Revista española de cardiología (English ed.)最新文献

{"title":"Potential role of closure time with adenosine diphosphate in the diagnosis of mitral prosthetic paravalvular leak and prognosis after repair","authors":"Yassin Belahnech,&nbsp;Gerard Martí-Aguasca,&nbsp;Bruno García del Blanco,&nbsp;Eduard Ródenas-Alesina,&nbsp;Arnau Subirà-Ingla,&nbsp;Sergio del Fresno,&nbsp;Augusto Sao-Avilés,&nbsp;Javier Solsona-Caravaca,&nbsp;Laura Galian-Gay,&nbsp;Rubén Fernández-Galera,&nbsp;Víctor González-Fernández,&nbsp;Neus Bellera-Gotarda,&nbsp;Vicenç Serra,&nbsp;Imanol Otaegui,&nbsp;Bernat Serra,&nbsp;Álvaro Calabuig,&nbsp;Toni Soriano-Colomé,&nbsp;Aitor Uribarri,&nbsp;Ignacio Ferreira-González","doi":"10.1016/j.rec.2026.02.001","DOIUrl":"10.1016/j.rec.2026.02.001","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Mitral paravalvular leak (PVL) is associated with hemolysis and heart failure. It has also been linked to shear stress-induced von Willebrand factor abnormalities that prolong closure time with adenosine diphosphate (CT-ADP). The aim of this study was to assess whether CT-ADP serves as a biomarker for mitral PVL diagnosis, follow-up, and prognosis after repair.</div></div><div><h3>Methods</h3><div>In this prospective study, 89 patients (27 with moderate-to-severe mitral PVL referred for closure, group 1; 31 with prosthetic mitral valves without PVL, group 2; and 31 controls without valvular disease, group 3) underwent laboratory assessment including hemolysis markers, congestion markers, and CT-ADP. Patients with PVL underwent percutaneous or surgical repair and were followed up at 3 and 12 months. ROC analysis, linear regression, and Cox models were used to evaluate the diagnostic and prognostic value of CT-ADP.</div></div><div><h3>Results</h3><div>CT-ADP was prolonged in PVL patients (median, 214<!--> <!-->seconds) vs control groups (86 seconds in group 2 and 74<!--> <!-->seconds in group 3; <em>P</em> &lt;<!--> <!-->.001). A cutoff of<!--> <!-->&gt; 135<!--> <!-->seconds showed excellent diagnostic accuracy (AUROC, 0.96; sensitivity 89%, specificity 97%). Postprocedural CT-ADP decreased significantly after successful repair (median decrease of 79<!--> <!-->seconds) but remained unchanged in those with residual leaks. Elevated postprocedural CT-ADP (&gt;155 s) identified persistent PVL and was associated with worse 1-year outcomes (HR, 21.37; <em>P</em> <!-->=<!--> <!-->.004), including death, heart failure or hemolysis-related readmission, and reintervention.</div></div><div><h3>Conclusions</h3><div>CT-ADP appears to be a promising biomarker for diagnosing and monitoring mitral PVL. It may add value to conventional markers by reflecting shear stress-related platelet dysfunction and predicting outcomes following PVL closure.</div></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 691-700"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year incidence and prognostic impact of new-onset heart failure after acute coronary syndromes: a population-based study (BEAT-HF)","authors":"Josep Comín Colet,&nbsp;María Basalo,&nbsp;Marc Llagostera,&nbsp;Emili Vela,&nbsp;Júlia Folguera,&nbsp;Isaac Llaó,&nbsp;Josep Gómez-Lara,&nbsp;David Monterde,&nbsp;Jordi Piera-Jiménez,&nbsp;Gerard Carot-Sans,&nbsp;Raúl Ramos-Polo,&nbsp;José María Verdú-Rotellar,&nbsp;Núria José-Bazán,&nbsp;Laia Lorenzo-Esteller,&nbsp;Silvia Jovells,&nbsp;Andreea Cosa,&nbsp;Pedro Moliner,&nbsp;Mireia Andrés Villarreal,&nbsp;Cristina Enjuanes-Grau,&nbsp;Oona Meroño","doi":"10.1016/j.rec.2026.02.003","DOIUrl":"10.1016/j.rec.2026.02.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Incident heart failure (iHF) impacts the downstream cardiovascular disease continuum, particularly after acute coronary syndromes (ACS). The aim of this study was to assess iHF after ACS from a population-based perspective, identify its risk factors, and analyze the associated clinical and resource burden.</div></div><div><h3>Methods</h3><div>Retrospective, population-based study including all individuals covered by the Catalonian public health care system, who were discharged after an ACS between January 1, 2011 and December 31, 2021. Integrated health care databases from multiple sources were used.