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Unveiling the storm: delirium coding trends among hospitalized Peruvian older adults. 揭秘风暴：秘鲁住院老年人谵妄编码趋势。
Dementia e Neuropsychologia Pub Date : 2025-01-17 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0200
Anthony Renzo Apuy, Camila Sofía Badell, Oscar Josue Ponce, Eloy Francisco Ruiz, Luis Enrique Palomino
{"title":"Unveiling the storm: delirium coding trends among hospitalized Peruvian older adults.","authors":"Anthony Renzo Apuy, Camila Sofía Badell, Oscar Josue Ponce, Eloy Francisco Ruiz, Luis Enrique Palomino","doi":"10.1590/1980-5764-DN-2024-0200","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0200","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240200"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment. 轻度认知障碍的神经精神症状和特定认知领域。
Dementia e Neuropsychologia Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0187
Lucas Luchesi Barnes, Lucas Francisco Botequio Mella, Francisca Daniele Ferreira Lopes, Amilton Dos Santos, Paulo Dalgalarrondo
{"title":"Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment.","authors":"Lucas Luchesi Barnes, Lucas Francisco Botequio Mella, Francisca Daniele Ferreira Lopes, Amilton Dos Santos, Paulo Dalgalarrondo","doi":"10.1590/1980-5764-DN-2024-0187","DOIUrl":"10.1590/1980-5764-DN-2024-0187","url":null,"abstract":"<p><p>Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear.</p><p><strong>Objective: </strong>This study aimed to assess whether there is a correlation between NPS and specific cognitive domains.</p><p><strong>Methods: </strong>A cross-sectional study which included 174 participants with MCI, aged 55 years or older. Differences in sociodemographic profile, neuroimaging, and neuropsychological tests between MCI participants with and without NPS were measured.</p><p><strong>Results: </strong>Participants with NPS had lower education and worse performance in attention tests and executive functions. Psychotic symptoms were correlated with deficits in visuospatial functions; irritability and agitation with inattention and deficit of inhibitory control; and depression with inattention.</p><p><strong>Conclusion: </strong>Correlations were found between some NPS with specific cognitive domains, especially psychotic symptoms, but also agitation, irritability, apathy, and depression.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Saint Paul, the Apostle, and the Gastaut-Geschwind syndrome. 圣保罗，使徒，以及加斯托- geschwind综合症。
Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0165
Leonardo Cruz de Souza, Guilherme Nogueira Mendes de Oliveira, Leandro Boson Gambogi, Ana Paula Gonçalves, Antônio Lúcio Teixeira
{"title":"Saint Paul, the Apostle, and the Gastaut-Geschwind syndrome.","authors":"Leonardo Cruz de Souza, Guilherme Nogueira Mendes de Oliveira, Leandro Boson Gambogi, Ana Paula Gonçalves, Antônio Lúcio Teixeira","doi":"10.1590/1980-5764-DN-2024-0165","DOIUrl":"10.1590/1980-5764-DN-2024-0165","url":null,"abstract":"<p><p>The interface between epilepsy and religiosity has been a long-standing matter of debate. Epilepsy has affected several religious leaders throughout history. Hyperreligiosity may be observed in patients with temporal lobe epilepsy as a component of the so-called Gastaut-Geschwind syndrome which involves other behavioral and personality traits such as hyposexuality, viscosity, philosophical concerns, sense of personal destiny, hypergraphy, emotionality, and irritability. Saint Paul, the Apostle, probably had temporal lobe epilepsy. He was a genius man of intellectual excellence and refined culture, whose life and writings exerted a decisive influence on Western history. The current paper investigates the elements of Gastaut-Geschwind syndrome in Saint Paul's life and Epistles and discusses the potential influence of these traits on Pauline theology.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240165"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiopathological mechanisms underlying Alzheimer's disease: a narrative review. 阿尔茨海默病的生理病理机制：叙述性回顾。
Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-VR01
Eliasz Engelhardt, Elisa de Paula França Resende, Karina Braga Gomes
