Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"Biomechanical feasibility of non-locking system in patient-specific mandibular reconstruction using fibular free flaps","authors":"Shengping Zhong ,&nbsp;Qimin Shi ,&nbsp;Jeroen Van Dessel ,&nbsp;Yifei Gu ,&nbsp;Heinz-Theo Lübbers ,&nbsp;Shoufeng Yang ,&nbsp;Yi Sun ,&nbsp;Constantinus Politis","doi":"10.1016/j.jmbbm.2023.106197","DOIUrl":"10.1016/j.jmbbm.2023.106197","url":null,"abstract":"<div><p><span>Mandibular reconstruction with free fibular flaps is frequently used to restore segmental defects. The osteosythesis, including locking and non-locking plate/screw systems, is essential to the mandibular reconstruction. Compared with the non-locking system that requires good adaption between plate and bone, the locking system appears to present a better performance by locking the plate to fixation screws. However, it also brings about limitations on screw options, a higher risk of screw failure, and difficulties in screw placement. Furthermore, its superiority is undermined by the advancing of patient-specific implant<span> design and additive manufacturing. A customized plate can be designed and fabricated to accurately match the mandibular contour for patient-specific mandibular reconstruction. Consequently, the non-locking system seems more practicable with such personalized plates, and its biomechanical feasibility ought to be estimated. </span></span>Finite element analyses of mandibular reconstruction assemblies were conducted for four most common segmental mandibular reconstructions regarding locking and non-locking systems under incisal biting and right molars clenching, during which the influencing factor of muscles’ capacity was introduced to simulate the practical loadings after mandibular resection and reconstruction surgeries. Much higher, somewhat lower, and similar maximum von Mises stresses are separately manifested by the patient-specific mandibular reconstruction plate (PSMRP), fixation screws, and reconstructed mandible with the non-locking system than those with the locking system. Equivalent maximum displacements are identified between PSMRPs, fixation screws, and reconstructed mandibles with the non-locking and locking system in all four reconstruction types during two masticatory tasks. Parallel maximum and minimum principal strain distributions are shared by the reconstructed mandibles with the non-locking and locking system in four mandibular reconstructions during both occlusions. Conclusively, it is feasible to use the non-locking system in case of patient-specific mandibular reconstruction with fibular free flaps based on the adequate safety, comparable stability, and analogous mechanobiology it presents compared with the locking system in a more manufacturable and economical way.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106197"},"PeriodicalIF":3.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of cross shear and contact pressure on the wear of UHMWPE-on-PEEK-OPTIMA™ for use in total knee replacement","authors":"Raelene M. Cowie ,&nbsp;Adam Briscoe ,&nbsp;Louise M. Jennings","doi":"10.1016/j.jmbbm.2023.106196","DOIUrl":"10.1016/j.jmbbm.2023.106196","url":null,"abstract":"<div><p>PEEK-OPTIMA™ polymer is being considered as an alternative material to cobalt chrome in the femoral component of total knee arthroplasty to give a metal-free knee replacement system. Simple geometry pin-on-plate wear simulation can be used to systematically investigate and understand the wear of materials under many different conditions. The aim of this study was to investigate the wear of UHMWPE-on-PEEK-OPTIMA™ under a range of contact pressure (2.1–80 MPa) and cross-shear ratio (0–0.18) conditions.</p><p>With increasing contact pressure, there was a trend of decreasing UHMWPE wear factor with a significant difference (p&lt;0.001) in the wear factor of UHMWPE under the different contact pressure conditions of interest. Under uniaxial motion (cross-shear ratio = 0), the wear of UHMWPE was low, introducing multi-axial motion increased the wear of the UHMWPE. There was a significant difference (p&lt;0.01) in the wear factor at different cross-shear ratios however, post hoc analysis showed only the study carried out under unidirectional motion to be significantly different from the other conditions.</p><p>With varying contact pressure and cross-shear ratio, the wear of UHMWPE against PEEK-OPTIMA™ polymer showed similar trends to previous studies of UHMWPE-on-cobalt chrome.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106196"},"PeriodicalIF":3.