Gabriela Garcia de Carvalho Laguna, Ana Beatriz Ferreira Gusmão, Breno Oliveira Marques, Níkolas Brayan da Silva Bragas, Isadora Bagues Rodrigues, Rafaela Souza Melo, Katiene Rodrigues Menezes de Azevedo
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Observations included variations in SHANK2 gene expression, lower concentrations of α-synuclein, higher β-synuclein in children with autism spectrum disorder (ASD), correlations between NCAM1 expression and motor skills, and higher brain-derived neurotrophic factor (BDNF) concentration compared to non-autistic children.</p><p><strong>Conclusions: </strong>Alterations in SHANK2, α-synuclein, β-synuclein, NCAM1, and BDNF in ASD suggest biomarkers and therapeutic targets for more effective interventions, improving care for autistic individuals.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240182"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136586/pdf/","citationCount":"0","resultStr":"{\"title\":\"Neuroplasticity in autism spectrum disorder: a systematic review.\",\"authors\":\"Gabriela Garcia de Carvalho Laguna, Ana Beatriz Ferreira Gusmão, Breno Oliveira Marques, Níkolas Brayan da Silva Bragas, Isadora Bagues Rodrigues, Rafaela Souza Melo, Katiene Rodrigues Menezes de Azevedo\",\"doi\":\"10.1590/1980-5764-DN-2024-0182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The brain's ability to adapt in response to stimuli is called neuroplasticity.</p><p><strong>Objective: </strong>This study investigates neuroplasticity in autistic individuals, focusing on neurobiological aspects, clinical correlations, and therapeutic interventions.</p><p><strong>Methods: </strong>This systematic review, registered in the International Prospective Register of Systematic Reviews-PROSPERO (ID: CRD42024522425) and guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA (2020) criteria, searched databases like Web of Science, Scopus, United States National Library of Medicine/ Medical Literature Analysis and Retrieval System Online (PubMed/Medline), Latin American and Caribbean Health Sciences Literature (LILACS), and Scientific Electronic Library Online (SciELO) for original articles published in 2018-2023.</p><p><strong>Results: </strong>Of the 2,316 studies found, 11 were selected, involving 1,943 autistic individuals, both children and adults. 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引用次数: 0
摘要
大脑适应刺激的能力被称为神经可塑性。目的：研究自闭症患者的神经可塑性，重点关注神经生物学方面、临床相关性和治疗干预。方法：本系统综述已在国际前瞻性系统综述登记册- prospero (ID：CRD42024522425)，并以系统评价和元分析首选报告项目- prisma（2020）标准为指导，检索Web of Science、Scopus、美国国家医学图书馆/医学文献分析和检索系统在线（PubMed/Medline）、拉丁美洲和加勒比健康科学文献（LILACS）和科学电子图书馆在线（SciELO）等数据库，检索2018-2023年发表的原创文章。结果：在发现的2316项研究中，有11项被选中，涉及1943名自闭症患者，包括儿童和成人。大多数研究使用Newcastle-Ottawa和Jadad量表被分类为高/中等质量。观察结果包括SHANK2基因表达的变化，自闭症谱系障碍（ASD）儿童α-突触核蛋白浓度较低，β-突触核蛋白浓度较高，NCAM1表达与运动技能之间的相关性，以及与非自闭症儿童相比，脑源性神经营养因子（BDNF）浓度较高。结论：SHANK2、α-突触核蛋白、β-突触核蛋白、NCAM1和BDNF在ASD中的变化为更有效的干预提供了生物标志物和治疗靶点，改善了对自闭症患者的护理。
Neuroplasticity in autism spectrum disorder: a systematic review.
The brain's ability to adapt in response to stimuli is called neuroplasticity.
Objective: This study investigates neuroplasticity in autistic individuals, focusing on neurobiological aspects, clinical correlations, and therapeutic interventions.
Methods: This systematic review, registered in the International Prospective Register of Systematic Reviews-PROSPERO (ID: CRD42024522425) and guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA (2020) criteria, searched databases like Web of Science, Scopus, United States National Library of Medicine/ Medical Literature Analysis and Retrieval System Online (PubMed/Medline), Latin American and Caribbean Health Sciences Literature (LILACS), and Scientific Electronic Library Online (SciELO) for original articles published in 2018-2023.
Results: Of the 2,316 studies found, 11 were selected, involving 1,943 autistic individuals, both children and adults. Most studies were classified as high/moderate quality using the Newcastle-Ottawa and Jadad scales. Observations included variations in SHANK2 gene expression, lower concentrations of α-synuclein, higher β-synuclein in children with autism spectrum disorder (ASD), correlations between NCAM1 expression and motor skills, and higher brain-derived neurotrophic factor (BDNF) concentration compared to non-autistic children.
Conclusions: Alterations in SHANK2, α-synuclein, β-synuclein, NCAM1, and BDNF in ASD suggest biomarkers and therapeutic targets for more effective interventions, improving care for autistic individuals.
期刊介绍：
Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.
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