Revista Espanola de Patologia最新文献_第8页

Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma COX-2、Ki-67、Bcl-2、Bax、VEGF和CD105在口腔鳞状细胞癌组织学分级中的免疫组织化学表达

Revista Espanola de Patologia Pub Date : 2023-07-01 DOI: 10.1016/j.patol.2023.02.005

Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga

{"title":"Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma","authors":"Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga","doi":"10.1016/j.patol.2023.02.005","DOIUrl":"10.1016/j.patol.2023.02.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.</p></div><div><h3>Objective</h3><p>Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.</p></div><div><h3>Material and methods</h3><p>The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.</p></div><div><h3>Results</h3><p>COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (<em>p</em>  <0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (<em>p</em>  <!-->0.05).</p></div><div><h3>Conclusion</h3><p>There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Mastocytosis with Associated Hematological Neoplasms. Diagnostic features and unique response pattern to tyrosine kinase inhibitors and allo-bone marrow transplantation therapy 系统性肥大细胞增多症伴相关血液系统肿瘤。酪氨酸激酶抑制剂和异基因骨髓移植治疗的诊断特征和独特反应模式

Revista Espanola de Patologia Pub Date : 2023-07-01 DOI: 10.1016/j.patol.2021.06.003

Irene Hernández Alconchel , Sonia González de Villambrosía , Andrés Insunza Gaminde , Santiago Montes Moreno

引用次数: 1

Viruela del mono con afectación de conductos ecrinos 猴痘伴汗管受累

Revista Espanola de Patologia Pub Date : 2023-07-01 DOI: 10.1016/j.patol.2023.01.001

Purificación de los Reyes Cano-Mármol , Laura Lorente-Gea , Matías Martínez Pérez , José Navarro Pascual , Enrique Poblet

引用次数: 0

Enfermedad de Paget extramamario primario de vulva concurrente con Lesión intraepitelial escamosa vulvar: reporte de caso 原发性外阴乳腺外Paget病并发外阴鳞状上皮内病变1例

Revista Espanola de Patologia Pub Date : 2023-07-01 DOI: 10.1016/j.patol.2021.12.002

Mercedes Bravo-Taxa , Luis Taxa-Rojas

引用次数: 0

Discordant results for ALK based on immunohistochemistry versus fluorescence in situ hybridization in a cohort of patients diagnosed with lung adenocarcinoma 在一组诊断为肺腺癌的患者中，基于免疫组织化学和荧光原位杂交的ALK结果不一致

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2023.02.001

Luisa Sará , Ana Shaia Clavijo , Jesus David Niño-Torres , Luisa M. Solarte , Angela Vergara , Olga M. Moreno , Jorge L. Rodríguez , Adriana Rojas

{"title":"Discordant results for ALK based on immunohistochemistry versus fluorescence in situ hybridization in a cohort of patients diagnosed with lung adenocarcinoma","authors":"Luisa Sará , Ana Shaia Clavijo , Jesus David Niño-Torres , Luisa M. Solarte , Angela Vergara , Olga M. Moreno , Jorge L. Rodríguez , Adriana Rojas","doi":"10.1016/j.patol.2023.02.001","DOIUrl":"10.1016/j.patol.2023.02.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Anaplastic lymphoma kinase (ALK) rearrangement located on the short arm of chromosome 2, region 2 and band 3 is frequent in lung cancer patients who respond to targeted therapies with ALK inhibitors Therefore, their identification has become a standard diagnostic test in patients with advanced NSCLS, as such chromosomal alterations may lead to the activation of important signalling pathways involved in cell survival and proliferation.</p></div><div><h3>Methods</h3><p>To investigate the <em>ALK</em> gene status, we performed FISH and IHC assays in 18 lung adenocarcinoma patients, 12 women and 6 men, aged between 29 and 85 years. Paraffin-embedded samples were analyzed in the Pathology Department of the Hospital Universitario San Ignacio.</p></div><div><h3>Results</h3><p>Results between the two techniques in 5 patients showed discordant patterns, being positive for FISH and negative for IHC. The borderline to define ALK positivity was set at 15%, These results present experimental evidence that the techniques differ in specific situations.</p></div><div><h3>Conclusions</h3><p>Our findings show that it is advisable to investigate the ALK gene status in patients with suspected lung cancer using both FISH and IHC in combination.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9339123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nueva actualización de las recomendaciones para la determinación de biomarcadores predictivos en el carcinoma de pulmón no célula pequeña: Consenso Nacional de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Oncología Médica 确定非小细胞肺癌预测生物标志物的建议的新更新：西班牙病理解剖学会和西班牙医学肿瘤学会的全国共识

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2023.02.002

Dolores Isla , María D. Lozano , Luis Paz-Ares , Clara Salas , Javier de Castro , Esther Conde , Enriqueta Felip , Javier Gómez-Román , Pilar Garrido , Ana Belén Enguita

