Dementia e Neuropsychologia最新文献

{"title":"Is Montreal Cognitive Assessment a valuable test for the differentiation of Alzheimer's disease, frontotemporal dementia, dementia with Lewy body, and vascular dementia?","authors":"Fatemeh Afrashteh, Mostafa Almasi-Dooghaee, Naser Kamyari, Rayan Rajabi, Hamid Reza Baradaran","doi":"10.1590/1980-5764-DN-2023-0124","DOIUrl":"10.1590/1980-5764-DN-2023-0124","url":null,"abstract":"<p><p>Dementia is one of the growing diseases in the world and has different types based on its definition. The Montreal Cognitive Assessment (MoCA) test has been employed to screen patients with dementia, cognitive impairment, and disruption of daily activities.</p><p><strong>Objective: </strong>This study examined the diagnostic value of the total MoCA score and its subscores in differentiating Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy body (DLB), and vascular dementia (VaD).</p><p><strong>Methods: </strong>A total of 241 patients (AD=110, FTD=90, DLB=28, and VaD=13) and 59 healthy persons, who were referred to a dementia clinic with memory impairment in Firoozgar Hospital, were included in this study. MoCA tests were performed in all patients and normal persons.</p><p><strong>Results: </strong>By using the receiver operating characteristic (ROC) curve and measuring the area under the curve (AUC) for the total MoCA score in each group, AUC was 0.616, 0.681, 0.6117, and 0.583 for differentiating AD, FTD, DLB, and VaD patients, respectively. Among the groups, just the VaD group showed no significant usefulness in using the total MoCA score to differentiate it. To compare MoCA subscores, AD patients had higher scores in digit span, literal fluency, and abstraction but lower delayed recall scores compared with FTD patients.</p><p><strong>Conclusion: </strong>The total MoCA score and its subscores could not differentiate people with different types of dementia in the setting of screening.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230124"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation, testing, and use of the \"iSupport for Dementia\" program in different countries: a systematic review.","authors":"Larissa Corrêa, Aline Cristina Martins Gratão, Déborah Oliveira, Elizabeth Joan Barham, Fabiana de Souza Orlandi, Keila Cristianne Trindade da Cruz, Ana Carolina Ottaviani, Diana Quirino Monteiro, Gustavo Carrijo Barbosa, Anabel Machado Cardoso Alvarenga Pilegis, Luana Aparecida da Rocha, Ludmyla Caroline de Souza Alves, Luiza Barros Maciel, Camila Rafael Ferreira Campos, Sofia Cristina Iost Pavarini","doi":"10.1590/1980-5764-DN-2023-0097","DOIUrl":"10.1590/1980-5764-DN-2023-0097","url":null,"abstract":"<p><p>The World Health Organization developed the \"iSupport for Dementia\" program for family caregivers of people with dementia.</p><p><strong>Objective: </strong>To explore studies on adaptation, randomized clinical trial protocols, and preliminary results of iSupport by unpaid caregivers of people living with dementia in different countries.</p><p><strong>Methods: </strong>Systematic review.</p><p><strong>Results: </strong>Ten cultural adaptation studies, eight randomized clinical trial protocols, and two preliminary results were included. Adaptation studies showed adjustments in terminology, design, and additional resources. Clinical trial protocols included burden as the primary outcome, and baseline, three months of intervention, and follow-up after six months. Studies with preliminary results found positive effects on the mental health and well-being of caregivers after using the program.</p><p><strong>Conclusion: </strong>iSupport is an online program of the World Health Organization in response to dementia in implementation in different countries.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230097"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in persons with mild cognitive impairment: a systematic review and meta-analysis.","authors":"Priya Gopalakrishnan, Shivani Tiwari, Ravishankar Nagaraja, Gopee Krishnan","doi":"10.1590/1980-5764-DN-2023-0093","DOIUrl":"10.1590/1980-5764-DN-2023-0093","url":null,"abstract":"<p><p>The global increase in the aging population has raised concerns over various age-related conditions like dementia and mild cognitive impairment (MCI) and their consequences on the affected persons. People with MCI exhibit cognitive deficits more significantly than expected for their age and literacy level. Though the nature of this condition is considered \"mild\", studies have reported that even more subtle deficits can influence the quality of life (QOL).</p><p><strong>Objective: </strong>The present work aimed at exploring and comparing QOL in older adults with and without MCI through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>After a detailed search of articles till May 2021 in the relevant electronic databases (PubMed Central, PubMed, Scopus, CINAHL Plus, Web of Science, ProQuest, and Cochrane) using the keywords \"mild cognitive impairment\", \"quality of life\", \"old\", \"old aged\", \"aged\", \"older adult\", \"geriatrics\", \"healthy controls\", \"healthy participants\", and \"normal controls\", we included 23 articles in the systematic review and 12 in the meta-analysis.