Revista Espanola de Patologia最新文献

{"title":"Tumor fibroso calcificante intestinal: reporte de caso","authors":"Gonzalo Nathaniel Cantú-Soriano ,&nbsp;Álvaro Lezid Padilla-Rodríguez","doi":"10.1016/j.patol.2023.11.003","DOIUrl":"https://doi.org/10.1016/j.patol.2023.11.003","url":null,"abstract":"<div><p>Calcifying fibrous tumor (CFT) is a rare benign lesion of mesenchymal origin that may present similar characteristics to other more common tumors. We present the case of a 36-year-old woman with a tumor in the proximal jejunum, initially suspected to be a gastrointestinal stromal tumor (GIST). Surgical resection was performed, revealing a well-demarcated nodule at the anti-mesenteric border with microscopic features typical of a calcifying fibrous tumor. The tumor cells were positive for CD34 and negative for other markers, differentiating it from other neoplasms. Calcifying fibrous tumors can be confused with more common tumors because of its appearance, but an accurate diagnosis supported by immunohistochemistry is essential. Complete surgical excision is usually curative.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 2","pages":"Pages 137-140"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic adenomatous polyp with florid presence of monoclonal lambda Russell bodies: Case report and etiopathogenic hypothesis","authors":"Adriano Martínez-Aracil ,&nbsp;Diego Polanco-Alonso ,&nbsp;Celina Stayerman ,&nbsp;Carlos Miguel ,&nbsp;Guiomar Pérez de Nanclares","doi":"10.1016/j.patol.2023.07.001","DOIUrl":"10.1016/j.patol.2023.07.001","url":null,"abstract":"<div><p>Russell bodies (RBs) are round eosinophilic intracytoplasmic inclusions formed by condensed immunoglobulins in mature plasma cells, which are called Mott cells. These cells are rarely found in the gastric tract, with even less cases reported in the colorectal region. There are still many questions about this event, as it is still unknown the relationship between the agents reported of increasing the probability of appearance of these cells and the generation of RBs. In this case report we describe the fifth patient presenting an infiltration of Mott cells in a colorectal polyp, being the second case with a monoclonal origin without a neoplastic cause, and the first one monoclonal for lambda. A comparison with previously similar reported cases is also done, and a possible etiopathogenic hypothesis proposed.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 2","pages":"Pages 111-115"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretación histopatológica de biopsias por tumores melanocíticos en localizaciones especiales","authors":"Caridad Socorro Castro ,&nbsp;Susana Hernández Delgado ,&nbsp;Rosayner García Palacios","doi":"10.1016/j.patol.2023.02.006","DOIUrl":"10.1016/j.patol.2023.02.006","url":null,"abstract":"<div><h3>Introduction and objective</h3><p>Melanoma is the leading cause of death from skin cancer in the world. Despite the advances in molecular diagnosis, the differential diagnosis between melanoma and benign melanocytic tumors relies on histopathology. However, not all of the criteria for the microscopy of a biopsy of a melanocytic tumor are applicable to all locations.</p></div><div><h3>Patients</h3><p>We highlight these difficulties in the presentation of 2<!--> <!-->cases of melanocytic tumors in unusual locations which were diagnostically challenging.</p></div><div><h3>Results</h3><p>After analyzing the relevant literature, the atypical histopathological characteristics of melanocytic tumors could be specified for unusual anatomical sites.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 48-52"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55189654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking inflammation and angiogenesis with fibrogenesis: Expression of FXIIIA, MMP-9, and VEGF in oral submucous fibrosis","authors":"Sheetal Choudhari ,&nbsp;Deepak Kulkarni ,&nbsp;Sangeeta Patankar ,&nbsp;Supriya Kheur ,&nbsp;Sachin Sarode","doi":"10.1016/j.patol.2023.11.005","DOIUrl":"10.1016/j.patol.2023.11.005","url":null,"abstract":"<div><h3>Objectives</h3><p>Interplay of Factor XIIIa (FXIIIa), a transglutaminase, responsible for cross-linking of matrix proteins, Matrix Metalloproteinase-9 (MMP-9), a gelatinase, and Vascular Endothelial Growth Factor (VEGF), an angiogenic inducer, were studied in relation to fibrogenesis and disease progression in oral submucous fibrosis (OSMF).</p></div><div><h3>Material and methods</h3><p>Immunohistochemical expression of markers was studied in 60 formalin-fixed paraffin-embedded tissue blocks of OSMF and 20 normal oral mucosal tissues. FXIIIa was studied quantitatively while MMP-9 and VEGF were assessed semi-quantitatively. Expression was compared with histopathological grades of OSMF.