Revista Espanola de Patologia最新文献_第4页

Tumor espermatocítico variante anaplásica sincrónico bilateral: reporte de una neoplasia infrecuente 双侧同步性无性变异无性精原细胞瘤：一种罕见肿瘤的报告

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2024.01.002

Rosalía Sarabia Ochoa, Juan Pablo García de la Torre

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Enteroblastic adenocarcinoma of the ampulla of Vater 瓦特氏腔肠细胞腺癌

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2024.01.004

Amanda Rodríguez-Villena , Alejandra Veliz-Domínguez , Irene González-García , Ignacio Ruz-Caracuel

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Extraskeletal myxoid chondrosarcoma metastasis to a Meckel's diverticulum adenocarcinoma 骨骼外肌样软骨肉瘤转移至梅克尔憩室腺癌

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2023.12.002

João Martins Gama , Rui Caetano Oliveira , Rúben Fonseca , Maria Augusta Cipriano , José Casanova

{"title":"Extraskeletal myxoid chondrosarcoma metastasis to a Meckel's diverticulum adenocarcinoma","authors":"João Martins Gama , Rui Caetano Oliveira , Rúben Fonseca , Maria Augusta Cipriano , José Casanova","doi":"10.1016/j.patol.2023.12.002","DOIUrl":"10.1016/j.patol.2023.12.002","url":null,"abstract":"<div><p>Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumour with a high local and distant metastasis rate and limited response to chemotherapy.</p><p>Meckel's diverticulum is the most frequent congenital anomaly, and it is associated with a considerable risk of malignant transformation.</p><p>In this case report, we describe a 50-year-old female patient with a history of extraskeletal myxoid chondrosarcoma of the lower limb and metastasis to the forearm who went to the emergency department with abdominal pain. The investigations revealed a caecal volvulus. A lesion in the middle third of the ileum was incidentally discovered and removed during surgery.</p><p>Pathology examination revealed a Meckel's diverticulum adenocarcinoma, with metastasis of extraskeletal myxoid chondrosarcoma.</p><p>Resection was complete; however, the patient had diffuse metastatic pulmonary disease and died eight months later due to disease progression.</p><p>This mechanism of tumour-to-tumour metastasis is described in other locations, but, regarding the Meckel's diverticulum, this is a unique situation, previously unreported in the literature.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S169988552400014X/pdfft?md5=f108a76f16b6e2afe503e9d7b1fa05de&pid=1-s2.0-S169988552400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140467028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impacto de la patología computacional en Patología 计算病理学对病理学的影响

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2024.03.001

Antonio Félix Conde Martín

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Principales tipos de quistes en dermatopatología: Parte 2 皮肤病理学中囊肿的主要类型：第二部分

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2023.11.007

María Teresa Fernández Figueras , Jacques Alzoghby-Abi Chaker , Miriam Fernandez-Parrado , Adriana García Herrera , María Garrido , Miguel Ángel Idoate Gastearena , Mar Llamas-Velasco , Carlos Monteagudo , José Onrubia , Noelia Pérez Muñoz , Juan José Ríos-Martín , José Luis Rodríguez Peralto , Eduardo Rozas Muñoz , Onofre Sanmartín , Ángel Santos-Briz , Carles Saus , José Manuel Suárez Peñaranda , Verónica Velasco Benito , María José Beato Merino , Ángel Fernandez-Flores

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Stromal osseous metaplasia in urothelial carcinoma of the bladder: An unusual and challenging feature. A case report 膀胱尿路上皮癌的基质骨化：一个不寻常且具有挑战性的特征。病例报告

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2023.09.002

Irene Iglesias de Ussel Galarreta, Francisco Javier Queipo Gutiérrez

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Tumor fibroso calcificante intestinal: reporte de caso 肠道钙化纤维瘤：病例报告

