Dementia e Neuropsychologia最新文献

{"title":"Lithium Intoxication as a cause of reversible dementia mimicking FDG PET features of Alzheimer's disease.","authors":"Alexandre Motta Mecê,&nbsp;Vitor Corsaletti Abreu,&nbsp;Gustavo Manginelli Lamas,&nbsp;Rafaella do Rosário Tacla,&nbsp;Thais Benício Minekawa,&nbsp;Celso Dario Ramos,&nbsp;Marcio Luiz Figueiredo Balthazar","doi":"10.1590/1980-5764-DN-2021-0105","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0105","url":null,"abstract":"<p><p>Rapidly progressive dementia (RPD) is a rare neurological disorder. Drug toxicity is among the differential diagnoses, including the use of lithium, in which an overdosage might cause cognitive dysfunction. Clinical suspicion, laboratory confirmation, and drug interruption are key points in the management of lithium intoxication. We described a 66-year-old female patient under treatment with lithium who developed an RPD associated with parkinsonian symptoms. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) showed an \"Alzheimer-like\" pattern, while cerebrospinal fluid biomarkers for the disease were negative. There was a significant clinical and radiological improvement after lithium interruption. Lithium intoxication is a potentially reversible cause of RPD, as demonstrated in this case report. Drug discontinuation should be considered even in patients with normal levels of this metal, if cognitive impairment is detected. ¹⁸F-FDG PET/CT images may show an \"Alzheimer-like\" image pattern in acute intoxication and are useful for monitoring these patients.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"249-252"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40024979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Autism Spectrum Quotient in a sample of Brazilian adults: analyses of normative data and performance.","authors":"Ana Luíza Costa Alves,&nbsp;Jonas Jardim de Paula,&nbsp;Débora Marques de Miranda,&nbsp;Marco Aurélio Romano-Silva","doi":"10.1590/1980-5764-DN-2021-0081","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0081","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is characterized by difficulties in social interaction and inflexible behaviors/interests. To quantify ASD traits in adults with preserved intelligence, the Autism Spectrum Quotient (AQ) was developed, which is a self-report instrument and one of the most used and recommended tools.</p><p><strong>Objectives: </strong>We aimed to present a descriptive analysis of the AQ in a sample of Brazilian adults with neurotypical development (n=385) and investigate how the scale performs in a clinical subsample (n=33).</p><p><strong>Methods: </strong>We recruited 1,024 participants. They answered the Self-Reporting Questionnaire-20 (SRQ-20), AQ, and about their psychiatric record. Then, we selected 385 participants without any psychiatric diagnosis to describe the distribution of the ASD traits. To investigate the AQ performance, we evaluated 33 adults with ASD and 19 adults with neurotypical development from the total sample (n=1,024).</p><p><strong>Results: </strong>ASD traits were normally distributed in the population, with high internal consistency. Of a total of 91 men, volunteers with 32 points (clinical cutoff point) or more scored higher than 93% of the control sample. Of a total of 294 women, those who got a clinical score on the scale scored higher than 97%. In the clinical subsample (n=33), the positive predictive value (PPV) of the AQ was 0.84, and the negative predictive value (NPV) was 0.7.</p><p><strong>Conclusions: </strong>The study population has a different profile compared to the original study regarding the AQ scale. ASD traits were normally distributed in the neurotypical sample, and the scale seems to have a satisfactory performance to predict ASD. Future studies are required to adequate the use of the scale in the Brazilian population.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"244-248"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40025517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-item version of Boston Naming Test: usefulness in the diagnosis of primary progressive aphasia, frontotemporal dementia, and Alzheimer's disease.","authors":"Héctor Gastón Graviotto,&nbsp;Marcos German Sorbara,&nbsp;Carlos Mario Turizo Rodriguez,&nbsp;Cecilia Serrano","doi":"10.1590/1980-5764-DN-2021-0043","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0043","url":null,"abstract":"<p><p>The 12-item version of the Boston Naming Test (BNT) was adapted to Argentina for the detection of dementia due to Alzheimer's disease (AD), with scores similar to the original 60-item version (sensitivity and specificity of 85 and 94%, respectively) without demographic influence (age and educational level). To date, no publications on the use of abbreviated BNT in other degenerative pathologies with language impairment have been reported.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the usefulness of 12-item BNT in primary progressive aphasia (PPA), the behavioral variant of frontotemporal dementia (FTDbv), and AD.