Dementia e Neuropsychologia最新文献

{"title":"Cognitive performance and active lifestyle in community-dwelling older adults.","authors":"Gabriela Dos Santos, Tiago Nascimento Ordonez, Beatriz Aparecida Ozello Gutierrez, Thais Bento Lima da Silva","doi":"10.1590/1980-5764-DN-2025-0431","DOIUrl":"10.1590/1980-5764-DN-2025-0431","url":null,"abstract":"<p><p>An active lifestyle promotes physical and mental health, improves social interaction, and provides cognitive stimulation, positively influencing mood and cognitive performance. However, lifestyle habits changed substantially after March 2020 due to the COVID-19 pandemic, particularly among high-risk groups such as older adults.</p><p><strong>Objective: </strong>To investigate the relationship between an active lifestyle and cognitive performance in community-dwelling older adults during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A cross-sectional study of 50 older adults enrolled at a community center was conducted. Cognitive status was assessed using the Addenbrooke's Cognitive Examination, whereas psychosocial indicators were assessed using the Control, Autonomy, Self-realization and Pleasure Scale, the Depression, Anxiety and Stress Scale, and the Geriatric Depression Scale. Leisure-time activities were assessed using the Brazilian Portuguese version of the Minnesota Leisure Time Activities Questionnaire, based on retrospective self-report of activities performed over the previous 12 months.</p><p><strong>Results: </strong>Participants with greater engagement in the activities investigated had better cognitive performance (p=0.021) and fewer depressive symptoms, although the difference was not statistically significant (p=0.060). Physical activity was associated with fewer anxiety symptoms (p=0.013) and greater autonomy (p=0.047). Engagement in intellectually stimulating activities was associated with better performance across all cognitive domains assessed.</p><p><strong>Conclusion: </strong>An active lifestyle was associated with better cognitive functioning and mental health in older adults.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250431"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive training effects in mild cognitive impairment with and without amyloid pathology.","authors":"Nadia Aparecida Bossa, Geraldo Busatto, Ricardo Nitrini, Sonia Maria Dozzi Brucki, Eliane Correa Miotto","doi":"10.1590/1980-5764-DN-2025-0398","DOIUrl":"10.1590/1980-5764-DN-2025-0398","url":null,"abstract":"<p><p>Imagery-based cognitive training (CT) is a promising strategy for individuals with amnestic mild cognitive impairment (aMCI). However, there is a lack of studies investigating its differential impact in aMCI with and without amyloid pathology.</p><p><strong>Objective: </strong>To investigate the effects of CT based on mental imagery on episodic memory in individuals with amyloid-positive aMCI (Aβ+), amyloid-negative aMCI (Aβ-), and healthy controls (HC).</p><p><strong>Methods: </strong>Fifty-five participants were included: Aβ+aMCI (n=19), Aβ-aMCI (n=20), and HC (n=16), aged 51-89 years, with more than 6 years of education. Amyloid status was confirmed by 11C-PiB PET. All participants completed pre- and post-training neuropsychological assessments and attended six individual online CT sessions. Performance was assessed using the logical memory test (LM), Rey Auditory Verbal Learning Test (RAVLT), and generalization tasks (GT I-II).</p><p><strong>Results: </strong>Data were analyzed using the Shapiro-Wilk, Levene, Wilcoxon, ANOVA, Kruskal-Wallis, and Bonferroni tests. Significant improvements in immediate episodic memory (LM I, RAVLT A1-A5) were observed in the Aβ+ and Aβ-groups, particularly in the Aβ-aMCI group. Delayed recall (LM II, RAVLT A7) increased, although without statistical significance. All groups showed gains in generalization tasks, supporting the benefit of CT.</p><p><strong>Conclusion: </strong>Unimodal CT based on mental imagery promoted gains in immediate episodic memory across all groups. Although delayed recall gains were not statistically significant, the strategy was internalized and generalized. Similar responsiveness in Aβ+ and Aβ-groups suggest preserved compensatory mechanisms despite amyloid pathology. These findings suggest more robust effects at the level of encoding than consolidation, which may vary according to task characteristics and underlying neural integrity.