{"title":"Physiopathological mechanisms underlying Alzheimer's disease: a narrative review.","authors":"Eliasz Engelhardt, Elisa de Paula França Resende, Karina Braga Gomes","doi":"10.1590/1980-5764-DN-2024-VR01","DOIUrl":"10.1590/1980-5764-DN-2024-VR01","url":null,"abstract":"<p><p>The neuropathological signature of Alzheimer's disease (AD) comprises mainly amyloid plaques, and neurofibrillary tangles, resulting in synaptic and neuronal loss. These pathological structures stem from amyloid dysfunctional metabolism according to the amyloid cascade hypothesis, leading to the formation of plaques, and apparently inducing the initiation of the abnormal tau pathway, with phosphorylation and aggregation of these proteins, ultimately causing the formation of tangles. In this narrative review, the existing hypothesis related to the pathophysiology of AD were compiled, and biological pathways were highlighted in order to identify the molecules that could represent biological markers of the disease, necessary to establish early diagnosis, as well as the selection of patients for therapeutical interventional strategies.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e2024VR01"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperglycemia-induced isolated aphasic status epilepticus a case-report and literature review. 高血糖诱发孤立性癫痫持续状态1例报告及文献复习。
Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0177
Jedsada Khieukhajee, Suphasit Seoratanaphunt, Krittima Asavaveeradech, Sunisa Hangsapruek
{"title":"Hyperglycemia-induced isolated aphasic status epilepticus a case-report and literature review.","authors":"Jedsada Khieukhajee, Suphasit Seoratanaphunt, Krittima Asavaveeradech, Sunisa Hangsapruek","doi":"10.1590/1980-5764-DN-2024-0177","DOIUrl":"10.1590/1980-5764-DN-2024-0177","url":null,"abstract":"<p><p>Neurological manifestations of nonketotic hyperglycemia are frequently seen, with mainly symptoms of confusion or coma. While hyperglycemia-induced seizures are less common, isolated aphasic status epilepticus is very rare, difficult to diagnose, and may be unrecognized by clinicians. In this case report, a 51-year-old man who presented with confusion and incoherent speech for two weeks is discussed. He was diagnosed with nonketotic hyperglycemia, whose electroencephalography (EEG) findings were suggestive of isolated aphasic status epilepticus. His magnetic resonance imaging (MRI) of the brain showed subcortical T2/FLAIR hypointense lesions with cortical T2/FLAIR hyperintensities and restricted diffusion. Although this condition usually responds well to intensive insulin therapy and fluid replacement, many researchers found some persistent aphasic seizures that did not improve until the addition of anti-seizure medications (ASMs).</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240177"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to familial dysfunction and cognitive decline in aging: the "health, wellbeing, and aging" (SABE) longitudinal population-based study. 对家庭功能障碍和衰老认知能力下降的回应：“健康、幸福和衰老”（SABE）纵向人群研究。
Dementia e Neuropsychologia Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0146R
Diego Ferreira da Silva, Juliana Nery Souza-Talarico, Jair Licio Ferreira Santos, Yeda Aparecida de Oliveira Duarte
{"title":"Reply to familial dysfunction and cognitive decline in aging: the \"health, wellbeing, and aging\" (SABE) longitudinal population-based study.","authors":"Diego Ferreira da Silva, Juliana Nery Souza-Talarico, Jair Licio Ferreira Santos, Yeda Aparecida de Oliveira Duarte","doi":"10.1590/1980-5764-DN-2024-0146R","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0146R","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240146R"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial risk of cognitive changes in the elderly. 老年人认知变化的家族性风险。
Dementia e Neuropsychologia Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0146
Johnnatas Mikael Lopes, Amanda Cirilo de Oliveira Lins, Rafael Limeira Cavalcanti, Jeisyane Acsa Santos do Nascimento, Luan Andrade Carvalho, Pedro Vitor Vieira Freire, Anna Beatriz Machado Lima, Achilles de Souza Andrade
