Dementia e Neuropsychologia最新文献_第2页

What are the reasons for the repeated failures of clinical trials with anti-amyloid drugs for AD treatment?

Dementia e Neuropsychologia Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2025-E001

Orestes Vicente Forlenza, Breno José Alencar Pires Barbosa

引用次数: 0

The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration.

Dementia e Neuropsychologia Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0226

Eliasz Engelhardt, Lea Tenenholz Grinberg

{"title":"The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration.","authors":"Eliasz Engelhardt, Lea Tenenholz Grinberg","doi":"10.1590/1980-5764-DN-2024-0226","DOIUrl":"10.1590/1980-5764-DN-2024-0226","url":null,"abstract":"Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), which includes a behavioral variant, and primary progressive aphasia, with its non-fluent and semantic variants, and related conditions with parkinsonism or motoneuron disease features. The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy. Oskar Fischer significantly advanced this field by detailing the histopathological features of these conditions, such as the 'spongiform cortical wasting', and identifying characteristic neuronal changes such as the 'ballooned cells'. Fischer's contributions, alongside those of contemporaries like Alois Alzheimer, laid the foundation for understanding FTLD histopathology. Here, Fischer's overlooked work is spotlighted, advocating for a greater recognition, which he rightfully deserves for his contributions to the field of neurodegenerative diseases.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240226"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative discourse analysis of logical memory recall in normal elderly from rural and urban areas.

Dementia e Neuropsychologia Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0164

Lúcia Inês de Araújo, Sérgio Leme da Silva, Leonardo Caixeta

{"title":"Comparative discourse analysis of logical memory recall in normal elderly from rural and urban areas.","authors":"Lúcia Inês de Araújo, Sérgio Leme da Silva, Leonardo Caixeta","doi":"10.1590/1980-5764-DN-2024-0164","DOIUrl":"10.1590/1980-5764-DN-2024-0164","url":null,"abstract":"This study examined the nature of errors in prose recall made in normal aging from different cultural backgrounds: rural and urban areas.Objective: The aim of this study was to examine the nature of errors in prose recall made in normal aging from different cultural backgrounds.Methods: We evaluated neurologically normal elderly divided into two groups: 12 subjects resident in a rural area in Central Brazil (group 1, called \"Interior\") and 10 subjects from a metropolitan area in a big city in Central Brazil (group 2, called \"Metropolis\"). Responses by 22 nondemented older adults to the Logical Memory subtest of the Wechsler Memory Scale were examined in a propositional analysis.Results: Healthy older adults from rural areas (interior group) showed good immediate recalls, but had deficits in retention over a delay. Subjects from urban areas made errors of omission, not commission, at immediate recall.Conclusion: These errors probably reflect difficulty with attentional control rather than memory per se. There are differences in the performance of the elderly when considering different levels of education for neuropsychological tests associated with immediate recalls (but not with delayed recall), suggesting that working memory systems may be more impacted by years of schooling than the coding memory system.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health outcomes in dementia caregivers: a systematic review of yoga-based interventions.

Dementia e Neuropsychologia Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0151

Paula Pillar Pinto, Andrea Camaz Deslandes, Helena Moraes

{"title":"Mental health outcomes in dementia caregivers: a systematic review of yoga-based interventions.","authors":"Paula Pillar Pinto, Andrea Camaz Deslandes, Helena Moraes","doi":"10.1590/1980-5764-DN-2024-0151","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0151","url":null,"abstract":"Mind-body interventions have been explored to enhance the psychological well-being of dementia caregivers; however, the specific effects of yoga practice remain underexamined.Objective: The aim of this study was to investigate the benefits of yoga on quality of life (QoL), life satisfaction, psychological well-being, attention, self-compassion, perceived stress, anxiety, depression, and caregiver burden for dementia caregivers.Methods: A comprehensive search was conducted on September 11, 2024, in databases including SciELO, PubMed, BVSalud, Web of Science, Embase, and PsycINFO, focusing on the effects of yoga for informal dementia caregivers compared to passive or active control groups through randomized and non-randomized trials. An initial review reduced 284 to 180 unique records; 172 studies were excluded, leaving 8 that met the inclusion criteria. Two authors independently selected and extracted data using a data extraction sheet based on the Cochrane Consumers and Communication Review Group. The Cochrane Risk of Bias tools (ROB2 and ROBINS-I) were employed to evaluate bias risk.Results: The review included three randomized and five non-randomized studies with a total of 161 participants, predominantly female (wives and daughters), with ages ranging from 39 to 76 years. Four studies utilized hatha yoga, while four employed non-traditional yoga. Significant improvements were observed in QoL, depression, stress, anxiety, and self-compassion, but not in caregiver burden. Furthermore, positive effects were more pronounced in face-to-face or online interventions than in recorded videos. On average, studies exhibited a moderate risk of bias.Conclusion: Yoga practice can serve as an effective intervention for enhancing the psychological aspects of dementia caregivers.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent validity of a new screening test to evaluate the information processing speed.

