Regina Wilson, Halil Tekiner, Steven H Yale, Eileen S Yale
{"title":"Scorpion sting without Kounis syndrome or tako-tsubo cardiomyopathy.","authors":"Regina Wilson, Halil Tekiner, Steven H Yale, Eileen S Yale","doi":"10.1016/j.rec.2025.04.008","DOIUrl":"10.1016/j.rec.2025.04.008","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Fernández Ruiz, Martín Ruiz Ortiz, Consuelo Fernández-Avilés Irache, Ana María Rodríguez Almodóvar, Mónica Delgado Ortega, Fátima Esteban Martínez, Adriana Resúa Collazo, Gloria Heredia Campos, Rafael González Manzanares, José López Aguilera, Juan Carlos Castillo Domínguez, Manuel Anguita Sánchez, Manuel Pan Álvarez-Ossorio, Dolores Mesa Rubio
{"title":"Right ventricular-pulmonary arterial coupling as a predictor of death or heart failure admission in patients with severe tricuspid regurgitation.","authors":"Ana Fernández Ruiz, Martín Ruiz Ortiz, Consuelo Fernández-Avilés Irache, Ana María Rodríguez Almodóvar, Mónica Delgado Ortega, Fátima Esteban Martínez, Adriana Resúa Collazo, Gloria Heredia Campos, Rafael González Manzanares, José López Aguilera, Juan Carlos Castillo Domínguez, Manuel Anguita Sánchez, Manuel Pan Álvarez-Ossorio, Dolores Mesa Rubio","doi":"10.1016/j.rec.2025.04.009","DOIUrl":"10.1016/j.rec.2025.04.009","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>The right ventricular-pulmonary arterial coupling, evaluated by tricuspid annular plane systolic excursion and pulmonary artery systolic pressure ratio (TAPSE/PASP), has been studied in the prognostic assessment of severe tricuspid regurgitation only in selected populations and mainly in relation to all-cause mortality.</p><p><strong>Methods: </strong>We retrospectively included all adult patients with severe tricuspid regurgitation who underwent echocardiography at a tertiary care hospital between January 1, 2008, and December 31, 2017. We investigated the association of TAPSE/PASP, either as a continuous variable or dichotomized at <0.31mm/mmHg, with the combined endpoint of mortality and heart failure (HF) admission, as well as its usefulness in several subgroups of interest.</p><p><strong>Results: </strong>A total of 474 patients (70±13 years; 71% women) were included, with a median follow-up of 5 [p25-75, 2-7] years. During follow-up, 285 patients died and 192 experienced 481 HF admissions. Patients with TAPSE/PASP <0.31mm/mmHg had significantly worse HF admission-free survival at median follow-up (25% vs 53%, P <.0005). The discriminative ability of TAPSE/PASP was statistically significant (area under the curve, 0.69; 95%CI, 0.65-0.74; P <.0005). After multivariate adjustment, TAPSE/PASP remained an independent predictor of the combined endpoint (HR, 0.017; 95%CI, 0.004-0.075; P <.0005), with significant incremental prognostic value over clinical variables (P <.0005). The performance of the index was consistent in patients with pacemaker/defibrillator leads or prior cardiac surgery, but not in those with reduced ejection fraction.</p><p><strong>Conclusions: </strong>In this cohort of patients with severe tricuspid regurgitation, TAPSE/PASP was a strong independent predictor of HF admission or mortality during long-term follow-up.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Ortiz-Bautista, Luis Almenar-Bonet, David Couto-Mallón, José González-Costello, Javier Segovia-Cubero, Diego Rangel-Sousa, Joan Guzmán-Bofarull, Antonia Pomares-Varó, Juan F Delgado-Jiménez, Beatriz Díaz-Molina, Iris P Garrido-Bravo, Teresa Blasco-Peiró, María Del Val Groba Marco, Javier Muñiz-García, Francisco González-Vílchez
{"title":"Severe primary graft dysfunction after heart transplant: trends and outcomes in a contemporary Spanish cohort.","authors":"Carlos Ortiz-Bautista, Luis Almenar-Bonet, David Couto-Mallón, José González-Costello, Javier Segovia-Cubero, Diego Rangel-Sousa, Joan Guzmán-Bofarull, Antonia Pomares-Varó, Juan F Delgado-Jiménez, Beatriz Díaz-Molina, Iris P Garrido-Bravo, Teresa Blasco-Peiró, María Del Val Groba Marco, Javier Muñiz-García, Francisco González-Vílchez","doi":"10.1016/j.rec.2025.04.006","DOIUrl":"10.1016/j.rec.2025.04.006","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Severe primary graft dysfunction (PGD) is the leading cause of early mortality following heart transplant (HT). This study analyzed the temporal trends and mortality associated with severe PGD, identified risk factors, and developed a predictive model based on a contemporary cohort.