Dementia e Neuropsychologia最新文献

{"title":"Use of transcranial magnetic stimulation in the treatment of nonfluent primary progressive aphasia: a case report.","authors":"Natália Maria Lins Martins, Tathiana Baczynski, Larissa Sena, Romário de Macedo Espíndola, Natia Horato, Antonio Egidio Nardi, Valeska Marinho","doi":"10.1590/1980-5764-DN-2023-0021","DOIUrl":"10.1590/1980-5764-DN-2023-0021","url":null,"abstract":"<p><p>Primary progressive aphasia comprises a group of neurodegenerative diseases characterized by progressive speech and language dysfunction. Neuroimaging (structural and functional), biomarkers, and neuropsychological assessments allow for early diagnosis. However, there is no pharmacological treatment for the disease. Speech and language therapy is the main rehabilitation strategy. In this case report, we describe a female patient diagnosed with nonfluent primary progressive aphasia who underwent sessions of high-frequency transcranial magnetic stimulation in the left dorsolateral prefrontal cortex and showed improvement in depression scores, naming tasks in oral and written speech, and comprehension tasks in oral and written discourse.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>iSupport-Brasil</i> for unpaid caregivers of people living with dementia: protocol for a randomized and controlled clinical trial.","authors":"Aline Cristina Martins Gratão, Anabel Machado Cardoso, Ana Carolina Ottaviani, Camila Rafael Ferreira Campos, Déborah Cristina de Oliveira, Diana Quirino Monteiro, Elizabeth Joan Barham, Fabiana de Souza Orlandi, Gustavo Carrijo Barbosa, Keila Cristianne Trindade da Cruz, Larissa Corrêa, Luana Aparecida da Rocha, Ludmyla Caroline de Souza Alves, Luiza Barros Maciel, Lucélia Silva Nico, Maria Cristina Corrêa Lopes Hoffmann, Sofia Cristina Iost Pavarini","doi":"10.1590/1980-5764-DN-2023-0040","DOIUrl":"10.1590/1980-5764-DN-2023-0040","url":null,"abstract":"<p><p>Unpaid caregivers of people living with dementia tend to suffer mental health problems as a result of the negative effects associated with the care tasks. Thus, psychosocial interventions for this population group are necessary. iSupport is an online support program for caregivers that was created by the World Health Organization.</p><p><strong>Objective: </strong>To describe the design of a randomized clinical trial to measure the efficacy of the <i>iSupport</i>-<i>Brasil</i> version on caregivers' mental health and well-being.</p><p><strong>Methods: </strong>The participants will be randomized into Intervention Group (IG) (n=195) and Control Group (CG) (n=195). For three months, the IG will access the <i>iSupport-Brasil</i> platform, the CG will enter the electronic page of the Brazilian Alzheimer's Association, and both groups will be emailed the preliminary version of the \"<i>Guia de cuidados para a pessoa idosa</i>\" e-book (a guide to providing care to the elderly) from the Ministry of Health. The data will be collected at three moments: baseline, and three and six months after the beginning of the intervention.</p><p><strong>Results: </strong>It is expected that it will be possible to provide diverse validity evidence about <i>iSupport-Brasil</i> as an online and free intervention alternative, as a preventive means and as a way to promote mental health among caregivers of people living with dementia.</p><p><strong>Conclusion: </strong>Through the evaluation protocol of this randomized clinical trial on the effects of the <i>iSupport-Brasil</i> program, it may become a reference for countries that plan to adapt and improve the iSupport program using digital health solutions.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational disparities in Brazil may interfere with the cognitive performance of Parkinson's disease patients.","authors":"Danielle Pessoa Lima, Janine de Carvalho Bonfadini, Alexandre Henrique Silva Carneiro, Samuel Brito de Almeida, Antonio Brazil Viana, Ana Cecília Nogueira E Silva, Jarbas de Sá Roriz, Pedro Braga","doi":"10.1590/1980-5764-DN-2022-0084","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2022-0084","url":null,"abstract":"<p><p>The prevalence of cognitive impairment in Parkinson's disease (PD) is about 20% to 60%. The Mini-Mental Status Examination (MMSE) is the most used cognitive screening test.</p><p><strong>Objective: </strong>To evaluate the influence of clinical and demographic characteristics, specifically the education level, on the MMSE score in PD patients of a northeast Brazilian sample.</p><p><strong>Methods: </strong>We performed a cross-sectional study of 198 PD patients at a Movement Disorders outpatient clinic in Fortaleza, CE, Brazil. Participants were assessed by detailed clinical history, modified Hoehn and Yahr staging (HY), geriatric depression scale (GDS) and MMSE.