</p><p><strong>Results: </strong>The quality of all the included articles were assessed using the Modified Downs and Black tool. Most of the studies in the systematic review demonstrated differences in QOL scores in older adults with MCI compared to healthy older adults. However, meta-analysis findings suggest that older adults with MCI had statistically non-significant yet lower differences in QOL compared to their healthy counterparts.</p><p><strong>Conclusion: </strong>Future research should focus on developing QOL assessment tools specifically for older adults with MCI and follow-up studies that could provide better knowledge of their changing cognitive profile and life quality.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230093"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep and Alzheimer's disease: a systematic review.","authors":"Paul Nichol Galan Gonzales, Steven Gayoles Villaraza, Joseree-Ann Catindig Dela Rosa","doi":"10.1590/1980-5764-DN-2023-0049","DOIUrl":"10.1590/1980-5764-DN-2023-0049","url":null,"abstract":"<p><p>It is estimated that 45% of individuals with cognitive impairment experience sleep disturbances prior to the onset of cognitive symptoms. Assessing sleeping problems and enhancing sleep quality are critical first steps to reduce the risk of cognitive impairment.</p><p><strong>Objective: </strong>To review existing literature based on predefined eligibility criteria to understand the connection between sleep disturbance and Alzheimer's disease.</p><p><strong>Methods: </strong>A thorough and systematic evaluation of numerous studies was carried out to assess one or more of the following epidemiological factors: (1) sleep disorders, (2) cognitive impairment, and (3) risk estimates for cognitive impairment due to sleep.</p><p><strong>Results: </strong>Studies suggest that individuals who experience memory loss may encounter sleep disturbances before noticing other symptoms. Numerous sleep disorders, such as excessive and inadequate sleep duration, poor sleep quality, circadian rhythm abnormalities, insomnia, and obstructive sleep apnea were found to increase the risk of cognitive dysfunction and dementia. Additionally, lower sleep quality and shorter sleep duration have been linked to higher cerebral-β-amyloid levels. Objective evidence for the development of cognitive impairment is provided by the architecture of sleep stages. Patients experiencing sleep problems may benefit from specific types of sleep medicine as a preventative measure against cognitive decline.</p><p><strong>Conclusion: </strong>Sleep disorders can have adverse effects on cognitive health. The duration and quality of sleep are fundamental factors for maintaining a healthy brain as we age. Proper sleep can aid prevent cognitive impairment, particularly Alzheimer's disease and dementia.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230049"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between stress levels and coping techniques in caregivers of children with autism spectrum disorder in Chile, 2021.","authors":"Bárbara Cerda-Aedo","doi":"10.1590/1980-5764-DN-2022-0112","DOIUrl":"10.1590/1980-5764-DN-2022-0112","url":null,"abstract":"<p><p>Today, talking about autism spectrum disorder (ASD) is the same as talking about cases that occur in one in 160 births worldwide. Some of them will be able to live independently when they grow up while others will have less autonomy and will be more dependent, requiring the support of caregivers throughout their lives.</p><p><strong>Objective: </strong>Understanding the emotional burden that this could generate on parents, we sought to analyze the level of stress and coping techniques in caregivers of children with ASD in Chile, 2021.</p><p><strong>Methods: </strong>Interview with a sample composed of 61 parents or guardians of people with ASD.</p><p><strong>Results: </strong>After data analysis, it was possible to perform a statistically significant correlation (p=0.002) between the level of stress and the coping strategies (problem-solving, self-criticism, emotional expression, wishful thinking, social support, cognitive restructuring, problem avoidance, and social withdrawal). In addition, positive strategies that reduce stress levels in parents or caregivers of children with ASD were identified (problem resolution, cognitive restructuring, social support, and emotional expression).</p><p><strong>Conclusion: </strong>Through this research, it was possible to respond to each of the stated objectives, managing to determine what were the characteristics of caregivers and their main difficulties. It was also observed that the majority lost the possibility of working to dedicate themselves to the care of the diagnosed person.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20220112"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of young-onset Alzheimer's disease and other dementias: a secondary analysis of the global burden of disease study, 2019.","authors":"Diego Fernando Rojas-Gualdrón, Manuela Sánchez Henao, Carlos Alberto Uribe Zuluaga, Alejandro Espinosa Henao, Clara Angela Gómez Henck","doi":"10.1590/1980-5764-DN-2024-0134","DOIUrl":"10.1590/1980-5764-DN-2024-0134","url":null,"abstract":"<p><p>The aging of the world population has led to an increase in the epidemiology and burden of Alzheimer's disease and other dementias.