Journal of the Taiwan Institute of Chemical Engineers最新文献

{"title":"Improved corrosion resistance of mild steel with poly (vinyl pyrrolidone) incorporated zinc phosphate coating","authors":"S. Ayesha Barsana ,&nbsp;P. Magesan ,&nbsp;K. Jayamoorthy ,&nbsp;M.J. Umapathy","doi":"10.1016/j.jtice.2025.106363","DOIUrl":"10.1016/j.jtice.2025.106363","url":null,"abstract":"<div><h3>Background</h3><div>Exploring new additives for coatings to protect surfaces is always a topic of interest. This study explores the enhancement of corrosion resistance in mild steel by applying poly(vinyl pyrrolidone) (PVP) incorporated zinc phosphate coating.</div></div><div><h3>Methods</h3><div>The corrosion resistance of the coatings was assessed in both neutral (3.5 % NaCl) and acidic (0.5 M HCl) aqueous environments using electrochemical impedance and potentiodynamic polarization techniques.</div></div><div><h3>Significant findings</h3><div>A thorough analysis of the newly formed coatings revealed that the PVP had reduced the phosphate crystallite size from 32.9 nm of conventional zinc phosphate coating to 21.7 nm and resulted more compact coatings with increased crystal density and reduced cracks. Besides, the added PVP reduced the dissolved iron content and the hydrophilicity of the coating. The corrosion rate calculated from potentiodynamic polarization curves revealed that the addition PVP to the phosphating bath lowered the corrosion rate more than six times compared to the coating formulated without PVP in a neutral environment. The salt spray test showed that the PVP enhanced the coating’s corrosion resistance, highlighting its potential for preventing corrosion in mild steel used in this environment.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106363"},"PeriodicalIF":6.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic hydrophobic fluoroethylene-vinyl ester polymer-based superhydrophobic coating with superior anticorrosion properties for metal protection","authors":"Yue Ma ,&nbsp;Jinxue Li ,&nbsp;Shuhui Li ,&nbsp;Zunzhao Li ,&nbsp;Wei Zhao ,&nbsp;Yuezhen Bin","doi":"10.1016/j.jtice.2025.106382","DOIUrl":"10.1016/j.jtice.2025.106382","url":null,"abstract":"<div><h3>Background</h3><div>Metal corrosion remains a significant challenge in industrial applications, while high-performance anti-corrosion coatings provide an effective solution for protecting metal surfaces from environmental degradation.</div></div><div><h3>Methods</h3><div>In this study, chlorotrifluoroethylene (CTFE), vinyl acetate (VAc), dodecafluoroheptyl methacrylate (DFMA), and hydroxybutyl vinyl ether (HBVE) monomers with crosslinking sites were selected to synthesize intrinsically hydrophobic fluoroethylene-vinyl ester (FEVE) polymers via solution polymerization. Subsequently, unmodified SiO₂ particles were directly compounded with the CTFE-VAc-DFMA-HBVE polymer to prepare a superhydrophobic coating (CVDH-SiO₂) by air spraying. The above polymer-based coating containing only 18 wt% unmodified nano-SiO₂ exhibits remarkable superhydrophobicity. Investigations into the surface self-cleaning and antifouling properties of the superhydrophobic coatings demonstrate their ability to return to a clean state even after exposure to contaminants such as carbon powder and muddy water. Furthermore, the coatings display outstanding corrosion resistance, with a low-frequency impedance value |Z|_0.01 _Hz reaching 1.23 × 10⁹∼1.35 × 10¹⁰ Ω·cm², which is five orders of magnitude higher than that of the bare steel (|Z|_{0.01 Hz}=1.37 × 10⁴ Ω·cm²). These findings indicate that the CVDH-SiO₂ coatings offer exceptional corrosion protection for metals.</div></div><div><h3>Significant Findings</h3><div>This study offers new possibilities for the practical engineering applications of superhydrophobic coating technology in heavy corrosion protection, antifouling, and other industrial fields.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106382"},"PeriodicalIF":6.