Dementia e Neuropsychologia最新文献

{"title":"Systematic review of Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR) studies: normative data, clinical validity, and correlations with biomarkers.","authors":"Priscila Mara Lorencini Selingardi, Clarisse Vasconcelos Friedlaender, Murilo Ricardo Zibetti, Gabriela Cabral Paciência, Paulo Caramelli, Mônica Sanches Yassuda","doi":"10.1590/1980-5764-DN-2025-0399","DOIUrl":"10.1590/1980-5764-DN-2025-0399","url":null,"abstract":"<p><p>The Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR), developed by Grober and Buschke, is widely used to assess episodic memory and detect impairments, particularly in Alzheimer's disease (AD). Recommended by the International Working Group (IWG) for early diagnosis, no prior review has synthesized its findings. This study reviewed articles on norms, clinical validity, and correlations with neuropathological biomarkers. Sixty-four studies were selected out of 728, covering normative data, clinical validation, and biomarker associations. The FCSRT-IR has normative data from seven countries and shows high diagnostic accuracy for mild cognitive impairment (MCI) and dementia, especially AD. In 20 studies, test scores significantly correlated with AD biomarkers. Thus, the FCSRT-IR supports early identification of episodic memory deficits, proving to be a valuable neuropsychological assessment tool.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250399"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia's mortality in America: a local, regional, and temporal evaluation.","authors":"Lucas Casagrande Passoni Lopes","doi":"10.1590/1980-5764-DN-2025-0298","DOIUrl":"10.1590/1980-5764-DN-2025-0298","url":null,"abstract":"<p><p>Dementia is a leading global health challenge. Despite its burden, data from American countries remain scarce and fragmented. This lack of robust evidence impedes regional planning and policy-making.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the temporal trends of dementia's mortality in America with a local and regional approach.</p><p><strong>Methods: </strong>This ecological time-series study analyzed age-adjusted dementia mortality rates across American countries between 2000 and 2019. Data were obtained from Pan American Health Organization and cross-validated with national and international sources. Joinpoint regression was used to estimate annual percent change, identifying significant temporal trends in mortality.</p><p><strong>Results: </strong>Between 2000 and 2019, dementia mortality rates were highest in the Insular Americas and varied widely across countries. The United States, Canada, and several Central and South American nations exhibited elevated rates, while others, such as Paraguay and Venezuela, reported consistently low values. National trends were heterogeneous, with some countries showing steady declines and others persistent or erratic increases.</p><p><strong>Conclusion: </strong>This study highlights significant temporal trends in American dementia mortality, identifying critical areas for public health intervention and offering a foundation for future research on healthcare equity and cancer outcomes.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250298"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-Mental State Examination for telephone use in highly educated and socially active older adults: a descriptive study.","authors":"Thaís Bento Lima da Silva, Gabriela Dos Santos, Tiago Nascimento Ordonez, Sabrina Aparecida da Silva, Maria Antônia Antunes Fernandes, Wellington Lourenço Oliveira, Diana Dos Santos Bacelar, Laydiane Alves Costa, Ana Paula Bagli Moreira, Edna Letícia Queiroz, Gabriela Cristina Siqueira, Rosa Yuka Sato Chubaci, Henrique Salmazo da Silva, Beatriz Aparecida Ozello Gutierrez, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2025-0365","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2025-0365","url":null,"abstract":"<p><p>With population aging, the growing concern about cognitive decline and dementias highlights the need for early and accessible cognitive assessment. In this context, a telephone-adapted version of the Mini-Mental State Examination, the Brazilian Telephone Version of the Mini-Mental State Examination (Braztel-MMSE), was developed.</p><p><strong>Objective: </strong>The aim of the study was to compare cognitive performance assessed by the Braztel-MMSE, administered by telephone, with the traditional Mini-Mental State Examination (MMSE), administered in person, in highly educated older adults without diagnosed dementia or depression, and who are socially engaged.</p><p><strong>Methods: </strong>This is a descriptive cross-sectional study. The initial sample consisted of 578 older adults who completed the Braztel-MMSE during the screening phase of a clinical trial. Of these, a subsample of 190 older adults completed the traditional MMSE after 18 months. Data were analyzed descriptively and inferentially to compare scores obtained from both instruments.</p><p><strong>Results: </strong>The results showed a significant correlation between scores on the Braztel-MMSE and the traditional MMSE (Spearman's rho=0.354, p<0.001). Bland-Altman analysis revealed satisfactory agreement between the two cognitive assessment methods, with a mean difference of 0.002 between scores.