Dementia e Neuropsychologia最新文献

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Cerebrospinal fluid levels of hypothalamic-pituitary-adrenal axis hormones in MCI and dementia due to Alzheimer's disease: a systematic review. 下丘脑-垂体-肾上腺轴激素在 MCI 和阿尔茨海默病所致痴呆症中的脑脊液水平:系统综述。
Dementia e Neuropsychologia Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0031
Felipe Duarte-Zambrano, Jorge A Barrero, Ismena Mockus
{"title":"Cerebrospinal fluid levels of hypothalamic-pituitary-adrenal axis hormones in MCI and dementia due to Alzheimer's disease: a systematic review.","authors":"Felipe Duarte-Zambrano, Jorge A Barrero, Ismena Mockus","doi":"10.1590/1980-5764-DN-2023-0031","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0031","url":null,"abstract":"<p><p>Underlying the neuropsychological manifestations of Alzheimer's disease (AD), hypothalamic-pituitary-adrenal (HPA) axis dysregulation and subsequent hypercortisolemia have been proposed as major mechanisms driving AD progression from mild cognitive impairment (MCI) to the onset of dementia. Nonetheless, changes in cerebrospinal fluid (CSF) levels of HPA axis hormones remain controversial despite their potential in AD diagnosis and prognosis testing.</p><p><strong>Objective: </strong>This study aimed to review the evidence of the variation in CSF levels of CRH, ACTH, and cortisol in subjects with mild cognitive impairment (MCI) and AD compared with subjects without cognitive disorders.</p><p><strong>Methods: </strong>A systematic review was conducted in MEDLINE, EMBASE, and Web of Science databases on July 5, 2022.</p><p><strong>Results: </strong>Seventeen observational studies were included. The results from the compiled investigations showed that individuals with AD exhibit a significant elevation of CSF cortisol levels which appear to correlate with the presence of the ApoE-ε4 allele, being higher in those homozygous for this allele. The variation of CSF CRH and ACTH levels in AD, on the other hand, is still inconclusive. Moreover, most studies found no significant difference in CSF cortisol levels in individuals with MCI compared to healthy subjects and patients with AD.</p><p><strong>Conclusion: </strong>The findings gathered in this review disclose a significant elevation of CSF cortisol levels in AD. Future investigations are warranted to elucidate the potential use of CSF cortisol as a biomarker in AD-associated dementia.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT. 左撇子非流利型原发性进行性失语症患者的交叉性失语症与左侧不对称脑SPECT。
Dementia e Neuropsychologia Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2022-0095
Paulo Roberto de Brito-Marques, Janaina Mariana de Araujo Miranda Brito-Marques
{"title":"Crossed aphasia in a left-handed patient with non-fluent variant of primary progressive aphasia with left asymmetric brain SPECT.","authors":"Paulo Roberto de Brito-Marques, Janaina Mariana de Araujo Miranda Brito-Marques","doi":"10.1590/1980-5764-DN-2022-0095","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2022-0095","url":null,"abstract":"<p><p>Primary progressive aphasia is a clinical syndrome caused by neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term \"crossed aphasia\" denotes an acquired language dysfunction caused by a lesion in the ipsilateral hemisphere to the dominant hand.</p><p><strong>Objective: </strong>To describe a case of crossed aphasia in a 60-year-old left-handed patient with a non-fluent variant of primary progressive aphasia diagnosis (age of onset=52), evidenced by a left asymmetry on brain SPECT scan.</p><p><strong>Methods: </strong>Clinical and family history, the Edinburgh Handedness Inventory, Measurement of Functional Activities in Older Adults in the Community, the \"Mini-Mental State Examination\", the Trail Making Test, the Tower of London, and the Neuropsychological assessment for dementia, and neuroimaging studies were carried out.</p><p><strong>Results: </strong>Neuropsychological assessment showed severe cognitive impairment, especially regarding language. The magnetic resonance imaging showed important signs of cortico-subcortical atrophy, with predominance in the frontal and temporal lobes. The single-photon emission computed tomography scan showed moderate to severe hypoperfusion in the left cerebral hemisphere, including the hippocampus.</p><p><strong>Conclusion: </strong>We described a clinical case of crossed aphasia in a left-handed woman with a non-fluent variant of primary progressive aphasia with asymmetry on brain SPECT, mainly on the left, followed up for seven years.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of reading and watching fiction on the development of social cognition: a systematic review. 阅读和观看小说对社会认知发展的影响:系统综述。