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decellularized porcine urinary bladder matrix as a dynamic biomaterial scaffold for myocardial cell adhesion","authors":"Po-Shun Hsu ,&nbsp;Ming-Fa Hsieh ,&nbsp;Ming-You Shie ,&nbsp;Wen-Ching Hsieh ,&nbsp;Chun-Fan Lung ,&nbsp;Yen-Hong Lin ,&nbsp;Chao-Ling Yao ,&nbsp;Chien-Sung Tsai ,&nbsp;Yi-Chiung Hsu","doi":"10.1016/j.jtice.2025.106325","DOIUrl":"10.1016/j.jtice.2025.106325","url":null,"abstract":"<div><h3>Background</h3><div>Porcine urinary bladder matrix (UBM) is a promising extracellular matrix-derived scaffold due to its excellent biocompatibility and structural integrity. Tissue engineering approaches for cardiac repair require scaffolds that promote myocardial cell adhesion and physiological function. This study investigates the potential of UBM as a dynamic culture scaffold for myocardial cell adhesion and activity.</div></div><div><h3>Methods</h3><div>UBM scaffolds were prepared by decellularizing porcine bladder tissue to remove cellular components while preserving the extracellular matrix. Cardiomyocytes were seeded onto the UBM scaffold and cultured under dynamic conditions using a custom-designed perfusion system to simulate physiological flow. Calcium ion activity was monitored to assess the functionality of myocardial cells.</div></div><div><h3>Significant Findings</h3><div>The decellularized UBM scaffold demonstrated high compatibility and supported adequate adhesion of myocardial cells under dynamic culture conditions. Although cardiomyocytes remained viable and adhered well to the scaffold, the calcium assay used in this study measured extracellular calcium levels in the supernatant and does not reflect intracellular calcium flux or contractile activity. Nonetheless, the sustained release of calcium ions from the UBM scaffold suggests bioactivity that may contribute to supporting cardiac tissue development.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"176 ","pages":"Article 106325"},"PeriodicalIF":6.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient adsorption of malachite green by layered double hydroxide loaded biochar: Characterization, performance, mechanisms and soil remediation","authors":"Jingyuan Wang,&nbsp;Hongjuan Bai,&nbsp;Wenling Gao,&nbsp;Junhang Chen,&nbsp;Mengen Ren,&nbsp;Dan Liu,&nbsp;Qiaofei Zhang,&nbsp;Zhimin Du","doi":"10.1016/j.jtice.2025.106380","DOIUrl":"10.1016/j.jtice.2025.106380","url":null,"abstract":"<div><h3>Background</h3><div>Malachite green (MG), a toxic dye commonly found in industrial wastewater, poses significant environmental and health risks, necessitating the development of efficient removal methods.</div></div><div><h3>Methods</h3><div>This study explores the efficient adsorption of MG by Mg-Al-layered double hydroxide-loaded biochar (Mg-Al-LDH/PSBC) derived from peanut shells. The adsorbent was characterized using various techniques, including SEM, FTIR, XPS, and BET analysis. Adsorption experiments were conducted to determine the maximum adsorption capacity. Isotherm and thermodynamic models, in conjunction with density functional theory (DFT) simulations, were employed to analyze the adsorption behavior and elucidate the molecular-level interactions between MG and the adsorbent materials.</div></div><div><h3>Significant Findings</h3><div>Batch experiments revealed a maximum adsorption capacity of 155 mg/g driven by chemisorption, ion exchange, electrostatic attraction, π-π interactions, and hydrogen bonding. The adsorption kinetics followed pseudo-first-order and pseudo-second-order models, and the isotherms were well described by the Redlich-Peterson and Koble-Corrigan models. Thermodynamic studies indicated that the adsorption was endothermic and spontaneous. DFT calculation highlighted the crucial role of the -N-CH₃ group of MG in the surface interactions. The spent adsorbent improved soil physicochemical properties, enhanced fertility, and promoted plant growth, suggesting agricultural potential. Mg-Al-LDH/PSBC thus proves to be an effective and sustainable adsorbent for MG removal.