Dementia e Neuropsychologia最新文献

{"title":"Selective Kanji agraphia in crossed aphasia after right-hemisphere infarction: a case report.","authors":"Takahiro Kowari","doi":"10.1590/1980-5764-DN-2025-0464","DOIUrl":"10.1590/1980-5764-DN-2025-0464","url":null,"abstract":"<p><p>Crossed aphasia is a rare form of aphasia in right-handed individuals with right-hemisphere lesions. We report a man aged 67 years who developed crossed aphasia after a right posterior cerebral artery infarction involving the occipital lobe, thalamus, and medial parietal lobe. Neurological and neuropsychological examinations revealed mild anomic aphasia with preserved repetition and comprehension, left homonymous hemianopia, unilateral spatial neglect, prosopagnosia, and no apraxia. Writing showed a marked script-specific dissociation: kana writing was intact, whereas kanji writing was severely impaired and dominated by recall-failure errors (>90%), with few orthographic or component errors. One-year follow-up using the same language and writing tasks demonstrated partial improvement in accuracy but a stable error profile dominated by recall failures. This rare case indicates that selective kanji agraphia can occur in crossed aphasia due to right-hemisphere lesions and suggests impaired access to the visual orthographic lexicon with atypical hemispheric lateralization of writing functions in Japanese.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2025464"},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When exome analysis is the key for your patient with cognitive decline: a case report.","authors":"Antonio Avelino Mendes, Igor Fortunato da Silva, Daniel Santos Uchoa, Isabela Caldeira de Oliveira, Julian Leticia de Freitas, Maria Sheila Guimarães Rocha, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2025-0384","DOIUrl":"10.1590/1980-5764-DN-2025-0384","url":null,"abstract":"<p><p>Vanishing white matter (VWM) disease is a leukodystrophy caused by mutations in <i>EIF2B1-5</i> genes, which impair cellular stress responses and protein synthesis regulation, leading to astrocytic dysfunction and white matter degeneration. While typically a pediatric condition, adult-onset cases are increasingly recognized. We report a 39-year-old Brazilian woman with a six-year history of progressive cognitive decline, gait impairment, and rapid deterioration following an infection. Neurological examination revealed spastic tetraparesis and severe cognitive impairment. Brain magnetic resonance imaging (MRI) showed diffuse white matter abnormalities with cystic degeneration. Whole-exome sequencing identified a homozygous <i>EIF2B3</i> c.260C>T (p.Ala87Val) variant, previously associated with a founder effect in Quebec but not reported in Brazil. This case highlights the phenotypic variability of VWM, stress-triggered exacerbations, and the importance of genetic testing in adult patients with cognitive decline. It also expands the genotypic diversity of VWM in Brazil and underscores the need for multidisciplinary care.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250384"},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in Alzheimer's disease randomized controlled trials: a bibliometric analysis.","authors":"Sanam Hosseinpoor-Dashatani, Narges Ebrahimi","doi":"10.1590/1980-5764-DN-2025-0423","DOIUrl":"10.1590/1980-5764-DN-2025-0423","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common form of dementia worldwide, creating substantial clinical and socioeconomic burdens. Randomized controlled trials (RCTs) provide the highest level of evidence to evaluate interventions, yet global publication trends and thematic evolution have not been systematically analyzed.</p><p><strong>Objective: </strong>As far as we are aware, there has been no bibliometric analysis that has thoroughly assessed RCTs in AD, despite their pivotal influence on the development of treatment and prevention strategies. Therefore, in this study, we conducted a bibliometric mapping analysis of global RCTs on AD.</p><p><strong>Methods: </strong>A bibliometric analysis of human RCTs on AD from September 2010 to September 2025 was conducted using PubMed and Web of Science. VOSviewer was employed for keyword co-occurrence, co-authorship mapping, and co-citation analyses to identify research themes, collaborations, and temporal trends.</p><p><strong>Results: </strong>A total of 4,482 RCTs were identified, revealing five main themes: pharmacological interventions, lifestyle and prevention strategies, pathophysiological mechanisms, cognitive and behavioral interventions, and clinical trial methodology. After 2015, focus shifted from traditional pharmacology to multidomain, prevention-oriented, and precision-driven approaches. Emerging topics included digital health, gut microbiome, and machine learning. Collaboration networks highlighted the dominance of the US and Europe, with rapid growth in Asia and emerging regions.</p><p><strong>Conclusion: </strong>Findings indicate a paradigm shift in AD RCTs toward integrative, technology-enabled designs, emphasizing both pharmacological and non-pharmacological strategies. These trends can guide future global research priorities and intervention development.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250423"},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between subjective well-being and cognitive performance in older adults.","authors":"Sabrina Aparecida da Silva, Tiago Nascimento Ordonez, Gabriela Dos Santos, Henrique Salmazo da Silva, Maria Antônia Antunes de Souza, Diana Dos Santos Bacelar, Laydiane Alves Costa, Rosa Yuka Sato Chubaci, Beatriz Aparecida Ozello Gutierrez, Allan Gustavo Bregola, Alexsandro Roberto Nascimento Ordonez, Sonia Maria Dozzi Brucki, Thais Bento Lima da Silva","doi":"10.1590/1980-5764-DN-2025-0452","DOIUrl":"10.1590/1980-5764-DN-2025-0452","url":null,"abstract":"<p><p>The study of subjective well-being (SWB) is fundamental to positive psychology, being considered a potential protective factor for health and the maintenance of cognitive reserve during aging. Despite international evidence, there are gaps in the Brazilian literature regarding how specific components of SWB relate to different cognitive domains.