Dementia e Neuropsychologia Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0066
Júlia Ferreira Rezende, Nadia Shigaeff
{"title":"The effects of reading and watching fiction on the development of social cognition: a systematic review.","authors":"Júlia Ferreira Rezende, Nadia Shigaeff","doi":"10.1590/1980-5764-DN-2023-0066","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0066","url":null,"abstract":"<p><p>Social cognition is an umbrella term used to address the set of neurocognitive processes involved in effective social interaction, such as Theory of Mind and empathy, and is important for understanding of others' intentions and actions and decision making. Narratives can serve as tools for learning social norms and understanding other people, as they involve mental simulations of social interactions. This review aimed to gather the results of current studies on the effects of reading and watching fiction movies on the development of social cognition. We included 16 publications, all of which were empirical studies. The results showed that, depending on individual factors, as well as on the specifics of the intervention, both reading and watching movies seem to influence the processes of development of social cognition, especially if associated with concomitant or subsequent activities, such as discussions. More research is needed to understand the specific details of this relationship.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who are the speech and language therapists who work with primary progressive aphasia in Brazil? An exploratory cross-sectional survey study. 谁是巴西从事原发性进行性失语症治疗的言语和语言治疗师?一项探索性横断面调查研究。
Dementia e Neuropsychologia Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0016
Amanda Gorziza da Silva, Eduardo Kunz Beux, Gabriela Denicol Santos, Luísa Todeschini Englert, Márcia Lorena Fagundes Chaves, Brian Lawlor, Bárbara Costa Beber
{"title":"Who are the speech and language therapists who work with primary progressive aphasia in Brazil? An exploratory cross-sectional survey study.","authors":"Amanda Gorziza da Silva, Eduardo Kunz Beux, Gabriela Denicol Santos, Luísa Todeschini Englert, Márcia Lorena Fagundes Chaves, Brian Lawlor, Bárbara Costa Beber","doi":"10.1590/1980-5764-DN-2023-0016","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2023-0016","url":null,"abstract":"<p><p>Primary Progressive Aphasia (PPA) is a progressive language disorder associated with frontotemporal impairment and mainly affects the left hemisphere of the brain. In general, this condition compromises abilities related to comprehension and expression of language. The diagnosis of PPA depends on in-depth knowledge regarding functions of language, neurology, and neuropsychology. Speech and language therapists (SLTs) have a pivotal role in the diagnosis and rehabilitation of PPA. The absence of these professionals involved in the diagnosis and rehabilitation may reflect on the quality of care of people with PPA.</p><p><strong>Objective: </strong>To identify the sociodemographic, educational, and professional practice characteristics of SLTs who work with people with PPA in Brazil.</p><p><strong>Methods: </strong>An online questionnaire was disseminated to reach SLTs across Brazil. The questionnaire collected information regarding sociodemographics, training and education, practice (time, setting, service provision), and sources of referral.</p><p><strong>Results: </strong>The study included 71 participants (95.8% women). Specialization was the most frequent educational level followed by master's degree, and participants where mainly from the Southeast and South regions of Brazil. Neurologists were the professionals who most referred patients with PPA to SLTs. Finally, SLTs worked primarily in homecare settings and provided mainly individual therapy services.</p><p><strong>Conclusion: </strong>SLTs who work with PPA in Brazil can be characterized mainly as professionals with postgraduate degrees, relatively young, and from the South and Southeast regions of Brazil.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normalization of Rowland Universal Dementia Assessment Scale (RUDAS) in Chilean older people. 智利老年人罗兰德痴呆症通用评估量表(RUDAS)的正常化。
Dementia e Neuropsychologia Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0033