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2023.11.003

Gonzalo Nathaniel Cantú-Soriano , Álvaro Lezid Padilla-Rodríguez

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Colonic adenomatous polyp with florid presence of monoclonal lambda Russell bodies: Case report and etiopathogenic hypothesis 结肠腺瘤性息肉伴有大量单克隆λ-拉塞尔体：病例报告和病因假设

Revista Espanola de Patologia Pub Date : 2024-04-01 DOI: 10.1016/j.patol.2023.07.001

Adriano Martínez-Aracil , Diego Polanco-Alonso , Celina Stayerman , Carlos Miguel , Guiomar Pérez de Nanclares

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Interpretación histopatológica de biopsias por tumores melanocíticos en localizaciones especiales 特殊部位黑色素细胞肿瘤活检组织病理学解读

Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.02.006

Caridad Socorro Castro , Susana Hernández Delgado , Rosayner García Palacios

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Linking inflammation and angiogenesis with fibrogenesis: Expression of FXIIIA, MMP-9, and VEGF in oral submucous fibrosis 将炎症和血管生成与纤维化联系起来：口腔黏膜下纤维化中 FXIIIA、MMP-9 和血管内皮生长因子的表达

Revista Espanola de Patologia Pub Date : 2024-01-01 DOI: 10.1016/j.patol.2023.11.005

Sheetal Choudhari , Deepak Kulkarni , Sangeeta Patankar , Supriya Kheur , Sachin Sarode

{"title":"Linking inflammation and angiogenesis with fibrogenesis: Expression of FXIIIA, MMP-9, and VEGF in oral submucous fibrosis","authors":"Sheetal Choudhari , Deepak Kulkarni , Sangeeta Patankar , Supriya Kheur , Sachin Sarode","doi":"10.1016/j.patol.2023.11.005","DOIUrl":"10.1016/j.patol.2023.11.005","url":null,"abstract":"<div><h3>Objectives</h3><p>Interplay of Factor XIIIa (FXIIIa), a transglutaminase, responsible for cross-linking of matrix proteins, Matrix Metalloproteinase-9 (MMP-9), a gelatinase, and Vascular Endothelial Growth Factor (VEGF), an angiogenic inducer, were studied in relation to fibrogenesis and disease progression in oral submucous fibrosis (OSMF).</p></div><div><h3>Material and methods</h3><p>Immunohistochemical expression of markers was studied in 60 formalin-fixed paraffin-embedded tissue blocks of OSMF and 20 normal oral mucosal tissues. FXIIIa was studied quantitatively while MMP-9 and VEGF were assessed semi-quantitatively. Expression was compared with histopathological grades of OSMF.</p></div><div><h3>Results</h3><p>FXIIIa expression significantly increased in OSMF (<em>p-value 0.000</em>). However, expression decreased and cells became quiescent with increasing grades (<em>p-value 0.000</em>). MMP-9 (<em>p-value</em> epithelium <em>0.011</em>, <em>p-value connective tissue 0.000</em>) and VEGF expression (<em>p-value epithelium 0.000</em>, <em>connective tissue 0.000</em>) increased in OSMF. A negative correlation between FXIIIa and MMP-9 (−0.653) in early grade (<em>p-value of 0.021</em>) and a positive correlation between FXIIIa and VEGF (0.595) (<em>p-value of 0.032</em>) was found in the moderate grade OSMF. Regression analysis showed a significant association (<em>p</em>  <em>0.01</em>) of FXIIIa in OSMF and with increasing grades of OSMF.</p></div><div><h3>Conclusion</h3><p>FXIIIa may play a crucial role in initiation of fibrosis in OSMF. MMP-9 may have a diverse role to play in OSMF as a regulator of fibrosis. VEGF may show an angio-fibrotic switch and contribute to fibrosis in OSMF. These cytokines may show altered function and can contribute to fibrosis and chronicity of disease due to changes in the microenvironment. Tissue stiffness in OSMF itself creates an environment that enhances the chronicity of the disease.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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