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250398"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13516658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar cognitive affective syndrome (Schmahmann syndrome) following isolated cerebellar infarction.","authors":"Mochamad Iskandarsyah Agung Ramadhan, Diatri Nari Lastri, Yetty Ramli, Pukovisa Prawiroharjo","doi":"10.1590/1980-5764-DN-2026-0500","DOIUrl":"10.1590/1980-5764-DN-2026-0500","url":null,"abstract":"<p><p>The cerebellum plays an important role in higher-order cognition through cerebrocerebellar networks. Lesions affecting this structure may result in cerebellar cognitive affective syndrome (CCAS), which is frequently underrecognized by routine cognitive screening tools. We reported a 69-year-old right-handed man who presented with 18 months of forgetfulness, impaired concentration, and irritability following a documented left cerebellar infarction. Neurological examination revealed cerebellar signs without cortical deficits. Brain magnetic resonance imaging (MRI) demonstrated a left cerebellar infarct with hemorrhagic transformation. While the Mini-Mental State Examination (MMSE) was normal and the Montreal Cognitive Assessment (MoCA) showed mild impairment, detailed neuropsychological assessment using CCAS Scale (CCAS-S) confirmed definite CCAS. This case highlights the importance of cerebellum-specific cognitive assessment in patients with isolated cerebellar stroke, as conventional screening tools might underestimate multidomain cognitive and affective disturbances.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20260500"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bells test: assessment of visual-attention disorders in school children (case study from Marrakech, Morocco).","authors":"Hanane Achaq, Ahmed Ahami Omar Touhami, Safia Basla, Gouddar Ghoufrane, Raja Moussaoui, Issam Majid, Omar Amahmid, Youness Rakibi, Zakaria Ouhaz, Said Chakiri","doi":"10.1590/1980-5764-DN-2026-0478","DOIUrl":"10.1590/1980-5764-DN-2026-0478","url":null,"abstract":"<p><p>Various learning disorders affect children without any sensory (vision, hearing), psychiatric, or neurological impairments, even when they have adequate intelligence and a suitable social environment. These children have difficulties in learning to read, write, spell, calculate, express themselves, or concentrate.</p><p><strong>Objective: </strong>To demonstrate the importance of the Bells test in young students without visuospatial complaints and to evaluate the test in different levels of schooling, age groups, and genders.</p><p><strong>Methods: </strong>Among the one hundred (100) middle school students enrolled in the second year of middle school, sixty (60) students were selected to be tested using the Bells test. This test consists of a sheet containing 315 small drawings, including 35 bells. The participants are required to circle as many bells as possible (the test time is limited to three minutes).</p><p><strong>Results: </strong>The percentage of students suspected of having hemineglect is 8.33% or 5/60. Students who forgot their left bells exhibited right hemineglect, while those who forgot their right bells exhibited left hemineglect. Furthermore, 16/60 students surveyed obtained a negative score on the left-right hemineglect calculation, representing 26.66%. Omissions were slightly more frequent on the right side. A statistical analysis revealed a non-significant correlation between the two sexes.</p><p><strong>Conclusion: </strong>Identifying neuro-visual disorders in school-aged children, regardless of their age, would allow us to prevent these disorders from impacting learning, treat them in a specific manner, and determine the neurological origin of the disorder in a child experiencing difficulties.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20260478"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning approach to mild cognitive impairment detection from electroencephalogram signals.","authors":"Hemlata Sandip Ohal, Shamla Mantri","doi":"10.1590/1980-5764-DN-2025-0364","DOIUrl":"10.1590/1980-5764-DN-2025-0364","url":null,"abstract":"<p><p>Mild cognitive impairment (MCI) is an important condition that may progress to Alzheimer disease (AD) or other types of dementia. If MCI can be detected early, timely interventions may be implemented. Traditional diagnostic methods rely on neuropsychological tests and imaging studies but have limitations in terms of efficiency and accessibility. Therefore, electroencephalogram (EEG)-based deep learning approaches represent promising developments that may offer new frameworks for the early diagnosis of MCI.</p><p><strong>Objective: </strong>This study aimed to develop a long short-term memory (LSTM)-based architecture for classifying MCI using EEG signals. The temporal characteristics of EEG signals may reveal meaningful information that improves classification performance.</p><p><strong>Methods: </strong>A publicly available EEG dataset comprising 27 subjects (11 MCI; 16 normal) was used. Raw EEG signals were preprocessed using band-pass filtering, Independent Component Analysis, and segmentation. The 64-node LSTM model was trained using processed EEG segments for binary classification. The model was evaluated using standard performance metrics.</p><p><strong>Results: </strong>The proposed LSTM-based model achieved an accuracy of 98.14% for MCI <i>versus</i> normal classification, outperforming conventional algorithms such as K-Nearest Neighbors (KNN) and Support Vector Machine (SVM). The model also demonstrated high precision (99.21%), recall (98.69%), and F1-score (98.95%). The confusion matrix showed 4,774 normal and 3,257 MCI segments correctly classified, with very few misclassifications, highlighting its strong discriminative capability.