Consuelo Sepúlveda-Ibarra, Fernando Henríquez Chaparro, Anthony Marcotti, Guillermo Soto, Andrea Slachevsky
{"title":"Normalization of Rowland Universal Dementia Assessment Scale (RUDAS) in Chilean older people.","authors":"Consuelo Sepúlveda-Ibarra, Fernando Henríquez Chaparro, Anthony Marcotti, Guillermo Soto, Andrea Slachevsky","doi":"10.1590/1980-5764-DN-2023-0033","DOIUrl":"10.1590/1980-5764-DN-2023-0033","url":null,"abstract":"<p><p>Rowland Universal Dementia Assessment Scale (RUDAS) is a cognitive screening that evaluates older people with low educational levels. In Chile, there are no normative data to assess this population.</p><p><strong>Objective: </strong>To obtain normative data on RUDAS in older Chilean people with up to 12 years of schooling, and to determine whether age and schooling years influence a person's performance on RUDAS and on the items that constitute it.</p><p><strong>Methods: </strong>A group of cognitively healthy people 60 years old or over, with up to 12 schooling years was evaluated (n=135). Multiple regression models were applied to obtain normative data on RUDAS, according to age and schooling years, and to measure the effects of schooling on different items.</p><p><strong>Results: </strong>Regression analysis showed that none of the items had schooling as a significant predictor, except for the visuoconstruction item. The variables age and schooling explained 12.6% (R^2=0.126) of the RUDAS total score variance. The item visuoconstruction was the most associated with the educational level (OR=1,147).</p><p><strong>Conclusion: </strong>This study showed that RUDAS is a recommended instrument for evaluating older people with low educational levels. However, more studies are needed to prove the validity of the RUDAS on Chilean older people.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The presence of depressive symptoms and cognitive performance among older individuals with and without self-reported chronic diseases. 患有和未患有自述慢性疾病的老年人是否存在抑郁症状和认知能力。
Dementia e Neuropsychologia Pub Date : 2023-12-04 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0035
Thaís Bento Lima da Silva, Tiago Nascimento Ordonez, Guilherme Alves da Silva, Maria Antônia Antunes de Souza, Sabrina Aparecida da Silva, Gabriela Dos Santos, Beatriz Aparecida Ozello Gutierrez, Ana Paula Bagli Moreira, Laydiane Alves Costa, Luiz Carlos de Moraes, Patrícia Prata Lessa, Neide Pereira Cardoso, Mitsuru Sakaguchi, Henrique Salmazo da Silva, Sonia Maria Dozzi Brucki
{"title":"The presence of depressive symptoms and cognitive performance among older individuals with and without self-reported chronic diseases.","authors":"Thaís Bento Lima da Silva, Tiago Nascimento Ordonez, Guilherme Alves da Silva, Maria Antônia Antunes de Souza, Sabrina Aparecida da Silva, Gabriela Dos Santos, Beatriz Aparecida Ozello Gutierrez, Ana Paula Bagli Moreira, Laydiane Alves Costa, Luiz Carlos de Moraes, Patrícia Prata Lessa, Neide Pereira Cardoso, Mitsuru Sakaguchi, Henrique Salmazo da Silva, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2023-0035","DOIUrl":"10.1590/1980-5764-DN-2023-0035","url":null,"abstract":"<p><p>Dementias secondary to cardiovascular diseases are the second cause of neurogenerative diseases. These conditions can be prevented by controlling risk factors, and it is necessary to observe the relationship between chronic diseases.</p><p><strong>Objective: </strong>to know the influence of chronic non-communicable diseases on cognition and depressive symptoms in the elderly, amid the COVID-19 pandemic.</p><p><strong>Methods: </strong>578 older adults were evaluated using a sociodemographic questionnaire, the Brazilian Telephone version of the Mini Mental State Examination (Braztel-MMSE), the Geriatric Depression Scale (GDS-15) and an open questionnaire related to NCDs.</p><p><strong>Results: </strong>the association of Non-Communicable Diseases (NCD) with age, depressive symptoms and schooling was confirmed.</p><p><strong>Conclusion: </strong>no association with cognitive decline was evident due to the relationship of high schooling of participants and control of NCDs.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors influencing older adults' satisfaction with caregivers' communication. 影响老年人对照顾者沟通满意度的因素。
Dementia e Neuropsychologia Pub Date : 2023-12-04 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0069
El Mahjoub El Harsi, Ouafa Izel, Abdelhafid Benksim, Mohamed Cherkaoui
