Dementia e Neuropsychologia最新文献

{"title":"Brain insulin resistance and Alzheimer's disease: a systematic review.","authors":"Luis Jesuino de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Letícia Góes de Carvalho Lourenço, Gabriela Correia Matos de Oliveira","doi":"10.1590/1980-5764-DN-2023-0032","DOIUrl":"10.1590/1980-5764-DN-2023-0032","url":null,"abstract":"<p><p>The disability of cells to react to insulin, causing glucose intolerance and hyperglycemia, is referred to as insulin resistance. This clinical condition, which has been well-researched in organs such as adipose tissue, muscle, and liver, has been linked to neurodegenerative diseases like Alzheimer's disease (AD) when it occurs in the brain.</p><p><strong>Objective: </strong>The authors aimed to gather data from the current literature on brain insulin resistance (BIR) and its likely repercussions on neurodegenerative disorders, more specifically AD, through a systematic review.</p><p><strong>Methods: </strong>A comprehensive search was conducted in multiple medical databases, including the Cochrane Central Register of Controlled Trials, EMBASE, Medical Literature Analysis and Retrieval System Online (Medline), and PubMed^®, employing the descriptors: \"insulin resistance\", \"brain insulin resistance\", \"Alzheimer's disease\", \"neurodegeneration\", and \"cognition\". The authors focused their search on English-language studies published between 2000 and 2023 that investigated the influence of BIR on neurodegenerative disorders or offered insights into BIR's underlying mechanisms. Seventeen studies that met the inclusion criteria were selected.</p><p><strong>Results: </strong>The results indicate that BIR is a phenomenon observed in a variety of neurodegenerative disorders, including AD. Studies suggest that impaired glucose utilization and uptake, reduced adenosine triphosphate (ATP) production, and synaptic plasticity changes caused by BIR are linked to cognitive problems. However, conflicting results were observed regarding the association between AD and BIR, with some studies suggesting no association.</p><p><strong>Conclusion: </strong>Based on the evaluated studies, it can be concluded that the association between AD and BIR remains inconclusive, and additional research is needed to elucidate this relationship.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230032"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study.","authors":"Nariana Mattos Figueiredo Sousa, Ana Claudia Paradella Freitas Maranhão, Lucia Willadino Braga","doi":"10.1590/1980-5764-DN-2023-0053","DOIUrl":"10.1590/1980-5764-DN-2023-0053","url":null,"abstract":"<p><p>COVID-19 is a multisystem disease caused by the RNA virus (coronavirus 2 or SARS-CoV-2) that can impact cognitive measures.</p><p><strong>Objective: </strong>To identify the main cognitive and neuropsychiatric symptoms in adults who had no cognitive complaints prior to the infection. Specifically, to observe the trajectory of cognitive and neuropsychiatric performance after 6 months.</p><p><strong>Methods: </strong>This is a retrospective longitudinal study. Forty-nine patients (29 reassessed after 6 months), with a positive PCR test, with no prior cognitive complaints that only presented after the infection and without a history of structural, neurodegenerative or psychiatric neurological diseases. A brief cognitive assessment battery (MoCA), the Trail Making Test (TMT-A, B, ∆), and the Verbal Fluency Test were used, as well as the scales (Hospital Anxiety and Depression Scale-HADS, Fatigue Severity Scale-FSS). Correlation tests and group comparison were used for descriptive and inferential statistics. Level of significance of α=5%.</p><p><strong>Results: </strong>Mean age of 50.4 (11.3), 12.7 (2.8) years of education, higher percentage of women (69.8%). No psycho-emotional improvement (depression and anxiety) was observed between the evaluations, and patients maintained the subjective complaint of cognitive changes. The HAD-Anxiety scale showed a significant correlation with TMT-B errors. The subgroup participating in cognitive stimulation and psychoeducation showed improvement in the global cognition measure and the executive attention test.</p><p><strong>Conclusion: </strong>Our results corroborate other studies that found that cognitive dysfunctions in post-COVID-19 patients can persist for months after disease remission, as well as psycho-emotional symptoms, even in individuals with mild infection. Future studies, with an increase in casuistry and control samples, are necessary for greater evidence of these results.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230053"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and functional status among older adults with cognitive impairment: data from the second wave of the FIBRA study.","authors":"Beatriz Raz Franco de Santana, Flávia Silva Arbex Borim, Daniela de Assumpção, Anita Liberalesso Neri, Mônica Sanches Yassuda","doi":"10.1590/1980-5764-DN-2023-0051","DOIUrl":"10.1590/1980-5764-DN-2023-0051","url":null,"abstract":"<p><p>Frailty is defined as a recognizable state of increased vulnerability resulting from age-associated decline of function in various physiological systems, such that the ability to deal with acute or everyday stressors is compromised.</p><p><strong>Objective: </strong>The aim of the study was to characterize the sample of older adults with cognitive impairment, according to the frailty status indirectly assessed by family members, other clinical and sociodemographic variables; and to assess the overlap of clinical conditions evaluated in this sample with cognitive impairment.