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616123005490/pdfft?md5=2f472a62a6efdcb91fcb290bfb271c1a&pid=1-s2.0-S1751616123005490-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of in vitro ribosylation on the dynamic fracture behavior of mature bovine cortical bone","authors":"Tanner Snow ,&nbsp;William Woolley ,&nbsp;Claire Acevedo ,&nbsp;Owen T. Kingstedt","doi":"10.1016/j.jmbbm.2023.106171","DOIUrl":"10.1016/j.jmbbm.2023.106171","url":null,"abstract":"<div><p><span><span><span><span>In this study, the fracture behavior of ribosylated bovine cortical bone is investigated under loading conditions simulating a fall event. Single edge </span>notched specimens<span>, separated into a control group (n = 11) and a ribosylated group (n = 8), were extracted from the mid-diaphysis of a single bovine femur harvested from a mature cow. A seven-day ribosylation process results in the accumulation of Advanced-Glycation End Products (AGEs) cross-links and AGE adducts. Specimens were subjected to symmetric three point bending (opening mode) and an impact velocity of 1.6 m/s using a drop tower. Near-crack displacement fields up to fracture initiation<span> are determined from high-speed images post-processed using digital image correlation. A constrained over-deterministic least </span></span></span>squares regression<span><span> and orthotropic material linear elastic </span>fracture mechanics theory are used to extract the in-plane critical </span></span>stress intensity factors<span> at fracture initiation (i.e., fracture initiation toughness values). Statistically significant differences were not observed when comparing the in-plane fracture initiation toughness values (</span></span><span><math><mrow><mi>p</mi><mo>≥</mo><mn>0</mn><mo>.</mo><mn>96</mn></mrow></math></span><span>) or energy release rate (</span><span><math><mrow><mi>p</mi><mo>=</mo><mn>0</mn><mo>.</mo><mn>90</mn></mrow></math></span>) between the control and seven-day ribosylated groups. The intrinsic variability of bone may require high sample numbers in order to achieve an adequately powered experiment when assessing dynamic fracture behavior. While there are no detectable differences due to the ribosylation treatment investigated, this is likely due to the limited sample sizes utilized.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106171"},"PeriodicalIF":3.9,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61567030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced lithium disilicate: A comparative evaluation of translucency and fatigue failure load to other ceramics for monolithic restorations","authors":"Júlia Saccol Freitas ,&nbsp;Luiza Freitas Brum Souza ,&nbsp;Fernando Zurlo Dellazzana ,&nbsp;Tamires Motta Rensch da Silva ,&nbsp;Luiza Ribeiro ,&nbsp;Gabriel Kalil Rocha Pereira ,&nbsp;Liliana Gressler May","doi":"10.1016/j.jmbbm.2023.106192","DOIUrl":"10.1016/j.jmbbm.2023.106192","url":null,"abstract":"<div><p>The aim of this <em>in vitro</em><span> study was to evaluate the surface roughness<span><span>, translucency, fatigue failure load (FFL), and number of cycles for fatigue failure (CFF) of a recently released lithia-based material called advanced lithium disilicate and three other ceramics indicated for monolithic restorations. First, ALD (advanced lithium disilicate, CEREC Tessera, Dentsply Sirona), LD (lithium disilicate, IPS e. max CAD, Ivoclar), LS (lithium silicate-disilicate, Suprinity, Vita Zahnfabrik), and 4Y-PSZ (Yttria-stabilized zirconia, IPS e.max ZirCAD MT, Ivoclar) discs (n = 15, Ø = 10 mm and thickness = 1.0 mm) were fabricated from CAD/CAM blocks/discs, A2 shade. The discs were sintered/crystallized and subsequently analyzed by a rugosimeter (Mitutoyo SJ-410) to determine Ra and Rz surface roughness parameters. Next, they were evaluated to determine the translucency parameter (TP) using a bench-top spectrophotometer (SP60, EX-Rite). The discs were subsequently cemented to glass fiber epoxy resin discs, and the specimens were tested under cyclic loading (Step-test), immersed in distilled water at a frequency of 20 Hz, with an initial </span>cyclic load<span><span> of 200 N for 5,000 cycles and increments of 50 N every 10,000 cycles until failure. Fatigue failure load (FFL) and number of cycles for fatigue failure (CFF) were recorded for subsequent Kaplan Meier analysis, with post-hoc Mantel-Cox and Weibull analysis (α = 0.05). Complementary fractographic, topographic and energy dispersive spectroscopy analyses (EDS) were performed. 