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106380"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile synthesis of zeolite-based MOF composites for cobalt ion separation from simulated wastewater","authors":"Ting Pan,&nbsp;Shuyuan Liu,&nbsp;Qi Zhou,&nbsp;Li Yu,&nbsp;Yue Wang,&nbsp;Xiayuan Zhu,&nbsp;Ruotian Li,&nbsp;Ying Wang,&nbsp;Xiaoqin Pu,&nbsp;Guoyuan Yuan","doi":"10.1016/j.jtice.2025.106381","DOIUrl":"10.1016/j.jtice.2025.106381","url":null,"abstract":"<div><h3>Background</h3><div>With the acceleration of industrialization, heavy metal pollution has attracted worldwide attention. As an important heavy metal, cobalt is widely used in fields such as batteries, alloys, and catalysts. However, due to environmental issues and the toxicity of heavy metals, it is crucial to separate cobalt ions from wastewater.</div></div><div><h3>Methods</h3><div>Zeolitic (Ze) MOF architectures were fabricated through solvent-mediated coordination with aluminosilicate substrates, demonstrating enhanced cobalt(II) sequestration efficacy in synthetic wastewater remediation. Ze serves as a stable, low-cost molecular sieve, providing structural support and Al³⁺ ions for MOF formation. The composites, including Ze-MOFs(Al), Ze-MOFs(Al)-NH₂, and Ze-MOFs(Al)-(OH)₂, were characterized using XRD, FT-IR, SEM, and BET analysis. Their adsorption performance was evaluated under varying conditions, with the adsorption mechanisms explored in detail.</div></div><div><h3>Significant findings</h3><div>Ze-MOFs(Al) exhibited the highest adsorption capacity (228.3 mg/g) and selective adsorption ability in mixed solutions of Co(II), Li(I), K(I), Mg(II), and Ca(II), underscoring its potential for wastewater treatment. Research on fixed-bed dynamic adsorption revealed adherence to the Thomas model, showing a dynamic adsorption capacity (208.7 mg/g) nearly equivalent to the theoretical static capacity, suggesting a diffusion-driven process. This research provides valuable insights into the development of low-cost, efficient materials for cobalt ion separation from wastewater.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106381"},"PeriodicalIF":6.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal upcycling of polyoxymethylene waste on heterogeneous Mn catalyst: The effect of reaction medium","authors":"Shuting Fu ,&nbsp;Doeun Choi ,&nbsp;Nam Sun Kim ,&nbsp;Yong Tae Kim ,&nbsp;Jechan Lee","doi":"10.1016/j.jtice.2025.106376","DOIUrl":"10.1016/j.jtice.2025.106376","url":null,"abstract":"<div><h3>Background</h3><div>Polyoxymethylene (POM), an engineering thermoplastic widely used in various applications, is difficult to recycle due to its high stiffness and excellent stability. Hydrothermal conversion has emerged as a promising method for recycling POM, offering moderate operating conditions, reduced harmful emissions, and selective production of valuable chemicals like methanol and formic acid. Recent studies show that catalytic hydrothermal processes can further enhance efficiency and selectivity, though homogeneous catalysts raise concerns about recovery and environmental safety. In contrast, heterogeneous catalysts offer better recyclability and reduce the risk of hazardous waste generation.</div></div><div><h3>Methods</h3><div>This study proposes a hydrothermal conversion process as a POM recycling method. A Mn catalyst supported on activated carbon (Mn/AC) and different reaction media (N₂ and CO₂) are applied to the hydrothermal POM conversion as an alternative approach against homogeneous catalytic POM conversion. The effects of reaction temperature (220–260 °C), reaction medium (N₂ vs. CO₂), and the catalyst presence on the hydrothermal POM conversion are investigated.</div></div><div><h3>Significant Findings</h3><div>The hydrothermal POM conversion leads to formic acid, methanol, and 1,3,5-trioxane as major reaction products. Formic acid reached its highest yield of 9.79 wt% at 240 °C without the catalyst under N₂ atmosphere. Under CO₂ atmosphere, methanol production peaked at 1.54 wt% at 260 °C with the Mn/AC catalyst. The highest yield of 1,3,5-trioxane (1.08 wt%) was observed at 220 °C under N₂ atmosphere with the Mn/AC catalyst. Therefore, due to the optimal conditions required for each target product, process parameters must be strategically controlled to meet specific production goals. The experimental findings open up the possibility of using heterogeneous catalysts for hydrothermal POM conversion to recover its monomeric compounds.