Dementia e Neuropsychologia最新文献

{"title":"Economic evaluation of non-pharmacological interventions in Alzheimer's disease.","authors":"Margarida Sobral, Susana Oliveira","doi":"10.1590/1980-5764-DN-2024-0219","DOIUrl":"10.1590/1980-5764-DN-2024-0219","url":null,"abstract":"<p><p>Alzheimer's disease (AD) has significant physical, psychological, and socioeconomic impacts, shortens life expectancy, and reduces quality of life. Non-pharmacological interventions (NPIs) in dementia provide health gains.</p><p><strong>Objective: </strong>The aim of this study was to conduct a cost-utility study of NPIs in AD, assessing both the costs and health gains associated with cognitive stimulation interventions in AD patients.</p><p><strong>Methods: </strong>A sample of 40 patients undergoing NPIs and another 40 individuals (control group) were included. Data collected included sociodemographic, clinical, cognitive, and functional information, as well as health status, quality of life, and outpatient costs.</p><p><strong>Results: </strong>The NPI, considering the discounted cost value of €21,621.31 and the discounted quality-adjusted life year (QALY) gain of 0.81333, resulted in an estimated cost per QALY of €26,583.76. This cost per QALY is within the threshold generally considered acceptable by regulatory authorities in Portugal and in several European countries.</p><p><strong>Conclusion: </strong>This study supports the recommendation that interventions adjusted to the needs of patients with AD should be implemented, which may include NPIs providing both health gains and economic value.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240219"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticity in autism spectrum disorder: a systematic review.","authors":"Gabriela Garcia de Carvalho Laguna, Ana Beatriz Ferreira Gusmão, Breno Oliveira Marques, Níkolas Brayan da Silva Bragas, Isadora Bagues Rodrigues, Rafaela Souza Melo, Katiene Rodrigues Menezes de Azevedo","doi":"10.1590/1980-5764-DN-2024-0182","DOIUrl":"10.1590/1980-5764-DN-2024-0182","url":null,"abstract":"<p><p>The brain's ability to adapt in response to stimuli is called neuroplasticity.</p><p><strong>Objective: </strong>This study investigates neuroplasticity in autistic individuals, focusing on neurobiological aspects, clinical correlations, and therapeutic interventions.</p><p><strong>Methods: </strong>This systematic review, registered in the International Prospective Register of Systematic Reviews-PROSPERO (ID: CRD42024522425) and guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA (2020) criteria, searched databases like Web of Science, Scopus, United States National Library of Medicine/ Medical Literature Analysis and Retrieval System Online (PubMed/Medline), Latin American and Caribbean Health Sciences Literature (LILACS), and Scientific Electronic Library Online (SciELO) for original articles published in 2018-2023.</p><p><strong>Results: </strong>Of the 2,316 studies found, 11 were selected, involving 1,943 autistic individuals, both children and adults. Most studies were classified as high/moderate quality using the Newcastle-Ottawa and Jadad scales. Observations included variations in SHANK2 gene expression, lower concentrations of α-synuclein, higher β-synuclein in children with autism spectrum disorder (ASD), correlations between NCAM1 expression and motor skills, and higher brain-derived neurotrophic factor (BDNF) concentration compared to non-autistic children.</p><p><strong>Conclusions: </strong>Alterations in SHANK2, α-synuclein, β-synuclein, NCAM1, and BDNF in ASD suggest biomarkers and therapeutic targets for more effective interventions, improving care for autistic individuals.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with family caregiver burden of patients with dementia.","authors":"Andressa Hermes-Pereira, Mariana Goulart, Renata Kochhann, Artur Francisco Schumacher-Schuh","doi":"10.1590/1980-5764-DN-2024-0190","DOIUrl":"10.1590/1980-5764-DN-2024-0190","url":null,"abstract":"<p><p>Neuropsychiatric symptoms of dementia, also known as behavioral and psychological symptoms of dementia, are extremely common. These symptoms represent one of the main causes of burden and distress among caregivers and can lead to decline in their physical and mental health.</p><p><strong>Objective: </strong>This study aimed to identify predominant characteristics in a sample of Brazilian outpatient dementia patients and explore which symptoms exert the greatest influence on caregiver burden.</p><p><strong>Methods: </strong>This was a cross-sectional study involving 119 caregivers. Stepwise regression analysis was used, with caregiver burden as the dependent variable and depressive symptoms, caregiver distress due to neuropsychiatric symptoms, and quality of life as independent variables in the final model.</p><p><strong>Results: </strong>Regression analysis identified three different models as predictors of caregiver burden. The first model, composed of depressive symptoms, predicted 34% of caregiver burden (p≤0.000). The second model, composed of depressive symptoms and caregiver distress due to neuropsychiatric symptoms, predicted 49% (p≤0.000). The third model, composed of depressive symptoms, caregiver distress due to neuropsychiatric symptoms, and quality of life, predicted 52% (p≤0.008).</p><p><strong>Conclusion: </strong>Our findings indicate that problematic behaviors in dementia patients, depressive symptoms, and quality of life are associated with the level of caregiver burden and distress. Further research is needed to differentiate these findings among different types of dementia and to better understand how caregivers' individual characteristics influence their own burden.