Dementia e Neuropsychologia最新文献_第3页

Diagnostic accuracy of interleukin-6, interleukin-10 and tumor necrosis factor alpha cytokine levels in patients with mild cognitive impairment: systematic review and meta-analysis. 轻度认知障碍患者白细胞介素-6、白细胞介素-10和肿瘤坏死因子α细胞因子水平的诊断准确性：系统综述和荟萃分析。

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0027

Alana Mara Inácio de Aquino, Kedma Anne Lima Gomes, Letícia Lorena Melo de Brito, Luciana Domingos de Lima, Eneas Ricardo de Morais Gomes, Suellen Mary Marinho Dos Santos Andrade

{"title":"Diagnostic accuracy of interleukin-6, interleukin-10 and tumor necrosis factor alpha cytokine levels in patients with mild cognitive impairment: systematic review and meta-analysis.","authors":"Alana Mara Inácio de Aquino, Kedma Anne Lima Gomes, Letícia Lorena Melo de Brito, Luciana Domingos de Lima, Eneas Ricardo de Morais Gomes, Suellen Mary Marinho Dos Santos Andrade","doi":"10.1590/1980-5764-DN-2023-0027","DOIUrl":"10.1590/1980-5764-DN-2023-0027","url":null,"abstract":"There is growing evidence suggesting an association between neurodegeneration and inflammation playing a role in the pathogenesis of age-associated diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI).Objective: A systematic review and meta-analysis were performed to verify evidence on the diagnostic accuracy parameters of the inflammatory cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α).Methods: A search of Medical Literature Analysis and Retrieval System Online (Medline), Scientific Electronic Library Online (SciELO), Web of Science and Science Direct databases was performed and nine observational studies associated with peripheral inflammatory biomarkers in MCI were identified. Mean (±standard deviation - SD) concentrations of these biomarkers and values of true positives, true negatives, false positives and false negatives for MCI and healthy controls (HC) were extracted from these studies.Results: Significantly higher levels of IL-10 were observed in subjects in the MCI group and Mini-Mental State Examination (MMSE) scores were lower compared to HC. For the other investigations, no differences were found between the groups. Our meta-analysis for the TNF-α biomarker revealed high heterogeneity between studies in terms of sensitivity and specificity.Conclusion: These findings do not support the involvement of inflammatory biomarkers for detection of MCI, although significant heterogeneity was observed. More studies are needed to evaluate the role of these cytokines in MCI, as well as in other stages of cognitive decline and all-cause dementias.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic and Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) differences in corticobasal syndrome: comparison of two cases. 皮质基底综合征的表型和[18F]氟脱氧葡萄糖正电子发射断层扫描（FDG PET）差异：两个病例的比较。

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0085

Thais Winkeler Beltrão, Eduardo Barbosa de Albuquerque Maranhão, Victor Adill Gomes Correia, Pedro Mota de Albuquerque, Mariana Gonçalves Maciel Pinheiro, Rayanne Acioli Lins Santos, Luiz Eduardo Duarte Borges Nunes, Simone Cristina Soares Brandão, Breno José Alencar Pires Barbosa

{"title":"Phenotypic and Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) differences in corticobasal syndrome: comparison of two cases.","authors":"Thais Winkeler Beltrão, Eduardo Barbosa de Albuquerque Maranhão, Victor Adill Gomes Correia, Pedro Mota de Albuquerque, Mariana Gonçalves Maciel Pinheiro, Rayanne Acioli Lins Santos, Luiz Eduardo Duarte Borges Nunes, Simone Cristina Soares Brandão, Breno José Alencar Pires Barbosa","doi":"10.1590/1980-5764-DN-2023-0085","DOIUrl":"10.1590/1980-5764-DN-2023-0085","url":null,"abstract":"Corticobasal syndrome (CBS) is a rare cause of dementia and comprises varied combinations of subcortical signs (akinetic-rigid parkinsonism, dystonia, or myoclonus) with cortical signs (apraxia, alien hand or cortical sensory deficit), usually asymmetric. We aimed to report and compare the clinical and neuroimaging presentation of two patients diagnosed with CBS. While case 1 had severe non-fluent aphasia associated with mild apraxia and limb rigidity, case 2 had a more posterior cognitive impairment, with a different language pattern associated with marked visuospatial errors and hemineglect. FDG PET played a significant role in diagnosis, suggesting, in the first case, corticobasal degeneration and, in the second, Alzheimer's disease pattern. CBS has been widely studied with the advent of new in vivo methods such as brain FDG PET. Studies that deepen the phenotypic and biomarker heterogeneity of CBS will be of great importance for better classification, prognosis, and treatment of the condition.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pontine myelinolysis with an uncommon manifestation of hallucination: a case report. 伴有不常见幻觉表现的桥脑髓鞘溶解症：病例报告。

