{"title":"From the stethoscope to artificial intelligence: decoding tricuspid disease.","authors":"Covadonga Fernández-Golfín, Ana García-Martín","doi":"10.1016/j.rec.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.rec.2025.03.011","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge Sanz-Sánchez, Sandra Santos Martínez, Eva Rumiz González, Juan Francisco Oteo Domínguez, David Tejada Ponce, Antonio Gómez Menchero, Guillermo Sánchez Elvira, Georgina Fuertes Ferre, Fernando Rivero Crespo, Antonela Lukic Otanovic, José Díaz Fernández, Eladio Galindo Fernández, Cristóbal Urbano Carrillo, Neus Salvatella Giralt, Mauricio Torres Sánchez, Arturo García Touchard, Borja Ibáñez Cabeza, Giulio Stefanini, Fernando Alfonso Manterola, Héctor García García, Ignacio J Amat-Santos
{"title":"Reduced stent strategy versus conventional percutaneous coronary revascularization in patients presenting with STEMI: the COPERNICAN trial.","authors":"Jorge Sanz-Sánchez, Sandra Santos Martínez, Eva Rumiz González, Juan Francisco Oteo Domínguez, David Tejada Ponce, Antonio Gómez Menchero, Guillermo Sánchez Elvira, Georgina Fuertes Ferre, Fernando Rivero Crespo, Antonela Lukic Otanovic, José Díaz Fernández, Eladio Galindo Fernández, Cristóbal Urbano Carrillo, Neus Salvatella Giralt, Mauricio Torres Sánchez, Arturo García Touchard, Borja Ibáñez Cabeza, Giulio Stefanini, Fernando Alfonso Manterola, Héctor García García, Ignacio J Amat-Santos","doi":"10.1016/j.rec.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.rec.2025.05.005","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Primary percutaneous coronary intervention (PCI) with drug-eluting stent implantation (DES) is the standard of treatment in patients presenting with ST-segment elevation myocardial infarction (STEMI). However, target lesion failure can occur due to stent underexpansion, malapposition, hypersensitivity, fracture, and neoatherosclerosis. Drug-coated balloons (DCB) represent a potential alternative supported by the concept of \"leaving nothing behind.\" The aim is to compare a reduced stent strategy based on DCB- with DES-PCI in patients presenting with STEMI.</p><p><strong>Methods: </strong>Prospective, pragmatic, multicenter, noninferiority, randomized clinical trial.</p><p><strong>Results: </strong>A total of 1 272 patients presenting with STEMI will be randomized to any paclitaxel-DCB vs any sirolimus-DES (both with CE approval) for all culprit and nonculprit lesions during PCI. The primary endpoint will be target-lesion failure: cardiac death, target-vessel myocardial infarction, or ischemia-driven target lesion revascularization at 12-month follow-up. An independent clinical events committee masked to treatment allocation will adjudicate all suspected events. Clinical follow-up will be performed after 1 month (30 days ± 5 days) and 1 year (365 days ± 30 days). An extended follow-up at 3, 5, and 10 years is planned..</p><p><strong>Conclusions: </strong>The COPERNICAN trial will be the first randomized study comparing clinical outcomes of DCB vs DES in STEMI patients.</p><p><strong>Clinicaltrials: </strong>gov: NCT06353594.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio Cinza-Sanjurjo, Pilar Mazón-Ramos, Daniel Rey-Aldana, Alfonso Varela-Román, Manuel Portela-Romero, José R González-Juanatey
{"title":"The continuity of care in primary care is associated with a more favorable prognosis in patients referred to a cardiology service.","authors":"Sergio Cinza-Sanjurjo, Pilar Mazón-Ramos, Daniel Rey-Aldana, Alfonso Varela-Román, Manuel Portela-Romero, José R González-Juanatey","doi":"10.1016/j.rec.