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240190"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness during the COVID-19 pandemic: A potential risk factor for post-pandemic cognitive decline in older adults without dementia.","authors":"Alaa Harb, Juliana Nery Souza-Talarico, Grace Willey, Fernanda Carini da Silva, Maria Clara Ferreira de Jesus, Jennifer Deberg","doi":"10.1590/1980-5764-DN-2024-0256","DOIUrl":"10.1590/1980-5764-DN-2024-0256","url":null,"abstract":"<p><p>The COVID-19 pandemic has exacerbated loneliness and social isolation among older adults, raising concerns about their mental and physical well-being. While loneliness's adverse effects on health are well-documented, its specific impact on cognitive health during the pandemic remains under investigation.</p><p><strong>Objective: </strong>The aim of this study was to examine the association between loneliness during the COVID-19 pandemic and cognitive decline in cognitively unimpaired older adults by synthesizing evidence from primary studies.</p><p><strong>Methods: </strong>A comprehensive search strategy was employed across multiple databases, including MEDLINE (PubMed), CINAHL (EBSCO), PsycINFO (EBSCO), EMBASE, Scopus, AgeLine, and ProQuest, following PRISMA guidelines. Studies were selected to examine the association between loneliness and cognitive function in cognitively unimpaired older adults (aged ≥50 years) during the COVID-19 pandemic.</p><p><strong>Results: </strong>A total of eight studies were included from 1,384 search results, reviewing data from 10,449 cognitively unimpaired older adults. A total of six studies found significant associations between loneliness or social isolation and subjective cognitive decline (SCD). Only one study linked loneliness to lower objective cognitive performance. Notably, half of the studies considered key covariates, such as depression, which could mediate the relationship between loneliness and cognitive decline.</p><p><strong>Conclusion: </strong>Loneliness during the COVID-19 pandemic is linked to SCD in older adults, though objective evidence is limited. The pandemic underscored the long-term impact of social isolation on cognition and mental health, highlighting the need for standardized neuropsychological tools and key covariates in studies to identify those at risk.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240256"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of the Brief Cognitive Screening Battery: Indonesian version.","authors":"Fasihah Irfani Fitri, Dina Nazriani, Octaviasari Agatha Dachi, Ricardo Nitrini, Paulo Caramelli","doi":"10.1590/1980-5764-DN-2024-0250","DOIUrl":"10.1590/1980-5764-DN-2024-0250","url":null,"abstract":"<p><p>Dementia is a significant public health challenge, particularly in low- and middle-income countries such as Indonesia, where underdiagnosis is common.</p><p><strong>Objective: </strong>To investigate the psychometric properties of the Brief Cognitive Screening Battery - Indonesian Version (BCSB-INA), a culturally-adapted tool aimed at improving the early detection of dementia.</p><p><strong>Methods: </strong>The tool was tested on a sample of 140 older adults, covering various cognitive domains through multiple subscales. Data were analyzed using bootstrap resampling, Kaiser-Meyer-Olkin (KMO) test, Confirmatory Factor Analysis (CFA), and reliability assessments such as Cronbach's Alpha.</p><p><strong>Results: </strong>The overall reliability, measured by Cronbach's Alpha, was high (α=0.968). The KMO test yielded a value of 0.889, indicating sample adequacy for factor analysis. The CFA indicated that most dimensions achieved satisfactory validity, with the majority of items demonstrating acceptable factor loadings.</p><p><strong>Conclusions: </strong>BCSB-INA has demonstrated good reliability and validity throughout its dimensions, suggesting its applicability for use in cognitive assessments in the Indonesian context.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240250"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the diagnosis and management of depressive and cognitive disorders in older adults: a case report.","authors":"Nour Regaieg, Dorra Mnif, Emna Smaoui, Fatma Guermazi, Salma Sakka, Ines Feki, Imen Baâti, Jawaher Masmoudi","doi":"10.1590/1980-5764-DN-2025-0295","DOIUrl":"10.1590/1980-5764-DN-2025-0295","url":null,"abstract":"<p><p>Dementia with Lewy Bodies and depression are two common conditions in older adults that can share clinical similarities or coexist. We aim to highlight the diagnostic and therapeutic challenges of these two pathologies through the case of Mrs. S., a 67-year-old patient admitted to the psychiatric department for agitation and insomnia. Her symptoms initially presented as depression, followed by severe agitation. In the admission interview, we observed an anxious patient with bradyphemia, primarily focused on well-detailed visual hallucinations related to death. Upon neurological examination, we identified Parkinsonian syndrome. The patient was treated with quetiapine 200 mg/day and sertraline 50 mg/day, leading to a marked improvement in both depressive and Parkinsonian symptoms. Ultimately, the diagnosis was a major depressive episode with psychotic and melancholic features as part of a bipolar II disorder. In neuropsychiatric presentations of dementia with Lewy Bodies, cognitive and neurological evaluations should always be considered. In some cases, clinical evolution remains the only means of distinguishing between depression and dementia with Lewy Bodies.