</p><p><strong>Methods: </strong>Data were extracted from the follow-up database of the Frailty in Brazilian Older Adults (FIBRA) study (2016-2017). The sample consisted of 130 elderly people with cognitive impairment assessed by the Mini Mental State Examination (MMSE). The scores for the Clinical Dementia Scale (CDR), Cornell Scale for Depression in Dementia and Functional Activities Questionnaire were described. Frailty was indirectly measured through questions answered by family members about the five criteria that compose the frailty phenotype.</p><p><strong>Results: </strong>The sample consisted mostly of older women (n=91) with a mean age of 82.4 (SD=5.3) years, mean schooling of 3.3 years (SD=3.07), widowed (47.7%) and who lived with children and/or grandchildren (68%). More than half had multimorbidity (74.90%), 39.5% had depression symptoms suggestive of major depression, 57% had impaired functionality, 49.3% were frail, 37.6% pre-frail, and 13.10% robust.</p><p><strong>Conclusion: </strong>Among older adults with cognitive impairment, frailty and functional limitations are common.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230051"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenges for early intervention and its effects on the prognosis of autism spectrum disorder: a systematic review.","authors":"Jackson Frederico Pires, Caroline Cajuela Grattão, Regiane Maria Ribeiro Gomes","doi":"10.1590/1980-5764-DN-2023-0034","DOIUrl":"10.1590/1980-5764-DN-2023-0034","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is expressed with neurobehavioral symptoms of different degrees of intensity. It is estimated that, for every three cases detected, there are two cases that reach adulthood without treatment.</p><p><strong>Objective: </strong>To establish what challenges are still present in the implementation of early intervention (EI) and its effects on the prognosis of ASD.</p><p><strong>Methods: </strong>A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma) methodology was carried out in the PubMed and ScienceDirect databases in January 2023. The search keywords were \"autism spectrum disorder\", \"early intervention\" and \"prognosis\".</p><p><strong>Results: </strong>Sixteen studies were included, two randomized and 14 non-randomized. Knowledge about the signs of ASD, diagnostic and therapeutic methods, age at the start of treatment, and socioeconomic factors were the main challenges encountered in the implementation of the EI.</p><p><strong>Conclusion: </strong>EI is capable of modifying the prognosis of ASD and challenges in its implementation persist, especially in developing regions with low socioeconomic status.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230034"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long COVID: neurological manifestations - an updated narrative review.","authors":"José Wagner Leonel, Gabriella Cunha Vieira Ciurleo, Alissa Moura Formiga, Thais de Maria Frota Vasconcelos, Marcello Holanda de Andrade, Werbety Lucas Queiroz Feitosa, Antônio Alves Sobreira-Neto, Chiara Gübel Portugal, Lorenzo Marinho Morais, Samuel Cavalcante Marinho, Emanuel de Assis Bertulino Martins Gomes, Esther de Alencar Araripe Falcão Feitosa, Emmanuelle Silva Tavares Sobreira, Reinaldo Barreto Oriá, Manoel Alves Sobreira-Neto, Pedro Braga-Neto","doi":"10.1590/1980-5764-DN-2023-0076","DOIUrl":"10.1590/1980-5764-DN-2023-0076","url":null,"abstract":"<p><p>Infection with the SARS-CoV-2 virus can lead to neurological symptoms in the acute phase and in the Long COVID phase. These symptoms usually involve cognition, sleep, smell disorders, psychiatric manifestations, headache and others. This condition is more commonly described in young adults and women. This symptomatology can follow severe or mild cases of the disease. The importance of this issue resides in the high prevalence of neurological symptoms in the Long COVID phase, which entails significant morbidity in this population. In addition, such a condition is associated with high health care costs, with some estimates hovering around 3.7 trillion US dollars. In this review, we will sequentially describe the current knowledge about the most prevalent neurological symptoms in Long COVID, as well as their pathophysiology and possible biomarkers.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"18 ","pages":"e20230076"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-amyloid therapies do not slow Alzheimer's disease progression.","authors":"Markku Kurkinen","doi":"10.1590/1980-5764-DN-2023-0099","DOIUrl":"10.1590/1980-5764-DN-2023-0099","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"17 ","pages":"e20230099"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's research after full approval of lecanemab: impetus and variety.","authors":"Timothy Daly","doi":"10.1590/1980-5764-DN-2023-0064","DOIUrl":"10.1590/1980-5764-DN-2023-0064","url":null,"abstract":"","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"17 ","pages":"e20230064"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of the persian version of the modified telephone interview for cognitive status among community-dwelling older adults in Iran.","authors":"Fatemeh Ghonoodi, Farshad Sharifi, Hooman Shahsavari, Sahar Keyvanloo Shahrestanaki, Elham Navab","doi":"10.1590/1980-5764-DN-2023-0020","DOIUrl":"10.1590/1980-5764-DN-2023-0020","url":null,"abstract":"<p><p>Due to the increase in the population of the elderly, there is a growing trend in some diseases such as cognitive disorders (dementia) which are common in this era, and the diagnosis and treatment of this disease are still facing challenges. Therefore, early identification of cognitive disorders is of particular importance. In this regard, the use of any tool or cognitive tests may not be enough to diagnose dementia in the early stages and a special tool is needed.