</p></div><div><h3>Results</h3><p>FXIIIa expression significantly increased in OSMF (<em>p-value 0.000</em>). However, expression decreased and cells became quiescent with increasing grades (<em>p-value 0.000</em>). MMP-9 (<em>p-value</em> epithelium <em>0.011</em>, <em>p-value connective tissue 0.000</em>) and VEGF expression (<em>p-value epithelium 0.000</em>, <em>connective tissue 0.000</em>) increased in OSMF. A negative correlation between FXIIIa and MMP-9 (−0.653) in early grade (<em>p-value of 0.021</em>) and a positive correlation between FXIIIa and VEGF (0.595) (<em>p-value of 0.032</em>) was found in the moderate grade OSMF. Regression analysis showed a significant association (<em>p</em> <!-->&lt;<!--> <em>0.01</em>) of FXIIIa in OSMF and with increasing grades of OSMF.</p></div><div><h3>Conclusion</h3><p>FXIIIa may play a crucial role in initiation of fibrosis in OSMF. MMP-9 may have a diverse role to play in OSMF as a regulator of fibrosis. VEGF may show an angio-fibrotic switch and contribute to fibrosis in OSMF. These cytokines may show altered function and can contribute to fibrosis and chronicity of disease due to changes in the microenvironment. Tissue stiffness in OSMF itself creates an environment that enhances the chronicity of the disease.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 15-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico clínico-patológico de la neoplasia de células dendríticas plasmocitoides blásticas: reporte de 3 casos","authors":"Iván Rienda ,&nbsp;Vicent Martínez-Cózar ,&nbsp;Ignacio Torres-Navarro ,&nbsp;Margarita Llavador","doi":"10.1016/j.patol.2023.04.003","DOIUrl":"10.1016/j.patol.2023.04.003","url":null,"abstract":"<div><p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease with a poor prognosis. It frequently affects the skin; indeed, dermal lesions may be the first clinical manifestation.</p><p>We report three cases of BPDCN where the patients presented with skin lesions and describe the clinical, histopathological and immunohistochemical findings, its molecular characteristics and metastatic work-up.</p><p>One of the patients remains in a clinical trial with IMGN632, a molecule directed against CD123, while the other two patients died after different therapeutic regimens.</p><p>BPDCN is a complex diagnostic challenge which, together with its poor prognosis, requires close clinical-pathological cooperation in order to accelerate its diagnosis and offer early therapeutic alternatives with drugs directed against specific molecular targets.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 53-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant “triton” tumor of the lower extremity with a history of fracture","authors":"Diogo Nóbrega Catelas ,&nbsp;Sérgio Pita ,&nbsp;André Coelho ,&nbsp;Vânia Oliveira ,&nbsp;Pedro Cardoso","doi":"10.1016/j.patol.2023.06.004","DOIUrl":"10.1016/j.patol.2023.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Malignant triton tumor (MTT) is a rare and aggressive subtype of malignant peripheral nerve sheath tumor consisting of a neurogenic tumor with rhabdomyoblastic differentiation. Only 170 cases have been reported to date, two-thirds occurring in young patients with neurofibromatosis type 1 and the remaining third presenting as a sporadic tumor.</p></div><div><h3>Case presentation</h3><p>We present the case of a 49-year-old man with a sporadic grade 2 MTT of the lower limb which had had a previous tibial fracture. The patient underwent an above-knee amputation. Five months post-operatively metastases were present in the liver and vertebral column causing compression of the spinal cord, so decompressive radiotherapy and palliative chemotherapy were initiated.</p></div><div><h3>Conclusion</h3><p>Due to the precocious spread of the disease, we would suggest that adjuvant chemotherapy be considered for the eradication of micrometastases. To our knowledge, this is only the second reported case of an MTT arising in a site with a history of previous severe trauma.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 59-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135249002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of phosphatase and tensin homologue (PTEN) expression in gastric cancer and its relationship with histopathological findings","authors":"Seyed Amir Miratashi Yazdi ,&nbsp;Fatemeh Hoseini ,&nbsp;Arezoo Eftekhar Javadi ,&nbsp;Elham Nazar","doi":"10.1016/j.patol.2023.11.001","DOIUrl":"10.1016/j.patol.2023.11.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Phosphatase and tensin homologue (PTEN) is an important tumour suppressor in multi-step tumorigenesis. To establish the role of PTEN in gastric cancer progression, we examined the PTEN expression degree in gastric cancer tissues. We also explained the connection between PTEN expression and histopathological findings.