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20250295"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent transient global amnesia related to dural arteriovenous fistula.","authors":"Rafael Batista João, Raquel Filgueiras Mattos","doi":"10.1590/1980-5764-DN-2024-0222","DOIUrl":"10.1590/1980-5764-DN-2024-0222","url":null,"abstract":"<p><p>Transient global amnesia (TGA) is a syndrome characterized by the sudden onset of anterograde amnesia, typically lasting for a few to less than 24 h. This condition is considered benign, as it is usually self-limited and unrelated to brain lesions; however, TGA may less frequently occur due to vascular brain changes. We report a rare case of a 66-year-old male with a diagnosis of recurrent TGA associated with a brain dural arteriovenous fistula (DAVF), alongside the absence of clear triggering and risk factors. He was submitted to embolization and remained event-free until his last attempt, 18 months after the surgical procedure. The case presentation follows a brief literature review on TGA and the pathophysiological mechanisms probably underpinning its occasional correlation with brain DAVF.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240222"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving participants' recruitment in dementia-related studies on social media through colloquial language in Lima, Peru.","authors":"Belén Custodio, Maria Mora-Pinzon, Rosa Montesinos, Maria Eugenia Godoy, José Carlos Huilca, Katherine Agüero, Nilton Custodio","doi":"10.1590/1980-5764-DN-2024-0232","DOIUrl":"10.1590/1980-5764-DN-2024-0232","url":null,"abstract":"<p><p>Recruitment for dementia research remains a persistent challenge, particularly when trying to reach underrepresented groups such as Latin Americans with traditional enrollment strategies.</p><p><strong>Objective: </strong>In this retrospective case study, we investigate two communication approaches used on social media to recruit participants for a dementia research study in Lima, Peru.</p><p><strong>Methods: </strong>Initially, recruitment materials featured medical terminology, which was later replaced by colloquial language to make the content more accessible.</p><p><strong>Results: </strong>According to the results, using simpler and more relatable language led to an increase in participants' contacts and enrollments. This suggests that culturally tailored communication strategies may be more effective in reaching diverse populations.</p><p><strong>Conclusion: </strong>The findings highlight the importance of adapting research recruitment efforts to the target community's cultural and linguistic context to improve engagement in dementia studies.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual field defect as the first manifestation of Alzheimer's disease.","authors":"Marcelo Houat de Brito, Artur Martins Coutinho, Carla Rachel Ono, Eduardo Sturzeneker Trés, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2025-0292","DOIUrl":"10.1590/1980-5764-DN-2025-0292","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20250292"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pupillary response test as a potential early diagnosis biomarker of Alzheimer's disease.","authors":"Robert Shen, Yuda Turana, Yvonne Suzy Handajani, Lukas, Nelly Tina Widjaja, Nova Eka Budiyanta, Reiner Adi Putra Sumarta, Celine Gabriella Wahyudi, Hans Timothy Wijaya, Jimmy Fransisco Abadinta Barus, Linda Suryakusuma, Poppy Kristina Sasmita, Tara Puspitarini Sani","doi":"10.1590/1980-5764-DN-2024-0153","DOIUrl":"10.1590/1980-5764-DN-2024-0153","url":null,"abstract":"<p><p>Psychometric tests as the gold-standard for diagnosing Alzheimer's disease (AD) tend to be inefficient, nonreproducible, and are affected by many factors. Research on pupillary response in AD is not novel; however, there has not been a single study providing the diagnostic value of pupillary response parameters as a recommendation for their potential use for early AD diagnosis.</p><p><strong>Objective: </strong>To investigate pupillary response parameters as clinical biomarkers of AD that are dynamic, affordable, efficient, and objective (non-operator dependent).</p><p><strong>Methods: </strong>A cross-sectional study on pupillary response parameters was conducted, with comparative and correlation-analytical tests between pupillary response and the Mini-Mental State Examination cognitive score. The diagnostic value of pupillary response parameters was obtained by determining the cutoff point of each parameter by calculating the sensitivity, specificity, Youden's maximum index, Area Under the Curve (AUC) value from the Receiver Operating Characteristic (ROC) curve, positive predictive value, and negative predictive value. Pupillary response parameters were classified into four types: size, response time, velocity, and acceleration.</p><p><strong>Results: </strong>There were 128 respondents in total, consisting of cognitively-unimpaired young adults, cognitively-unimpaired older adults, and cognitively-impaired older adults. The pupillary response values without involving acceleration parameters were reliable. The diagnostic value of change in pupil size, the maximum and the average constriction velocity parameters have normal cognitive cutoff scores of 1.77 mm (sensitivity: 61.3%; specificity: 80%; positive predictive value [PPV]: 47.76%; negative predictive value [NPV]: 86.88%), ≥4.43 mm/s (sensitivity: 70.4%; specificity: 58.5%; PPV: 46.93%; NPV: 78.48%), and 3.12 mm/s (sensitivity: 70.4%; specificity: 55.0%; PPV: 45.83%; NPV: 77.5%), respectively.</p><p><strong>Conclusions: </strong>Pupillary response, in particular changes in constriction and velocity, can be potentially used as an early diagnostic biomarker for AD.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240153"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}