</div></div><div><h3>Results</h3><div>Among 83 357 patients without previous HF who were discharged after ACS, 23.3% developed iHF during follow-up. The main risk factors for developing iHF after ACS included age (sHR, per year 1.03; 95%CI, 1.03-1.04), very low income (sHR, 2.08; 95%CI, 1.56-2.78), and Killip class II-III at presentation (sHR, 2.16; 95%CI, 2.06-2.27). Compared with patients without iHF, those who developed iHF had markedly higher rates of all-cause mortality (3.44-fold), major adverse cardiac events (2.75-fold), and substantially greater health care expenditure, mainly driven by hospitalizations.</div></div><div><h3>Conclusions</h3><div>One in 4 ACS survivors developed HF within 10 years, with major consequences for survival, morbidity, and health care costs. Socioeconomic status emerged as a determinant comparable to traditional clinical risk factors, suggesting the importance of targeted strategies to improve early identification and prevention of HF after ACS, particularly in socioeconomically vulnerable populations.</div><div>Registered at ClinicalTrials.gov (NCT06255418).</div></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 701-712"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gatekeeping before ischemia testing in chronic coronary syndromes: how far should we go?","authors":"Joel Hernández Sevillano,&nbsp;Ana Devesa","doi":"10.1016/j.rec.2026.02.002","DOIUrl":"10.1016/j.rec.2026.02.002","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 667-669"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic coartation stenting in young population: height matters","authors":"Andrea Amici,&nbsp;Ga-Lem Bethge-Ng,&nbsp;Peter Ewert,&nbsp;Katarzyna Gendera,&nbsp;Stanimir Georgiev,&nbsp;Andreas Eicken,&nbsp;Maria von Stumm,&nbsp;Felix Berger,&nbsp;Pinar Bambul-Heck","doi":"10.1016/j.rec.2025.12.018","DOIUrl":"10.1016/j.rec.2025.12.018","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Stent implantation is an established treatment for aortic coarctation (CoA) in adults. In pediatric patients, however, ongoing somatic growth necessitates repeated stent redilations, and the optimal timing of these procedures remains undefined. This retrospective study aimed to identify an objective association between stent diameter and body growth parameters, thereby providing a basis for prognostic assessment and structured planning of redilation strategies.</div></div><div><h3>Methods</h3><div>In the derivation cohort, all stent implantations and redilations performed in 155 patients younger than 20 years with CoA at a tertiary center were analyzed (218 interventions; median age 10.1 years, IQR, 3.4-14.4). The findings were subsequently validated in an independent validation cohort from another tertiary center, comprising 198 patients (323 interventions; median age 7.5 years, IQR, 1.3-14.6).</div></div><div><h3>Results</h3><div>To assess the association between stent diameter and body growth parameters, correlation analyses were performed. Despite interindividual variability, a significant linear correlation between stent diameter and body height was identified (τ: 0.737, <em>P</em> <!-->≤<!--> <!-->.001) and this finding was confirmed in the validation cohort. Based on this relationship, a formula, f(x)<!--> <!-->=<!--> <!-->0.0831<!--> <!-->·<!--> <!-->x<!--> <!-->+<!--> <!-->1.86, where x represents body height, was derived to estimate the appropriate stent diameter. This formula yields minimum and maximum reference body heights for each stent diameter, which are reached at different ages depending on individual growth velocity. These results were subsequently translated into sex-specific reference tables.</div></div><div><h3>Conclusions</h3><div>The derived formula enables prediction of the required stent diameter and the anticipated number of subsequent catheter-based procedures, thereby supporting rapid estimation of intervention timing throughout somatic growth.