4Y-PSZ showed higher survival (p &lt; 0.05), with higher FFL and CFF (1077 N; 180,333 cycles), followed by LD (980 N; 161,000 cycles), LS (937 N; 152,333 cycles) and ALD (910 N; 147,000 cycles). No differences were observed between the tested groups regarding Weibull modulus. ALD presented TP (28.14) equal to DL (28.27) and higher than LS (25.51). All lithia-based materials had higher translucency than 4Y-PSZ (TP = 8.62) (p &lt; 0.05). ALD appears to have a similar </span>elemental composition<span><span> to LD and LSD for oxygen and silicon. ALD and LSD have a similar </span>zirconium content. Fractures originated on the cemented surface of the ceramic discs. Lithia-based ceramics showed lower surface roughness, with ALD (Ra = 0.04 μm; Rz = 0.66 μm) showing the lowest values (p &lt; 0.05). Despite showing lower FFL when compared to LD and 4Y-PSZ, ALD has compatible translucency and mechanical fatigue performance with its indication for fabricating monolithic, anterior and posterior adhesively cemented single-unit restorations. However, further studies are needed to substantiate its clinical performance.</span></span></span></span></p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106192"},"PeriodicalIF":3.9,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compromised homeostasis in aged carotid arteries revealed by microstructural studies of elastic lamellae","authors":"Anastasia Gkousioudi ,&nbsp;Taisiya Sigaeva ,&nbsp;Xunjie Yu ,&nbsp;Francesca Seta ,&nbsp;Richard D. Wainford ,&nbsp;Yanhang Zhang","doi":"10.1016/j.jmbbm.2023.106187","DOIUrl":"10.1016/j.jmbbm.2023.106187","url":null,"abstract":"<div><p><span><span>Healthy arteries are continuously subjected to diverse mechanical stimuli and adapt in order to maintain a mechanical homeostasis which is characterized by a uniform distribution of wall stresses. However, aging may compromise the homeostatic microenvironment within arteries. Structural heterogeneity has been suggested as a potential microstructural mechanism that could lead to homogeneous stress distribution across the arterial wall. Our previous study on the unfolding and stretching of the elastic lamellae revealed the underlying microstructural mechanism for equalizing the </span>circumferential<span><span> stresses through wall; inner elastic layers are wavier and unfold more than the outer layers which helps to evenly distribute lamellar stretching (Yu et al., 2018). In this study, we investigated the effect of aging on lamellar deformation and its implications for tissue homeostasis. Common carotid arteries from aged mice were imaged under a multi-photon microscope while subjected to biaxial extension and inflation at five different pressures ranging from 0 up to 120 mmHg. Lamellar unfolding during </span>pressurization<span> was then determined from the reconstructed cross-sectional images of elastic lamellae. Tissue-level circumferential stretch was combined with the lamellar unfolding to calculate lamellar stretching. Our results revealed that the straightness gradient of aged elastic lamellae is similar to the young ones. However, during pressurization, the inner elastic lamella of the aged mice unfolded significantly more than the inner layer in young arteries. An important finding of our study is the uneven increase in inter-lamellar space which contributed to a nonuniform stretching of the elastic lamellae of aged mice arteries, elevated stress gradient, and a shifting of the load-bearing component to adventitia. Our results shed light into the complex microstructural mechanisms that take place in aging and adversely affect arterial </span></span></span>mechanical behavior and homeostasis.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106187"},"PeriodicalIF":3.9,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depth profiling via nanoindentation for characterisation of the elastic modulus and hydraulic properties of thin hydrogel layers","authors":"Dichu Xu ,&nbsp;Maria Luisa Hernandez Miranda ,&nbsp;Nicholas D. Evans ,&nbsp;Bram G. Sengers ,&nbsp;Martin Browne ,&nbsp;Richard B. Cook","doi":"10.1016/j.jmbbm.2023.106195","DOIUrl":"10.1016/j.jmbbm.2023.106195","url":null,"abstract":"<div><p>The accurate determination of the mechanical properties of hydrogels is of fundamental importance for a range of applications, including in assessing the effect of stiffness on cell behaviour. This is a particular issue when using thin hydrogel layers adherent to stiff substrate supports, as the apparent stiffness can be significantly influenced by the constraint of the underlying impermeable substrate, leading to inaccurate measurements of the elastic modulus and permeability of thin hydrogel layers. This study used depth profiling nanoindentation and a poroelastic model for spherical indentation to identify the elastic moduli and hydraulic conductivity of thin polyacrylamide (PAAm) hydrogel layers (∼27 μm–782 μm thick) on impermeable substrates. The apparent stiffness of thin PAAm layers increased with indentation depth and was significantly greater than those of thicker hydrogels, which showed no influence of indentation depth. The hydraulic conductivity decreased as the geometrical confinement of hydrogels increased, indicating that the fluid became more constrained within the confinement areas. The impact of geometrical confinement on the apparent modulus and hydraulic conductivity of thin PAAm hydrogel layers was then established, and their elastic moduli and intrinsic permeability were determined in relation to this effect. This study offers valuable insights into the mechanical characterisation of thin PAAm hydrogel layers used for the fundamental study of cell mechanobiology.