Dementia e NeuropsychologiaPub Date : 2026-04-20eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2025-0419
Marcio Soto-Añari, Claudia Rivera-Fernández, Manuel Montemurro, Francisco Ceric, María Del Carmen Tejada, Andrés Muñoz-Najar, María Gracia Carbajal, Edmarie Guzmán-Vélez, Yakeel T Quiroz
{"title":"Subjective cognitive decline, and its cognitive and emotional correlates in Peruvian older adults.","authors":"Marcio Soto-Añari, Claudia Rivera-Fernández, Manuel Montemurro, Francisco Ceric, María Del Carmen Tejada, Andrés Muñoz-Najar, María Gracia Carbajal, Edmarie Guzmán-Vélez, Yakeel T Quiroz","doi":"10.1590/1980-5764-DN-2025-0419","DOIUrl":"10.1590/1980-5764-DN-2025-0419","url":null,"abstract":"<p><p>Subjective cognitive decline (SCD) is a known risk factor for dementia, yet its association with objective cognition and emotional state remains underexplored in Latin American populations.</p><p><strong>Objective: </strong>The aim of this study was to explore the relationship between SCD, objective cognition, and emotional state in older adults from Arequipa, Peru.</p><p><strong>Methods: </strong>This study investigated these relationships in 43 older adults from Arequipa, Peru, classified as having SCD (n=17), mild cognitive impairment (n=12), or normal cognition (n=14). Participants underwent assessments of global cognition, subjective decline (via the E-Cog), objective cognitive domains, and emotional state.</p><p><strong>Results: </strong>Findings showed a significant association between SCD and emotional disorders, with emotional symptoms correlating with total E-Cog scores and specific domains such as memory, language, planning, and organization. Additionally, general cognition, long-term memory, and cognitive flexibility were associated with deficits in visuospatial processing, attention, and executive function.</p><p><strong>Conclusions: </strong>These results underscore the need to account for emotional factors when evaluating the relationship between SCD and objective cognitive performance.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2025419"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-04-20eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2025-0450
Beatriz Pires Paes, Julia Carolina Ribeiro Batista da Silva, Pedro Manzke de Carvalho, André Gustavo Fonseca Ferreira
{"title":"Long-term clinical progression of Sneddon syndrome associated with antiphospholipid syndrome.","authors":"Beatriz Pires Paes, Julia Carolina Ribeiro Batista da Silva, Pedro Manzke de Carvalho, André Gustavo Fonseca Ferreira","doi":"10.1590/1980-5764-DN-2025-0450","DOIUrl":"10.1590/1980-5764-DN-2025-0450","url":null,"abstract":"<p><p>Sneddon syndrome (SS) is a rare neurocutaneous disorder characterized by livedo racemosa and recurrent cerebrovascular events, frequently associated with antiphospholipid syndrome (APS). We report a 10-year follow-up of a 62-year-old man diagnosed with SS and APS. Initial presentation included seizures and ischemic lesions on brain magnetic resonance imaging (MRI). Over the years, he developed progressive livedo racemosa, progression of ischemic brain lesions, and cognitive decline. This case illustrates the natural course of SS, despite adequate therapy.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2025450"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-04-20eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2025-0383
Yuichiro Inatomi, Minoru Matsuda
{"title":"Description of a priest in a medieval Japanese essay, \"Tsurezuregusa\": is this the first report of frontotemporal dementia?","authors":"Yuichiro Inatomi, Minoru Matsuda","doi":"10.1590/1980-5764-DN-2025-0383","DOIUrl":"10.1590/1980-5764-DN-2025-0383","url":null,"abstract":"<p><p>In Tsurezuregusa, a medieval Japanese essay written by Kenkō, a priest with the characteristics of behavioral variant frontotemporal dementia (bvFTD), has been described. He had characteristics such as early behavioral disinhibition; loss of sympathy and empathy; perseverative, stereotyped, and compulsive/ritualistic behavior; and hyperorality and dietary changes. Based on the diagnostic criteria for bvFTD, it is possible that he had probable bvFTD. According to the essay, despite his abnormal behavior, the priest had adapted to his surroundings, including the temple where he worked. His successful adaptation was likely due to the tolerance of people around him and/or the education he had acquired before the onset of the disease, which may have functioned as a \"cognitive reserve.\"</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2025383"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-04-20eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2025-0316