</p><p><strong>Conclusion: </strong>This study demonstrates that the telephone-administered Braztel-MMSE shows good agreement with the traditional face-to-face MMSE. These findings suggest that the Braztel-MMSE can be a useful and valid tool for cognitive screening in contexts where in-person evaluation is not feasible, including long-term clinical trials.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250365"},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12843192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalizations due to Alzheimer's disease in Brazil during the COVID-19 pandemic: an update on frequency, mortality, and costs.","authors":"Pedro Carrión Carvalho, Giovana Busnardo Voltolini, Amanda Goedert, Vitória Kovari Carmona Chiaratti, Eduardo Holsbach Cantarelli, Júlia Costa Francisco, Tanize Bechorner Almeida, Ismael Paulo Burigo","doi":"10.1590/1980-5764-DN-2025-0322","DOIUrl":"10.1590/1980-5764-DN-2025-0322","url":null,"abstract":"<p><p>Hospitalizations related to Alzheimer's disease (AD) impose a growing burden on health systems, but recent, nationally representative estimates for Brazil are limited.</p><p><strong>Objective: </strong>To describe the epidemiological profile of hospital admissions due to AD in Brazil from 2018 to 2024.</p><p><strong>Methods: </strong>Ecological time-series study using the Hospital Information System of the Brazilian Unified Health System (SIH/SUS), accessed via the Department of Informatics of the SUS (DATASUS). We included all regions and states from January 2018 to December 2024. Admissions were identified by the International Classification of Diseases, 10^th Revision (ICD-10) codes G30.0-G30.9 and F00.0-F00.9. Variables comprised sex, age group, race/color, admission type (urgent/elective), in-hospital mortality, length of stay, and hospital costs. Temporal trends were evaluated with linear regression.</p><p><strong>Results: </strong>From 2018 to 2024, 11,212 AD-related hospitalizations were recorded; 79.4% were urgent. The Southeast had the highest absolute number (47.8%), followed by the South (25.1%), Northeast (17.2%), Midwest (6.5%), and North (3.4%). Females accounted for 65% of admissions and 64.7% of in-hospital deaths. Older adults, especially those ≥80 years, represented most hospitalizations (59.3%) and deaths (69.7%). Total hospital expenditures exceeded R$ 14 million, with the Southeast concentrating >60% of national costs. No significant linear trend was detected in annual rates.</p><p><strong>Conclusion: </strong>Urgent admissions comprised the majority of AD hospitalizations nationwide, with the Southeast presenting the highest numbers. The predominance of older female patients and high in-hospital mortality underscore the need for targeted clinical and public health strategies. Rising expenditures reinforce investment in health infrastructure and long-term dementia-care policies in Brazil.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250322"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Logopenic variant of primary progressive aphasia in a bilingual non-Alzheimer's disease octogenarian.","authors":"Ícaro Araújo de Sousa, Bruno Henrique Carneiro Costa, Isabel Junqueira de Almeida, Maria Teresa Carthery-Goulart, Marcelo Houat de Brito, Matheus Miranda de Holanda, Tibor Rilho Perroco, Regina Miksian Magaldi, Sonia Maria Dozzi Brucki","doi":"10.1590/1980-5764-DN-2025-0379","DOIUrl":"10.1590/1980-5764-DN-2025-0379","url":null,"abstract":"<p><p>A highly educated and intellectually active 84-year-old male presented with word-finding pauses and impaired sentence repetition, with preserved single-word comprehension, reading, and writing, a clinical profile consistent with the logopenic variant of primary progressive aphasia (lvPPA). Interestingly, the initial symptom was difficulty with auditory verbal comprehension in Portuguese, his second language, while comprehension in English remained initially preserved. Structural and functional imaging revealed no atrophy in the temporoparietal region or cortical hypometabolism. Plasma biomarkers, including Aβ42/40 and plasma-measured tau phosphorylated at threonine 217 (p-tau217), were within normal limits, arguing against biological Alzheimer's disease (AD). This case illustrates a rare constellation of findings - bilingual asymmetry, negative AD biomarkers, and unremarkable neuroimaging - suggestive of a non-Alzheimer's pathology. Alternative etiologies such as primary age-related tauopathy (PART) and argyrophilic grain disease (AGD) are discussed, emphasizing the utility of fluid biomarkers in distinguishing phenocopies within the lvPPA spectrum.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250379"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community knowledge of dementia: a cross-sectional study in the Southeast region of Brazil.","authors":"Laura Costa de Oliveira Lima, Bruna de Bonifácio Heck, Nami Dezotti, Julia Mikami Kato, Thiago Issa, Maria Izaura Sedoguti Scudeler Agnollitto, Nereida Kilza da Costa Lima, Julio Cesar Moriguti","doi":"10.1590/1980-5764-DN-2025-0323","DOIUrl":"10.1590/1980-5764-DN-2025-0323","url":null,"abstract":"<p><p>There is a gap in the literature regarding popular knowledge about dementia. Although dementia affects older individuals more frequently, it does not belong to senescence. Lack of awareness contributes to the normalization of cognitive decline, delaying the search for healthcare services, diagnosis, and treatments.</p><p><strong>Objective: </strong>Assess the population's knowledge about dementia and its relationship with socioeconomic characteristics.