.1016/j.patol.2021.05.002

Belén Tristán Martín , Grevelyn Sosa Rotundo , Laura López Brasal , Isabel Alemany Benítez

引用次数: 0