Dementia e Neuropsychologia Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0183

Camila Fernanda Cabrera Zavala, Oscar Agustín Porta, Alén Martín, Edison Vega Valderrama, María Del Rosario Lis, Wilson Gualotuña Pachacama, Diana Soto

{"title":"Concurrent validity of a new screening test to evaluate the information processing speed.","authors":"Camila Fernanda Cabrera Zavala, Oscar Agustín Porta, Alén Martín, Edison Vega Valderrama, María Del Rosario Lis, Wilson Gualotuña Pachacama, Diana Soto","doi":"10.1590/1980-5764-DN-2024-0183","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0183","url":null,"abstract":"Information processing speed (IPS) evaluates the time at which a person reacts to a stimulus. The Wechsler for Adults-III (WAIS-III) includes this domain in the digit symbol test (DS-T).Objective: The aim of this study was to validate a new screening test that could measure the IPS in association with the individual's age and scholarship.Methods: A new instrument to measure the IPS was constructed, automatic cashier test (AC-T), and for its validation, the DS-T was also carried out.Results: The media of time use in the ACT was 12.3 s; the media of hits in the DS-T was 38.8, with a p<0.0001 and R2: 0.40.Conclusion: P-value showed a linear association between the two tests, but the R2 results showed a low association between these. In the same way, the correlation between both tests is promising, since it shows that both are tests that measure the IPS in a different way with different constructs such as the verbal fluency test that is also used to evaluate IPS. On the other hand, both tests exposed that the scholarship positively influences the IPS.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the storm: delirium coding trends among hospitalized Peruvian older adults. 揭秘风暴：秘鲁住院老年人谵妄编码趋势。

Dementia e Neuropsychologia Pub Date : 2025-01-17 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0200

Anthony Renzo Apuy, Camila Sofía Badell, Oscar Josue Ponce, Eloy Francisco Ruiz, Luis Enrique Palomino

引用次数: 0

Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment. 轻度认知障碍的神经精神症状和特定认知领域。

Dementia e Neuropsychologia Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0187

Lucas Luchesi Barnes, Lucas Francisco Botequio Mella, Francisca Daniele Ferreira Lopes, Amilton Dos Santos, Paulo Dalgalarrondo

{"title":"Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment.","authors":"Lucas Luchesi Barnes, Lucas Francisco Botequio Mella, Francisca Daniele Ferreira Lopes, Amilton Dos Santos, Paulo Dalgalarrondo","doi":"10.1590/1980-5764-DN-2024-0187","DOIUrl":"10.1590/1980-5764-DN-2024-0187","url":null,"abstract":"Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear.Objective: This study aimed to assess whether there is a correlation between NPS and specific cognitive domains.Methods: A cross-sectional study which included 174 participants with MCI, aged 55 years or older. Differences in sociodemographic profile, neuroimaging, and neuropsychological tests between MCI participants with and without NPS were measured.Results: Participants with NPS had lower education and worse performance in attention tests and executive functions. Psychotic symptoms were correlated with deficits in visuospatial functions; irritability and agitation with inattention and deficit of inhibitory control; and depression with inattention.Conclusion: Correlations were found between some NPS with specific cognitive domains, especially psychotic symptoms, but also agitation, irritability, apathy, and depression.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saint Paul, the Apostle, and the Gastaut-Geschwind syndrome. 圣保罗，使徒，以及加斯托- geschwind综合症。

Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0165

Leonardo Cruz de Souza, Guilherme Nogueira Mendes de Oliveira, Leandro Boson Gambogi, Ana Paula Gonçalves, Antônio Lúcio Teixeira

引用次数: 0

Physiopathological mechanisms underlying Alzheimer's disease: a narrative review. 阿尔茨海默病的生理病理机制：叙述性回顾。

Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-VR01

Eliasz Engelhardt, Elisa de Paula França Resende, Karina Braga Gomes

引用次数: 0

Hyperglycemia-induced isolated aphasic status epilepticus a case-report and literature review. 高血糖诱发孤立性癫痫持续状态1例报告及文献复习。

Dementia e Neuropsychologia Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-0177

Jedsada Khieukhajee, Suphasit Seoratanaphunt, Krittima Asavaveeradech, Sunisa Hangsapruek

引用次数: 0