</p><p><strong>Methods: </strong>Cross-sectional study with a semi-structured questionnaire administered in person to a convenience sample of residents of Ribeirão Preto, São Paulo, Brazil. Descriptive and inferential statistical analyses were conducted. Significance level: p<0.05.</p><p><strong>Results: </strong>Three hundred residents were interviewed. Among them, 189 (63%) were unaware of the meaning of dementia. In a multivariable regression, higher income increased the odds of knowing what dementia is compared to the lowest income group (adjusted Odds Ratio [aOR]=4.29, 95% confidence interval [95%CI] 1.40-14.11, <i>p</i>=0.013). Working in healthcare (aOR=3.30, 95%CI 1.24-9.66, <i>p</i>=0.021) or having relatives in this sector (aOR=2.16, 95%CI 1.16-4.07, <i>p</i>=0.016) increased the probability of awareness. Limited awareness of risk factors was observed, along with the normalization of dementia signs and symptoms, which were commonly perceived as part of normal aging.</p><p><strong>Conclusion: </strong>Significant lack of knowledge on the subject was observed, particularly among socioeconomic vulnerable individuals. Dementia was not widely recognized as a pathological and preventable condition. Given an aging society, this study provides a critical foundation for future public health initiatives and research aimed at improving dementia literacy and promoting early intervention.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250323"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke caused by cerebral amyloid angiopathy: a case of difficult diagnosis.","authors":"Rocío Campos Gamarra, Carla Villanueva Colina, Jimmy Palacios-García","doi":"10.1590/1980-5764-DN-2025-0288","DOIUrl":"10.1590/1980-5764-DN-2025-0288","url":null,"abstract":"<p><p>Cerebral amyloid angiopathy is a common cause of intracerebral hemorrhage, most often occurring in older adults and in patients with dementia. One of its main differential diagnoses is hypertensive intracerebral hemorrhage. This is a case report of a hypertensive male patient who presented to the emergency department with short-term amnesia and Broca's aphasia. The initial diagnosis was hemorrhagic stroke of hypertensive etiology. However, subsequent diagnostic tests revealed that the bleeding was due to amyloid angiopathy. This case highlights the similarities and differences in the diagnosis and management of both etiologies, emphasizing the importance of establishing an accurate and timely differential diagnosis.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"20 ","pages":"e20250288"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12714328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Recurrent transient global amnesia related to dural arteriovenous fistula.","authors":"","doi":"10.1590/1980-5764-DN-2024-0222-ER","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0222-ER","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1590/1980-5764-DN-2024-0222.].</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Normative data of the Spanish version of the Montreal Cognitive Assessment (MoCA) in older individuals from Peru.","authors":"","doi":"10.1590/1980-5764-DN-2024-0261-ER","DOIUrl":"https://doi.org/10.1590/1980-5764-DN-2024-0261-ER","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1590/1980-5764-DN-2024-0261.].</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Brazilian version of the \"Caregiver Guilt Questionnaire\" (CGQ-BR).","authors":"Katia Carreira Pfutzenreuter, Andrés Losada-Baltar, María Márquez-González, Deusivania Vieira da Silva Falcão","doi":"10.1590/1980-5764-DN-2025-0325","DOIUrl":"10.1590/1980-5764-DN-2025-0325","url":null,"abstract":"<p><p>The \"Caregiver Guilt Questionnaire\" CGQ was originally developed in Spain and contains 22 self-report items covering the following factors: guilt about doing wrong by the care recipient, guilt about failing to meet the challenges of caregiving, guilt about self-care, guilt over feeling negative emotions while caregiving, and guilt about neglecting other relatives.</p><p><strong>Objective: </strong>To analyze the psychometric properties of the Brazilian version of the CGQ.</p><p><strong>Methods: </strong>The sample was established for convenience, consisting of 153 family caregivers of people with Alzheimer's disease. The following measures were applied: a sociodemographic questionnaire, the CGQ, the Depression, Anxiety and Stress Scale (DASS-21), and the Life Satisfaction Scale. An exploratory factor analysis was performed for analyzing construct validity to obtain evidence of validity with internal structure and external correlation measures.</p><p><strong>Results: </strong>The exploratory factor analysis identified five factors with 22 items, which explained 71% of the total variance. Criterion validity was supported by positive associations between CGQ-BR scores and levels of depression, anxiety, and stress, and a negative association with life satisfaction. Good to excellent reliability indexes were found for the total score and subscales.</p><p><strong>Conclusion: </strong>The psychometric properties of the CGQ-BR, when applied to a sample of family caregivers of people with Alzheimer's disease in the Brazilian population, proved to be a valid tool for measuring feelings of guilt. The findings suggest that this tool can be used in clinical and research settings with caregivers.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":"19 ","pages":"e20250325"},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}