{"title":"Familial risk of cognitive changes in the elderly.","authors":"Johnnatas Mikael Lopes, Amanda Cirilo de Oliveira Lins, Rafael Limeira Cavalcanti, Jeisyane Acsa Santos do Nascimento, Luan Andrade Carvalho, Pedro Vitor Vieira Freire, Anna Beatriz Machado Lima, Achilles de Souza Andrade","doi":"10.1590/1980-5764-DN-2024-0146","DOIUrl":"10.1590/1980-5764-DN-2024-0146","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240146"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardization in the judgment of line orientation test in elderly people in Northeast Brazil. 巴西东北部老年人线取向测试判断的规范化。
Dementia e Neuropsychologia Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0130
Paulo Roberto de Brito-Marques, Janaina Mariana de Araujo Miranda Brito-Marques, Cácia Carolina de Carvalho Silva Miranda, Herickssen Gustavo Medeiros-Silva
{"title":"Standardization in the judgment of line orientation test in elderly people in Northeast Brazil.","authors":"Paulo Roberto de Brito-Marques, Janaina Mariana de Araujo Miranda Brito-Marques, Cácia Carolina de Carvalho Silva Miranda, Herickssen Gustavo Medeiros-Silva","doi":"10.1590/1980-5764-DN-2024-0130","DOIUrl":"10.1590/1980-5764-DN-2024-0130","url":null,"abstract":"<p><p>Aging is generally associated with a decline in cognition when compared to adulthood. The changes most seen are in attention, perception, working memory, short-term memory, free recall, and processing speed. Certain changes in the Judgment of Line Orientation (JLO) test may be present in elderly people.</p><p><strong>Objective: </strong>The objective of this study was to describe the difference among age, sex, schooling, Mini-Mental State (MMS), and Mini-Mental State Examination (MMSE) when compared to the JLO test in elderly people. The second is to assess the clinical use of the JLO test in elderly people's cognitive decline in Northeast Brazil.</p><p><strong>Methods: </strong>A cross-sectional, randomized study was carried out on 280 elderly people, between 60 and 89 years old, and the mean age was 69.4 (±6.8 years SD); 73.9% of the females lived in Olinda City, State of Pernambuco, Brazil. Age was stratified every 5 years between 60 and 89 years old, and schooling was divided into four subgroups between illiterate and more than 8 years of schooling. Each participant was submitted to an analysis of age, sex, schooling, risk factors, MMS, modified MMSE, and a JLO test.</p><p><strong>Results: </strong>There was no statistical difference between the sexes. However, there was a statistical difference when compared to the JLO test and age (p<0.012), schooling (p<0.001), MMS (p<0.001), and modified MMSE (p<0.001).</p><p><strong>Conclusion: </strong>We observed that with a cutoff point of 18 points, the JLO test is indicated to assess visuospatial and visuoperceptive changes in elderly people in Northeast Brazil.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240130"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting multilingualism in dementia research, prevention, and discourse. 在痴呆症的研究、预防和论述中促进使用多种语言。
Dementia e Neuropsychologia Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0201
Timothy Daly
{"title":"Promoting multilingualism in dementia research, prevention, and discourse.","authors":"Timothy Daly","doi":"10.1590/1980-5764-DN-2024-0201","DOIUrl":"10.1590/1980-5764-DN-2024-0201","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240201"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward enhanced understanding and rigor: addressing limitations in studying dementia symptoms and caregiver interventions. 增强理解和严谨性：解决研究痴呆症状和护理干预的局限性。
Dementia e Neuropsychologia Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0148
Guilherme Nobre Nogueira, Wilson da Silva Rocha Vidal, Nicole Custódio Porto Silva
{"title":"Toward enhanced understanding and rigor: addressing limitations in studying dementia symptoms and caregiver interventions.","authors":"Guilherme Nobre Nogueira, Wilson da Silva Rocha Vidal, Nicole Custódio Porto Silva","doi":"10.1590/1980-5764-DN-2024-0148","DOIUrl":"10.1590/1980-5764-DN-2024-0148","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240148"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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