Revista Espanola de Patologia最新文献

{"title":"Expression of TRIM29 and its association with p40 and TTF1 in lung carcinoma","authors":"Neelima Kumari ,&nbsp;Sana Ahuja ,&nbsp;Satyadev Rana ,&nbsp;Jayati Chakraborty ,&nbsp;Dipti Gothi ,&nbsp;Anand Kumar Verma","doi":"10.1016/j.patol.2025.100849","DOIUrl":"10.1016/j.patol.2025.100849","url":null,"abstract":"<div><h3>Background</h3><div>Lung cancer is a leading global cause of cancer-related mortality, with over 1.8 million deaths annually. Non-small cell lung carcinoma (NSCLC) is the predominant subtype, further classified into squamous cell carcinoma (SCC) and adenocarcinoma (ADC) based on immunohistochemical markers such as p40 and TTF1. TRIM29, a member of the TRIM protein family, has been implicated in various cancers and is associated with poor prognosis. This study evaluates TRIM29 expression and its correlation with p40 and TTF1 in NSCLC subtypes.</div></div><div><h3>Materials and methods</h3><div>This prospective observational study included 45 core biopsy samples of lung carcinoma and was conducted over 18 months at a tertiary care hospital in New Delhi. Immunohistochemical analysis of TRIM29, p40, and TTF1 expression was performed. TRIM29 expression was assessed semi-quantitatively, based on intensity and proportion scores.</div></div><div><h3>Results</h3><div>Of the 45 cases, 38 (84.4%) were NSCLC, and 7 (15.6%) were small cell lung carcinoma (SCLC). TRIM29 expression was significantly higher in NSCLC compared to SCLC (<em>p</em> <!-->&lt;<!--> <!-->0.001). Among NSCLC cases, TRIM29 positivity was observed in 86.9% of SCC cases and 30.8% of ADC cases (<em>p</em> <!-->=<!--> <!-->0.001). TRIM29 demonstrated a strong positive association with p40 (86.9%) and an inverse correlation with TTF1 (77.7%; <em>p</em> <!-->&lt;<!--> <!-->0.0001).</div></div><div><h3>Conclusion</h3><div>TRIM29 is a promising biomarker for NSCLC, particularly in differentiating SCC from ADC. Its strong association with p40, coupled with an inverse relationship with TTF1, enhances its diagnostic utility. Further studies are needed to explore its role in lung cancer pathogenesis and prognosis.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100849"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Engrailed developmental genes in gynaecological cancer","authors":"Valeria Meraz Alvarado,&nbsp;Marco Antonio Fuentes García,&nbsp;Mauricio Salcedo Vargas,&nbsp;Ricardo López Romero","doi":"10.1016/j.patol.2025.100848","DOIUrl":"10.1016/j.patol.2025.100848","url":null,"abstract":"<div><div>Homeobox genes encode a superfamily of transcriptional regulators involved in the growth and development of human tissues and organs. Engrailed (En) genes are homeodomain genes, which have transcription factor functions and play a significant role in vertebrate embryonic development. The EN proteins comprise two members, Engrailed-1 (EN1) and Engrailed-2 (EN2). These proteins have been implicated in cancer development in various adult tissues, acting either as oncogenes or tumour suppressors depending on the context and cell type. Their expression has also been investigated in urinary cancers such as prostate and bladder cancer, where they have been proposed as non-invasive biomarkers detectable in urine. Studies in gynaecological tissues have suggested EN1 and EN2 may act as oncogenes in breast and ovarian cancer; however, research into their roles in other gynaecological cancers, such as endometrial, cervical and vaginal cancer, remains preliminary.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100848"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiosarcoma developing in an ovarian fibroma: A case report","authors":"Ana L. Nocito ,&nbsp;Sandra I. Sarancone","doi":"10.1016/j.patol.2025.100855","DOIUrl":"10.1016/j.patol.2025.100855","url":null,"abstract":"<div><div>Angiosarcomas are malignant vascular tumors primarily located in the dermis or soft tissues predominantly in the head and neck region. Ovarian localization is extremely rare, with only a few published cases. A 63-year-old patient was admitted to the hospital due to severe pain in the hypogastric and abdominal regions. The condition was interpreted as an acute abdomen and referred to surgery, and an ovarian tumor that measured 23<!--> <!-->cm<!--> <!-->×<!--> <!-->11<!--> <!-->cm<!--> <!-->×<!--> <!-->5<!--> <!-->cm and weighed 7500<!--> <!-->g was resected. Macroscopically, the cut surface showed two well-defined areas: one consisting of a matte white tissue with a fascicular appearance and firm consistency and the other hemorrhagic with necrotic areas. Histological examination revealed two patterns: one characterized by a proliferation of spindle-shaped cells without atypia, and the other by neoplastic proliferation with marked atypia, forming vascular channels or fascicles. The vascular component was positive for CD31, CD34, and ERG. The findings were interpreted as an angiosarcoma associated with a fibroma, and the patient died in the immediate postoperative period. The low incidence and ominous prognosis of primary or metastatic ovarian angiosarcomas have been confirmed. Regarding the histogenesis, a strong likelihood exists of a relationship with the ovary's rich vascular network. In both well-differentiated and poorly differentiated cases, it is crucial to consider differential diagnoses and perform immunohistochemical techniques, which can assist in achieving an accurate diagnosis. The association between fibroma and angiosarcoma is poorly understood and the histogenesis remains unclear.