Journal of the Taiwan Institute of Chemical Engineers最新文献

{"title":"Effect of oxy-vanadium (IV) and oxy-zirconium (IV) ions in O,N-bidentate arylhydrazone complexes on their catalytic and biological potentials that supported via computerized usages","authors":"Mohamed Shaker S. Adam , Omar M. El-Hady , Mohamed M. Makhlouf , Abrar Bayazeed , Nashwa M. El-Metwaly , Ahmad Desoky M. Mohamad","doi":"10.1016/j.jtice.2021.104168","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.104168","url":null,"abstract":"<div><h3>Background</h3><p>Based on the high coordination behavior of arylhydrazones, as pincer chelating agents, the purpose of this research is to study the synthesis, characterization and reactivity of two mononuclear oxy-vanadium (IV) and oxy- zirconium (IV) complexes (VO(ALz)<sub>2</sub> and ZrO(ALz)<sub>2</sub>, respectively) of <em>O,N</em>-monobasic bidenate arylhydazone derivative (2-((2-(2,4-dinitrophenyl) hydrazineylidene)methyl)-4-nitrophenol, HALz).</p></div><div><h3>Methods</h3><p>Various spectroscopic methods were applied to characterize the chemical structures of the ligand and their O=M<sup>4+</sup>-complexes (NMR, UV-Vis., Mass and IR spectra). Their reactivity was estimated catalytically and biologically.</p></div><div><h3>The significant findings</h3><p>Here, the function of the oxy-highly charged metal ion of (O=M<sup>4+</sup>: V<sup>4+</sup> and Zr<sup>4+</sup>-ions) on reactivity of their arylhydrazone complexes was reported catalytically and biologically. The differentiation in the catalytic features of VO(ALz)<sub>2</sub> and ZrO(ALz)<sub>2</sub> depends on the type of O=M<sup>4+</sup> ion, which examined in the aerobic oxidation of benzyl alcohol using <em>tert</em>-butyl hydroperoxide (<em><sup>t</sup></em>BuOOH) under solvent free atmosphere at 90 °C (the optimized conditions). VO(ALz)<sub>2</sub> exhibited little more progressed catalytic potential (2 h with 89% yield of benzaldehyde) over that of ZrO(ALz)<sub>2</sub> (6 h with 82% yield of benzaldehyde). The electron-oxygen gain/loss of O=M<sup>4+</sup> ion in its complex catalyst displayed the major role for progressing of its catalytic potential. The catalytic oxidation of secondary alcohols to their corresponded ketones was performed with VO(ALz)<sub>2</sub> and ZrO(ALz)<sub>2</sub> catalysts. A mechanistic pathway was proposed depending on <em>via</em> DFT approach and on spectroscopic aspects.</p><p>The biological action of HALz, VO(ALz)<sub>2</sub> and ZrO(ALz)<sub>2</sub> were studied within their binding action towards <em>ct</em>DNA (through UV–Visible spectroscopy and viscosity measuring) depending on the type of O=M<sup>4+</sup> ion in their reagents. The interaction of HALz, VO(ALz)<sub>2</sub> and ZrO(ALz)<sub>2</sub> and was evaluated with the binding constant (2.85, 6.07 and 5.42 × 10<sup>5</sup> mol<sup>−1</sup> dm<sup>3</sup>, respectively), which referred to their high reactivity towards <em>ct</em>DNA. In addition, the values of Gibbs’ free energy supported their <em>ct</em>NDA interaction (-31.11, -32.99 and -32.71 kJ mol<sup>−1</sup>, respectively). Both V<sup>4+</sup> and Zr<sup>4+</sup> ions in their complexes promoted their reactivity as antioxidant, antimicrobial and anticancer reagents more that their uncoordinated HALz ligand. The interaction with DNA-pockets was investigated through in-silico ways regarding pharmacophore query and MOE-docking module, to strengthen the biological screening. Considerably, the current MO-complexes with their ","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104168"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2303627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatile Thiol- and Amino-Functionalized Silatranes for in-situ polymerization and Immobilization of Gold Nanoparticles","authors":"Shi-Wen Chen ,&nbsp;Tran Thi Anh Hong ,&nbsp;Chun-Tung Chiang ,&nbsp;Lai-Kwan Chau ,&nbsp;Chun-Jen Huang","doi":"10.1016/j.jtice.2021.10.029","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.10.029","url":null,"abstract":"<div><h3>Background</h3><p>Organosilanes have been massively implemented as building blocks in the fields of sol–gel material synthesis, surface functionalization, and nanotechnology. However, organosilane has been humbled by limitations, such as poor reproducibility, fast hydrolysis and heterogeneous molecular orientation. An emerging silatrane is gaining tremendous interest due to the unique tricyclic caged structure and transannular N→Si dative bond to provide chemical stability in aqueous solution and controllable deposition on surfaces.