Advancements in the treatment of Alzheimer's disease: a comprehensive review.

Q3 Medicine
Dementia e Neuropsychologia Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI:10.1590/1980-5764-DN-2024-0204
Srushti Rajanna, Prajwal Pradeep Gundale, Apoorva Dev Mahadevaiah
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引用次数: 0

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. Despite being the most common cause of dementia, effective treatments have been elusive. However, recent years have witnessed significant advancements in understanding and treating Alzheimer's. Key to these advancements is the shift toward targeted therapies tailored to individual genetic and biomarker profiles, promising more effective outcomes while minimizing side effects. The integration of advanced neuroimaging techniques has revolutionized early diagnosis and disease monitoring, enabling proactive intervention strategies that may alter disease trajectories. This review provides an overview of these advancements, focusing on disease-modifying therapies, symptomatic treatments, combination therapies, lifestyle interventions, biomarker development, innovative drug delivery systems, immunotherapy, gene therapy, and neuroprotective agents.

阿尔茨海默病治疗进展综述
阿尔茨海默病(AD)是一种进行性神经退行性疾病,以认知能力下降、记忆丧失和行为改变为特征。尽管它是痴呆症最常见的病因,但有效的治疗方法一直难以捉摸。然而,近年来在了解和治疗阿尔茨海默病方面取得了重大进展。这些进步的关键是转向针对个体遗传和生物标志物的靶向治疗,承诺更有效的结果,同时最大限度地减少副作用。先进的神经成像技术的整合已经彻底改变了早期诊断和疾病监测,使主动干预策略可能改变疾病轨迹。本文综述了这些进展,重点是疾病改善疗法、对症治疗、联合治疗、生活方式干预、生物标志物开发、创新药物输送系统、免疫治疗、基因治疗和神经保护剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dementia e Neuropsychologia
Dementia e Neuropsychologia Medicine-Geriatrics and Gerontology
CiteScore
2.20
自引率
0.00%
发文量
58
审稿时长
8 weeks
期刊介绍: Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.
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