</p><p><strong>Conclusion: </strong>This study highlights the potential of LSTM networks for early MCI detection. The findings suggest that deep learning-driven EEG analysis may be a valuable tool for noninvasive and scalable cognitive health assessments.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250364"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verb fluency task in individuals with mild cognitive impairment and dementia: a scoping review.","authors":"Emily Viega Alves, Fernanda Mambrini Só E Silva, Victória Tizeli Souza, Maira Rozenfeld Olchik, Bárbara Costa Beber, Raphael Machado Castilhos","doi":"10.1590/1980-5764-DN-2026-0476","DOIUrl":"10.1590/1980-5764-DN-2026-0476","url":null,"abstract":"<p><p>Verb fluency tasks have shown promise in detecting and monitoring neurocognitive disorders, such as mild cognitive impairment (MCI) and dementia, due to their higher syntactic and executive demands.</p><p><strong>Objective: </strong>To map evidence on the assessment of verb fluency in individuals with MCI and dementia, focusing on methodologies, performance patterns, and diagnostic accuracy.</p><p><strong>Methods: </strong>A scoping review was conducted following PRISMA-ScR guidelines. Studies assessing verb fluency in individuals with MCI or dementia were included, without language or publication date restrictions. Searches were performed in PubMed, LILACS, SciELO, Embase, and Scopus.</p><p><strong>Results: </strong>Sixteen studies met the inclusion criteria, most with cross-sectional designs and quantitative analyses. Performance followed a consistent gradient, with individuals with dementia showing the greatest impairment, followed by those with MCI and healthy controls. Evidence suggested predictive value for disease progression, contributions to differential diagnosis, and associations with frontotemporal dysfunction. Diagnostic accuracy was moderate.</p><p><strong>Conclusion: </strong>Verb fluency performance reflects the severity of cognitive impairment and may complement other clinical and neuropsychological measures, despite methodological variability.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20260476"},"PeriodicalIF":0.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the intestinal microbial profile in mild cognitive impairment and Alzheimer's disease.","authors":"Martin Medrano, Mar Pacheco-Herrero, Zunilda Borges, Johan de la Rosa Laureano, Jesabelle Dominguez-Garcia, Ruth Gil-Ventura, Gelanys Castro-Tejada","doi":"10.1590/1980-5764-DN-2025-0440","DOIUrl":"10.1590/1980-5764-DN-2025-0440","url":null,"abstract":"<p><p>Alzheimer's disease (AD) and mild cognitive impairment (MCI) are major contributors to dementia, with growing prevalence in Latin America. Evidence suggests that gut microbiota alterations may influence neurodegeneration, but data on Hispanic population are lacking.</p><p><strong>Objective: </strong>Characterize gut microbiota in individuals with AD, MCI, and controls in the Dominican Republic, exploring clinical, demographic, and dietary associations.</p><p><strong>Methods: </strong>Prospective-translational study including 88 participants aged ≥60 years. Performed clinical, cognitive, and functional assessments. Stool samples analyzed using 16S rRNA gene sequencing. Bioinformatic processing using Quantitative Insights into Microbial Ecology Version 2 (QIIME2) and R. Alpha and beta diversity, taxonomy, and differential abundance were evaluated. Dietary influences were assessed using PERMANOVA.</p><p><strong>Results: </strong>No significant differences in alpha diversity (Shannon index 4-5, Simpson index 0.94-0.99, p>0.05) or beta diversity (p>0.05) were observed between groups. Firmicutes (51.9%) and Bacteroidota (34.1%) dominated the microbiota. Higher Desulfobacterota abundance in MCI and AD (0.54 and 0.61%, respectively, vs. 0.34% in controls; p<0.05). The Firmicutes/Bacteroidota ratio was lower in men with MCI (1.09) compared to controls and AD (1.70). MCI and AD were associated with increased levels of the genera Bilophila, Odoribacter, and Parabacteroides (p<0.05) and reduced levels of Mitsuokella and Eubacterium ruminantium. Dietary interactions, e.g., mango, lettuce, and carrot, influenced specific taxa (p<0.05).</p><p><strong>Conclusion: </strong>This study pioneers gut microbiota characterization in AD and MCI in the Dominican Republic, identifying microbial alterations in cognitive impairment and highlighting regional dietary and ethnic factors. Longitudinal and multi-omics studies are warranted to clarify causality and therapeutic potential.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250440"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of domain specific cognitive impairment in older adults in North India.","authors":"Shubhanjali Roy, Shomik Ray","doi":"10.1590/1980-5764-DN-2025-0396","DOIUrl":"10.1590/1980-5764-DN-2025-0396","url":null,"abstract":"<p><p>The rapid growth of India's elderly population necessitates understanding the determinants of cognitive health.</p><p><strong>Objective: </strong>This study examined the prevalence of cognitive impairment and its association with socio-demographic, health, and behavioural factors among community-dwelling older adults in urban Delhi.