</p><p><strong>Objective: </strong>To describe the global burden of young-onset Alzheimer's disease and other dementias by world region and income through a secondary analysis of the Global Burden of Disease Study 2019.</p><p><strong>Methods: </strong>This is a descriptive cross-sectional ecological study. Data by sex and five-year age groups from 40 to 64 years were extracted from the Global Burden of Disease Study results tool. We performed a descriptive analysis of prevalence, incidence, deaths, disability-adjusted life years, years of life lost, and years lived with disability.</p><p><strong>Results: </strong>In 2019, young-onset Alzheimer's disease and other dementias presented a prevalence of 2.67 cases and an incidence of 0.44 per 1,000 inhabitants globally. It carried a significant burden, resulting in 1.16 disability-adjusted life years per 1,000 inhabitants, primarily due to years of life lost, and to a lesser extent due to years lived with disability. East Asia & the Pacific, Latin America & the Caribbean, and North America are the most affected regions. Burden rates are consistently higher among women; no gradient was observed by country income. Smoking was the most relevant risk factor, presenting a broad difference by country income level.</p><p><strong>Conclusion: </strong>The global burden of young-onset Alzheimer's disease and other dementias may reshape healthcare requirements and the societal impact of dementias, and its understanding is relevant to inform decisions related to service offerings and research agendas.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20240134"},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological aspects of reversible cerebral vasoconstriction syndrome.","authors":"Ícaro Araújo de Sousa, Analina de Freitas Azevedo, Arthur de Oliveira Veras, Marx Lima de Barros-Araújo, Elizeu Pereira Dos Santos, Maria Andreia da Nóbrega Marques, Maria Paula Foss, Raimundo Pereira Silva-Néto, Irapuá Ferreira Ricarte, Octávio Marques Pontes-Neto","doi":"10.1590/1980-5764-DN-2023-0117","DOIUrl":"10.1590/1980-5764-DN-2023-0117","url":null,"abstract":"<p><p>Despite the increasing knowledge in the past years, only minimal attention has been directed to the neuropsychological aspects and the prevalence of cognitive impairment associated with reversible cerebral vasoconstriction syndrome (RCVS).</p><p><strong>Objective: </strong>To describe the frequency and expand the understanding of cognitive dysfunction in RCVS.</p><p><strong>Methods: </strong>The neuropsychological evaluation was performed using a battery consisting of specific neuropsychological instruments that were administered to patients diagnosed with RCVS. A triage was conducted to exclude other potential causes of cognitive impairment. Performance on the tests was treated as a categorical variable, and a cutoff of -1.5 Z-score was adopted to indicate impaired performance.</p><p><strong>Results: </strong>Seven patients diagnosed with RCVS were evaluated, all of whom had a bachelor's degree and normal score in the Mini-Mental State Examination. The average time between diagnosis and neuropsychological evaluation was 1.8 years. Among the patients, 85.6% (n=6) exhibited performance below that of the normal population in at least two of the administered tests. Specifically, 71.4% (n=5) showed alterations in tests from the Psychological Battery for Attention Assessment, with impairment observed in concentrated (n=1), divided (n=3), or alternating (n=4) attention. Furthermore, 28.6% (n=2) demonstrated impairments in the Phonological Verbal Fluency Task, another 28.6% (n=2) exhibited difficulties copying elements of the Rey Complex Figure, and 14.3% (n=1) displayed lower performance in the Five-Digit test, all indicating executive dysfunction.</p><p><strong>Conclusion: </strong>This study provides evidence that cognitive impairment associated with RCVS is more prevalent than previously believed and has not received sufficient attention. Specifically, attention and executive functions are the cognitive domains most significantly impacted by RCVS.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230117"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episodic memory improvement in illiterate adults attending late-life education irrespective of low socioeconomic status: insights from the PROAME study.","authors":"Emma Patrice Ruppert, João Victor de Faria Rocha, Aída Lourandes da Silva, Kelle Luisa Dos Santos Tomaz, Clarisse Vasconcelos Friedlaender, Joanna de Castro Magalhães Assenção, Luciana Paula Rincon, Norton Gray Ferreira Ribeiro, Dulce Constantina de Souza Santos, Ana Paula Zacarias Lima, Isabel Elaine Allen, Paulo Caramelli, Lea Tenenholz Grinberg, Francisca Izabel Pereira Maciel, Elisa de Paula França Resende","doi":"10.1590/1980-5764-DN-2023-0098","DOIUrl":"10.1590/1980-5764-DN-2023-0098","url":null,"abstract":"<p><p>The majority of people with dementia live in low or middle-income countries (LMICs) where resources that play a crucial role in brain health, such as quality education, are still not widely available. In Brazil, illiteracy remains a prevalent issue, especially in communities with lower socioeconomic status (SES). The PROAME study set out to explore basic education in illiterate adults as a means to improve cognitive reserve.