Revista Espanola de Patologia最新文献_第6页

¿Qué es la Patología Moderna? Notas para la formación de un residente de Anatomía Patológica contemporáneo 什么是现代病理学？现代解剖病理学住院医师培训笔记。

Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2024.01.001

Jesús Machuca-Aguado , Manuel Salto-Tellez

引用次数: 0

El enigma de la enfermedad de Enrique IV, rey de Castilla: ¿padeció síndrome de McCune-Albright/displasia fibrosa? 卡斯蒂利亚国王亨利四世疾病之谜：他患有麦考恩-奥尔布赖特综合征/纤维发育不良？

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.06.003

M. Teresa Tuñón Álvarez , Adolfo Ruiz Calleja , Guiomar Pérez de Nanclares

{"title":"El enigma de la enfermedad de Enrique IV, rey de Castilla: ¿padeció síndrome de McCune-Albright/displasia fibrosa?","authors":"M. Teresa Tuñón Álvarez , Adolfo Ruiz Calleja , Guiomar Pérez de Nanclares","doi":"10.1016/j.patol.2023.06.003","DOIUrl":"https://doi.org/10.1016/j.patol.2023.06.003","url":null,"abstract":"<div><h3>Background</h3><p>Henry IV King of Castile, last king of the Trastámara dynasty, was the brother of Isabella the Catholic. He is known as “the impotent”. Based on previous descriptions by historians and biographers, Gregorio Marañón in 1922 described him as “eunuchoid dysplastic with acromegalic reaction and clear schizoid features”.</p></div><div><h3>Methods</h3><p>In 1946, a post-mortem inspection was carried out on the mummified corpse found in the Monastery of Guadalupe. A written document and some photographs were recorded. We have collected the signs and symptoms described and applied the international classification of diseases recommended by the World Health Organisation, ICD11-2023. We have relied on the coins issued in the money of Henry IV, on which we have identified enlargement of the thyroid gland.</p></div><div><h3>Results</h3><p>With the data available at this time, we suggest that Henry IV most probably suffered from: facial and polyostotic bone dysplasia, kyphosis, limb limping, multiple endocrine disorders, acromegaly with macrognatia, nodular thyroid disease, malodorous diaphoresis, erectile dysfunction, hypospadias, abnormal sexual development, “feminoid pelvis”, abdominal colic, oligodontia and dental displacement. It is possible that he also suffered from: precocious puberty, renal lithiasis with debilitating phosphaturia, carpal tunnel, thrombopenia and growth hormone-producing pituitary hyperplasia or adenoma.</p></div><div><h3>Conclusion</h3><p>We suggest that Henry IV may have suffered from McCune–Albrigth syndrome associated with fibrous dysplasia, a rare disease due to gain-of-function mutations in the <em>GNAS</em> gene.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67739319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estudio de variantes genéticas en 169 pacientes de cáncer de pulmón no microcítico 169例非小细胞肺癌患者的遗传变异研究

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.06.002

Lydia Formanti Alonso , Lidia Atienza Cuevas , Raquel Romero García , Javier Mohigefer Barrera , Juan Jesús del Río Ignacio , Antonio Santisteban Espejo , Irene Bernal Florindo , Inmaculada Catalina Fernández , Marcial García Rojo

