Revista Espanola de Patologia最新文献_第3页

Current perspectives on neurodegenerative diseases: from clinical autopsy to precision medicine 神经退行性疾病的当前观点：从临床尸检到精准医学

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Revista Espanola de Patologia Pub Date : 2026-04-01 Epub Date: 2026-04-22 DOI: 10.1016/j.patol.2026.100876

Alberto Rábano

引用次数: 0

Lymphomatoid papulosis: A challenge in the differential diagnosis of ulcerative lesions of the oral mucosa 类淋巴瘤丘疹病：口腔黏膜溃疡性病变鉴别诊断的挑战。

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Revista Espanola de Patologia Pub Date : 2026-04-01 Epub Date: 2026-04-09 DOI: 10.1016/j.patol.2026.100870

Henar Anadón Valero , Lucas Andreu Roche , Sara Navarro Júlvez , Lucía Prieto-Torres , Mar Garcia-Garcia

引用次数: 0

Development and validation of a CNN model for grading oral epithelial dysplasia 口腔上皮发育不良分级的CNN模型的建立和验证。

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Revista Espanola de Patologia Pub Date : 2026-04-01 Epub Date: 2026-03-31 DOI: 10.1016/j.patol.2026.100869

Chetan Belaldavar , Punnya V. Angadi , Uma Mudenagudi , Ujwala Patil , Ramesh Ashok Tabib

{"title":"Development and validation of a CNN model for grading oral epithelial dysplasia","authors":"Chetan Belaldavar , Punnya V. Angadi , Uma Mudenagudi , Ujwala Patil , Ramesh Ashok Tabib","doi":"10.1016/j.patol.2026.100869","DOIUrl":"10.1016/j.patol.2026.100869","url":null,"abstract":"<div><h3>Background</h3><div>Diagnosis of oral epithelial dysplasia (OED), particularly grading, is challenging as it shows inter- and intra-observer variability. New technologies to assist pathologists are needed to decrease variability and enhance reproducibility. AI has brought about a new wave of increased precision in oncological pathology. High accuracy and objectivity in OED grading may now be attainable in histopathology because of AI tools such as deep learning.</div></div><div><h3>Methods</h3><div>A deep learning model, Densenet121, was developed for automated and reliable grading of OED according to the 2017 WHO classification (mild, moderate, and severe). The dataset comprised 1500 images, and slides were digitised at 4×, 10× and 40× magnification. We developed and trained a classification model.</div></div><div><h3>Results</h3><div>Overall performance of the Densenet 121 model was good, with accuracy above 80% across all magnifications. However, the 10× magnification yielded a good accuracy of 92.7%, precision of 92.8% and recall of 92.5%. For classification into mild, moderate, and severe categories, accuracy reached 91%, with good precision and recall.</div></div><div><h3>Conclusion</h3><div>DenseNet121 achieves high accuracy making it computationally efficient. This model was able to distinguish between normal epithelium and different grades of OED. These findings support the potential role of AI-based tools in reducing variability in grading dysplasia.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 2","pages":"Article 100869"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamoid eccrine ductal carcinoma: A case report and review of the literature 鳞状上皮导管癌1例报告及文献复习。

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Revista Espanola de Patologia Pub Date : 2026-04-01 Epub Date: 2026-03-31 DOI: 10.1016/j.patol.2026.100867

Laura López-Solache , María Blanco-Bellas , Adrián Santiago López-Caamaño , Alejandro Vilas-Sueiro

引用次数: 0

Rare malignant transformation of struma ovarii into follicular thyroid carcinoma: A case report 罕见卵巢甲状腺肿恶性转化为滤泡性甲状腺癌1例

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-16 DOI: 10.1016/j.patol.2025.100852