</div></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 670-679"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone scintigraphy as a marker of reversibility in hydroxychloroquine-induced cardiomyopathy","authors":"Lucía Fernández Gassó,&nbsp;Elena Ruiz-Bravo,&nbsp;Luis Domínguez Gadea,&nbsp;Sara Quinones Garrido,&nbsp;Raúl Moreno,&nbsp;Gema Bonilla Hernán","doi":"10.1016/j.rec.2025.12.024","DOIUrl":"10.1016/j.rec.2025.12.024","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 729-731"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a VO2max Z-score model for fitness assessment in a healthy Spanish pediatric population","authors":"Esteban Peiró-Molina,&nbsp;Arthur Gavotto,&nbsp;Julien Robert,&nbsp;Mathieu Andrianoely,&nbsp;Erika Rezola,&nbsp;Begoña Manso,&nbsp;Francisco-José Ferrer-Sargues,&nbsp;José Ignacio Carrasco-Moreno,&nbsp;Stefan Matecki,&nbsp;Alfred Hager,&nbsp;Naomi Gauthier,&nbsp;Suellen Moli Yin,&nbsp;Sophie Guillaumont,&nbsp;Thibault Mura,&nbsp;José Miguel Blanco Borreguero,&nbsp;Pascal Amedro,&nbsp;on behalf of the QUALIREHAB study group","doi":"10.1016/j.rec.2026.02.006","DOIUrl":"10.1016/j.rec.2026.02.006","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Maximal oxygen uptake is the gold standard for assessing aerobic capacity in children and adolescents. Its interpretation requires robust reference models. A pediatric Z-score model has recently been developed, but external validation in independent cohorts is essential to confirm its applicability.</div></div><div><h3>Methods</h3><div>We conducted a multicenter validation study including a total of 1046 healthy participants (mean age, 12.0 <!--> <!-->± 2.6 years), composed of 2 cohorts: a prospective Spanish validation cohort (n <!--> <!-->=<!--> <!--> 175) and a previously published reference cohort (n <!--> <!-->=<!--> <!--> 871). The Z-score model was compared with historical weight- and height-based linear equations in terms of correlation, prediction error, and classification of impaired aerobic fitness. Subgroup analyses were performed by sex and body mass index.</div></div><div><h3>Results</h3><div>The Z-score model showed the strongest correlation between predicted and observed maximal oxygen uptake (R² <!--> <!-->=<!--> <!--> 0.70), outperforming weight-based (R² <!--> <!-->=<!--> <!--> 0.64) and height-based (R² <!--> <!-->=<!--> <!--> 0.66) equations. It yielded smaller prediction errors among body mass index groups and identified 14% of participants as having impaired aerobic fitness, compared with 20% and 23% using weight- and height-based reference models, respectively. The Z-score model showed improved consistency and reduced bias, particularly in overweight participants.</div></div><div><h3>Conclusions</h3><div>The pediatric Z-score model demonstrated superior accuracy, consistency, and classification reliability compared with linear equations in a large, independent Spanish cohort. Its adoption may enhance the interpretation of pediatric cardiopulmonary exercise testing, support early identification of reduced aerobic fitness, and guide prevention strategies and tailored interventions.</div><div>Registered on ClinicalTrials.gov (NCT04876209).</div></div>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 680-690"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Team-based VA-ECMO cardiopulmonary resuscitation: a good partner in refractory out-of-hospital cardiac arrest","authors":"Carlos Roca-Guerrero,&nbsp;Oreste Lanza,&nbsp;Teresa López-Sobrino,&nbsp;Elena Sandoval-Martínez,&nbsp;Silvia Pérez-Ortega,&nbsp;Rut Andrea","doi":"10.1016/j.rec.2025.12.011","DOIUrl":"10.1016/j.rec.2025.12.011","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 721-723"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter mitral valve replacement. The beginning of a new era","authors":"Ángel Sánchez-Recalde,&nbsp;Ariana González-Gómez,&nbsp;Covadonga Fernández-Golfín,&nbsp;Luisa Salido-Tahoces,&nbsp;Eduardo Martín Montero,&nbsp;José L. Zamorano","doi":"10.1016/j.rec.2025.12.012","DOIUrl":"10.1016/j.rec.2025.12.012","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 723-726"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transseptal puncture for PFO with atrial septal aneurysm closure","authors":"Kun Wang,&nbsp;Yong-Kang Liu","doi":"10.1016/j.rec.2025.11.009","DOIUrl":"10.1016/j.rec.2025.11.009","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 732-733"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential percutaneous approach to carcinoid tricuspid regurgitation","authors":"María Fernández,&nbsp;Isaac Pascual,&nbsp;Pablo Avanzas","doi":"10.1016/j.rec.2026.04.009","DOIUrl":"10.1016/j.rec.2026.04.009","url":null,"abstract":"","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":"79 8","pages":"Pages 734-735"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}