</p></div><div><h3>Materials and methods</h3><p>Our study was cross-sectional and made up of 50 patients with known gastric cancer. Immunohistochemical staining for PTEN was done on gastric cancer tissues. Tumour behaviour was estimated by histopathological assessments.</p></div><div><h3>Results</h3><p>Twenty-seven (54%) of the 50 patients had PTEN staining. The evaluation of the connection between PTEN expression and demographic data and tumour behaviours revealed no meaningful relationship between PTEN expression and patients’ age, gender, tumour site and size, tumour type, tumour grade and stage, neural, and lymphovascular invasion (<em>P</em>-value<!--> <!-->&gt;<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>PTEN expression level is expected to be a significant molecular event in the progression of gastric cancer and may be a predictive marker for gastric cancer behaviours dependent on society.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 3-8"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principales tipos de quistes en dermatopatología: parte 1","authors":"María Teresa Fernández Figueras ,&nbsp;Jacques Alzoghby-Abi Chaker ,&nbsp;Miriam Fernandez-Parrado ,&nbsp;Adriana García Herrera ,&nbsp;María Garrido ,&nbsp;Miguel Ángel Idoate Gastearena ,&nbsp;Mar Llamas-Velasco ,&nbsp;Carlos Monteagudo ,&nbsp;José Onrubia ,&nbsp;Noelia Pérez Muñoz ,&nbsp;Juan José Ríos-Martín ,&nbsp;José Luis Rodríguez Peralto ,&nbsp;Eduardo Rozas Muñoz ,&nbsp;Onofre Sanmartín ,&nbsp;Ángel Santos-Briz ,&nbsp;Carles Saus ,&nbsp;José Manuel Suárez Peñaranda ,&nbsp;Verónica Velasco Benito ,&nbsp;María José Beato Merino ,&nbsp;Ángel Fernandez-Flores","doi":"10.1016/j.patol.2023.11.006","DOIUrl":"10.1016/j.patol.2023.11.006","url":null,"abstract":"<div><p>Cystic structures represent one of the most common findings in dermatopathology. These encompass both cystic tumors and pseudocysts resulting from the accumulation of certain substances, such as mucin. In a two-part series (of which this is the first part), we have reviewed the principal types of cysts and pseudocysts that may be observed in cutaneous biopsies, examining their histopathological features and primary differential diagnoses. This first part encompasses infundibular cysts, eruptive dermoid cysts, pigmented follicular cysts, pilonidal cysts, tricholemmal cysts, milium cysts, hybrid cysts, bronchogenic cysts, as well as steatocystoma, hydrocystoma, and comedones.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 27-41"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A propósito de un caso de síndrome de Fraser. Autopsia de un feto de 37 semanas de gestación con múltiples malformaciones","authors":"Laura Sánchez Godoy,&nbsp;José Emilio Hernández Barceló","doi":"10.1016/j.patol.2023.07.002","DOIUrl":"10.1016/j.patol.2023.07.002","url":null,"abstract":"<div><p>Fraser syndrome or cryptophthalmos-syndactyly syndrome is a rare genetic disease, the diagnosis of which is based on a series of major and minor clinical criteria and that can be supported by genetic tests. This article presents the case of a fetal autopsy at 37 weeks of gestation with suspicion of CHAOS syndrome (congenital obstructive syndrome of the upper airways).</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 64-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocitoma de bajo grado en un teratoma retroperitoneal: reporte de caso","authors":"Eduardo Alfredo González Murillo,&nbsp;Eduardo Benavides Salas,&nbsp;María Margarita Vizcaino Lozano","doi":"10.1016/j.patol.2023.08.003","DOIUrl":"10.1016/j.patol.2023.08.003","url":null,"abstract":"<div><p>Teratomas are neoplasms originate from germ cells and can undergo malignant transformation, the World Health Organization (WHO) classified them as teratoma with somatic-type malignancy which is uncommon and sarcomas are the histological type with the highest incidence. It is important to identify this type of tumors because influences the prognosis and survival of the patient.</p><p>We present the case of a 5-month-old male, who began his condition at one month-old with constipation and increase of the abdominal circumference, imaging studies revealed an abdominal lesion, he was treated with chemotherapy and surgery. The histopathological report was immature teratoma, grade 1, with a focus of nervous tissue showing characteristics of low-grade astrocytoma.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"57 1","pages":"Pages 71-74"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135848698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}