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100855"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and clinical predictive factors in appendiceal mucinous neoplasms: A retrospective analysis of 49 cases","authors":"Carmen Rodríguez García ,&nbsp;David Ramos Soler ,&nbsp;Nuria Rausell Fontestad ,&nbsp;Carmen Gutiérrez Sánchez ,&nbsp;Pablo Guerrero Antolino ,&nbsp;Franscico Giner Segura","doi":"10.1016/j.patol.2025.100847","DOIUrl":"10.1016/j.patol.2025.100847","url":null,"abstract":"<div><div>Appendiceal mucinous neoplasms (AMNs) represent an infrequent type of appendiceal tumour, characterised by their potential for aggressive biological behaviour and the possibility of developing peritoneal carcinomatosis. There is still uncertainty about which variables can predict the clinical evolution and recurrence risk of this disease. The primary objective of this study is to reevaluate cases of AMN diagnosed at our institution to identify morphological and clinical factors that may serve as predictors of recurrence. A retrospective study of 49 patients diagnosed with AMN at tertiary hospital from 2011 to 2023 was carried out. Histological parameters, such as architectural pattern, mitotic index, and loss of polarity, along with pre- and post-operative clinical data were collected. Variables significantly associated with the first recurrence were surgical reintervention (<em>p</em> <!-->=<!--> <!-->0.002), death due to AMN (<em>p</em> <!-->=<!--> <!-->0.008), carcinomatosis at diagnosis (<em>p</em> <!-->=<!--> <!-->0.003), adjuvant therapy (<em>p</em> <!-->=<!--> <!-->0.01), TNM stage (<em>p</em> <!-->=<!--> <!-->0.01), morphological pattern (<em>p</em> <!-->=<!--> <!-->0.02), and loss of nuclear polarity (<em>p</em> <!-->=<!--> <!-->0.02). Survival analysis revealed that an undulating pattern (<em>p</em> <!-->=<!--> <!-->0.04) and the presence of micropapillary structures (<em>p</em> <!-->=<!--> <!-->0.01) were associated with an increased risk of recurrence. In contrast, the risk of recurrence decreased with increasing age (<em>p</em> <!-->=<!--> <!-->0.02) and focal loss of nuclear polarity. The risk was higher in cases classified as HAMN (<em>p</em> <!-->=<!--> <!-->0.008). The results indicate that age and focal loss of nuclear polarity are inversely correlated with recurrence risk, while an undulating pattern and the presence of micropapillary structures are directly correlated with time to first recurrence. These findings contribute to improved risk stratification and the optimization of therapeutic strategies for patients with AMN.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100847"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time as a measure of workload in Anatomical Pathology: Implications for human resource management","authors":"Francesc Tresserra ,&nbsp;Antonio Martínez Lorente","doi":"10.1016/j.patol.2026.100865","DOIUrl":"10.1016/j.patol.2026.100865","url":null,"abstract":"","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100865"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granular cell tumour of non-neural origin, ALK positive: Case report and literature review","authors":"Viviana Dávila Flores ,&nbsp;Alicia Sánz ,&nbsp;Michelle Jurado ,&nbsp;Susana Ramos ,&nbsp;Rafael Sánchez","doi":"10.1016/j.patol.2025.100853","DOIUrl":"10.1016/j.patol.2025.100853","url":null,"abstract":"<div><div>Non-neural granular cell tumour (NNGCT) is a rare cutaneous neoplasm characterised by the absence of S100 expression and a differentiation of uncertain lineage. We present the case of a 13-year-old male patient with a cutaneous lesion on the left wrist, initially diagnosed as pilomatrixoma. Histological analysis revealed a proliferation of spindle-shaped cells with eosinophilic granular cytoplasm and immunohistochemical positivity for ALK, NKI/C3, CD10, and CD68, with negativity for S100. ALK positivity in this case supports the hypothesis of a potential genetic alteration shared with other ALK-positive tumours. The patient had a favourable outcome following tumour excision, with no evidence of recurrence or metastasis. This case contributes to the characterisation of ALK-positive NNGCT and highlights its relevance in the differential diagnosis of cutaneous granular cell tumours.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100853"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleomorphic liposarcoma of the breast","authors":"Miriam Rubiera Valdés ,&nbsp;Inés Gómez de la Riva ,&nbsp;José María Alonso de la Campa ,&nbsp;Adela Alonso Fernández-Velásco","doi":"10.1016/j.patol.2025.100851","DOIUrl":"10.1016/j.patol.2025.100851","url":null,"abstract":"<div><div>Primary sarcomas of the breast are exceptionally rare, accounting for fewer than 1% of malignant breast lesions. Mammary liposarcomas comprise less than 5% of all breast sarcomas, and among these, primary pleomorphic liposarcoma is particularly uncommon, with a reported frequency of less than 0.01% of malignant breast lesions. It is a highly aggressive tumour, characterised by a high recurrence rate. The characteristic microscopic findings of pleomorphic liposarcoma include atypical lipomatous cells with marked nuclear pleomorphism, as well as abundant lipoblasts, frequent mitoses, and extensive areas of necrosis. In this article, we present a case of primary pleomorphic liposarcoma of the breast.