{"title":"Factors influencing older adults' satisfaction with caregivers' communication.","authors":"El Mahjoub El Harsi, Ouafa Izel, Abdelhafid Benksim, Mohamed Cherkaoui","doi":"10.1590/1980-5764-DN-2023-0069","DOIUrl":"10.1590/1980-5764-DN-2023-0069","url":null,"abstract":"<p><p>Effective communication skills are crucial for caregivers to provide quality care and meet the unique needs of patients of all ages. However, older patients have specific communication requirements, and their satisfaction depends on several factors.</p><p><strong>Objective: </strong>This study aimed to evaluate the level of satisfaction among older adults in Marrakech, Morocco, regarding the communication skills of their caregivers, and to identify the factors influencing this satisfaction.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted between March and July 2022 among 204 people aged 60 years and older who presented to the Mouhamed VI University Hospital of Marrakech, Morocco, for various care services. The older adults' satisfaction with caregivers' communication was assessed by the American Board of Internal Medicine (ABIM) patient satisfaction questionnaire. Sociodemographic and clinical characteristics of the participants were collected through interview and consultation of medical records. Multiple linear regression was used to determine potential factors influencing the total satisfaction score.</p><p><strong>Results: </strong>The total satisfaction score of older adults with caregiver' communication was 2.55±0.95 and the mean scores of the lowest subscales were answering questions, greeting and listening. Analysis revealed that having visual disorders (B=-0.276±0.12; p=0.029) and receiving affective touch from caregivers (B=0.745±0.12; p=0.001) were the main factors associated with older adults' satisfaction with caregiver' communication.</p><p><strong>Conclusion: </strong>Older people are not sufficiently satisfied with caregivers' communication skills, especially those with vision problems and those who have not received affective touch from caregivers. Caregivers need to be aware of the specific needs of older patients and use appropriate communication techniques.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Floor and ceiling effects on the Montreal Cognitive Assessment in patients with Parkinson's disease in Brazil. 巴西帕金森病患者在蒙特利尔认知评估中的下限和上限效应。
Dementia e Neuropsychologia Pub Date : 2023-12-04 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0022
Brenda Hanae Bentes Koshimoto, Pedro Renato de Paula Brandão, Vanderci Borges, Henrique Ballalai Ferraz, Artur Francisco Schumacher-Schuh, Carlos Roberto de Mello Rieder, Maira Rozenfeld Olchik, Ignacio Fernandez Mata, Vitor Tumas, Bruno Lopes Santos-Lobato
{"title":"Floor and ceiling effects on the Montreal Cognitive Assessment in patients with Parkinson's disease in Brazil.","authors":"Brenda Hanae Bentes Koshimoto, Pedro Renato de Paula Brandão, Vanderci Borges, Henrique Ballalai Ferraz, Artur Francisco Schumacher-Schuh, Carlos Roberto de Mello Rieder, Maira Rozenfeld Olchik, Ignacio Fernandez Mata, Vitor Tumas, Bruno Lopes Santos-Lobato","doi":"10.1590/1980-5764-DN-2023-0022","DOIUrl":"10.1590/1980-5764-DN-2023-0022","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a common neurodegenerative disease associated with cognitive impairment. The Montreal Cognitive Assessment (MoCA) has been used as a recommended global cognition scale for patients with PD, but there are some concerns about its application, partially due to the floor and ceiling effects.</p><p><strong>Objective: </strong>To explore the floor and ceiling effects on the MoCA in patients with PD in Brazil.</p><p><strong>Methods: </strong>Cross-sectional study with data from patients with PD from five Brazilian Movement Disorders Clinics, excluding individuals with a possible diagnosis of dementia. We analyzed the total score of the MoCA, as well as its seven cognitive domains. The floor and ceiling effects were evaluated for the total MoCA score and domains. Multivariate analyses were performed to detect factors associated with floor and ceiling effects.</p><p><strong>Results: </strong>We evaluated data from 366 patients with PD and approximately 19% of individuals had less than five years of education. For the total MoCA score, there was no floor or ceiling effect. There was a floor effect in the abstraction and delayed memory recall domains in 20% of our sample. The ceiling effect was demonstrated in all domains (80.8% more common in naming and 89% orientation), except delayed recall. Education was the main factor associated with the floor and ceiling effects, independent of region, sex, age at evaluation, and disease duration.</p><p><strong>Conclusion: </strong>The floor and ceiling effects are present in specific domains of the MoCA in Brazil, with a strong impact on education. Further adaptations of the MoCA structure for underrepresented populations may reduce these negative effects.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-derived neurotrophic factor interplay with oxidative stress: neuropathology approach in potential biomarker of Alzheimer's disease. 脑源性神经营养因子与氧化应激的相互作用:阿尔茨海默病潜在生物标志物的神经病理学方法。
