Dementia e Neuropsychologia最新文献_第2页

Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review. 诊断运动认知危险综合征的评价标准：范围综述。

Dementia e Neuropsychologia Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0208

Luisa Veríssimo Sampaio, Gislane Ferreira de Melo, Yandra Lima, Angela Maria Sacramento, Hudson Azevedo Pinheiro, Gustavo de Azevedo Carvalho

{"title":"Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review.","authors":"Luisa Veríssimo Sampaio, Gislane Ferreira de Melo, Yandra Lima, Angela Maria Sacramento, Hudson Azevedo Pinheiro, Gustavo de Azevedo Carvalho","doi":"10.1590/1980-5764-DN-2024-0208","DOIUrl":"10.1590/1980-5764-DN-2024-0208","url":null,"abstract":"Dementia encompasses a range of cognitive disorders marked by declining abilities in attention, memory, and social cognition. Considering this theme, motoric cognitive risk syndrome arises as a promising response to long-term care and early dementia detection although it is a pre-dementia stage.Objective: Considering that the early identification of individuals at higher risk of developing dementia could be key for the development of preventive actions, we conducted a scoping review to investigate the instruments used for the diagnosis of motoric cognitive risk syndrome.Methods: we searched ten electronic databases for studies presenting the assessment of motoric cognitive risk syndrome published between 2019 and 2023. Two independent reviewers screened studies according to including criteria using Mendeley Desktop software to collect, eliminate duplicates and facilitate full-text readings.Results: From an initial 225 publications related to motoric cognitive risk syndrome, 67 studies were considered eligible for full-text review. Some of those studies presented information for more than one sample, totalizing 82 studies in this scoping review.Conclusion: Although the diagnostic criteria to identify motoric cognitive risk syndrome are well defined in the literature, there is no description of a structured protocol or list of instruments recommended to evaluate this condition.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240208"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing higher-order visual functions: seeing beyond a flat earth. 评估高阶视觉功能：超越平坦的地球。

Dementia e Neuropsychologia Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0206

Henrique Soares Dutra Oliveira, Danielle Calil de Sousa, Sarah Teixeira Camargos, Francisco Cardoso, Paulo Caramelli

引用次数: 0

Normative data of the Spanish version of the Montreal Cognitive Assessment (MoCA) in older individuals from Peru. 西班牙语版蒙特利尔认知评估（MoCA）在秘鲁老年人中的规范性数据。

Dementia e Neuropsychologia Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0261

Lucia Bulgarelli, Emilia Gyr, Jose Villanueva, Koni Mejía, Claudia Mejía, Renato Paredes, Sheyla Blumen

{"title":"Normative data of the Spanish version of the Montreal Cognitive Assessment (MoCA) in older individuals from Peru.","authors":"Lucia Bulgarelli, Emilia Gyr, Jose Villanueva, Koni Mejía, Claudia Mejía, Renato Paredes, Sheyla Blumen","doi":"10.1590/1980-5764-DN-2024-0261","DOIUrl":"10.1590/1980-5764-DN-2024-0261","url":null,"abstract":"The Montreal Cognitive Assessment (MoCA) has proven to be an effective tool for detecting early dementia in older adults. However, in the Latin American region, there are few available norms of the Spanish version. The Peruvian population faces major healthcare barriers to early screening, so it is important to validate this instrument within this population.Objective: To standardise the Spanish version of the MoCA for the older population in Lima, addressing the critical need for culturally and demographically adapted cognitive evaluation tools in Peru.Methods: The test was administered to 338 ambulatory and homebound adults aged 60 to 80 (216 women) from three institutions: San Miguel District Municipality, San José Obrero Polyclinic in Barranco, and EDMECON in Surco. we computed regression-based norms adjusted for age and education.Results: Sex was not a predictor of the total scores of MoCA. Moreover, age (R2=0.12) and education (R2=0.24) significantly influenced cognitive performance, with education being the strongest predictor. A raw score above 18 indicates normal cognitive performance for the total sample.Conclusions: We provided normative data and cutoff scores for older Peruvians, supporting the clinical use of the MoCA in Peru and setting a benchmark for future test standardizations in the region.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240261"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between sleep deprivation and the worsening of mood disorders in health professionals working night shifts. 夜班卫生专业人员睡眠剥夺与情绪障碍恶化的关系

Dementia e Neuropsychologia Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0186

Alexandre Almeida da Silva, Bianca Araujo Vieira, Júlio César Claudino Dos Santos