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.rec.2025.03.010","url":null,"abstract":"<p><p>Introduction and objectives To analyze the relationship between continuity of care in primary care and hospitalizations and mortality among patients referred from primary care to a cardiology service. Methods Continuity of care was assessed using 3 measures: a) whether the referral was made by the patient's regular family medicine physician (FMP) or a different FMP, b) FMP turnover within a patient panel, and c) turnover of the referring FMP among different patient panels. The association between continuity of care and hospitalizations and mortality was assessed using a multivariate analysis, with adjustment for potential confounding variables. The results are expressed as odds ratios (OR) with 95% confidence intervals (95%CI). Results A total of 67 889 patients, referred from 2010 to 2023, were included, of whom 80.5% were referred by their FMP. Patients referred by an FMP other than their own had a higher annual referral rate (2.3 [2.9]) vs 1.5 [0.6]); P < .001) and were assigned to panels with a higher referral rate (10.5 [12.7] vs 1.6 (1.1]; P < .001). Patients referred by their FMP had a lower risk of overall hospitalizations (OR, 0.90; 95%CI, 0.86-0.94), hospitalizations for cardiovascular causes (OR, 0.88; 95%IC, 0.82-0.95), all-cause mortality (OR, 0.84; 95%CI, 0.80-0.89), cardiovascular-related mortality (OR, 0.86; 95%CI, 0.78-0.96), and heart failure-related mortality (OR, 0.77; 95%CI, 0.66-0.89). Conclusions Continuity of care, measured by the persistence of the FMP within the same patient panel, improves health outcomes by reducing hospitalizations and mortality, as well as the number of cardiology service referrals. Full English text available from: www.revespcardiol.org/en.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Rubini Giménez, Luca Koechlin, Pedro López-Ayala, Carlos Spagnuolo, Jasper Boeddinghaus, Karin Wildi, Thomas Nestelberger, Hanna Tkachenko, Daniel Basic, Emel Kaplan, Jude Formambuh, Paolo Bima, Jonas Glaeser, Luca Crisanti, Óscar Miró, F Javier Martín-Sánchez, Michael Christ, Dagmar I Keller, Danielle M Gualandro, Damian Kawecki, Katharina Rentsch, Andreas Buser, Ivo Strebel, Felix Mahfoud, Christian Mueller
{"title":"Clinical implications of sex-specific upper reference limits for high-sensitivity cardiac troponin I in myocardial infarction diagnosis.","authors":"María Rubini Giménez, Luca Koechlin, Pedro López-Ayala, Carlos Spagnuolo, Jasper Boeddinghaus, Karin Wildi, Thomas Nestelberger, Hanna Tkachenko, Daniel Basic, Emel Kaplan, Jude Formambuh, Paolo Bima, Jonas Glaeser, Luca Crisanti, Óscar Miró, F Javier Martín-Sánchez, Michael Christ, Dagmar I Keller, Danielle M Gualandro, Damian Kawecki, Katharina Rentsch, Andreas Buser, Ivo Strebel, Felix Mahfoud, Christian Mueller","doi":"10.1016/j.rec.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.rec.2025.05.003","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>It is unclear whether applying sex-specific rather than uniform upper reference limits (URLs) for high-sensitivity cardiac troponin I (hs-cTnI) improves diagnostic equity between women and men with suspected myocardial infarction (MI). We compared the diagnostic performance of these 2 approaches.</p><p><strong>Methods: </strong>In an international, prospective, multicenter study of patients presenting with suspected MI, the final diagnosis was centrally adjudicated twice by 2 independent cardiologists using all available information, including serial measurements of hs-cTnI-Architect, once using the uniform URL (26.2 ng/L) and once using sex-specific URLs (women: 15.6 ng/L; men: 34.2 ng/L). The primary outcome was the diagnostic performance of uniform vs sex-specific URLs at presentation for MI.</p><p><strong>Results: </strong>Among 7137 eligible patients, 2434 were women (34%), median age 65 years, and 4703 were men (66%), median age 59 years. Using the uniform URL, 348 women and 880 men were adjudicated as having MI. At presentation, the sensitivity and specificity of hs-cTnI were high and similar in women (77%; 95%CI, 72-81, and 93%; 95%CI, 92-94, respectively) and men (79%; 95%CI, 77-82, and 94%; 95%CI, 93-94). Using sex-specific URLs, the sensitivity and specificity were 85% (95%CI, 81-89) and 91% (95%CI, 89-92) in women vs 74% (95%CI, 71-77), and 95% (95%CI, 94-95) in men (P < .001). Using sex-specific URLs, diagnostic reclassification occurred in 27 patients, 12 women (upgrade to MI) and 15 men (downgrade from MI), representing 0.4%, (95%CI, 0.3-0.6) of all patients.