Dementia e Neuropsychologia Pub Date : 2023-12-04 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2023-0012
Robert Shen, Christian Ardianto, Celia Celia, Veronika Maria Sidharta, Poppy Kristina Sasmita, Irawan Satriotomo, Yuda Turana
{"title":"Brain-derived neurotrophic factor interplay with oxidative stress: neuropathology approach in potential biomarker of Alzheimer's disease.","authors":"Robert Shen, Christian Ardianto, Celia Celia, Veronika Maria Sidharta, Poppy Kristina Sasmita, Irawan Satriotomo, Yuda Turana","doi":"10.1590/1980-5764-DN-2023-0012","DOIUrl":"10.1590/1980-5764-DN-2023-0012","url":null,"abstract":"<p><p>The aging population poses a serious challenge concerning an increased prevalence of Alzheimer's disease (AD) and its impact on global burden, morbidity, and mortality. Oxidative stress, as a molecular hallmark that causes susceptibility in AD, interplays to other AD-related neuropathology cascades and decreases the expression of central and circulation brain-derived neurotrophic factor (BDNF), an essential neurotrophin that serves as nerve development and survival, and synaptic plasticity in AD. By its significant correlation with the molecular and clinical progression of AD, BDNF can potentially be used as an objectively accurate biomarker for AD diagnosis and progressivity follow-up in future clinical practice. This comprehensive review highlights the oxidative stress interplay with BDNF in AD neuropathology and its potential use as an AD biomarker.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a brief digital cognitive test based on the paradigm of stimulus equivalence in a sample of older adults. 在老年人样本中开发和验证基于刺激等效范式的简短数字认知测试。
Dementia e Neuropsychologia Pub Date : 2023-12-04 eCollection Date: 2023-01-01 DOI: 10.1590/1980-5764-DN-2022-0050
Marcos Hortes Nisihara Chagas, Andreza Gomes Spiller Nery, Ana Julia de Lima Bomfim, Natalia Mario Aggio
{"title":"Development and validation of a brief digital cognitive test based on the paradigm of stimulus equivalence in a sample of older adults.","authors":"Marcos Hortes Nisihara Chagas, Andreza Gomes Spiller Nery, Ana Julia de Lima Bomfim, Natalia Mario Aggio","doi":"10.1590/1980-5764-DN-2022-0050","DOIUrl":"10.1590/1980-5764-DN-2022-0050","url":null,"abstract":"<p><p>With the technological advancement and democratization of electronic devices, computerized cognitive tests have been increasingly used in the clinical context to evaluate cognitive performance in individuals.</p><p><strong>Objective: </strong>This study aimed to propose a brief digital cognitive test based on the paradigm of stimulus equivalence and assess its convergent validity by comparing it with traditionally applied tests.</p><p><strong>Methods: </strong>The study was carried out with a non-probabilistic sample of 50 older adults selected from a public call through the communication media, health units, and day centers of a city in the countryside of São Paulo. Participants were assessed by the brief digital cognitive test, Mini-Mental State Examination, Brief Cognitive Screening Battery, and the Five Digit Test.</p><p><strong>Results: </strong>Participants had a mean age of 71.23 years (standard deviation [SD]: ±9.36) and a mean of 7.15 years of schooling (SD: ±5.34). The mean time to answer the test was 5.33 minutes (SD: ±1.92). There were statistically significant correlations between traditional and digital tests in most domains evaluated. In addition, considering the total score of the digital test, the test could discriminate participants with and without cognitive impairment: area under the ROC curve=0.765; 95%CI 0.630-0.901.</p><p><strong>Conclusion: </strong>The brief digital cognitive test, using the stimulus equivalence paradigm, is an easy-to-apply and valid instrument for the investigation of cognitive impairment in older adults.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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