</p><p><strong>Methods: </strong>A total of 2029 HT performed between 2010 and 2020 in 14 Spanish centers were retrospectively analyzed. Patients with and without severe PGD were compared. Logistic regression was used to identify predictors of severe PGD and to generate a risk score. Model performance was assessed in terms of calibration and discrimination.</p><p><strong>Results: </strong>The incidence of severe PGD was 10%, with an increase observed over the last 5 years (8% vs 11%). However, 30-day and 1-ear mortality declined significantly (59.1% vs 38.8% and 69.7% vs 58.8%, respectively). Independent predictors of severe PGD included extracorporeal membrane oxygenation (OR, 2.79), pretransplant ventricular assist devices (OR, 2.11), donor-to-recipient weight ratio <0.8 (OR, 2.11), and congenital heart disease (OR, 2.11). A risk score was created, showing good calibration but limited discriminative ability.</p><p><strong>Conclusions: </strong>Despite a rising incidence of severe PGD, mortality showed a marked decrease. Predictors of severe PGD included congenital heart disease, a donor-to-recipient weight ratio <0.8, and the use of extracorporeal membrane oxygenation or pretransplant ventricular assist devices. The predictive model showed good calibration but only moderate discriminative performance.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atrial fibrillation and myocardial infarction: a bidirectional relationship with more questions than answers.","authors":"Alfredo Bardají, Gabriel Martín, Sandra Cabrera","doi":"10.1016/j.rec.2025.02.022","DOIUrl":"10.1016/j.rec.2025.02.022","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epicardial atrial flutter bridge. Not too deep to go.","authors":"Alejandro Carta-Bergaz, Ángel Arenal-Maíz","doi":"10.1016/j.rec.2025.04.003","DOIUrl":"10.1016/j.rec.2025.04.003","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Barriales-Villa, Luis Escobar-López, David Vilanova Larena, Joel Salazar-Mendiguchía, Ainara Echeto, Ignacio Hernández, Elena Rebollo-Gómez, Juan Ramón Gimeno
{"title":"Clinical management and healthcare resource utilization among patients with obstructive hypertrophic cardiomyopathy in Spain: a real-world study.","authors":"Roberto Barriales-Villa, Luis Escobar-López, David Vilanova Larena, Joel Salazar-Mendiguchía, Ainara Echeto, Ignacio Hernández, Elena Rebollo-Gómez, Juan Ramón Gimeno","doi":"10.1016/j.rec.2025.04.004","DOIUrl":"10.1016/j.rec.2025.04.004","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Obstructive hypertrophic cardiomyopathy (oHCM), whose symptoms range from dyspnea to heart failure or sudden cardiac death, accounts for approximately 70% of all hypertrophic cardiomyopathy cases. This study aimed to analyze the lack of comprehensive data on oHCM management and determine its clinical and economic burden in Spain.</p><p><strong>Methods: </strong>This retrospective observational study, based on electronic medical records (BIG-PAC), enrolled adults from 1 January 2014, to 31 October 2022, from the time of HCM diagnosis. The analysis focused on epidemiology, patient characteristics and management, transitions between New York Heart Association (NYHA) functional classes, healthcare resource utilization (HCRU), and associated costs.</p><p><strong>Results: </strong>A total of 752 oHCM patients were included (mean age: 63 years; male: 57.6%). NYHA functional classification at diagnosis was as follows: 12% NYHA-I, 47.9% NYHA-II, 31.5% NYHA-III, and 8.6% NYHA-IV. The prevalence of HCM and oHCM was 28 and 7 per 10 000 individuals, respectively. Patients received a mean of 2.4 (SD 1.5) treatments, mainly beta-blockers. Only patients in NYHA classes III and IV underwent septal reduction therapies (SRT) (13.1% and 47.7%, respectively); 38.7% and 35.5% of NYHA-III and -IV patients who received SRT, respectively, improved to a lower NYHA class. Symptom severity, as measured by NYHA class, was associated with increased rates of hospitalization, cardiovascular events, mortality, and higher HCRU and costs. Mean annualized, direct, adjusted health care costs ranged from €4142 (95%CI: €3110-€5175) in NYHA-I to €16 677 (95%CI: €15 482-€17 872) in NYHA-IV.</p><p><strong>Conclusions: </strong>This is the first Spanish study to evaluate oHCM patient management and to demonstrate its impact in terms of increased hospitalizations, mortality, HCRU, and healthcare costs, trends that parallel the progression of symptoms by NYHA functional class. Patients who underwent SRT showed partial symptom improvement.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}