</p><p><strong>Results: </strong>We found that 68% of patients had MMSE scores below the Brazilian thresholds, which were based in Brucki et al. study (2003). There was a statistically significant difference in the bivariate analysis between educational level and cut-off classification for MMSE. More years of formal schooling were associated with more patients scoring below threshold. We found that 75%, 68.8%, and 79.7% of individuals with more than 11, 9 to 11, and 4 to 8 years of formal schooling, respectively, were below the suggested Brazilian Brucki's threshold. GDS and age were negatively correlated with total MMSE and all its domains. There was no correlation between disease duration and MMSE. Subjects with hallucinations had lower scores.</p><p><strong>Conclusion: </strong>Most of the sample had lower performance according to Brazilian thresholds, but there was no control group and no neuropsychological test in this study. Further studies in northeast Brazil are needed to review MMSE cut-off values.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive profile of patients with and without speech impairment in Parkinson's disease.","authors":"Nariana Mattos Figueiredo Sousa, Juliana de Fátima Garcia Diniz, Ana Paula Galvão, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2022-0093","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2022-0093","url":null,"abstract":"<p><p>Cognitive functions have been the subject of studies evaluating the pathophysiological mechanism of speech control.</p><p><strong>Objective: </strong>To compare the groups of patients with and without speech disorders with cognitive assessment, demographic, and clinical data (disease duration, functionality, and motor symptoms).</p><p><strong>Methods: </strong>Retrospective, cross-sectional study. Patients were evaluated using the Addenbrooke's Cognitive Examination III and neuropsychological tests. The following speech subsystems were analyzed: articulation, phonation, resonance, and prosody, through auditory-perceptual evaluation (based on the Protocol for the Evaluation of Acquired Speech Disorders in Individuals with Parkinson's Disease - PADAF Protocol tests), observing aspects of speech programming and execution. The patients were distributed into three subgroups (normal cognition, mild cognitive impairment, and dementia). After speech evaluation, they were divided into two subgroups (with and without speech disorders).</p><p><strong>Results: </strong>A total of 150 patients participated in this study, 104 men and 46 women, 63.58 (8.81) years of age, 11.03 (4.00) years of schooling, 6.61 (4.69) years of disease progression, and with the highest proportion of individuals in stage I-II of the Hoehn & Yarh (H&Y) scale (86, or 57.33%). Statistically significant differences were observed between subgroups with and without speech alteration. Worse performance was verified in the Trail Making Test (TMT) TMT-Δ and a tendency of difference in the TMT-B of the subgroup with speech disorders, in addition to worse severity of motor symptoms (H&Y) and cognitive complaints.</p><p><strong>Conclusion: </strong>Individuals with speech disorders brought more frequent cognitive complaints and impairment below expected in tests assessing executive functions. Future studies, with stratification by type of speech disorder, are necessary to contribute to and validate these results.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home care for the elderly with dementia: a systematic review.","authors":"Luísa Pelucio, Marcia Cristina Nascimento Dourado, Laiana Azevedo Quagliato, Antonio Egidio Nardi","doi":"10.1590/1980-5764-DN-2022-0052","DOIUrl":"10.1590/1980-5764-DN-2022-0052","url":null,"abstract":"<p><strong>Objetive: </strong>With the global population aging, there is a growing need for home-based care to meet the health needs of the elderly. However, the quality of care provided to the aged population is now arguably a significant challenge for most healthcare systems worldwide.</p><p><strong>Methods: </strong>The present review included 13 original studies on home care and its effects on dementia patients, describing how patient care and adequate treatment can be collaborative for their improvement, for case management, and optimizing pain control and specificities.</p><p><strong>Results: </strong>Among the findings, it was evidenced that the environment impacts the form of care, once being at home can improve communication and global monitoring of dementia patients.</p><p><strong>Conclusion: </strong>In addition to the results analyzed in this review, there is a need for future, well-designed studies on the different aspects of home care, highlighting the importance of evaluating the type of care for each patient in the quest to optimize the care.