Hicham Mejdouli, Sana El Fadeli, Hakima Amor, Abdellatif Baali, Nadia Ouzennou
{"title":"Self-perception of aging and associated factors among older adults in Morocco.","authors":"Hicham Mejdouli, Sana El Fadeli, Hakima Amor, Abdellatif Baali, Nadia Ouzennou","doi":"10.1590/1980-5764-DN-2025-0316","DOIUrl":"10.1590/1980-5764-DN-2025-0316","url":null,"abstract":"<p><p>Self-perception of aging is considered one of the indicators of health and vulnerability. Understanding how older adults perceive their aging can be an effective way to develop strategies to prevent vulnerability and promote healthy aging.</p><p><strong>Objective: </strong>The aim of this study was to investigate the self-perception of aging and its associated factors in a group of older adults in Morocco to contribute to healthy aging.</p><p><strong>Methods: </strong>This was a cross-sectional study conducted between June 2022 and July 2023 among 496 people aged 60 years and over who visited health centers in the province of Essaouira. A positive or negative self-perception of aging was established using the Attitudes Toward Own Aging subscale, which includes five items from the Philadelphia Geriatric Center Morale Scale. Sociodemographic characteristics and data related to lifestyle and health status were collected through interviews, by consulting health records, and were supplemented with anthropometric measurements. Binary logistic regression was used to determine the potential factors influencing self-perception of aging.</p><p><strong>Results: </strong>A negative self-perception of aging was identified in 21.4% of participants. Multivariate analysis revealed that being unmarried (OR 2.027; 95%CI 1.261-3.259), having depressive symptoms (OR 1.729; 95%CI 1.082-2.765), and being dependent (OR 1.926; 95%CI 1.134-3.272) were the main factors statistically associated with a negative self-perception of aging.</p><p><strong>Conclusion: </strong>A strategy to prevent loneliness and social isolation, as well as screening programs for depression and dependency in older adults, could contribute to successful and healthy aging.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250316"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-04-03eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2026-0475
Daniel Souza Gonçalves de Araujo
{"title":"Methodological concerns regarding stepwise regression and construct overlap in caregiver burden research.","authors":"Daniel Souza Gonçalves de Araujo","doi":"10.1590/1980-5764-DN-2026-0475","DOIUrl":"10.1590/1980-5764-DN-2026-0475","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20260475"},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-03-23eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2026-A001
{"title":"Thanks to Editorial Board of <i>Dementia & Neuropsychology</i>.","authors":"","doi":"10.1590/1980-5764-DN-2026-A001","DOIUrl":"10.1590/1980-5764-DN-2026-A001","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e2026A001"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Translation of the Dimensional Apathy Scale to Brazilian Portuguese to assess people living with HIV.","authors":"Fernando Nonato de Carvalho Fagundes, Aleida Nazareth Soares, Ratko Radakovic, Sindy Sthefany Sousa Silva, Adriana Silvina Pagano, Antônio Lúcio Teixeira, Alexandre Sampaio Moura","doi":"10.1590/1980-5764-DN-2025-0343","DOIUrl":"10.1590/1980-5764-DN-2025-0343","url":null,"abstract":"<p><p>Neurocognitive and behavioral disorders are common among people living with HIV (PLHIV) and can be associated with apathy. The use of a valid and reliable instrument to identify apathy among PLHIV could allow early diagnosis and proper management of this condition.</p><p><strong>Objective: </strong>The aim of this paper was to translate, cross-culturally adapt, and validate the caregiver-rated Dimensional Apathy Scale (DAS) in PLHIV in Brazil.