Revista Espanola de Patologia最新文献_第7页

Pulmonary angiostrongyliasis: Two cases of atypical manifestations of Angiostrongylus costaricensis in Guatemala 肺管圆线虫病：两例非典型表现的管圆线虫在危地马拉

Revista Espanola de Patologia Pub Date : 2025-07-01 Epub Date: 2025-04-08 DOI: 10.1016/j.patol.2025.100821

Juan Carlos Santis-Mejía, Roberto Orozco, Victor Argueta

引用次数: 0

Synchronous adenocarcinoma of the endometrium and colon in a woman with Lynch syndrome associated with a mutation of the MSH6 gene Lynch综合征女性与MSH6基因突变相关的子宫内膜和结肠同步腺癌

Revista Espanola de Patologia Pub Date : 2025-07-01 Epub Date: 2025-04-10 DOI: 10.1016/j.patol.2025.100826

Andrés Felipe Valencia Cardona , Jhoan Sebastián Cruz Barbosa , Armando Cortés Buelvas

{"title":"Synchronous adenocarcinoma of the endometrium and colon in a woman with Lynch syndrome associated with a mutation of the MSH6 gene","authors":"Andrés Felipe Valencia Cardona , Jhoan Sebastián Cruz Barbosa , Armando Cortés Buelvas","doi":"10.1016/j.patol.2025.100826","DOIUrl":"10.1016/j.patol.2025.100826","url":null,"abstract":"<div><h3>Introduction</h3><div>Lynch syndrome (LS) is an autosomal dominant genetic condition, accounting for an estimated prevalence of 2–3% of the causes of hereditary colorectal carcinoma. In addition, it increases the risk of endometrial and ovarian cancer, among others.</div></div><div><h3>Case report</h3><div>A 56-year-old woman with a 6-month history of pelvic pain, dyspareunia and hypermenorrhoea. Family history: her mother died of endometrial cancer at the age of 71, and her younger brother died of gastric cancer at the age of 61. A transvaginal ultrasound revealed a 20mm thickening of the endometrium, and the biopsy showed a FIGO 2 endometrioid carcinoma. Abdominal MRI demonstrated diffuse thickening of the rectum, while colonoscopy revealed an infiltrative, ulcerated tumour lesion in the sigmoid colon and a lesion in the rectum, consistent with invasive adenocarcinoma of the colon and adenoma with high-grade dysplasia in the rectal biopsy. Simultaneous surgical resection was indicated. A molecular panel confirmed a mutation in the MSH6 gene, confirming Lynch syndrome.</div></div><div><h3>Conclusions</h3><div>A rare case of Lynch syndrome associated with an MSH6 gene mutation, diagnosed with synchronous endometrial carcinoma and adenocarcinoma of the sigmoid colon.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 3","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicystic peritoneal mesothelioma with floret-like multinucleated giant cells: A case report 腹膜多囊间皮瘤伴小花样多核巨细胞1例

Revista Espanola de Patologia Pub Date : 2025-07-01 Epub Date: 2025-04-10 DOI: 10.1016/j.patol.2025.100828

Robert Ricardo Rodríguez Carpio, Carlos Hörndler Argarate, Sandra Vicente Arregui, María Francisca Perulero Martín, Leticia Ollero Domenche

引用次数: 0

Bilateral primary ovarian clear cell carcinoma in a multiparous perimenopausal woman 多产围绝经期妇女双侧原发性卵巢透明细胞癌1例

Revista Espanola de Patologia Pub Date : 2025-07-01 Epub Date: 2025-04-18 DOI: 10.1016/j.patol.2025.100823