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication board in locked-in syndrome: a practical interaction method with the patient.","authors":"Gabriel de Deus Vieira, Zenóbio Cosme Gonçalves Ferreira, Lucas Nóbrega, Francisco Saulo Sampaio Cardoso, Eduardo Martins Leal, Rachel Schlindwein","doi":"10.1590/1980-5764-DN-2023-0041","DOIUrl":"10.1590/1980-5764-DN-2023-0041","url":null,"abstract":"<p><p>Locked-in syndrome is a neurological condition characterized by tetraplegia, mutism, preservation of vertical eye movement, superior eyelid movement, and intact consciousness, making it impossible for the patient to communicate properly. We herein describe a case to analyze the practice of developing a method of communication for a patient with locked-in syndrome. Two communication boards were created, adapted to the Portuguese language, as well as a shortcut to inquire about the physical and emotional patient's well-being. We had difficulty with the initial communication board, due to the patient's low education level, so we adapted a new one to the patient's social context, including a shortcut to inquire about physical and emotional well-being. The communication board had a positive impact on treatment development and the patient's life.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adaptation of the everyday cognition scale (M-ECog) in older Mexican adults with cognitive impairment.","authors":"Sara Gloria Aguilar-Navarro,&nbsp;Brenda Lorena Pillajo Sánchez,&nbsp;Lidia Antonia Gutiérrez Gutiérrez,&nbsp;Natalia Arias-Trejo,&nbsp;Yakeel T Quiroz,&nbsp;Alberto José Mimenza Alvarado","doi":"10.1590/1980-5764-DN-2023-0011","DOIUrl":"10.1590/1980-5764-DN-2023-0011","url":null,"abstract":"<p><p>The Everyday Cognition (ECog) scale was created to evaluate the functional abilities of older adults across a wide range of abilities between normal aging and dementia. ECog screens cognitive alterations such as subjective cognitive decline (SCD) and mild cognitive impairment (MCI). This early recognition is done by the measurement of the ability to perform the activities of daily living (ADLs).</p><p><strong>Objective: </strong>To establish the cross-cultural adaptation, validity, and reliability of the ECog Mexican version (M-ECog) in participants with: SCD, MCI, and dementia coming from a memory clinic.</p><p><strong>Methods: </strong>There were 200 patients and their respective informants in a memory clinic of a third level hospital in Mexico City. Four groups were studied: 50 cognitively healthy (CH), 50 SCD, 50 MCI, and 50 dementia. The clinical evaluation included: sociodemographic and health characteristics, cognitive status by the Mini-Mental State Evaluation (MMSE) and Montreal Cognitive Evaluation Spanish version (MoCA-E), and caregiver information (informants) about the difficulty in ADLs as well as the ECog Spanish version (M-ECog).</p><p><strong>Results: </strong>The M-ECog was significantly correlated with MMSE, MoCA-E, and ADLs. It showed the ability to discriminate the different cognitive declines (Cronbach's alpha 0.881). The intra-class correlation coefficient was 0.877 (95% confidence interval - CI, 0.850-0.902; p<0.001). The patient's group area under curve (AUC) of M-ECog for SCD was 0.70 (95%CI 0.58-0.82, p<0.005), for MCI it was 0.94 (95%CI 0.89-0.99, p<0.001) and for dementia 0.86 (95%CI 0.79-0.92, p<0.001).</p><p><strong>Conclusion: </strong>The M-ECog scale proves to be valid and reliable for measuring everyday abilities mediated by cognition. It is self-applicable without requiring extensive prior formation. It is useful to screen for SCD and MCI in older Mexican adults.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family dysfunction and cognitive decline in aging: the \"Health, Wellbeing, and Aging\" (SABE) longitudinal population-based study.","authors":"Diego Ferreira Silva,&nbsp;Juliana Nery Souza-Talarico,&nbsp;Jair Licio Ferreira Santos,&nbsp;Yeda Aparecida Oliveira Duarte","doi":"10.1590/1980-5764-DN-2022-0109","DOIUrl":"10.1590/1980-5764-DN-2022-0109","url":null,"abstract":"<p><p>Stress during aging is not uncommon and dysfunctional family relationships are important sources of stress in the elderly. Considering the potential stressor that family dysfunction represents, it is questioned whether prolonged exposure to dysfunctional family arrangements can contribute to cognitive decline in aging.</p><p><strong>Objective: </strong>To verify whether family dysfunction is a predictive factor of cognitive decline in aging.</p><p><strong>Methods: </strong>Secondary study with analysis of existing data from the longitudinal, population-based study \"Health, Wellbeing and Aging\" (SABE). Data from 791 elderly people from two cohorts of the SABE study between 2006 and 2015 were analyzed. Family dysfunction was assessed using the Apgar family instrument, while cognitive performance was assessed using the Mini-Mental State Examination (MMSE), verbal fluency (animals) and digit length in reverse order. Cognitive decline was measured by the difference in scores in the period between 2006 and 2015.</p><p><strong>Results: </strong>Approximately 10% of the sample had family dysfunction. The familial Apgar score was not associated with decline on MMSE (p=0.732), verbal fluency (p=0.852) and digit span scores (p=0.718). Scores related to cognition and family functionality, such as age, education, living alone, depression and family Apgar, do not explain cognitive decline.