</p><p><strong>Methods: </strong>Notably, 47 patients with probable AD (NIA-AA 2011) - clinical dementia rating (CDR) 0.5-1, 55 with FTDbv, 17 with PPA, and 46 controls were evaluated and matched for age and education. Exclusion criteria were as follows: alcoholism, other previous neurological or psychiatric illnesses, and education <4 years. All were assessed with a full neuropsychological battery and a 12-item version of BNT.</p><p><strong>Results: </strong>Median scores of 12-item BNT were as follows: PPA: 3.87 (SD=2.99), AD: 6.13 (SD=3.03); FTDbv: 8.41 (SD=2.53); and controls: 10.22 (SD=1.82). Receiver Operating Characteristic (ROC) curves were plotted.</p><p><strong>Conclusions: </strong>The 12-item version of BNT can be useful, simple, and fast to identify and differentiate PPA, FTDbv, and AD from controls while retaining the discriminative ability of the original version.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"181-186"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40025518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization and diagnostic utility of the Frontal Assessment Battery for healthy people and patients with dementia in the Chilean population.","authors":"Fabrissio Grandi, David Martínez-Pernía, Mario Parra, Loreto Olavarria, David Huepe, Patricia Alegria, Álvaro Aliaga, Patricia Lillo, Carolina Delgado, Marcela Tenorio, Ricardo Rosas, Oscar López, James Becker, Andrea Slachevsky","doi":"10.1590/1980-5764-DN-2021-0059","DOIUrl":"10.1590/1980-5764-DN-2021-0059","url":null,"abstract":"<p><p>The Frontal Assessment Battery (FAB) is a screening test that measures executive functions. Although this instrument has been validated in several countries, its diagnostic utility in a Chilean population has not been studied yet.</p><p><strong>Objectives: </strong>This study aimed to (1) adapt FAB in a Chilean population; (2) study the psychometric properties of the FAB in a Chilean population; (3) assess the sociodemographic influence in the performance of the FAB in a sample of healthy controls (HC); and (4) develop normative data for this healthy group.</p><p><strong>Methods: </strong>A HC (n=344) and a group of patients with dementia (n=156) were assessed with the Chilean version of FAB.</p><p><strong>Results: </strong>FAB showed good internal consistency (Cronbach's alpha=0.79) and acceptable validity based on the relationship with other variables. Factor analysis showed the unidimensionality of the instrument. Significant differences were found in the total FAB value between the HC and dementia groups. With the matched sample, the established cutoff point was 13.5, showing a sensitivity of 80.8% and a specificity of 90.4%. Regression analysis showed that education and age significantly predicted FAB performance in the healthy group. Finally, normative data are provided.</p><p><strong>Conclusions: </strong>This study shows that FAB is a useful tool to discriminate between healthy people and people with dementia. However, further studies are needed to explore the capacity of the instrument to characterize the dysexecutive syndrome in people with dementia in the Chilean population.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous psychological interventions by videoconferencing for caregivers of people with dementia: an integrative review.","authors":"Maryam Furlan Ayoub,&nbsp;Yara Luana Pereira de Souza,&nbsp;Thiago de Almeida,&nbsp;Deusivania Vieira da Silva Falcão","doi":"10.1590/1980-5764-DN-2021-0069","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0069","url":null,"abstract":"<p><p>The COVID-19 pandemic has created the need to develop psychological interventions to support people with dementia and their caregivers in the context of social distancing. This study sought to investigate, systematize, and report results of scientific studies published in the past 5 years on synchronous online psychological interventions using videoconferencing for informal caregivers of people with dementia. The PubMed, BIREME, and Web of Science databases were searched using the descriptors \"caregiver,\" \"dementia,\" \"online,\" and \"intervention.\" Six international studies were included in the review. Results demonstrated, in general, that this modality of intervention was acceptable, feasible, and promoted benefits for the health, quality of life, and well-being of caregivers. A need was identified for further studies investigating synchronous online interventions that include follow-up and a control group to further the evidence on the effectiveness and feasibility of this type of therapeutic intervention.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cross-cultural adaptation, and validity of the Brazilian version of the Cognitive Function Instrument.","authors":"Adalberto Studart-Neto,&nbsp;Natália Cristina Moraes,&nbsp;Raphael Ribeiro Spera,&nbsp;Silvia Stahl Merlin,&nbsp;Jacy Bezerra Parmera,&nbsp;Omar Jaluul,&nbsp;Mônica SanchesYassuda,&nbsp;Sonia Maria Dozzi Brucki,&nbsp;Ricardo Nitrini","doi":"10.1590/1980-5764-DN-2021-0057","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0057","url":null,"abstract":"<p><p>Subjective cognitive decline (SCD) is defined as a self-perception of a progressive cognitive impairment, which is not detected objectively through neuropsychological tests. The Alzheimer's Disease Cooperative Study developed the Cognitive Function Instrument (CFI) to evaluate individuals with SCD. The CFI consists of two versions, namely, a self-report and a partner report.