{"title":"Estudio de variantes genéticas en 169 pacientes de cáncer de pulmón no microcítico","authors":"Lydia Formanti Alonso , Lidia Atienza Cuevas , Raquel Romero García , Javier Mohigefer Barrera , Juan Jesús del Río Ignacio , Antonio Santisteban Espejo , Irene Bernal Florindo , Inmaculada Catalina Fernández , Marcial García Rojo","doi":"10.1016/j.patol.2023.06.002","DOIUrl":"10.1016/j.patol.2023.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Lung cancer is the leading cause of cancer death in our country. Non-small cell lung cancer (NSCLC) represents the paradigm of personalized medicine. The main objective of this study is analysing the distribution of the most frequently described clinically significant variants in NSCLC, in our environment.</p></div><div><h3>Material and methods</h3><p>We studied the immunohistochemical expression of TTF1, p40 and PD-L1 and the genetic variants frequency using Next-Generation Sequencing (NGS) with a panel of 52 genes, in 174 NSCLC paraffin-embedded samples in 169 patients (111 men and 52 women) from the province of Cádiz.</p></div><div><h3>Results</h3><p>The immunohistochemical expression of TTF1, p40 and PD-L1 was positive in 87%, 0% and 46% in adenocarcinoma, and 0%, 100% and 41% in squamous cell carcinoma. In NGS, the most common single nucleotide variants (SNVs) were KRAS (36%), EGFR (14%), BRAF (10%), PIK3CA (8%), and MET (3%). The most frequent copy number variants (CNVs) were amplifications in NF1 (30%), EGFR (18%), CCND1 (9%), MYC (9%) and KRAS (7%). In women, SNV in EGFR are more frequent than in men (<em>P</em>  =.007361) or in EGFR (<em>P</em>  <!-->.0001). Gene fusions were detected in 16 patients (9.47%), in 9 cases in the MET gene.</p></div><div><h3>Conclusions</h3><p>We detected associations, not described so far, between immunohistochemical expression and specific gene variants, which could have an impact on the treatment of NSCLC patients.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47649897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of SOX10 expression in predicting perineural invasion in gastric cancer SOX10表达在预测胃癌神经周围浸润中的价值

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.05.003

Seyed Amir Miratashi Yazdi , Atieh Moghtadaie , Elham Nazar

{"title":"The value of SOX10 expression in predicting perineural invasion in gastric cancer","authors":"Seyed Amir Miratashi Yazdi , Atieh Moghtadaie , Elham Nazar","doi":"10.1016/j.patol.2023.05.003","DOIUrl":"10.1016/j.patol.2023.05.003","url":null,"abstract":"<div><h3>Background</h3><p>SRY-related HMG-box 10 (SOX10) protein has a confirmed role in the regulation of neural cell proliferation and differentiation. It is now suggested that the changes in SOX10 expression may be linked to neural invasion by cancer cells. We aimed to assess the value of SOX10 expression in predicting perineural invasion in gastric cancer.</p></div><div><h3>Methods</h3><p>A cross-sectional study was performed on 40 patients with gastric cancer. To assess perineural invasion, Hematoxylin & Eosin stained slides were examined. The expression of SOX10 was also examined by immunohistochemistry.</p></div><div><h3>Results</h3><p>Our study showed higher perineural invasion in those with SOX10 positivity as compared to those without SOX10 expression (64.0% vs. 6.7%, <em>p</em>  <!-->0.001). No association was revealed between other baseline variables and SOX10 positivity. The expression of this marker increased the chance of neural invasion up to 17 times as indicated by the multivariable regression modeling. Multivariable regression modeling indicated that the chance of neural invasion increased up to 17 times in cases of SOX10 positivity.</p></div><div><h3>Conclusion</h3><p>Overexpression of SOX10 is closely associated with the risk of perineural invasion in gastric cancer.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48714434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JUNTOS, FORMAMOS UN GRAN EQUIPO, LA SEAP!! 我们一起组成了一个伟大的团队，La Seap！！

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.09.001

Dr. Santiago Ramón, Cajal Agüeras

引用次数: 0

An incidental traditional serrated adenoma of the gallbladder: A case report 胆囊偶发传统锯齿状腺瘤1例

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2022.12.002

Emilio I. Abecia Martínez, Guillermo Ríos Ballestín, Jennifer Castillo Malla, Neus Martínez Arnau, Carlos Hörndler Argarate

引用次数: 0

Misleading images of ductal carcinoma in situ: 4 lymph nodes with metastasis 导管原位癌的错误图像：4个淋巴结转移。

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.08.001

Emilio I. Abecia Martínez , Andrea Carilla Sanromán , Liliana Leon , Lucas Sanz Monge , Beatriz Eizaguirre Zarza