</p><p><strong>Methods: </strong>We followed five steps: translation, back translation, cultural adaptation, pretest, and test-retest. A pretest (n=20) and test-retest (n=80) were conducted with PLHIV from an HIV Referral Center in Brazil between August 2022 and March 2023. We determined the content validity index (CVI), Cronbach's alpha, and the intraclass correlation coefficient (ICC). To assess convergent and discriminant validity, apathy scores were correlated with cognitive function, as assessed by the International HIV Dementia Scale (IHDS), and depressive symptoms, as assessed by the Patient Health Questionnaire (PHQ-9).</p><p><strong>Results: </strong>Participants were predominantly male (82.5%), with a mean age of 41.7 (±13.4) years and a mean duration of infection of 8.1 (±1.9) years. The mean CVI of the Brazilian DAS version (DAS-Br) was 0.97. The translated version showed acceptable internal consistency (Cronbach's alpha: 0.727 (95%CI 0.632-0.806)) and good test-retest reliability (ICC 0.888 (95%CI 0.823-0.929). There was a moderate correlation between DAS-Br scores and depressive symptoms (r=0.425, p<0.01) and a nonsignificant correlation with cognition (r=0.167; p>0.05).</p><p><strong>Conclusion: </strong>The translation and cross-cultural adaptation of the DAS into Brazilian Portuguese resulted in a valid and reliable instrument for assessing apathy in PLHIV.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250343"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-03-23eCollection Date: 2025-01-01DOI: 10.1590/1980-5764-DN-2025-E002
Mônica Sanches Yassuda
{"title":"Introduction to the special issue on Down syndrome.","authors":"Mônica Sanches Yassuda","doi":"10.1590/1980-5764-DN-2025-E002","DOIUrl":"10.1590/1980-5764-DN-2025-E002","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 Suppl 1","pages":"e2025E002"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dementia e NeuropsychologiaPub Date : 2026-03-23eCollection Date: 2026-01-01DOI: 10.1590/1980-5764-DN-2025-0413
Antônio Jaeger, Eduarda Xavier Carreira, Gabriel Gomide, Natália Araújo Sundfeld da Gama, Morgana Cavalcante de Queiroz, Paulo Caramelli, Lucas Porcello Schilling, Leonardo Cruz de Souza
{"title":"Spatial memory retrieval under cueing in behavioral frontotemporal dementia and Alzheimer's disease.","authors":"Antônio Jaeger, Eduarda Xavier Carreira, Gabriel Gomide, Natália Araújo Sundfeld da Gama, Morgana Cavalcante de Queiroz, Paulo Caramelli, Lucas Porcello Schilling, Leonardo Cruz de Souza","doi":"10.1590/1980-5764-DN-2025-0413","DOIUrl":"10.1590/1980-5764-DN-2025-0413","url":null,"abstract":"<p><p>Recent studies indicate that episodic memory is impaired in behavioral variant frontotemporal dementia (bvFTD), with deficits as severe as those seen in Alzheimer's disease (AD). Also, both bvFTD and AD patients exhibit executive dysfunction, but the extent to which such dysfunction contributes to memory impairments remains unclear.</p><p><strong>Objective: </strong>The aim of this study was to investigate interactions between executive functions and episodic memory in AD and bvFTD by manipulating executive control in a spatial source memory task.</p><p><strong>Methods: </strong>Twenty bvFTD patients, 18 AD patients, and 20 healthy controls completed a source memory test in which they should remember whether objects were previously seen on the left or right side of a computer screen. Critically, arrow cues (66.7% valid, 33.3% invalid) indicated the likely prior location of each object during retrieval.</p><p><strong>Results: </strong>bvFTD and AD patients showed overall similar memory performances but were impaired compared to controls. While cueing affected memory performances of controls and bvFTD patients, AD patients showed undistinguishable performances after valid and invalid cueing.</p><p><strong>Conclusion: </strong>These findings support the notion that episodic memory deficits in bvFTD can be as severe as in AD and demonstrate that, unlike bvFTD patients, patients with AD show difficulties in using information conveyed by cues during memory judgments, probably because of underlying attentional deficits.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250413"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}