Adil Aziz Khan, Charanjeet Ahluwalia, Sana Ahuja

{"title":"Rare malignant transformation of struma ovarii into follicular thyroid carcinoma: A case report","authors":"Adil Aziz Khan, Charanjeet Ahluwalia, Sana Ahuja","doi":"10.1016/j.patol.2025.100852","DOIUrl":"10.1016/j.patol.2025.100852","url":null,"abstract":"<div><div><em>Struma ovarii</em> is a rare monodermal ovarian teratoma primarily composed of thyroid tissue, accounting for 2–5% of all ovarian teratomas. Although generally benign, about 5% may undergo malignant transformation, predominantly into papillary thyroid carcinoma, with follicular thyroid carcinoma being exceptionally rare. A 46-year-old Asian woman presented with abdominal pain. Imaging studies identified a solid-cystic ovarian mass with elevated CA-125 levels. Surgical intervention was performed, and histopathological examination confirmed the malignant transformation of <em>struma ovarii</em> into follicular thyroid carcinoma. Post-operative PET-CT and hormone level assessments showed no residual disease. The patient is currently under regular follow-up. This case illustrates the rarity and diagnostic challenges associated with malignant <em>struma ovarii</em>. It underscores the importance of extensive sampling and a multidisciplinary approach for effective management. Given the lack of standardized treatment guidelines, personalised care and close follow-up are essential, with consideration of aggressive treatment based on risk assessment.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100852"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malakoplakia mimicking pelvic malignancy with liver metastasis and peritoneal carcinomatosis 酷似盆腔恶性肿瘤伴肝转移和腹膜癌的斑疹

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-16 DOI: 10.1016/j.patol.2025.100854

Hector Chavarria, Tanvi V. Joshi, Jatinder Kumar, Jennifer Young Pierce, Christopher E. Keel

{"title":"Malakoplakia mimicking pelvic malignancy with liver metastasis and peritoneal carcinomatosis","authors":"Hector Chavarria, Tanvi V. Joshi, Jatinder Kumar, Jennifer Young Pierce, Christopher E. Keel","doi":"10.1016/j.patol.2025.100854","DOIUrl":"10.1016/j.patol.2025.100854","url":null,"abstract":"<div><div>Malakoplakia is a rare chronic inflammatory condition characterised by defective macrophage function, most commonly affecting the genitourinary tract. Although usually localised, it may occasionally present as a mass-forming lesion mimicking malignancy. We report the case of a 46-year-old woman presenting with a pelvic mass, acute kidney injury, and hydroureteronephrosis. Imaging demonstrated a necrotic 10.3cm pelvic mass with lymphadenopathy and hepatic lesions, raising suspicion of metastatic gynaecological malignancy. Surgical exploration identified a fibrotic, thickened pelvic peritoneum with extensive histiocytic inflammation.</div><div>Histopathological evaluation confirmed malakoplakia, characterised by Michaelis-Gutmann bodies and histiocytes positive for CD68. Microbiological analysis identified <em>Escherichia coli</em> as the infectious agent. The clinical and radiological features of malakoplakia can closely mimic malignancy, posing a significant diagnostic challenge. Histopathological examination remains crucial for definitive diagnosis, particularly in distinguishing malakoplakia from metastatic urological or gynaecological malignancies. Immunohistochemistry and special stains, such as von Kossa, assist in confirmation. This case underscores the importance of considering malakoplakia in the differential diagnosis of pelvic masses, including those with suspected metastasis. Early recognition can prevent misdiagnosis and unnecessary surgical intervention, highlighting the need for multidisciplinary management.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100854"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pure non-gestational ovarian choriocarcinoma in a postmenopausal woman coexisting with a clear cell adenofibroma and endometriosis foci: A case report and review of the literature 绝经后妇女纯非妊娠期卵巢绒毛膜癌合并透明细胞腺纤维瘤和子宫内膜异位症病灶：1例报告和文献复习

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1016/j.patol.2026.100856

Ainhoa Ordoñez Arrillaga , Miguel Ángel Resano Abarzuza , Marta Rezola Bajineta , Begoña Aguiar Losada , Yessica P. Rodríguez-Velandia , Manuel Moreno Valladares , Iraide Bernal Simón , Ibon Jaunarena Marín , Irune Ruiz Díaz