</p></div><div><h3>Methods</h3><p>Aminopropyl silatrane (APS), Mercaptopropyl silatrane (MPS) and 3-Mercaptopropyl trimethoxysilane (MPTMS) were applied to modification of silicon oxide<span> substrates to in-situ graft hydrophilic polymers and immobilize gold nanoparticles<span> (AuNPs). Thin and uniform silatrane coatings have been proved by atomic force spectroscopy, ellipsometry and X-ray photoelectron spectroscopy.</span></span></p></div><div><h3>Significant Findings</h3><p>Antifouling poly(ethylene glycol) methacrylate (PEGMA) was grafted separately on MPS and MPTMS via surface-initiated thiol-ene photopolymerization. We found that MPS-PEGMA films were 30% superior to MPTMS-PEGMA films in protein repellency. Moreover, APS and MPS were co-deposited to attract and conjugate gold nanoparticles. AuNPs cluster size on APS films was found to increase 3.43 times along with broader AuNPs absorbance peaks after acid treatment, whereas cluster size increased only 4% on mixed silatrane-modified films. These discoveries are pertinent to robust and versatile properties that silatrane offers.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104129"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2303628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic membrane cathode integrated in a proton exchange membrane-free microbial fuel cell for coking wastewater treatment","authors":"Yizhen Zhang ,&nbsp;Yueshi Zheng ,&nbsp;Qian Zhang ,&nbsp;Jiaqi Sun ,&nbsp;Shoukai Wang ,&nbsp;Luyang An ,&nbsp;Lifen Liu","doi":"10.1016/j.jtice.2021.10.017","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.10.017","url":null,"abstract":"<div><h3>Background</h3><p>Coking wastewater (CW) is characterized by complex composition, high concentration and toxicity, thereby challenging the treatment technologies. Traditional microbial fuel cell (MFC) is deficient in effluent quality and capital cost. Therefore, integrating the catalytic electrode membrane in separation process in MFC is promising for actual wastewater treatment, while replacing proton exchange membrane (PEM) to reduce cost.</p></div><div><h3>Methods</h3><p>A CNF-CFO/PM membrane (blended with carbon nanofiber-CoFe₂O₄, polyvinylidene fluoride) was prepared via casting and phase inversion. By using this membrane as cathode, activated carbon-loaded electrogenic bacteria as bio-anode, the catalytic membrane cathode-MFC system (CM-MFC) was constructed with quartz sand separating layer (QSL) replacing PEM.</p></div><div><h3>Significant findings</h3><p>Modification with CNF-CFO catalyst effectively improved the catalytic and anti-fouling (membrane foulants) property of membrane cathode. The optimal activity of CM-MFC was achieved under 36 h (HRT), with the COD decreasing from 4325.0-5074.3 mg L⁻¹ to 50.0-92.8 mg L⁻¹, and the stable output voltage of ∼0.40 V. The high-throughput sequencing results clarified that the enriched electrogenic bacteria coexisted with other anaerobic bacteria in the anodic chamber and functioned for electron transfer and organics removal. Integrating with the catalysis and filtration processes of membrane cathode, the effluent quality after primary treatment in the anodic chamber was further enhanced.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104117"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3138825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation of proteins by square-wave pulsed field and inversion field capillary electrophoresis","authors":"Jiaxin Huang ,&nbsp;Yatian Zhang ,&nbsp;Chunxian Tao ,&nbsp;Shanni Li ,&nbsp;Qingxiang You ,&nbsp;Dawei Zhang ,&nbsp;Zhenqing Li ,&nbsp;Yoshinori Yamaguchi","doi":"10.1016/j.jtice.2021.11.012","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.11.012","url":null,"abstract":"<div><h3>Background</h3><p>Capillary electrophoresis (CE) is an effective method for protein analysis. Although previous researchers have proved that the separation performance of large DNA molecules was improved by pulsed field capillary electrophoresis (PFCE), there is lack of research about proteins separation by PFCE.