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106376"},"PeriodicalIF":6.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fe addition on the selective hydrogenation of maleic anhydride to succinic anhydride over Ni/SiO2 catalyst","authors":"Yuanzhen Ren ,&nbsp;Shizhe Liu ,&nbsp;Chenjie Zhu ,&nbsp;Jinhong Zhou ,&nbsp;Xiaolin Zhu ,&nbsp;Chunyi Li ,&nbsp;Chaohe Yang ,&nbsp;Guowei Wang","doi":"10.1016/j.jtice.2025.106379","DOIUrl":"10.1016/j.jtice.2025.106379","url":null,"abstract":"<div><h3>Background</h3><div>Succinic anhydride is a downstream product of the hydrogenation of maleic anhydride and an important intermediate in organic synthesis. Iron was added to Ni-based catalysts to improve the hydrogenation performance under milder reaction conditions.</div></div><div><h3>Methods</h3><div>A series of 5Ni-Fe/SiO₂ catalysts with varying Ni/Fe molar ratios were prepared, and their catalytic activities for the hydrogenation of maleic anhydride to succinic anhydride were evaluated. The catalysts were characterized using a range of techniques, including N₂ adsorption and desorption, XRD, H₂-TPR, NH₃-TPD, Py-IR, XPS, and CO-TPD.</div></div><div><h3>Significant findings</h3><div>The optimum performance can be achieved when the molar ratio of Ni/Fe equals to 4/1, with 100 % of maleic anhydride conversion and 87 % of selectivity to succinic anhydride. Fe addition facilitates good dispersion of the active metals, reduces their reduction temperature, modifies the electronic properties of Ni species and increases the amount of Lewis acid sites and active metal sites, resulting in increased selectivity towards succinic anhydride. However, the introduction of excessive amount of Fe could lead to adverse effects such as catalyst surface coverage and pore blockage, leading to a decrease in the hydrogenation performance.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106379"},"PeriodicalIF":6.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on gas diffusion during the calcination of LiNi0.8Co0.1Mn0.1O2 cathode materials","authors":"Zhaodong Chen ,&nbsp;Baikang Hou ,&nbsp;Mingyang Zhang ,&nbsp;Yuqing Wang ,&nbsp;Hailong Peng ,&nbsp;Ruifeng Dou ,&nbsp;Wen Zhi ,&nbsp;Xunliang Liu","doi":"10.1016/j.jtice.2025.106364","DOIUrl":"10.1016/j.jtice.2025.106364","url":null,"abstract":"<div><h3>Background</h3><div>LiNi_0.8Co_0.1Mn_0.1O₂ (NCM811) is an important raw material for lithium batteries, and its preparation undergoes oxidation reactions. Therefore, the concentration of oxygen affects the oxidation reaction and ultimately the calcination quality of the cathode material.</div></div><div><h3>Methods</h3><div>In this paper, the permeability of calcined raw materials (the porosities were 0.4059, 0.4358, 0.4555, 0.4965, and 0.5661) under different calcination conditions was first evaluated experimentally, and then the corresponding friction factors were obtained by numerical simulation and compared with the experimental results (error was less than 13%), and the reliability of the model and experimental results was confirmed.</div></div><div><h3>Significant findings</h3><div>On this basis, the effective diffusion coefficient of the calcined raw material was calculated and compared with the classical formula, and the error was less than 4.72%. The work in this paper has certain guiding importance for the in-depth analysis of the gas diffusion mechanism inside the cathode material and provides a basis for the subsequent study of the relationship between the calcined raw material stack thickness and the gas concentration.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106364"},"PeriodicalIF":6.