</p><p><strong>Objective: </strong>This manuscript aims to explore the relationship between SES and learning, as well as cognitive outcomes, in an older illiterate population.</p><p><strong>Methods: </strong>This six-month clinical trial (NCT04473235) involved 108 participants, of which 77 concluded all assessments, enrolled in late-life basic education. SES assessments included Quality of Urban Living Index, Municipal Human Development Index and Household SES calculated for each participant. Cognitive assessments encompassed the Free and Cued Selective Reminding Test (FCSRT), a word list to assess reading, and the Beta III matrix.</p><p><strong>Results: </strong>The sample consisted primarily of women, with a mean age of 58.5. Participants improved their reading (p=0.01) and their FCSRT (p=0.003). Regarding episodic memory, women outperformed men (p=0.007) and younger participants improved more than their older counterparts (p=0.001). There was no association observed between SES and cognitive outcomes.</p><p><strong>Conclusion: </strong>Irrespective of SES, participants demonstrated positive outcomes after attending basic education. These findings highlight that late life education could be an important non-pharmacologic preventative measure, especially in LMICs.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230098"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of interleukin-6, interleukin-10 and tumor necrosis factor alpha cytokine levels in patients with mild cognitive impairment: systematic review and meta-analysis.","authors":"Alana Mara Inácio de Aquino, Kedma Anne Lima Gomes, Letícia Lorena Melo de Brito, Luciana Domingos de Lima, Eneas Ricardo de Morais Gomes, Suellen Mary Marinho Dos Santos Andrade","doi":"10.1590/1980-5764-DN-2023-0027","DOIUrl":"10.1590/1980-5764-DN-2023-0027","url":null,"abstract":"<p><p>There is growing evidence suggesting an association between neurodegeneration and inflammation playing a role in the pathogenesis of age-associated diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI).</p><p><strong>Objective: </strong>A systematic review and meta-analysis were performed to verify evidence on the diagnostic accuracy parameters of the inflammatory cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α).</p><p><strong>Methods: </strong>A search of Medical Literature Analysis and Retrieval System Online (Medline), Scientific Electronic Library Online (SciELO), Web of Science and Science Direct databases was performed and nine observational studies associated with peripheral inflammatory biomarkers in MCI were identified. Mean (±standard deviation - SD) concentrations of these biomarkers and values of true positives, true negatives, false positives and false negatives for MCI and healthy controls (HC) were extracted from these studies.</p><p><strong>Results: </strong>Significantly higher levels of IL-10 were observed in subjects in the MCI group and Mini-Mental State Examination (MMSE) scores were lower compared to HC. For the other investigations, no differences were found between the groups. Our meta-analysis for the TNF-α biomarker revealed high heterogeneity between studies in terms of sensitivity and specificity.</p><p><strong>Conclusion: </strong>These findings do not support the involvement of inflammatory biomarkers for detection of MCI, although significant heterogeneity was observed. More studies are needed to evaluate the role of these cytokines in MCI, as well as in other stages of cognitive decline and all-cause dementias.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230027"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) differences in corticobasal syndrome: comparison of two cases.","authors":"Thais Winkeler Beltrão, Eduardo Barbosa de Albuquerque Maranhão, Victor Adill Gomes Correia, Pedro Mota de Albuquerque, Mariana Gonçalves Maciel Pinheiro, Rayanne Acioli Lins Santos, Luiz Eduardo Duarte Borges Nunes, Simone Cristina Soares Brandão, Breno José Alencar Pires Barbosa","doi":"10.1590/1980-5764-DN-2023-0085","DOIUrl":"10.1590/1980-5764-DN-2023-0085","url":null,"abstract":"<p><p>Corticobasal syndrome (CBS) is a rare cause of dementia and comprises varied combinations of subcortical signs (akinetic-rigid parkinsonism, dystonia, or myoclonus) with cortical signs (apraxia, alien hand or cortical sensory deficit), usually asymmetric. We aimed to report and compare the clinical and neuroimaging presentation of two patients diagnosed with CBS. While case 1 had severe non-fluent aphasia associated with mild apraxia and limb rigidity, case 2 had a more posterior cognitive impairment, with a different language pattern associated with marked visuospatial errors and hemineglect. FDG PET played a significant role in diagnosis, suggesting, in the first case, corticobasal degeneration and, in the second, Alzheimer's disease pattern. CBS has been widely studied with the advent of new <i>in vivo</i> methods such as brain FDG PET. Studies that deepen the phenotypic and biomarker heterogeneity of CBS will be of great importance for better classification, prognosis, and treatment of the condition.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230085"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}