</p></div><div><h3>Methods</h3><p>Herein, we systematically investigated the separation performance of proteins sized from 44 kDa to 200 kDa under square wave and inversion electric field, respectively.</p></div><div><h3>Findings</h3><p>Results showed that for pulsed electric field with same forward and backward time duration, there was a resonance frequency for protein molecule re-orientation and applied frequency, and the apparent mobility (<em>μ</em>) was the lowest at the resonance frequency. <em>μ</em> was positively correlated to modulation depth (<em>M</em>) if <em>M</em> was below 200%, while <em>μ</em> was negatively correlated to <em>M</em> if <em>M</em> was higher than 200%. For CE with same forward and backward voltage, it demonstrated that <em>μ</em> dropped as <em>M</em> went up, but the separation performance for proteins with high molecular mass improved. Through PFCE, albumin and α- globulins in human serum were also resolved within 7 min. Such a work may shed new light on the analysis of proteins by PFCE.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104145"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2219592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocrystalline silver coatings on steel by electrodeposition from non-polluting aqueous baths and its antibacterial activity","authors":"Manal A. El Sayed ,&nbsp;Nahla T. Elazab ,&nbsp;Malek Gassoumi ,&nbsp;Magdy A.M. Ibrahim","doi":"10.1016/j.jtice.2022.104212","DOIUrl":"https://doi.org/10.1016/j.jtice.2022.104212","url":null,"abstract":"<div><h3>Background</h3><p>Antimicrobial coatings are one way that could help inhibit the spread of germs. Despite significant research into a variety of antimicrobial coatings with varied formulas, silver-based coatings appear to be the most effective. Electrodeposition is a promising technology to synthesize nanocrystalline silver coatings which have a wide range of applications such as in microelectronics, aerospace, automotive, biotechnology, nanobiotechnology, bioengineering sciences, in addition to its antimicrobial characteristics. Regrettably, cyanide electrolyte which is commonly applied in industry for silver coatings is one of the most hazardous substances, raising serious health and environmental hazards. It is important that seek high environmentally friendly electrolytes alternative to cyanide electrolytes.</p></div><div><h3>Methods</h3><p>The nanocrystalline silver coatings were successfully synthesized via galvanostatic deposition on stainless steel surface from an environmentally friendly novel bath. The electrochemical measurements were made utilizing linear sweep voltammetry (LCV), and cyclic voltammetry (CV). A high field emission scanning electron microscope (FESEM) and X-ray diffraction analysis (XRD) were used to characterize the obtained silver coatings.</p></div><div><h3>Significant findings</h3><p>Bright and adherent nanocrystalline Ag coatings (nano-size ranging between 14.8 and 67.6 nm) were synthesized by direct galvanostatic electrodeposition on SS surface from a bath free from cyanide. This environmentally friendly, cyanide-free bath is characterized by its high stability, low cost, and high cathodic current efficiency. The morphology was strongly dependent on the electrolyte composition as well as on the run circumstances. The microhardness of Ag deposited from this bath has a relatively high value (120.2–158.7 kg f mm^-2) depending on the applied current density. Furthermore, the nanocrystalline silver coatings formed by these baths are excellent antibacterial agents versus a vast spectrum of gram-positive and gram-negative bacteria, particularly <em>Listeria</em> and <em>Streptococcus</em> bacteria.