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted from January to June 2023 among 290 adults aged ≥60 years in South-West Delhi, selected through multistage sampling. Data on socio-demographics, health status, and lifestyle were collected via structured interviews. Cognitive function was assessed using the Brief Interview for Mental Status (BIMS) and classified as intact, mild to moderate, or severe impairment. Principal Component Analysis (PCA) identified explanatory dimensions; multivariable ordinal logistic regression examined associations; and K-means clustering grouped participants by cognitive profiles.</p><p><strong>Results: </strong>Overall, 52.8% had intact cognition, 37.2% mild to moderate impairment, and 10% severe impairment. Severe impairment was most prevalent among those aged ≥81 years (61.5%) and with no formal education (55.2%), while intact cognition was highest among skilled workers (26.6%) and those with high school or higher education (43.8%). Significant factors included age, education, body mass index (BMI), physical activity, smoking, alcohol use, dietary intake, sleep quality, mental activity, and social engagement (all p<0.001). PCA yielded eight principal components capturing behavioral, health, and socio-demographic domains. K-means clustering identified two distinct cognitive profiles based on performance and associated factors.</p><p><strong>Conclusion: </strong>Cognitive status in older urban adults is shaped by modifiable health and lifestyle factors. Community-based interventions promoting physical activity, social participation, and healthy behaviors may help preserve cognition in aging populations.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250396"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological strategies for the management of Alzheimer's disease.","authors":"Gunaro Lucas Dos Santos de Oliveira, Amanda Gollo Bertollo","doi":"10.1590/1980-5764-DN-2025-0290","DOIUrl":"10.1590/1980-5764-DN-2025-0290","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a multifactorial neurodegenerative disease affecting various cognitive domains, requiring a holistic and integrated therapeutic approach. The treatment of AD goes beyond pharmacological interventions, also necessitating non-pharmacological therapies that can act synergistically, both with each other and with emerging pharmacological treatments, including new anti-amyloid therapies. These therapies aim to improve patients' quality of life and alleviate behavioral symptoms, such as agitation and depression, and delay disease progression. Current clinical and meta-analytic evidence suggests that these approaches can be effectively integrated with conventional treatment, offering a valuable alternative to enhance patients' overall well-being. However, further research is needed to deepen the understanding of the ideal combination of the new anti-amyloid therapies, to address the limitations of current evidence, and to robustly establish their effectiveness in the clinical context of AD, aiming to generate a broader and more lasting impact on disease treatment. This narrative review aims to synthesize the evidence on diverse non-pharmacological therapies for managing AD and discuss their practical implications for clinical care.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250290"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Othello syndrome as an early manifestation of Alzheimer's disease: an anatomoclinical case study.","authors":"Paulo Roberto de Brito Marques, Maria Luiza Vasconcelos Montenegro, Marcela Maria Cabral Ribeiro","doi":"10.1590/1980-5764-DN-2025-0461","DOIUrl":"10.1590/1980-5764-DN-2025-0461","url":null,"abstract":"<p><p>Othello syndrome (OS) is characterized by pathological jealousy toward one's spouse, usually marked by delusions of infidelity. We report the first case of OS in Brazil, similar to the case described by Alzheimer in 1906, in a 54-year-old right-handed patient diagnosed with Alzheimer's disease (AD). The diagnostic workup included a clinical history and a positive family history of dementia, the Clinical Dementia Rating (CDR) scale, the Edinburgh Handedness Inventory, and the Mini-Mental State Examination (MMSE). Electroencephalography revealed slow waves predominantly in the bilateral temporo-frontal regions. Cranial computed tomography showed diffuse cortico-subcortical atrophy compatible with the patient's age, as well as bilateral globus pallidus calcifications. Cerebral single-photon emission computed tomography revealed hypoperfusion in the medial frontal and bilateral temporal regions, more pronounced on the left - particularly in the inferomedial portion of the left temporal lobe - along with mild supratentorial ventricular dilatation. Postmortem examination revealed moderate bilateral fronto-temporo-parietal atrophy, and microscopy showed the presence of senile plaques and neurofibrillary tangles. We report an unusual case of OS as the initial clinical manifestation, later diagnosed as AD.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250461"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}