{"title":"Nueva actualización de las recomendaciones para la determinación de biomarcadores predictivos en el carcinoma de pulmón no célula pequeña: Consenso Nacional de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Oncología Médica","authors":"Dolores Isla , María D. Lozano , Luis Paz-Ares , Clara Salas , Javier de Castro , Esther Conde , Enriqueta Felip , Javier Gómez-Román , Pilar Garrido , Ana Belén Enguita","doi":"10.1016/j.patol.2023.02.002","DOIUrl":"https://doi.org/10.1016/j.patol.2023.02.002","url":null,"abstract":"<div><p>Non-small cell lung cancer (NSCLC) presents the greatest number of identified therapeutic targets, some of which have therapeutic utility. Currently, detecting <em>EGFR</em>, <em>BRAF</em>, <em>KRAS</em> and <em>MET</em> mutations, <em>ALK</em>, <em>ROS1</em>, <em>NTRK</em> and <em>RET</em> translocations, and PD-L1 expression in these patients is considered essential. The use of next-generation sequencing (NGS) facilitates precise molecular diagnosis and allows the detection of other emerging mutations, such as the <em>HER2</em> mutation and predictive biomarkers for immunotherapy responses.</p><p>In this consensus, a group of experts in the diagnosis and treatment of NSCLC selected by the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM) have evaluated currently available information and propose a series of recommendations to optimize the detection and use of biomarkers in daily clinical practice.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49789358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distrofia de membrana basal epitelial corneal: a propósito de un caso 角膜上皮基底膜营养不良1例

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.03.003

Carolina Díaz Baena, Elena Gallego Domínguez, María Isabel Hierro Martín

引用次数: 0

Osteoclast-rich undifferentiated carcinoma of the bladder and the diagnostic usefulness of immunohistochemistry. A case report 富破骨细胞的膀胱癌及免疫组织化学的诊断价值。病例报告

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.01.002

Guillermo García-Porrero, José Joaquín Paricio Martínez, Laura Álvarez Gigli, Marta Abengózar Muela

引用次数: 0

Effect of non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP) terminology on surgical management concepts 具有乳头状特征的非侵袭性滤泡性甲状腺肿瘤(NIFTP)术语对手术管理概念的影响

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.11.001

Khaled Abdelwahab , Ahmed Abdallah , Islam H. Metwally , Shadi Awny , Omar Hamdy , Khadiga M. Ali , Mohammad Zuhdy

{"title":"Effect of non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP) terminology on surgical management concepts","authors":"Khaled Abdelwahab , Ahmed Abdallah , Islam H. Metwally , Shadi Awny , Omar Hamdy , Khadiga M. Ali , Mohammad Zuhdy","doi":"10.1016/j.patol.2022.11.001","DOIUrl":"10.1016/j.patol.2022.11.001","url":null,"abstract":"<div><h3>Background</h3><p>Despite the strict diagnostic criteria recently proposed for non-invasive follicular thyroid neoplasm with papillary-like features (NIFTP), its incidence is still unknown. Employing a retrospective analysis of the follicular variant of papillary thyroid carcinoma (FVPTC), we investigated the diagnosis, prevalence and postoperative course of NIFTP.</p></div><div><h3>Methods</h3><p>We examined retrospectively the records of 112 patients who had undergone thyroid surgery and had a postoperative diagnosis of FVPTC at our hospital from 2010 to 2021. All clinical, radiologic, and pathologic features were evaluated.</p></div><div><h3>Results</h3><p>Only 34 (27.9%) patients met the strict pathologic criteria for NIFTP; 11 cases having been diagnosed as NIFTP initially and 23 after re-evaluation of histopathologic slides. None of the 11 NIFTP patients underwent a 2-stage operation, in contrast to 10 (29.4%) patients initially diagnosed as FVPTC who had a completion thyroidectomy after the initial hemithyroidectomy. The median follow-up was 14.5 (ranging from 0 to 78) months. None of the cases developed a recurrence.</p></div><div><h3>Conclusion</h3><p>To avoid unnecessary treatment or the follow-up advised for papillary thyroid carcinoma, clinicians and pathologists should be familiar with the terminology and the corresponding diagnostic criteria for NIFTP and their impact on management.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9333866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hybrid neurofibroma/schwannoma of the orbit 眼眶混合型神经纤维瘤/神经鞘瘤

Revista Espanola de Patologia Pub Date : 2023-04-01 DOI: 10.1016/j.patol.2022.03.002

Lourdes Salazar-Huayna , Lourdes Naranjo , Cleofé Romagosa , Miguel Ángel Arcediano , Sahyly Siurana , Santiago Ramón y Cajal , Carme Dinarès

引用次数: 0