Adil Aziz Khan, Neeti Nagar, Charanjeet Ahluwalia, Sana Ahuja

{"title":"Bilateral primary ovarian clear cell carcinoma in a multiparous perimenopausal woman","authors":"Adil Aziz Khan, Neeti Nagar, Charanjeet Ahluwalia, Sana Ahuja","doi":"10.1016/j.patol.2025.100823","DOIUrl":"10.1016/j.patol.2025.100823","url":null,"abstract":"<div><div>Primary ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian carcinoma (EOC), accounting for 5–10% of EOCs in the U.S., with a higher prevalence in East Asia. It is characterized by clear cells forming solid, tubular, or papillary patterns, and presents diagnostic challenges due to its resemblance to renal clear cell carcinomas. Typically affecting nulliparous postmenopausal women, OCCC is associated with high recurrence rates and low sensitivity to platinum-based chemotherapy. We report a case of bilateral primary OCCC in a 45-year-old multiparous woman with no history of endometriosis. She presented with lower abdominal pain and swelling persisting for 7–8 months. Imaging revealed a large, heterogeneous abdominopelvic mass. Surgery included total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological and immunohistochemical analyses confirmed bilateral OCCC, with positive staining for AMACR, Napsin A, and PAX8, and negative results for WT1, ER, and PR. This case highlights the importance of thorough diagnostic evaluation in atypical presentations. The postoperative course was uneventful, and she subsequently received adjuvant therapy.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 3","pages":"Article 100823"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parotid rhabdomyosarcoma with spindle cell features masquerading as a benign salivary gland tumour: Pitfall alert 具有梭形细胞特征的腮腺横纹肌肉瘤伪装成良性唾液腺肿瘤：陷阱警报

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100808

Thotadamane Nagaraja Chandrashekhar , Apoorva Narayana Reddy , Priyadharshini Bargunam , Saba Afreen Raheem , Ragashree Apparasanahalli Siddalingamurthy

{"title":"Parotid rhabdomyosarcoma with spindle cell features masquerading as a benign salivary gland tumour: Pitfall alert","authors":"Thotadamane Nagaraja Chandrashekhar , Apoorva Narayana Reddy , Priyadharshini Bargunam , Saba Afreen Raheem , Ragashree Apparasanahalli Siddalingamurthy","doi":"10.1016/j.patol.2025.100808","DOIUrl":"10.1016/j.patol.2025.100808","url":null,"abstract":"<div><div>Rhabdomyosarcoma (RMS) is the most common sarcoma in children and adolescents, with the head and neck region, extremities, and genitourinary tract being the most common locations. Rhabdomyosarcoma of the salivary glands is rarely seen in children and can easily be mistaken for their benign counterparts. We report a case of rhabdomyosarcoma in the parotid region that clinically and cytologically masqueraded as a benign parotid gland tumour, leading to diagnostic difficulties. However, the excised specimen revealed histomorphological and immunophenotypic features consistent with rhabdomyosarcoma. The child underwent a total parotidectomy followed by chemotherapy and is doing well without recurrence. Although cytology is minimally invasive and has good specificity, there are rare cases, such as this one, where histopathology provided the definitive diagnosis. This report aims to raise awareness of RMS of the parotid gland among clinicians, cytopathologists, and radiologists, aiding in the early diagnosis and treatment of these cases.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 2","pages":"Article 100808"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritoneal carcinomatosis after lumboperitoneal shunt in a patient with a cancer of unknown primary site: Case report and review of the literature 原发部位不明的腰腹膜分流术后的腹膜癌：病例报告及文献复习

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100802

Miquel Piñol Ribas , Robert Begué , Víctor Martínez , Elena García Alonso , Santiago Miguelsanz , Sònia Gatius