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104212"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1673882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel porous heteroatom-doped biomass activated carbon nanoflakes for efficient solid-state symmetric supercapacitor devices","authors":"Mohammed Jalalah ,&nbsp;Siddheswar Rudra ,&nbsp;Belqasem Aljafari ,&nbsp;Muhammad Irfan ,&nbsp;Saleh S Almasabi ,&nbsp;Turki Alsuwian ,&nbsp;Akshay A. Patil ,&nbsp;Arpan Kumar Nayak ,&nbsp;Farid A. Harraz","doi":"10.1016/j.jtice.2021.11.015","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.11.015","url":null,"abstract":"<div><h3>Background</h3><p>Heteroatom-doped carbon structures derived from sustainable biomass for energy storage applications are a promising aspirant to the scientific community. Highly efficiency activated carbon materials derived from cheap, plentiful, but unwanted natural wastes are interestingly promising for large-scale applications.</p></div><div><h3>Methods</h3><p><span><span>Facile methods of chemical activation and carbonization using a simple </span>pyrolysis technique under inert atmosphere were applied to synthesize heteroatom-doped porous activated carbon nanoflakes using </span><em>Sechium edule</em> leaves as biomass precursor.</p></div><div><h3>Significant findings</h3><p>The research findings of the present work indicate large effective surface area and porosity of as-synthesized nitrogen-doped activated carbon nanoflakes that led to display excellent specific capacitance of 334 F g⁻¹ at 1 A g⁻¹ current density in strong acidic electrolyte using a three-electrode system. The electrokinetic analysis demonstrate that the major contribution of capacitive nature (90%) was observed to accumulate the total charge. Further, all solid-state symmetric supercapacitor (SSC) devices fabricated using as-synthesized carbon nanoflakes with gel electrolyte (PVA-H₂SO₄) exhibited a maximum capacitance of 114 F g⁻¹ at 1 A g⁻¹, a maximum energy density of 63.33 Wh kg⁻¹ and power density of 10 kW kg⁻¹. The retention of specific capacitance was found to be 93% with 5000 continuous cycles of charge-discharge process.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104148"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1673886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Preparing high ratio of trans/trans 2,2-bis(4-hydroxycyclohexyl)propane isomer by one-dimensional nickel-palladium catalyst” [Journal of the Taiwan Institute of Chemical Engineers 129 (2021), 15-25]","authors":"Ying-Chou Su,&nbsp;Cheng-Chien Wang,&nbsp;Chuh-Yung Chen","doi":"10.1016/j.jtice.2021.104183","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.104183","url":null,"abstract":"","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104183"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1673887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxyl-functionalized ultra-thin graphitic-carbon-nitrite nanosheets-accommodated polyvinyl alcohol membrane for pervaporation of isopropanol/water mixture","authors":"Hyeon Tae Shin ,&nbsp;Dong Uk Lee ,&nbsp;Shivshankar Chaudhari ,&nbsp;Seung Yong Choi ,&nbsp;Kie Yong Cho ,&nbsp;Min Young Shon ,&nbsp;Seung Eun Nam ,&nbsp;You In Park","doi":"10.1016/j.jtice.2021.10.026","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.10.026","url":null,"abstract":"<div><h3>Backgrounds</h3><p>This report describes, for pervaporation dehydration of IPA/water mixtures, different types of g-C3N4 nanosheets accommodated in a polyvinyl alcohol matrix, and coating on an alumina hollow fiber membranes were fabricated.</p></div><div><h3>Methods</h3><p>Namely, bulk g-C3N4 (BCN), from the thermal polymerization of a melamine precursor, followed by its exfoliation by acid treatment to prepare acid-treated g-C3N4 (ACN), further hydroxyl functionalization by glycidol treatment to obtain glycidol-modified g-C3N4 (GCN) were synthesized. As-synthesized BCN, ACN, and GCN sheets were characterized using FTIR, XRD, XPS, and AFM techniques. Dispersion of the BCN, ACN and GCN sheets in the PVA matrix was confirmed by FE- SEM, FT-IR, and DSC studies. Owing to the interfacial interaction between the g-C3N4 sheets and PVA, the mechanical strength of the membrane increased; it was more profound for GCN sheets accommodated membrane that attributed to hydrogen bonding interactions due to glycidol modification confirmed.</p></div><div><h3>Significant Findings</h3><p>In pervaporation tests, at a fixed content (2 wt.