{"title":"Misleading images of ductal carcinoma in situ: 4 lymph nodes with metastasis","authors":"Emilio I. Abecia Martínez , Andrea Carilla Sanromán , Liliana Leon , Lucas Sanz Monge , Beatriz Eizaguirre Zarza","doi":"10.1016/j.patol.2023.08.001","DOIUrl":"10.1016/j.patol.2023.08.001","url":null,"abstract":"<div><p>Since sentinel lymph node examination became routine, findings of benign ectopic breast tissue in lymph nodes have increased. We report images of ductal carcinoma in situ (DCIS) in four lymph nodes in a 76-year-old woman with bilateral breast carcinoma. The right lumpectomy showed intermixed invasive lobular and ductal carcinoma, plus DCIS. 19 nodes were isolated in the axillary lymphadenectomy, 4 of which displayed solid and cribriform DCIS. Myosin and p63 immunohistochemical techniques were positive, suggesting an erroneous diagnosis of “metastatic DCIS”. A further three cases of DCIS in lymph nodes have been previously reported, all with a distinct layer of myoepithelial cells with actin, myosin or p63. Biologically, these images of DCIS in lymph nodes are not credible and three major hypotheses have been proposed to explain these findings: <em>Iatrogenic Mechanical Transport</em>, <em>Revertant DCIS</em>, and <em>primary DCIS of lymph nodes</em>. We consider the first one the most plausible explanation. Our case is unique as several, rare findings are simultaneously observed. More new cases, together with additional immunohistochemical techniques and molecular testing on previous cases, are needed to find a definitive explanation of this histologic finding.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTNNB1 somatic mutations drive Wnt pathway activation in a case of incidental intranodal palisaded myofibroblastoma 一例偶发性结内栅栏状肌成纤维细胞瘤中CTNNB1体细胞突变驱动Wnt通路激活

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.02.003

Germán Moreno de Juan , Santiago Montes Moreno

引用次数: 0

Sarcoidosis cardíaca como causa muy infrecuente de muerte súbita en pacientes jóvenes asintomáticos 心脏结节病是无症状青年患者非常罕见的猝死原因

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.04.002

Francisco García-Molina , Francisco Martínez-Díaz , Juan Pedro Hernández del Rincón , Matias Martínez-Pérez , Francisco Pastor-Quirante

引用次数: 0

Aspectos prácticos sobre la determinación de PD-L1 en el tratamiento de carcinoma urotelial. Consenso del grupo de uropatología de la SEAP PD-L1检测在泌尿系癌治疗中的应用。SEAP泌尿病理学小组共识

Revista Espanola de Patologia Pub Date : 2023-10-01 DOI: 10.1016/j.patol.2023.05.001

Antonio López-Beltrán , Pilar González-Peramato , Julián Sanz-Ortega , Juan Daniel Prieto Cuadra , Isabel Trias , Rafael J. Luque Barona , María Eugenia Semidey , Pablo Maroto , Ferran Algaba

{"title":"Aspectos prácticos sobre la determinación de PD-L1 en el tratamiento de carcinoma urotelial. Consenso del grupo de uropatología de la SEAP","authors":"Antonio López-Beltrán , Pilar González-Peramato , Julián Sanz-Ortega , Juan Daniel Prieto Cuadra , Isabel Trias , Rafael J. Luque Barona , María Eugenia Semidey , Pablo Maroto , Ferran Algaba","doi":"10.1016/j.patol.2023.05.001","DOIUrl":"10.1016/j.patol.2023.05.001","url":null,"abstract":"<div><p>The recent addition of novel immunotherapy drugs for the treatment of urothelial carcinoma makes it necessary the establishment of criteria to harmonize the immunohistochemical assessment of PD-L1, both as a prognostic factor and for the selection of patients to be treated. In this scenario, a group of uropathologists from the Spanish Society of Pathological Anatomy, together with a medical oncologist as an external collaborator subspecialized in uro-oncology, have prepared this document of recommendations based on the available evidence. During PD-L1 assessment it is especially relevant the selection of the sample, its processing, the immunohistochemical platform and antibody used, and the algorithm applied in the interpretation of results. All these aspects must be indicated in the results report, which should be easily interpretable in a context of rapid evolution of immunological therapies.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55190030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0