</p><p><strong>Conclusions: </strong>Using a uniform URL for hs-cTnI provides high and similar diagnostic sensitivity and specificity in women and men. Contrary to expectations, sex-specific URLs introduced sex-related disparities. These findings support the use of a uniform rather than sex-specific URL in the diagnosis of MI.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Juan José Rufilanchas Sánchez.","authors":"José Luis Pomar","doi":"10.1016/j.rec.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.rec.2025.05.001","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regina Wilson, Halil Tekiner, Steven H Yale, Eileen S Yale
{"title":"Scorpion sting without Kounis syndrome or tako-tsubo cardiomyopathy.","authors":"Regina Wilson, Halil Tekiner, Steven H Yale, Eileen S Yale","doi":"10.1016/j.rec.2025.04.008","DOIUrl":"10.1016/j.rec.2025.04.008","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Fernández Ruiz, Martín Ruiz Ortiz, Consuelo Fernández-Avilés Irache, Ana María Rodríguez Almodóvar, Mónica Delgado Ortega, Fátima Esteban Martínez, Adriana Resúa Collazo, Gloria Heredia Campos, Rafael González Manzanares, José López Aguilera, Juan Carlos Castillo Domínguez, Manuel Anguita Sánchez, Manuel Pan Álvarez-Ossorio, Dolores Mesa Rubio
{"title":"Right ventricular-pulmonary arterial coupling as a predictor of death or heart failure admission in patients with severe tricuspid regurgitation.","authors":"Ana Fernández Ruiz, Martín Ruiz Ortiz, Consuelo Fernández-Avilés Irache, Ana María Rodríguez Almodóvar, Mónica Delgado Ortega, Fátima Esteban Martínez, Adriana Resúa Collazo, Gloria Heredia Campos, Rafael González Manzanares, José López Aguilera, Juan Carlos Castillo Domínguez, Manuel Anguita Sánchez, Manuel Pan Álvarez-Ossorio, Dolores Mesa Rubio","doi":"10.1016/j.rec.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.rec.2025.04.009","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Tight ventricular-pulmonary arterial coupling, evaluated by tricuspid annular plane systolic excursion and pulmonary artery systolic pressure ratio (TAPSE/PASP), has been studied in the prognostic assessment of severe tricuspid regurgitation only in selected populations and mainly in relation to all-cause mortality.</p><p><strong>Methods: </strong>We retrospectively included all adult patients with severe tricuspid regurgitation who underwent echocardiography at a tertiary care hospital between January 1, 2008, and December 31, 2017. We investigated the association of TAPSE/PASP, either as a continuous variable or dichotomized at < 0.31 mm/mmHg, with the combined endpoint of mortality and heart failure (HF) admission, as well as its usefulness in several subgroups of interest.</p><p><strong>Results: </strong>A total of 474 patients (70 ± 13 years; 71% women) were included, with a median follow-up of 5 [p25-75 2-7] years. During follow-up, 285 patients died and 192 experienced 481 HF admissions. Patients with TAPSE/PASP < 0.31 mm/mmHg had significantly worse HF admission-free survival at median follow-up (25% vs 53%, P < .0005). The discriminative ability of TAPSE/PASP was statistically significant (area under the curve, 0.69; 95%CI, 0.65-0.74; P < .0005). After multivariate adjustment, TAPSE/PASP remained an independent predictor of the combined endpoint (HR, 0.017; 95%CI, 0.004-0.075; P < .0005), with significant incremental prognostic value over clinical variables (P < .0005). The performance of the index was consistent in patients with pacemaker/defibrillator leads or prior cardiac surgery, but not in those with reduced ejection fraction.</p><p><strong>Conclusions: </strong>In this cohort of patients with severe tricuspid regurgitation, TAPSE/PASP was a strong independent predictor of HF admission or mortality during long-term follow-up.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}