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100851"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pott's puffy tumour: A report of 2 cases highlighting tuberculosis as a microbiological cause","authors":"Sana Ahuja ,&nbsp;Dipanker Singh Mankotia ,&nbsp;Sufian Zaheer","doi":"10.1016/j.patol.2025.100843","DOIUrl":"10.1016/j.patol.2025.100843","url":null,"abstract":"<div><div>Pott's puffy tumour (PPT), characterized by subperiosteal abscess formation secondary to frontal bone osteomyelitis, is a rare clinical entity. This case series highlights tuberculosis as an unexpected cause of PPT. Two cases of PPT, diagnosed histologically and surgically managed within a one-year period, were retrospectively analyzed. Clinical, radiological, operative, and histopathological findings were evaluated. Both cases, aged 12 and 26 years respectively, presented with forehead swelling, headache, and low-grade fever. Imaging revealed subperiosteal abscesses involving the frontal bone. Surgical exploration and drainage confirmed PPT, with unexpected histopathological findings of tuberculosis. Anti-tubercular therapy led to symptom resolution and lesion regression. These cases underscore the need to consider tuberculosis as a differential diagnosis in PPT. Timely diagnosis and appropriate anti-tubercular therapy are critical for successful management and prevention of complications. Awareness of tuberculosis as a possible aetiological factor is particularly important in regions with a high disease burden.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100843"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-meningothelial mesenchymal tumours of the CNS in the diagnostic practice of the pathologist","authors":"Karen Rocío Latorre Rodríguez ,&nbsp;Ana Laura Calderón-Garcidueñas","doi":"10.1016/j.patol.2025.100839","DOIUrl":"10.1016/j.patol.2025.100839","url":null,"abstract":"<div><h3>Introduction</h3><div>Primary mesenchymal tumours of the central nervous system with uncertain differentiation are rare. The 5th edition of the WHO classification groups three of these entities according to their molecular profiles into: intracranial mesenchymal tumours with FET-CREB fusion, sarcomas with CIC rearrangement, and primary intracranial sarcomas with DICER1 mutations. The objectives of this study were to carry out a systematic review of the literature and to determine whether a specific morphology predominates in relation to the proposed molecular types.</div></div><div><h3>Materials and methods</h3><div>A systematic review was performed using the PubMed database, with the search terms: “(sarcomas) and (central nervous system)”. Studies were included if they reported cases of patients with a diagnosis of primary sarcoma in the central nervous system (CNS) and provided information on both the molecular profile and histopathological characteristics.</div></div><div><h3>Results</h3><div>Of the 173 articles identified, eight were ultimately selected for analysis.</div></div><div><h3>Conclusions</h3><div>Histopathological differences were observed that may assist in diagnosis in the absence of molecular testing; however, follow-up data are required to evaluate the benefits of this classification in clinical practice.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100839"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic melanoma mimicking an angiomatoid fibrous histiocytoma","authors":"Caterina Fumagalli,&nbsp;Anna Mozos,&nbsp;Justyna Szafranska,&nbsp;Ruth Orellana","doi":"10.1016/j.patol.2025.100841","DOIUrl":"10.1016/j.patol.2025.100841","url":null,"abstract":"<div><div>Melanoma is known for its remarkable histopathological heterogeneity, capable of mimicking both epithelial and mesenchymal neoplasms. We report the case of a 46-year-old male who was externally diagnosed with sarcoma and presented with a subcutaneous pre-sternal mass comprising a proliferation of epithelioid–histiocytoid cells, hemosiderin deposition, and chronic inflammation, closely resembling an angiomatoid fibrous histiocytoma (AFH). A peripheral pseudo-capsule and a pericapsular lymphocytic cuff were also observed. Immunohistochemically, the tumour cells were focally positive for desmin and S100 protein, but negative for EMA, CD99 and CD68. Further studies demonstrated SOX10 positivity and identified a <em>BRAF</em> p.V600E mutation, findings consistent with melanoma. Review of the external clinical history confirmed that the patient had undergone surgery for a melanoma near the current lesion site three years earlier. In conclusion, the integration of histology, immunohistochemistry, molecular studies and clinical history is essential for the accurate diagnosis of melanoma and for avoiding misdiagnosis.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"58 4","pages":"Article 100841"},"PeriodicalIF":0.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}