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0068

Andreia Braga Mota Azzoni, Vitor Maia Arca, Eduardo Sousa de Melo

引用次数: 0

Musical hallucination or musical obsession? A differential diagnosis between two cases. 音乐幻觉还是音乐强迫症？两个病例的鉴别诊断

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0073

Octavio Pennella Fenelon Costa, Maria Luiza Dalcim, Sumaia Inaty Smaira, Gustavo Bigaton Lovadini

引用次数: 0

Expressive amusia and aphasia: the story of Maurice Ravel. 表达性失眠症和失语症：莫里斯-拉威尔的故事。

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0108

Sultan Darvesh, Meghan Kirsten Cash, Earl Martin, Eliasz Engelhardt

引用次数: 0

Psychosocial factors affected by burden in family caregivers of people with Alzheimer's disease. 影响阿尔茨海默病患者家庭照顾者负担的社会心理因素。

Dementia e Neuropsychologia Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0115

Edivaldo Lima de Araujo, Shirley Silva Lacerda

{"title":"Psychosocial factors affected by burden in family caregivers of people with Alzheimer's disease.","authors":"Edivaldo Lima de Araujo, Shirley Silva Lacerda","doi":"10.1590/1980-5764-DN-2023-0115","DOIUrl":"10.1590/1980-5764-DN-2023-0115","url":null,"abstract":"The world's population is experiencing an aging process, which is resulting in an increase in diseases such as Alzheimer's disease. Consequently, more and more people need care, which can lead to overload and harm to their family's quality of life.Objective: Identify the psychosocial factors affected by the burden on family caregivers of people with Alzheimer's disease.Methods: Forty-nine family caregivers of people with Alzheimer's disease, from a city in Minas Gerais, Brazil, participated in the study. They filled out a form of sociodemographic variables, and answered the Burden Interview Scale (BI-Zarit), Quality of Life in Alzheimer's Disease Caregiver version (CQoL-AD), the Depression, Anxiety and Stress Scale (DASS-21), the Mindfulness and Awareness Scale (MAAS) and the Clinical Dementia Rating Scale (CDR).Results: All participants were female with an average age of 54.26 (±8.99). Daughters comprised 77.55% of the sample, and 34.69% were sole caregivers. The Bi-Zarit scale positively and significantly correlated with DASS-21 Depression (r=0.440; p=0.002), DASS-21 Anxiety (r=0.415; p=0.003), DAAS-21 Stress (r=0.583; p<0.001). On the other hand, it showed a negative correlation with MAAS (r=-0.429; p=0.002) and CQoL-AD (r=-0.533; p<0.001).Conclusion: This study demonstrates that family caregivers of people with Alzheimer's disease may be overloaded, and that the heavier the burden, the lower level of attention, the worse quality of life and the greater the possibility for the caretaker to present symptoms of depression, anxiety, and stress.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is "biological Alzheimer's disease"? 什么是 "生物性阿尔茨海默病"？

Dementia e Neuropsychologia Pub Date : 2024-06-10 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2024-E001

引用次数: 0

Proposed protocol for post COVID-19 cognitive rehabilitation for attention and memory. COVID-19 后注意力和记忆力认知康复拟议方案。

Dementia e Neuropsychologia Pub Date : 2024-05-27 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0109