{"title":"Peritoneal carcinomatosis after lumboperitoneal shunt in a patient with a cancer of unknown primary site: Case report and review of the literature","authors":"Miquel Piñol Ribas , Robert Begué , Víctor Martínez , Elena García Alonso , Santiago Miguelsanz , Sònia Gatius","doi":"10.1016/j.patol.2025.100802","DOIUrl":"10.1016/j.patol.2025.100802","url":null,"abstract":"<div><div>Cancer of unknown primary site (CUP) often presents with atypical clinical behaviours that make identifying the primary tumour challenging. In this paper, we discuss the case of a patient with brain metastases from a CUP, which was ultimately diagnosed as pleomorphic carcinoma of the lung following autopsy. Clinically, the development of peritoneal carcinomatosis had reduced suspicion of a primary lung neoplasm, despite imaging tests initially suggesting this. However, the patient had previously undergone lumboperitoneal (LP) shunt insertion. The sequence of clinical events and autopsy findings strongly indicated that the LP shunt facilitated the metastatic spread.</div><div>In addition to this case report, we provide a systematic review of the literature on the role of ventriculoperitoneal (VP) and LP shunts in the metastatic dissemination of tumours. Although the spread of primary brain tumours via VP or LP shunts is rare, albeit well-documented, this phenomenon has been reported only twice for secondary tumours.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 2","pages":"Article 100802"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual tumour of the anterior mediastinum: Intrathymic bronchogenic cyst mimicking a thymoma 前纵隔异常肿瘤：胸腺内支气管源性囊肿，类似胸腺瘤

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100812

Mireia Rusca Giménez , Steffi Verónica Vidal Aguirre , Juan Gómez Tabales , Cristian Benavides de la Fuente

引用次数: 0

Papillary carcinoma in thyroglossal duct cyst: A case report 甲状腺舌管囊肿伴乳头状癌1例

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100809

Irene Salvador Marí , Elisa Ortega Pastor , Pedro Palao Moreno , Alejandra Canon Galusso , Enrique Monerris Garcia , Carmen Gómez Muñóz

引用次数: 0

GATA-3 biomarker as a confounding factor in a patient with intraocular metastasis from squamous cell carcinoma of the lung GATA-3生物标志物作为肺鳞状细胞癌眼内转移患者的混杂因素

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100805

Antonio Manuel Garrido-Hermosilla , Raquel Monge-Carmona , Rafael Perea-Pérez , Mariola Méndez-Muros , María Domínguez-Villalón , Luis Quintana-Barriga , Miguel Ángel Idoate-Gastearena

{"title":"GATA-3 biomarker as a confounding factor in a patient with intraocular metastasis from squamous cell carcinoma of the lung","authors":"Antonio Manuel Garrido-Hermosilla , Raquel Monge-Carmona , Rafael Perea-Pérez , Mariola Méndez-Muros , María Domínguez-Villalón , Luis Quintana-Barriga , Miguel Ángel Idoate-Gastearena","doi":"10.1016/j.patol.2025.100805","DOIUrl":"10.1016/j.patol.2025.100805","url":null,"abstract":"<div><div>Metastatic tumours to the retina are rare and are mainly found in the uvea (choroid, iris, or ciliary body). Despite their rarity, they pose a diagnostic challenge due to their diverse origins and subtle manifestations. This study examines the clinical characteristics and diagnostic challenges of retinal metastases through a literature review and a case involving a 74-year-old male with a painful blind left eye. Initially, the condition was diagnosed as transitional cell carcinoma retinal metastasis based on GATA-3 biomarker expression. Despite multiple examinations, including by retinologists, the finding was incidental, identified by the pathologist without prior suspicion. Through the analysis of clinical and radiological findings, we emphasize the importance of recognizing ocular symptoms as potential indicators of systemic malignancies, particularly in atypical presentations. We highlight the utility of immunohistochemical markers and radiological imaging in diagnosis and treatment guidance. Our findings stress the need for interdisciplinary collaboration between ophthalmologists, oncologists, and pathologists in the management of retinal metastases and thorough anatomical pathology evaluation.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 2","pages":"Article 100805"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The virtues of the Horacio Oliva Scholarship 奥拉西奥·奥利瓦奖学金的优点

Revista Espanola de Patologia Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1016/j.patol.2025.100810

Francisco Javier Torres Gómez , Consolación Sánchez Noriega , Francisco Navarro Lara

引用次数: 0