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106195"},"PeriodicalIF":3.9,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616123005489/pdfft?md5=903ea6b7b23bba7e7b1617dac657423b&pid=1-s2.0-S1751616123005489-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scaphoid numerical simulation of the critical loading until fracture","authors":"Ana B. Maroto ,&nbsp;Pedro Navas ,&nbsp;Felicia Alfano","doi":"10.1016/j.jmbbm.2023.106186","DOIUrl":"10.1016/j.jmbbm.2023.106186","url":null,"abstract":"<div><p>The numerical study of the scaphoid fracture, although it is relatively unexplored, can be of great clinical interest since it is highly common and can result in temporary or persistent disability.</p><p>In this manuscript, seven combinations of boundary conditions and contacts between adjacent bones, together with four different loads, simulating real hand movements, are assessed.</p><p>Three different fracture criteria for bones are employed to study the failure of the scaphoid with the aforementioned combination of interaction conditions. The results offer an interesting view of the accuracy of the possible interaction between adjacent bones. For future calculation, it would be possible to choose a combination of the balance between precision and computational cost savings.</p><p>This study provides a comprehensive assessment into the modeling of the scaphoid bone and its interactions with adjacent bones. The findings reveal that various choices of interactions can yield similar results, allowing for flexibility in selecting interaction models based on desired accuracy or computational efficiency. Ultimately, this study establishes a foundational understanding for future research on modeling scaphoid motion.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106186"},"PeriodicalIF":3.9,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective mechanical properties of frozen hydrogel with ice inclusions","authors":"Qinyun Yang ,&nbsp;Moxiao Li ,&nbsp;Xuechao Sun ,&nbsp;Ming Wang ,&nbsp;Shaobao Liu","doi":"10.1016/j.jmbbm.2023.106190","DOIUrl":"10.1016/j.jmbbm.2023.106190","url":null,"abstract":"<div><p><span>Hydrogel exhibits attractive mechanical properties<span><span><span> that can be regulated to be extremely tough, strong and resilient, adhesive and fatigue-resistant, thus enabling diverse applications ranging from tissue engineering scaffolds, flexible devices, to soft machines. As a liquid-filled porous material composed of </span>polymer networks and water, the hydrogel freezes at subzero temperatures into a new material composed of </span>polymer matrix<span> and ice inclusions: the frozen hydrogel displays dramatically altered mechanical properties, which can significantly affect its safety and reliability in practical applications. In this study, based upon the theory of homogenization, we predicted the effective mechanical properties (</span></span></span><em>e.g.</em><span><span><span>, Young's modulus<span>, shear modulus, bulk modulus and Poisson ratio) of a frozen hydrogel with periodically distributed longitudinal ice inclusions. We firstly estimated its longitudinal Young's modulus, longitudinal </span></span>Poisson ratio and plane strain bulk modulus using the self-consistent method, and then its longitudinal and transverse shear modulus using the generalized self-consistent method; further, the results were employed to calculate its transverse Young's modulus and transverse Poisson ratio. We validated the theoretical predictions against both </span>finite element (FE) simulation and experimental measurement results, with good agreement achieved. We found that the estimated transverse Poisson ratio ranges from 0.3 to 0.53 and, at low volume fraction of ice inclusions, exhibits a value larger than 0.5 that exceeds the Poisson ratios of both the polymer matrix and the ice inclusion (typically 0.33–0.35). Compared with other homogenization methods (</span><em>e.g.</em>, the rule of mixtures, the Halpin-Tsai equations, and the Mori-Tanaka method), the present approach is more accurate in predicting the effective mechanical properties (in particular, the transverse Poisson ratio) of frozen hydrogel. Our study provides theoretical support for the practical applications of frozen liquid-saturated porous materials such as hydrogel.