Letícia Silva Dutra, Nadia Shigaeff

{"title":"Proposed protocol for post COVID-19 cognitive rehabilitation for attention and memory.","authors":"Letícia Silva Dutra, Nadia Shigaeff","doi":"10.1590/1980-5764-DN-2023-0109","DOIUrl":"10.1590/1980-5764-DN-2023-0109","url":null,"abstract":"Since the beginning of the COVID-19 pandemic, many people suffered from Long Covid Syndrome, in which affected individuals do not recover immediately after the end of the infectious and inflammatory process caused by the virus. The most common neuropsychological symptoms of this syndrome are: memory decline, lack of attention, anxiety and depression.Objective: The purpose of this study was to develop a proposed cognitive rehabilitation protocol for post-COVID individuals with cognitive symptoms.Methods: A rehabilitation proposed protocol focusing on attention and memory was developed, based on the tests used in the neuropsychological evaluation of affected patients. Researchers held weekly sessions for six months, each lasting 60 minutes. Homework activities were also assigned and corrected in the following session. The attention and memory sessions were conducted with activities based on the applied tests.Results: Despite the methodological separation of attention and memory, the activities indirectly affect other cognitive functions and abilities, such as executive function, language, reasoning, execution strategies, and cognitive flexibility. A computer, a sheet of paper, and a pen were used to present the slides for the activities. Attention training included all types of attention: sustained, alternating, selective and divided. Memory training sessions included activities that stimulated both short-term and long-term memory. With each session, the difficulty of the activities was gradually increased.Conclusion: Cognitive rehabilitation already has more consolidated evidence about its effectiveness for the treatment of other pathologies, so it can be thought that it will also be a promising strategy for COVID-19 too.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring risk factors for dementia in middle-aged and older adults: a longitudinal study. 监测中老年人痴呆症的风险因素：一项纵向研究。

Dementia e Neuropsychologia Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0095

Bruna Moretti Luchesi, Mariana Tiemi Kajiyama, Amanda Rocha Abreu, Marcelo Kwiatkoski, Tatiana Carvalho Reis Martins

{"title":"Monitoring risk factors for dementia in middle-aged and older adults: a longitudinal study.","authors":"Bruna Moretti Luchesi, Mariana Tiemi Kajiyama, Amanda Rocha Abreu, Marcelo Kwiatkoski, Tatiana Carvalho Reis Martins","doi":"10.1590/1980-5764-DN-2023-0095","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0095","url":null,"abstract":"Given the importance of dementia syndrome and its impacts on the population, interest in studying modifiable risk factors for dementia is growing.Objective: To compare the prevalence of risk factors for dementia in middle-aged and older adults over a two-year period and to identify what variables in baseline were predictive of cognitive decline in the follow-up.Methods: Longitudinal and quantitative study, with follow-up evaluation after two years, conducted with 200 participants aged 45 years or more, registered in Primary Care Units. In the baseline (2018/2019) and follow-up (2021) assessments, sociodemographic data were collected, and cognitive performance and risk factors for dementia were evaluated (education, hearing loss, head trauma, high blood pressure, alcohol use, obesity, smoking, depressive symptoms, social isolation, physical inactivity, and diabetes mellitus). Data were compared using the McNemar's test. Individual multinomial logistic regression models were performed to identify the factors associated with cognitive decline after two years.Results: The percentages of low education, traumatic brain injury, and smoking remained the same in both assessments. There was a significant increase in the prevalence of high blood pressure (from 55.0 to 62.0%) and physical inactivity (from 58.5 to 74.5%) and a significant reduction in social isolation (from 25.0 to 18.0%). Participants with depressive symptoms in baseline had a higher risk of cognitive decline in follow-up.Conclusion: There was an increase in the prevalence of high blood pressure and physical inactivity and a reduction in social isolation after two years. Depressive symptoms predict cognitive decline.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on frontotemporal dementia: its impact on language, speech and behavior. 额颞叶痴呆症综述：对语言、言语和行为的影响。

Dementia e Neuropsychologia Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.1590/1980-5764-DN-2023-0072

Sha Abbas Mollah, Aditya Nayak, Swapna Barhai, Uddip Maity

{"title":"A comprehensive review on frontotemporal dementia: its impact on language, speech and behavior.","authors":"Sha Abbas Mollah, Aditya Nayak, Swapna Barhai, Uddip Maity","doi":"10.1590/1980-5764-DN-2023-0072","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0072","url":null,"abstract":"Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder defined by the selective deterioration of the frontal and temporal lobes of the brain. This comprehensive review explored the effect of FTD on language, speech, and behavior. Early symptoms include difficulty in word finding, reduced speech output, and comprehension deficits, often leading to aphasia. The study discussed the profound behavioral changes observed in FTD patients, including apathy, disinhibition, compulsive behaviors, and loss of empathy, the importance of an accurate and early diagnosis, and its challenges. We even reviewed the potential for targeted therapies and the essential role of multidisciplinary care in managing the language, speech, and behavioral aspects of FTD. By examining objective data and comprehensive research on the subject, this study offers valuable insights into FTD's profound effects on language, speech, and behavior, assisting in improved clinical management and potential therapeutic strategies for this devastating condition.","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0