</p><p><strong>Objective: </strong>This study aimed to translate CFI into Brazilian Portuguese, perform a cross-cultural adaptation, and validate the Brazilian version.</p><p><strong>Methods: </strong>The translation and transcultural adaptation process consisted of six stages, and the preliminary version was answered by a sample of individuals recruited among the patients' caregivers from a cognitive neurology outpatient clinic. Finally, the final Brazilian version of the CFI was applied to a sample of nondemented older adults to validate the instrument, which was divided into with and without SCD, according to the answer \"<i>yes</i>\" for the question: \"<i>Do you feel like your memory is becoming worse?</i>\".</p><p><strong>Results: </strong>The final version of CFI showed a high level of acceptability as an assessment tool in nondemented older adults. Participants with SCD had higher scores in the CFI self-report compared with those without complaints. In the receiver operating characteristic curve analysis, the area under the curve of the CFI self-report was 0.865 (95% confidence interval 0.779-0.951), and the cutoff score of 2.0 was the one that best distinguished the SCD group from the control group, with a sensitivity of 73.3% and a specificity of 81.5%.</p><p><strong>Conclusions: </strong>CFI proved to be an instrument with good accuracy and easy applicability to identify older adults with SCD.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39999627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Working memory and arithmetic impairments in children with FMR1 premutation and gray zone alleles.","authors":"Aline Aparecida Silva Martins,&nbsp;Giulia Moreira Paiva,&nbsp;Carolina Guimarães Ramos Matosinho,&nbsp;Elisângela Monteiro Coser,&nbsp;Pablo Augusto de Souza Fonseca,&nbsp;Vitor Geraldi Haase,&nbsp;Maria Raquel Santos Carvalho","doi":"10.1590/1980-5764-DN-2021-0035","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0035","url":null,"abstract":"<p><p>Expansive mutations in familial mental retardation 1 (<i>FMR1</i>) gene have been associated with different phenotypes. Full mutations are associated with intellectual disability and autism spectrum disorder; premutations are associated with math learning difficulties and working memory impairments. In gray zone, neuropsychological development has not yet been described.</p><p><strong>Objectives: </strong>This study aimed to describe the frequency of <i>FMR1</i> premutation and gray zone alleles in a school population sample representing a broad spectrum of variation in math achievement and detail school achievement and cognitive performance in the children identified with <i>FMR1</i> premutation or gray zone alleles.</p><p><strong>Methods: </strong>We described a two-phase study. In the first phase, 2,195 school-age children were screened for math achievement. In the second phase, 378 children with normal intelligence were neuropsychologically assessed and genotyped for <i>FMR1</i>. Of these, 121 children (61 girls) performed below percentile 25 in mathematics (MD group) and 257 children (146 girls) performed above percentile 25 (control group).</p><p><strong>Results: </strong>Four pupils presented expanded alleles, one premutation and three gray zone alleles. The girl with the premutation and one boy with a gray zone allele presented impairments in working memory and arithmetic performance below percentile 6, compatible with the diagnosis of developmental dyscalculia. These children's difficulties were not associated with inaccuracy of nonsymbolic number representations or literacy impairments. Dyscalculia in these children seems to be associated mainly with working memory impairments.</p><p><strong>Conclusions: </strong><i>FMR1</i> expansions in the gray zone may contribute to dyscalculia in otherwise healthy and normally intelligent children.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational status, testosterone replacement, and intelligence outcomes in Klinefelter syndrome.","authors":"Luciane Simonetti,&nbsp;Magnus Regios Dias da Silva,&nbsp;Claudia Berlim de Mello","doi":"10.1590/1980-5764-DN-2021-0049","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0049","url":null,"abstract":"<p><p>Most male hypergonadotropic hypogonadism associated with infertility can be attributed to a single genetic condition such as Klinefelter syndrome (KS). This disease's wide phenotypic variability is frequently associated with mosaic 47,XXY lineages and testosterone replacement. Early diagnosis and treatment have been associated with better cognitive and intellectual outcomes, but the scope of this influence requires further investigation.</p><p><strong>Objective: </strong>This study aimed to investigate the intelligence profile of a cohort of patients with KS, considering the influence of educational level and clinical variables.</p><p><strong>Methods: </strong>Twenty-nine (9-65 years) individuals were submitted to the measures of intelligence quotient (IQ) (Wechsler's Scales) and adaptive behavior (Vineland-II). Linear regression analysis included the participants' educational level and clinical variables (i.e., comorbidities and use of testosterone) as predictors and intellectual performance and adaptive behavior as outcomes.