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106190"},"PeriodicalIF":3.9,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrosion, surface, and tribological behavior of electrophoretically deposited polyether ether ketone coatings on 316L stainless steel for orthopedic applications","authors":"Khalil Ahmad ,&nbsp;Syeda Ammara Batool ,&nbsp;Muhammad Tahir Farooq ,&nbsp;Badar Minhas ,&nbsp;Jawad Manzur ,&nbsp;Muhammad Yasir ,&nbsp;Abdul Wadood ,&nbsp;Egemen Avcu ,&nbsp;Muhammad Atiq Ur Rehman","doi":"10.1016/j.jmbbm.2023.106188","DOIUrl":"10.1016/j.jmbbm.2023.106188","url":null,"abstract":"<div><p><span>Electrophoretic deposition (EPD) of </span>polyether ether ketone<span><span><span><span> (PEEK) coatings on metallic implants<span> has recently attracted a great deal of interest; however, further investigation into their corrosion, surface, and tribological properties is required for their clinical application. Using Potentiodynamic polarization and Mott-Schottky analysis of PEEK coatings, we analyzed the electrochemical corrosion behavior<span><span> of electrophoretically deposited PEEK coatings on 316L stainless steel (SS) substrates. In addition, the tribological behavior of the coatings was determined through pin-on-disc and scratch testing. Initially, the EPD parameters were optimized using a Taguchi Design of Experiment (DoE) approach. The coatings exhibited irregular shaped grains along with ∼66 μm of thickness. </span>Fourier transform<span> infrared spectroscopy confirmed the presence of functional groups ascribed with PEEK. The coatings were moderately hydrophobic and had an average roughness of ∼2 μm. The corrosion studies demonstrated promising features of current density and </span></span></span></span>corrosion potential, indicating that </span>corrosion resistance<span><span> significantly improves with PEEK coating. Electrochemical impedance spectroscopy also confirmed the corrosion resistance of PEEK coating. The coatings exhibited a slightly lower wear resistance than SS samples, but still possessed adequate wear and scratch resistance for </span>biomedical applications<span>. The current study confirmed that the PEEK coatings on metallic implants is effective for orthopedic applications where corrosion and </span></span></span>tribology are major concerns.</span></p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106188"},"PeriodicalIF":3.9,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drivers of vascular growth and remodeling: A computational framework to promote benign adaptation in the Ross procedure","authors":"Thibault Vervenne ,&nbsp;Lauranne Maes ,&nbsp;Lucas Van Hoof ,&nbsp;Filip Rega ,&nbsp;Nele Famaey","doi":"10.1016/j.jmbbm.2023.106170","DOIUrl":"10.1016/j.jmbbm.2023.106170","url":null,"abstract":"<div><p><span><span>In the sixties, Dr Donald Ross designed a surgical solution for young patients with aortic valve disease by using the patients’ own pulmonary valve. The Ross procedure is the only aortic valve replacement technique that can restore long-term survival and preserve quality of life. The main failure mode of the Ross procedure is wall dilatation, potentially leading to valve regurgitation and leakage. Dilatation occurs due to the inability of the pulmonary autograft to adapt to the sudden increase in loading when exposing to aortic pressures. Previous experimental data has shown that a permanent external support wrapped around the artery can prevent the acute dilatation of the arterial wall. However, the textile support leads to stress-shielding phenomena due to the loss of mechanical wall compliance. We present a pragmatic and modular computational framework of arterial growth and remodeling predicting the long-term outcomes of cardiovascular tissue adaptation, with and without textile wrapping. The model integrates mean, systolic and </span>diastolic pressures and assumes the resulting wall stresses to drive the biological remodeling rules. Rather than a single mean pressure or stress deviation from the homeostatic state, we demonstrate that only pulsatile stresses can predict available experimental results. Therefore, we suggest that a biodegradable external support could induce benign remodeling in the Ross procedure. Indeed, a biodegradable textile wrapped around the autograft fulfills the trade-off between prevention of acute dilatation on the one hand and recovery of arterial wall compliance on the other hand. After further validation, the computational framework can set the basis for the development of an actual biodegradable external support for the Ross procedure with optimized polymer </span>mechanical properties and degradation behavior.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"148 ","pages":"Article 106170"},"PeriodicalIF":3.9,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}