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144909019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrazole-based schiff bases as high-performance corrosion inhibitors for mild steel: Experimental and theoretical insights","authors":"Renu Khanna ,&nbsp;Meenakshi Dudi ,&nbsp;Gaurav Jhaa ,&nbsp;Hariom Dahiya","doi":"10.1016/j.jtice.2025.106361","DOIUrl":"10.1016/j.jtice.2025.106361","url":null,"abstract":"<div><h3>Background</h3><div>The increasing demand for effective corrosion inhibitors for mild steel (MS) in acidic environments has led to the exploration of pyrazole-based Schiff bases (PSBs). This study evaluates the corrosion inhibition performance of two PSB derivatives in 1 M HCl at temperatures ranging from 298 to 318 K.</div></div><div><h3>Methods</h3><div>Corrosion inhibition efficiency was assessed using potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and weight loss measurements. Surface morphology was analyzed through atomic force microscopy (AFM), field emission scanning electron microscopy (FE-SEM), and energy-dispersive spectroscopy (EDS). Contact angle (CA) measurements examined surface hydrophobicity, while activation energy and thermodynamic parameters provided insights into inhibition mechanisms. Density functional theory (DFT) and molecular dynamics (MD) simulations were employed to investigate electronic properties and adsorption behavior.</div></div><div><h3>Significant Findings</h3><div>The Schiff base derivatives, CMPNA and CMPAP, exhibited inhibition efficiencies of 95.27 % and 93.59 %, respectively, at 300 ppm and 298 K, as determined by EIS. Adsorption followed the Langmuir isotherm model, forming a protective layer via strong physical and chemical interactions. CA measurements confirmed enhanced hydrophobicity. Theoretical calculations supported experimental results, highlighting the potential of PSBs as efficient and eco-friendly corrosion inhibitors for MS protection in acidic media.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"178 ","pages":"Article 106361"},"PeriodicalIF":6.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical sensing glutathione, nicotinamide adenine dinucleotide and folic acid in biological fluids using silver nanoparticles dispersed polythionine/graphene nanoflakes nanocomposite modified glassy carbon electrode","authors":"J. Kalaiyarasi ,&nbsp;K. Pandian ,&nbsp;S.C.B. Gopinath","doi":"10.1016/j.jtice.2025.106346","DOIUrl":"10.1016/j.jtice.2025.106346","url":null,"abstract":"<div><h3>Background</h3><div>A new voltammetric sensor was developed for the simultaneous detection of glutathione (GSH), nicotinamide adenine dinucleotide (NADH), and folic acid (FA) using a PTH/GNF@AgNP-modified electrode.</div></div><div><h3>Methods</h3><div>This was achieved by uniformly dispersing green-synthesized silver nanoparticles (AgNPs) onto a stable polythionine/graphene nanoflakes (PTH/GNF) nanohybrid thin film in two stages. Characterization using physicochemical and electrochemical methods confirmed the formation of the nanocomposite film. The PTH/GNF@AgNP/GCE nanocomposite exhibited an enhanced electrocatalytic oxidation of GSH, NADH, and FA within physiological pH ranges. Under optimized conditions, the sensor enabled highly selective, sensitive, and simultaneous determination of these analytes using differential pulse voltammetry (DPV). The DPV technique shows a well-defined peak potential and higher current responses compared to cyclic voltammetry. The peak current displayed a linear dependence on the concentration: 1.3 µM to 46 mM for GSH and NADH, 1.3 µM to 50 mM for FA using DPV, with detection limits of 28 nM, 24 nM, and 14 nM for GSH, NADH, and FA, respectively.</div></div><div><h3>Significant Findings</h3><div>The fabricated sensor demonstrated a wider linear range, low detection limit, improved sensitivity, good stability, and recovery, allowing for simple, selective, and precise quantitative voltammetric detection of the three analytes. The sensor successfully detected the GSH, NADH, and FA individually and simultaneously inblood serum, urine and pharmaceutical forumlations with satisfactory results.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"176 ","pages":"Article 106346"},"PeriodicalIF":6.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}