</p><p><strong>Objective: </strong>The validity and reliability of the Persian version of the Modified Telephone Interview for Cognitive Status (P-TICS-M) in older adults living in the Iranian community for a comprehensive screening of mild cognitive impairment and dementia was investigated.</p><p><strong>Methods: </strong>In the first phase, translation, re-translation, and word-taking were performed by using the face validity and content validity. In the second phase, a stratified convenient sampling with 150 participants aged ≥60 years was conducted based on cognitive status using the global deterioration scale in 2018. The external and internal reliability of the P-TICS-M using the interclass correlation coefficient and Cronbach's alpha coefficient of total items of this tool were estimated.</p><p><strong>Results: </strong>The mean age of the participants was 68.6 (standard deviation±7.4) years. According to global deterioration scale, 87 (58.0%) had normal cognition, 40 (26.7%) had mild cognitive impairment, and 23 (15.3%) had dementia. The Spearman's correlation coefficient between P-TICS-M scores and Mini-Mental State Examination scale was 0.764. In exploratory factor analysis, seven domains were detected, which were compatible with those defined by the tool developer. The Cronbach's alpha of the P-TICS-M was 0.920. The absolute agreement between test-retest score was >0.90. The sensitivity of 92.2, 94.8, and 100%, and also the specificity of 79.4, 88.2, and 89.8% were calculated for detecting subjects with dementia, respectively. Furthermore, a mild cognitive impairment cutoff of >28 was determined.</p><p><strong>Conclusion: </strong>The development and validation of a P-TICS-M tool can be useful in identifying older adult people with cognitive impairment. Demographic characteristics (level of education, age) can also affect the cutoff point of this tool.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"17 ","pages":"e20230020"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of transcranial magnetic stimulation for neurodegenerative disease: a critical review.","authors":"Javier Moreno-Roco, Lucía Del Valle, Daniel Jiménez, Ignacio Acosta, José Luis Castillo, Thanuja Dharmadasa, Matthew C Kiernan, José Manuel Matamala","doi":"10.1590/1980-5764-DN-2023-0048","DOIUrl":"10.1590/1980-5764-DN-2023-0048","url":null,"abstract":"<p><p>Neurodegenerative diseases pose significant challenges due to their impact on brain structure, function, and cognition. As life expectancy rises, the prevalence of these disorders is rapidly increasing, resulting in substantial personal, familial, and societal burdens. Efforts have been made to optimize the diagnostic and therapeutic processes, primarily focusing on clinical, cognitive, and imaging characterization. However, the emergence of non-invasive brain stimulation techniques, specifically transcranial magnetic stimulation (TMS), offers unique functional insights and diagnostic potential. TMS allows direct evaluation of brain function, providing valuable information inaccessible through other methods. This review aims to summarize the current and potential diagnostic utility of TMS in investigating neurodegenerative diseases, highlighting its relevance to the field of cognitive neuroscience. The findings presented herein contribute to the growing body of research focused on improving our understanding and management of these debilitating conditions, particularly in regions with limited resources and a pressing need for innovative approaches.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"17 ","pages":"e20230048"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between burden and caregiver's sleep disturbances in dementia: a systematic review.","authors":"Bárbara Cristina da Costa Monteiro, Tatiana Teresa Belfort Almeida Dos Santos, Marcela Moreira Lima Nogueira, Marcia Cristina Nascimento Dourado","doi":"10.1590/1980-5764-DN-2023-0030","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0030","url":null,"abstract":"<p><p>Caregivers of people living with dementia (PLwD) have a high burden degree that leads to health issues, including sleep.</p><p><strong>Objective: </strong>This study aimed to analyze the impacts of the caregiving burden on caregiver's sleep disturbances.</p><p><strong>Methods: </strong>This systematic review involved a qualitative analysis of publications on Web of Science and Pubmed/Medline databases published between February 2018 and August 2022.</p><p><strong>Results: </strong>A total of 27 studies were identified and analyzed. Caregiver's sleep presents impairments in sleep latency, sleep fragmentation, sleep duration, subjective sleep quality, daytime dysfunction, and insomnia. Caregiver's distress and depressive symptoms have a dual relationship with sleep problems.</p><p><strong>Conclusion: </strong>Sleep disturbances presented by caregivers are correlated with higher burden levels and lead to more vulnerability to psychiatric symptoms and health issues.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"17 ","pages":"e20230030"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10727027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}