</p><p><strong>Conclusion: </strong>The findings indicate that family functioning is not associated with cognitive decline in community-dwelling elderly. New studies will be needed to analyze the qualitative characteristics of family relationships in the cognitive performance of the elderly.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia risk in patients with heart disease and depression.","authors":"Daniel Denisenko,&nbsp;Gladys Ekong,&nbsp;Harlan Spotts","doi":"10.1590/1980-5764-DN-2023-0024","DOIUrl":"10.1590/1980-5764-DN-2023-0024","url":null,"abstract":"<p><p>The high prevalence of Alzheimer's disease and dementia is a growing concern for healthcare systems and patients.</p><p><strong>Objective: </strong>The primary objective of our study was to assess the association of depression and heart disease on the risk of dementias like Alzheimer's disease or vascular dementia in patients.</p><p><strong>Methods: </strong>This retrospective study used electronic health records data that was provided by the HealthVerity™ Marketplace. The characteristics of the patient population were recorded and the risk of dementia was examined using adjusted logistic regression models.</p><p><strong>Results: </strong>The analysis included 49,735 participants and revealed that patients who have heart disease or depression had a higher risk of dementia. Patients who had both heart disease and depression were over three times more likely to have dementia and Alzheimer's disease, and over five times more likely to have vascular dementia compared to patients who only have a diagnosis of heart disease. Depression was associated with a fourfold increase in the risk of dementia. Participants with a diagnosis of most types of heart disease as well as depression had increased risk for developing dementia.</p><p><strong>Conclusion: </strong>This study revealed that patients with both heart disease and depression had increased odds of having dementia as well as vascular dementia and Alzheimer's disease. These findings may serve to support policies and healthcare decision-making to increase preventive measures for dementia and Alzheimer's disease among patients with both depression and heart disease.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of cerebral blood flow on volumetric loss related to Alzheimer's disease.","authors":"Maria Izaura Sedoguti Scudeler Agnollitto,&nbsp;Renata Ferranti Leoni,&nbsp;Maria Paula Foss,&nbsp;Julia Palaretti,&nbsp;Marcela Cayres,&nbsp;Vitor Pansarim,&nbsp;Julio Cesar Nather,&nbsp;Maria Clara Zanon Zotin,&nbsp;Eduardo Ferrioli,&nbsp;Nereida Kilza Lima,&nbsp;Antonio Carlos Dos Santos,&nbsp;Julio Cesar Moriguti","doi":"10.1590/1980-5764-DN-2023-0004","DOIUrl":"10.1590/1980-5764-DN-2023-0004","url":null,"abstract":"<p><p>CBF measured with Arterial Spin Labeling (ASL) obtained by Magnetic Resonance Imaging (MRI) may become an important biomarker by showing changes in early stages of AD, such as in the prodromal stage of Mild Cognitive Impairment (MCI).</p><p><strong>Objective: </strong>Verify the correlation between atrophy and CBF in patients with MCI and mild phase ADD, to demonstrate whether changes in CBF can be considered as vascular biomarkers in the diagnosis of the DA continuum.</p><p><strong>Methods: </strong>11 healthy volunteers, 16 MCI and 15 mild ADD were evaluated. Images of the brain were acquired, including CBF measured with Arterial Spin Labeling (ASL).</p><p><strong>Results: </strong>When comparing MCI with control, a reduction in normalized CBF was observed in left posterior cingulate (estimated difference -0.38; p=0.02), right posterior cingulate (estimated difference -0.45; p=0.02) and right precuneus (estimated difference -0.28; p <0.01); also increase in normalized CBF in right upper temporal pole (estimated difference 0.22; p=0.03). It was also observed that in MCI, the smaller the gray matter volume, the smaller the CBF in the left posterior cingulate; as well as the greater the cerebrospinal fluid volume, consequent to the encephalic volumetric reduction associated with atrophy, the greater the CBF in the right superior temporal pole. When comparing controls, MCI and mild AD, in relation to the other variables, no other correlations were observed between CBF and atrophy.</p><p><strong>Conclusion: </strong>In patients with MCI, the reduction of CBF in the left posterior cingulate correlated with gray matter atrophy, as well as the increase of CBF in the right upper temporal pole correlated with an increase in cerebrospinal fluid consequent to the encephalic volumetric reduction associated with atrophy, demonstrating the influence of CBF in AD related brain atrophy. These findings position CBF as a possible vascular biomarker for early-stage AD diagnoses.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}