%) for evaluating the modification effect, the best performance was obtained (flux= 0.199 kg/m2h and separation factor 139.8) with the GCN type g-C3N4 sheets accommodation amidst three types of g-C3N4 nanosheet-accommodated membranes delivered at an 80/20 (w/w, (IPA)/water) feed mixture at 40 °C.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104126"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2303536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Templated synthesis of CuCo2O4-modified g-C3N4 heterojunctions for enhanced photoreduction of Hg2+ under visible light","authors":"Hind Alshaikh ,&nbsp;Ahmed Shawky ,&nbsp;L. Selva Roselin","doi":"10.1016/j.jtice.2021.10.014","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.10.014","url":null,"abstract":"<div><h3>Background</h3><p>The accumulation of mercury (II) ions (Hg²⁺) in wastewater causes critical impacts on human health and the whole environment.</p></div><div><h3>Methods</h3><p>This study report an efficient synthesis of CuCo₂O₄/g-C₃N₄<span> p-n heterojunction by templated growth via triblock copolymer F-127 and mesoporous silica MCM-41 for enhanced photoreduction of Hg</span>²⁺.</p></div><div><h3>Significant Findings</h3><p>The 22.6 nm CuCo₂O₄<span> nanoparticles were anchored on g-C</span>₃N₄ at minor content (0.5−2.0 wt. %) as observed by TEM analysis. The formed heterojunctions exhibited mesoporous surface textures with high specific surface areas. In addition, the visible-light harvesting of g-C₃N₄ was improved by adding CuCo₂O₄ due to the reduction of the bandgap energy from 2.77 to 2.17 eV. The complete visible-light photocatalytic reduction of Hg²⁺ utilizing 1.5 wt.% CuCo₂O₄-modified g-C₃N₄ was realized with a tremendous rate of 286.5 µmol min⁻¹ after dose tuning at 1.5 gL⁻¹. The enhanced catalytic presentation of this innovative CuCo₂O₄/g-C₃N₄ is denoted to the significant separation of photoinduced carriers through the p-n heterojunction's interface. The bearable photocatalytic reduction of Hg²⁺ for five cycles was also established for the regenerated photocatalyst.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104114"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3078775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, bioanalytical, photophysical and chemo-phototherapeutic studies of heteroleptic Cu(II) complexes","authors":"Mudavath Ravi ,&nbsp;Mukka Satish Kumar ,&nbsp;B. Ushaiah ,&nbsp;Ch. Kishan Prasad ,&nbsp;Kunche Sudeepa ,&nbsp;Nayakini Anitha ,&nbsp;Sohail Nizamuddin ,&nbsp;Perugu Shyam ,&nbsp;Ch. Sarala Devi","doi":"10.1016/j.jtice.2021.10.012","DOIUrl":"https://doi.org/10.1016/j.jtice.2021.10.012","url":null,"abstract":"<div><h3>Background</h3><p>A broad investigation has been paid to design an alternative metal-based anticancer drug, bearing metal ions other than platinum, with more target specificity. In this regard, Cu(II) complexes showed a remarkable intercalation binding property with DNA which have received much attention in the development of efficient anticancer drugs.</p></div><div><h3>Methods</h3><p>A series of mononuclear ternary Cu(II) complexes A, B and C were prepared with H₂<span>L and auxiliary ligand. The synthesized H</span>₂L and corresponding complexes were characterized using various electroanalytical and physicochemical techniques. The thermodynamic parameters were calculated using Gibb's-Helmholtz, Arrhenius and Eyring equations. Morphology, binding energies of core electrons and crystallographic nature of the metal complexes were evaluated by SEM, XPS and PXRD techniques. Binding studies of the metal complexes with CT-DNA were conducted by absorption, fluorescence and viscometric methods.</p></div><div><h3>Significant Findings</h3><p>The pBR322 cleavage, antioxidant and molecular docking studies revealed the potent biological activity of title complexes. <em>In-vitro</em> cytotoxicity of these biologically active biomaterials tested against HeLa and MCF-7 by MTT assay and DAPI staining revealed their anticancer activity. Such results are supportive for advanced studies which would come through insight for their possible applications.</p></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"132 ","pages":"Article 104112"},"PeriodicalIF":5.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1950534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}