</p><p><strong>Results: </strong>Scores varied from intellectual deficiency to average ranges (82.5+15.8). There were significant differences between adult's and children's IQ and between verbal and nonverbal indexes. The level of education predicted both IQ and adaptive behavior. Testosterone replacement therapy and absence of seizures predicted only adaptive behavior.</p><p><strong>Conclusions: </strong>The level of education and hormonal therapy can be selectively implicated in the intellectual variability in KS.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39999629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of cognitive impairment in HIV patients: vertical and horizontal transmission.","authors":"Maria Rita Polo Gascón,&nbsp;Cauê Peter da Cruz Terra,&nbsp;Hestela de Lima Guerra,&nbsp;Carolina Fernandes Gualqui,&nbsp;Mara Cristina Souza De Lucia,&nbsp;Glaucia Rosana Guerra Benute,&nbsp;Luiz Augusto Marcondes Fonseca,&nbsp;Jorge Casseb,&nbsp;Jose Ernesto Vidal,&nbsp;Augusto César Penalva de Oliveira","doi":"10.1590/1980-5764-DN-2021-0023","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0023","url":null,"abstract":"<p><p>Antiretroviral treatment has significantly increased the survival of patients infected with HIV-1. However, with increased survival, cognitive changes associated with HIV are frequently observed in this population. The clinical manifestations of HIV changes can vary as a result of several aspects, including the virus transmission route. Several studies have pointed out premature neurological changes in vertically infected patients, while the manifestation of cognitive damage in adults may take a longer time.</p><p><strong>Objective: </strong>The aim of this study was to verify the prevalence of cognitive changes in patients with HIV via vertical transmission after the highly active antiretroviral therapy and the cognitive performance of these patients compared to a group of sexually infected patients.</p><p><strong>Methods: </strong>A total of 48 patients were evaluated, 25 with vertical transmission and 23 with sexual transmission, between May 2013 and February 2015 at the Institute of infectology Emilio Ribas. Neuropsychological tests were applied to assess cognitive performance, scales to assess symptoms of anxiety and depression, and sociodemographic questionnaire.</p><p><strong>Results: </strong>The results demonstrate that the frequency of cognitive impairment in vertically transmitted patients was higher than in sexually transmitted patients.</p><p><strong>Conclusions: </strong>These findings suggest that the deleterious effects of the HIV virus on the development of the central nervous system reverberate more strongly than in patients who acquire it after adulthood.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39999631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of two prognostic indexes to predict mortality in older adults with advanced dementia.","authors":"Beatriz Noele Azevedo Lopes,&nbsp;Flavia Barreto Garcez,&nbsp;Claudia Kimie Suemoto,&nbsp;Lilian Schafirovits Morillo","doi":"10.1590/1980-5764-DN-2021-0028","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2021-0028","url":null,"abstract":"<p><p>Dementia is a cause of disability among older adults. Accessing advanced dementia prognosis is a challenge.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the accuracy of the Charlson and Carey indexes in predicting 3-year survival of older adults with advanced dementia.</p><p><strong>Methods: </strong>This is a retrospective cohort study of 238 patients aged ≥60 years with advanced dementia from an outpatient clinic and classified as stage ≥6A by using the Functional Assessment Staging scale. We excluded patients with missing data. We reviewed the semi-structured interview (clinical, sociodemographic, and functional data) from the baseline visit. This information was used to calculate 3-year mortality risks according to the Charlson and Carey indexes. We used Cox proportional hazard models to evaluate the associations of all-cause mortality with both indexes, adjusted for sociodemographic variables. We used Harrell's C measure to determine the discrimination. We calculated the absolute differences between observed and predicted 3-year mortality risks for each index for calibration.</p><p><strong>Results: </strong>In 238 patients, the average age was 80.5±7.8 years, with 36% being men. The median follow-up time was 1.8 years (0.05-3.0). The 3-year all-cause mortality rate was 50% (119 deaths). The Carey index was associated with mortality, with one point increase related to a 15% increase in the mortality risk (hazard ratio [HR]=1.15, 95% confidence interval (95%CI) 1.06-1.25, p=0.001), even after adjustment. Accuracy for the Charlson index and Carey index was 0.55 (95%CI 0.49-0.60) and 0.60 (95%CI 0.52-0.62), respectively, with no difference between them (p=0.44).</p><p><strong>Conclusions: </strong>Both indexes had poor discrimination and calibration performances in predicting 3-year mortality in patients with advanced dementia.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"52-60"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}