{"title":"Pure non-gestational ovarian choriocarcinoma in a postmenopausal woman coexisting with a clear cell adenofibroma and endometriosis foci: A case report and review of the literature","authors":"Ainhoa Ordoñez Arrillaga , Miguel Ángel Resano Abarzuza , Marta Rezola Bajineta , Begoña Aguiar Losada , Yessica P. Rodríguez-Velandia , Manuel Moreno Valladares , Iraide Bernal Simón , Ibon Jaunarena Marín , Irune Ruiz Díaz","doi":"10.1016/j.patol.2026.100856","DOIUrl":"10.1016/j.patol.2026.100856","url":null,"abstract":"<div><div>Ovarian germ cell tumours are uncommon, with choriocarcinoma being the rarest of them. Among choriocarcinomas, the non-gestational type occurs mainly in premenarchal women, although cases have been described in postmenopausal women.</div><div>The distinction between gestational or non-gestational aetiology of choriocarcinoma is essential given the prognostic and therapeutic implications involved. The distinction between pure and mixed form of choriocarcinoma also has prognostic relevance.</div><div>Clear cell adenofibroma is a rare benign lesion, considered a precursor of clear cell carcinoma, with described association to endometriosis.</div><div>We present the case of a 72-year-old woman diagnosed at our centre with pure non-gestational choriocarcinoma, clear cell adenofibroma and foci of endometriosis present in the same ovary.</div><div>We performed a review of the literature, focusing on how to differentiate a gestational from a non-gestational choriocarcinoma and the pure form from the mixed form, as well as the described coexistence between germ cell and epithelial tumours.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100856"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric surgery as an acquired cause of pancreatic alpha-cell hyperplasia 胃手术是胰腺α细胞增生的后天原因

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-13 DOI: 10.1016/j.patol.2025.100850

Ricard Onieva Carbajo , Laia Casamitjana , Cristina Gener Jorge , Marta Vidal Borrego , Joan Carles Ferreres Piñas

{"title":"Gastric surgery as an acquired cause of pancreatic alpha-cell hyperplasia","authors":"Ricard Onieva Carbajo , Laia Casamitjana , Cristina Gener Jorge , Marta Vidal Borrego , Joan Carles Ferreres Piñas","doi":"10.1016/j.patol.2025.100850","DOIUrl":"10.1016/j.patol.2025.100850","url":null,"abstract":"<div><h3>Introduction</h3><div>Alpha-cell hyperplasia (ACH) is a rare condition, with only eighteen cases reported in the literature. Its primary cause is Mahvash disease, a hereditary disorder associated with pancreatic neuroendocrine tumours. Based on the experience of our site, previous gastric surgery (GS) is suspected to represent a potential acquired cause of ACH – the first such case described to date.</div></div><div><h3>Material and methods</h3><div>A case–control study was designed using pancreatic tissue samples, selecting six patients with a history of gastric surgery (GS) more than six months before, and twelve patients with GS less than six months before or no history of GS. Immunohistochemical staining for chromogranin, insulin and glucagon was performed. The neuroendocrine cellularity (NEC) area, type of cellularity, and distribution pattern were evaluated.</div></div><div><h3>Results</h3><div>The mean NEC area in the cases was 6.01%, compared to 3.18% in the controls (<em>p</em>   =0.013).</div></div><div><h3>Conclusions</h3><div>A history of CG may have histological correlates in pancreatic tissue, making it important to recognise these to avoid misdiagnosing a true ACH, which carries associated implications such as a high risk of tumour development and genetic transmission.</div></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":"59 1","pages":"Article 100850"},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Benign cutaneous plexiform hybrid tumour of perineurioma and cellular neurothekeoma: A rare diagnosis 良性皮肤丛状混合性瘤与细胞性神经瘤：罕见诊断

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-16 DOI: 10.1016/j.patol.2025.100846

Elena María García Pastor , Rosa María Castillo Muñoz , Elena Gallego Domínguez

引用次数: 0

Changes in the classification of malignant salivary gland tumours across the last three WHO editions 在过去三个世卫组织版本中恶性唾液腺肿瘤分类的变化

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Revista Espanola de Patologia Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1016/j.patol.2026.100857

Gonzalo Rojas-Alcayaga , Magdalena Pinto Ávila , Felipe Cáceres Villanueva , Iara Vargas Piña , Constanza Yutronic Adasme , Iván Gallegos Méndez

引用次数: 0