</p><p><strong>Objective: </strong>To analyze the relationship between subjective well-being and cognitive performance in cognitively healthy Brazilian older adults.</p><p><strong>Methods: </strong>A longitudinal study was conducted with 183 older adults (mean age 67.3 years). Scales for General Life Satisfaction (SGV), Domain-Referenced Life Satisfaction (SVRD), and the Positive and Negative Affect Scale were applied. Cognitive performance was assessed using the Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Mini-Mental State Examination (MMSE). Data were analyzed via Spearman's correlation matrix.</p><p><strong>Results: </strong>The sample showed a female predominance and high educational level (mean of 17 years). Participants exhibited high levels of SWB and good cognitive performance. General life satisfaction correlated positively with the MMSE and the attention/orientation domains of the ACE-R. Satisfaction with mental capacity (SVRD_Mental) showed a significant correlation with global performance in both cognitive tests. However, no significant correlations were found between affect states (positive or negative) and cognition in this sample.</p><p><strong>Conclusion: </strong>Healthy, highly educated older adults exhibit high levels of subjective well-being and satisfactory cognitive performance. The results reinforce the association between life satisfaction and cognitive reserve, suggesting that SWB may act as a marker of successful aging.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250452"},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric symptoms and social cognition in frontotemporal dementia and Alzheimer's disease.","authors":"Lucas de Andrade Saraiva, Elisa de Paula França Resende, Luciano Inácio Mariano, Danielly Silva Paula, Paulo Caramelli, João Vinícius Salgado, Leonardo Cruz de Souza","doi":"10.1590/1980-5764-DN-2025-0409","DOIUrl":"10.1590/1980-5764-DN-2025-0409","url":null,"abstract":"<p><p>Neuropsychiatric symptoms (NPS) are common in dementia and may hinder differential diagnosis between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Despite investigations of NPS and social cognition, particularly Theory of Mind (ToM) and emotion recognition, their precise, differential impact on social cognition in bvFTD versus AD remains less characterized.</p><p><strong>Objective: </strong>This study examined NPS in bvFTD and their association with social cognition, comparing results to AD.</p><p><strong>Methods: </strong>Patients with bvFTD (n=13) and AD (n=18) were assessed using neuropsychiatric and cognitive batteries measuring depression, anxiety, mania, and psychosis. Social cognition was evaluated with the Mini-Social and Emotional Assessment (mini-SEA), including the <i>Faux-Pas</i> test (ToM) and the Facial Emotion Recognition Test (FERT).</p><p><strong>Results: </strong>The groups did not differ in sex, education, or disease duration. Compared to AD, bvFTD patients had higher manic symptoms (p<0.001) and schizophrenia spectrum symptoms, particularly in negative (p<0.001) and resistance/hostility (p=0.034) symptoms. In bvFTD, depressive (p=0.020) and anxious (p=0.045) symptoms positively correlated with the <i>Faux-Pas</i> test, while positive psychotic symptoms correlated negatively (p=0.005). In AD, obsessive-compulsive (p=0.013) and disorganized psychotic symptoms (p=0.009) negatively correlated with the <i>Faux-Pas</i> test, while manic symptoms negatively correlated with the FERT (p=0.033).</p><p><strong>Conclusion: </strong>bvFTD patients displayed more schizophrenic and manic symptoms than AD, with NPS impacting social cognition differently in each condition.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250409"},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Thanks to Editorial Board of <i>Dementia & Neuropsychology</i>.","authors":"","doi":"10.1590/1980-5764-DN-2026-A001-ER","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2026-A001-ER","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1590/1980-5764-DN-2026-A001.].</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2026A001ER"},"PeriodicalIF":0.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148253994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of subjective cognitive decline in Brazil: a narrative review.","authors":"Isabele Sessa Soares, Adalberto Studart-Neto, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2025-0416","DOIUrl":"10.1590/1980-5764-DN-2025-0416","url":null,"abstract":"<p><p>Subjective cognitive decline (SCD) is characterized by the individual's self-perception of cognitive decline, without functional impairment and objective confirmation through neuropsychological testing. SCD has been studied as a possible clinical marker of early stages of neurodegenerative diseases, especially Alzheimer's disease. This article presents a narrative review of the available literature on the context of SCD in Brazil, covering conceptual aspects, diagnosis, etiologies, assessment measures used in the country, case outcomes, epidemiological data, and predictors of progression. Proposals for the evaluation and clinical monitoring of patients with SCD were also developed. Although there is growing scientific interest in the topic, gaps remain in the clinical approach to SCD, and a lack of national data and specific tools validated for the Brazilian population persists.