{"title":"The relationship between sleep deprivation and the worsening of mood disorders in health professionals working night shifts.","authors":"Alexandre Almeida da Silva, Bianca Araujo Vieira, Júlio César Claudino Dos Santos","doi":"10.1590/1980-5764-DN-2024-0186","DOIUrl":"10.1590/1980-5764-DN-2024-0186","url":null,"abstract":"Although the impact of sleep deprivation on the development of psychological disorders is widely recognized, little is known about the longitudinal relationship between sleep quality and mood disorders, specifically among health professionals.Objective: The objective of this study was to investigate the relationship between sleep quality and the incidence of mood disorders among health professionals who work night shifts, focusing on anxiety, depression, and stress.Methods: This is an observational, cross-sectional, and quantitative study, approved by the Ethics Committee of the Christus University Center (Unichristus), in accordance with Resolution 466/12. It was carried out using an online questionnaire via Google Forms, in the city of Fortaleza, Ceará.Results: A total of 45 health professionals from different areas took part in the survey, including nursing technicians, physiotherapists, nurses, and doctors. The results indicated a high incidence of sleep disorders, especially among nursing staff, with average scores of 11-13 on the Pittsburgh Sleep Quality Index (PSQI). The correlations found between sleep quality (as measured by the PSQI) and the symptoms of depression, anxiety, and stress were weak to moderate, with correlation coefficients (r) of 0.37, 0.44, and 0.48, respectively.Conclusion: The results suggest that there is an urgent need for interventions to improve sleep quality and reduce stress among health professionals working night shifts. Despite the promising findings, the study recommends further research to explore these relationships in more depth.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240186"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospecting salivary tau as a diagnostic for Alzheimer's type dementia. 唾液tau蛋白在阿尔茨海默氏型痴呆诊断中的应用前景。

Dementia e Neuropsychologia Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0253

Gustavo Alves Andrade Dos Santos, Francisco de Assis Carvalho do Vale, Valeria Paula Sassoli Fazan

{"title":"Prospecting salivary tau as a diagnostic for Alzheimer's type dementia.","authors":"Gustavo Alves Andrade Dos Santos, Francisco de Assis Carvalho do Vale, Valeria Paula Sassoli Fazan","doi":"10.1590/1980-5764-DN-2024-0253","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0253","url":null,"abstract":"Although recognized as one of the most critical and prevalent dementias, Alzheimer's disease (AD) still does not have an affirmative biological marker, being diagnosed by excluding other pathologies that present similar symptoms. In the last decade, advances have been made in researching pathophysiological phenomena related to AD, with the identification of probable biomarkers. Some of these substances have a direct action on the degenerative activity that involves AD and may be associated with other pathological processes, such as inflammation and diabetes.Objective: These occurrences led us to investigate further whether the levels of certain substances may be associated with the onset and progression of Alzheimer's disease. Biomarkers can be found in plasma, saliva and cerebrospinal fluid.Methods: This project investigated tau protein as a possible salivary biomarker in 76 patients, control group and Alzheimer's, with different age groups, to establish a positive correlation between the studied biomarker and AD.Results: Our findings showed that phosphorylated tau (pTAU) concentrations are higher in AD patients and somewhat lower in elderly patients without Alzheimer's, but in young patients without Alzheimer's the levels are much lower. Total tau had very similar levels in three groups evaluated.Conclusions: Based on these results, we believe in the possibility of using saliva as an auxiliary method in diagnosing Alzheimer's disease, with the advantages of low cost, non-invasiveness, and ease of collection. Still, more investigations will be needed to confirm this method presented.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240253"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intranasal insulin in Alzheimer disease (diabetes in situ?): a systematic review and meta-analysis. 鼻内胰岛素治疗阿尔茨海默病（原位糖尿病？）：一项系统综述和荟萃分析。

Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0191

Luís Jesuíno de Oliveira Andrade, Gabriela Matos, Luís Matos de Oliveira

{"title":"Intranasal insulin in Alzheimer disease (diabetes in situ?): a systematic review and meta-analysis.","authors":"Luís Jesuíno de Oliveira Andrade, Gabriela Matos, Luís Matos de Oliveira","doi":"10.1590/1980-5764-DN-2024-0191","DOIUrl":"10.1590/1980-5764-DN-2024-0191","url":null,"abstract":"Alzheimer disease (AD) is a neurodegenerative disorder. Evidence suggests that AD shares pathophysiological similarities with type 2 diabetes. Intranasal insulin (INI) has emerged as a potential therapeutic approach for AD by directly targeting the brain and modulating insulin signaling pathways.Objective: To evaluate the efficacy and safety of INI therapy for AD through a systematic review and meta-analysis of randomized controlled trials.Methods: A search of electronic databases, including PubMed, Web of Science, Scopus, and Embase, was conducted to identify relevant studies published up to June 2024. Inclusion criteria encompassed peer-reviewed original research articles focused on humans, investigating the therapeutic effects of INI administration on cognitive impairment associated with AD, and reporting quantitative data on cognitive outcomes, biomarkers, or pathological markers relevant to AD. A meta-analysis was conducted to quantitatively synthesize the effects of INI on cognitive outcomes.Results: A total of 647 articles were identified, and eight studies met the inclusion criteria. The overall odds ratio was 3.75 (95%CI 1.49-9.40). The test for overall effect showed a statistically significant difference (p<0.05). However, the I2 value indicated a high level of heterogeneity (85.5%), suggesting significant variability among the studies.Conclusion: While the current data is not yet conclusive enough to definitively establish INI as a standard treatment for AD, the evidence supporting its safety, efficacy, and reduced risk of systemic side effects suggests potential cognitive benefits for improving global cognition in patients with AD.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240191"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the treatment of Alzheimer's disease: a comprehensive review. 阿尔茨海默病治疗进展综述

Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0204

Srushti Rajanna, Prajwal Pradeep Gundale, Apoorva Dev Mahadevaiah

引用次数: 0

Co-occurrence of radiological signs of Marchiafava-Bignami disease and alcohol-related cerebellar degeneration. Marchiafava-Bignami病和酒精相关性小脑变性的影像学征象共同出现。

Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0216

Alberto Pereira Firmino, Maria Weryca de Souza Belo Silva, Beatriz Barbosa, Enrique Neves, Letícia Ellen Pereira, Thadeu Alexandre Paulino Sousa, Katie Moraes de Almondes, Clécio de Oliveira Godeiro, Rodrigo Alencar E Silva

引用次数: 0

Restless legs syndrome and ferritin levels in older adults with dementia: a cross-sectional study. 不宁腿综合征和老年痴呆患者的铁蛋白水平：一项横断面研究。

Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0218

Érica Dayanne Meireles Leite, Madson Alan Maximiano-Barreto, Letícia Lambert, Victor Oliveira Wercelens, Álan Luiz Éckeli, Marcos Hortes Nisihara Chagas

{"title":"Restless legs syndrome and ferritin levels in older adults with dementia: a cross-sectional study.","authors":"Érica Dayanne Meireles Leite, Madson Alan Maximiano-Barreto, Letícia Lambert, Victor Oliveira Wercelens, Álan Luiz Éckeli, Marcos Hortes Nisihara Chagas","doi":"10.1590/1980-5764-DN-2024-0218","DOIUrl":"10.1590/1980-5764-DN-2024-0218","url":null,"abstract":"In cases of dementia or major neurocognitive disorder, restless legs syndrome has not been extensively studied because the diagnosis relies on clinical assessments and self-reports from patients.Objective: The aim of this study was to investigate the association between Willis-Ekbom disease/restless legs syndrome and iron-deficiency anemia in older adults with dementia.Methods: A cross-sectional study was conducted with 70 older adults diagnosed with dementia and restless legs syndrome at a psychogeriatric clinic in the state of São Paulo, Brazil. The participants answered data collection instruments addressing sociodemographic characteristics, restless legs syndrome, neuropsychiatric symptoms, sleep quality, daytime sleepiness, and cognitive function. Creatinine, ferritin, red blood cells, hemoglobin, and hematocrit were determined by blood exams (the latter of which was collected from the patient records).Results: The sample was composed predominantly of individuals with mixed dementia (i.e., Alzheimer's disease+vascular dementia). Women accounted for 55.7% of the sample, with a mean age of 77.80±9.36 years. The prevalence of restless legs syndrome among the participants was found to be 15.7%. Individuals with this syndrome had greater frequencies of neuropsychiatric symptoms, poor sleep quality, higher BMI, and lower ferritin levels (p<0.05).Conclusion: The prevalence of restless legs syndrome among older adults with dementia was 15.7%, and individuals with this syndrome had ferritin deficiency.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240218"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health multidimensional evaluation of institutionalized older adults according to cognitive performance. 基于认知表现的机构老年人健康多维评价。

Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1590/1980-5764-DN-2024-0133

Beatriz Cintra Martins, Lilian Barbosa Ramos, Anna Karla Carneiro Roriz, Henrique Salmazo da Silva

{"title":"Health multidimensional evaluation of institutionalized older adults according to cognitive performance.","authors":"Beatriz Cintra Martins, Lilian Barbosa Ramos, Anna Karla Carneiro Roriz, Henrique Salmazo da Silva","doi":"10.1590/1980-5764-DN-2024-0133","DOIUrl":"10.1590/1980-5764-DN-2024-0133","url":null,"abstract":"The assessment of living and health conditions of the institutionalized older adults contributes to the development of health promotion measures. The high prevalence of cognitive decline in this population leads to unfavorable health outcomes, which can be prevented and managed.Objective: To investigate the health conditions of institutionalized older adults according to global cognitive performance.Methods: Cross-sectional study of institutionalized older adults in Brasília, Distrito Federal (DF) and Salvador, Bahia (BA) using questionnaires on multidimensional health assessment and the Mini-Mental State Examination (MMSE).Results: Of the 185 residents, 86 were evaluated, with the majority of the sample composed of women and people aged 80 years old or older. Cognitive decline in the MMSE was associated with greater difficulties in Activities of Daily Living (ADL) (62.5%). Lower performance on the MMSE was correlated with longer length of institutionalization (p=0.043), older age (p=0.004), poorer Geriatric Oral Health Assessment Index (GOHAI) (p=0.087), greater difficulty in ADL (p<0.001), and higher scores on the Bristol scale (p<0.001). Conversely, higher education (p<0.001), better scores on the Mini Nutritional Assessment (p=0.003), larger Calf Circumference (CC) (p=0.036), and Hand Grip Strength (HGS) (p=0.0467) were associated with better performance in the MMSE.Conclusion: The cognitive performance of institutionalized older people is correlated with sociodemographic and health variables. These results are oriented toward the formulation of public health policies and care management.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20240133"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0