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2025416"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Alzheimer's disease in asymptomatic individuals: a historical perspective.","authors":"Ricardo Nitrini","doi":"10.1590/1980-5764-DN-2026-0487","DOIUrl":"10.1590/1980-5764-DN-2026-0487","url":null,"abstract":"<p><p>The diagnosis of Alzheimer's disease (AD) based on biomarkers of the pathological process represents a significant change from previous criteria, which required the presence of dementia for AD diagnosis. These new criteria create difficulties in disclosing the diagnosis of AD to asymptomatic individuals. A similar example exists in the history of cognitive and behavioral disorders, where the risk of developing dementia paralytica (DP), a form of neurosyphilis (NS), could be detected even in the asymptomatic phase. Treatment in this phase of DP or in its early symptomatic phase was successful due to the discovery of new therapeutic modalities and new evolutionary biomarkers, which are not yet widely available in AD. This type of biomarker was very important in NS and will certainly be in AD, allowing for faster and less expensive clinical trials.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2026487"},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing cognitive impairment in drivers on hemodialysis through reaction time.","authors":"Áquilla Dos Anjos Couto, Karla Carlos, Juliana Alencar Fuzinohara, Rubens Baptista, Matheus de Lima Gomes, Eduardo Nascimento de Lima, Gilmar Fernandes do Prado","doi":"10.1590/1980-5764-DN-2025-0382","DOIUrl":"10.1590/1980-5764-DN-2025-0382","url":null,"abstract":"<p><p>End-stage kidney disease affects cognition and is associated with sleep disorders (SD), both increasing reaction time (RT) and impairing decision-making capacity.</p><p><strong>Objective: </strong>To evaluate sleep disorders, age, dialysis duration, and education level on the RT of Brazilian drivers undergoing hemodialysis (HD) and the feasibility of the method employed.</p><p><strong>Methods: </strong>We used tablet-based software to test the RT of 35 drivers undergoing HD and 32 controls. We did a clinical interview, examination, and chart review. The data were summarized and analyzed, which included conducting multiple linear regression. Significance was considered for p<0.05.</p><p><strong>Results: </strong>RT evaluation was well-received and effortless to carry out. Most patients were male (82.9%); the mean age was 52 years; two-thirds had been on HD for less than four years; 47.5% had 9.5 years or less of education; 14.3% had restless legs syndrome/Willis-Ekbom disease (RLS/WED); 68.6% showed a high likelihood of obstructive sleep apnea (OSA). HD patients showed higher RT than controls (p<0.001), and RT was positively associated with age (p<0.001). Less than 9.5 years of education and being on dialysis for over four years are associated with longer RT (p<0.05). Those with RLS/WED had shorter RT (p<0.001), age remained a significant predictor in the regression model, and patients on HD had longer RT than controls (p<0.001).</p><p><strong>Conclusion: </strong>Testing the RT of drivers on HD in the clinic environment is fully feasible. Patients on HD had longer RT than controls. RLS/WED patients showed shorter RT, but, as age increases, the RT is longer.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250382"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUPERA Online - Sensorial Moove: cognitive stimulation and education for active aging.","authors":"Djessica Hilton Peixoto, Kauane Macedo Barbosa, Gabriela Dos Santos, Tiago Nascimento Ordonez, Luiz Carlos de Moraes, Rosa Yuka Sato Chubaci, Beatriz Aparecida Ozello-Gutierrez, Thais Bento Lima-Silva","doi":"10.1590/1980-5764-DN-2025-0400","DOIUrl":"10.1590/1980-5764-DN-2025-0400","url":null,"abstract":"<p><p>Education for active aging, combined with technologies and cognitive games, promotes well-being, social engagement and cognitive stimulation in older adults.</p><p><strong>Objective: </strong>The aim of this study was to analyze the effects of digital games on cognitive stimulation in older adults, combined with an educational intervention on active aging.</p><p><strong>Methods: </strong>A workshop comprising 10 weekly 90-min sessions was run. Data collection was conducted online and involved application of a sociodemographics questionnaire. The protocol included the Cognitive Function Instrument, Geriatric Anxiety Inventory, Geriatric Depression Scale-15, Satisfaction with Life Scale, Social Support Scale of Medical Outcome Study, and Lubben Social Network Scale. Sessions were conducted by two monitors who were Gerontology graduates. A total of 31 older adults took part (mean age=67; standard deviation=6.40 years). Most participants were women (96.77%) and had complete higher educational level (77.42%).</p><p><strong>Results: </strong>On the post-test, participants had a mean score for cognitive performance of 416.43 points (scale 0-1,000), most notably for impulsivity control (55.93 points), followed by reaction time (43.93) and decision-taking (41.07). Participants showed a reduction in anxious and depressive symptoms, and improved self-perceived performance in cognitive skills.</p><p><strong>Conclusion: </strong>The digital cognitive games platform proved feasible and well accepted, showing potential for expanding self-awareness about aging and promoting cognitive and psychosocial health in older adults.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250400"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}