Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"A comprehensive methodology to assess human bone transversal toughness based on macroscopic specimens, the compliance method, and 3D bio-faithful numerical simulations","authors":"T. Kurtz ,&nbsp;Y. Godio-Raboutet ,&nbsp;F.L.B. Ribeiro ,&nbsp;J.-L. Tailhan","doi":"10.1016/j.jmbbm.2024.106869","DOIUrl":"10.1016/j.jmbbm.2024.106869","url":null,"abstract":"<div><div>This study proposes a method for assessing the transverse toughness of human long-bone cortical tissue. The method is based on a three-point bending test of pre-notched femur diaphysis segments, post-processed using the compliance method coupled with numerical simulations. Given the cracking nature of bone and if cracking processes remain confined to the crack tip, it is assumed that the compliance method can be used. Numerical simulations are based on a bio-faithful 3D reconstruction of the bones tested and a detailed consideration of the boundary and loading conditions of the mechanical test. The resulting toughness values obtained on embalmed bones range from <span><math><msub><mrow><mi>G</mi></mrow><mrow><mi>c</mi></mrow></msub></math></span>=4.3 to 7.1 N/mm. The assumptions made, the biofidelity of the simulations, and the ability of the method to determine an intrinsic toughness value of cortical bone, considered a heterogeneous material, are discussed. Although related to embalmed bones, and considering the limitations this state can induce, the toughness values obtained are consistent with data from the literature. Due to the larger specimen size, they are also more realistic, ensuring a complete description of the material’s crack extension resistance curve. They mainly characterize the medial and lateral quadrants of the bone transversal section. The study concludes that the proposed method provides a robust approach for assessing bone transversal toughness.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106869"},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The human patellar tendon is mechanically homogenous at its mid-substance","authors":"Adam Kositsky ,&nbsp;Lauri Stenroth ,&nbsp;Ervin Nippolainen ,&nbsp;Jari Torniainen ,&nbsp;Janne T.A. Mäkelä ,&nbsp;Petri Paakkari ,&nbsp;Tommi Paakkonen ,&nbsp;Heikki Kröger ,&nbsp;Juha Töyräs ,&nbsp;Isaac O. Afara ,&nbsp;Rami K. Korhonen","doi":"10.1016/j.jmbbm.2024.106875","DOIUrl":"10.1016/j.jmbbm.2024.106875","url":null,"abstract":"<div><div>The human patellar tendon contains distinct fascicle bundles across its mediolateral and anteroposterior regions. Studies have suggested region-specific behaviour during <em>in vivo</em> actions, but it is unclear whether such regional differences result from localized variation in composition and mechanical properties within the tendon itself. Furthermore, the viscoelastic properties of any region of the human patellar tendon have not been well described previously. Here, a comprehensive investigation of the composition and material properties of six regions (three mediolateral × two anteroposterior) of the human patellar tendon was performed on tendons harvested from eight cadaver knees. Thorough viscoelastic (stress relaxation and sinusoidal) and elastic (failure) mechanical tests were conducted on dumbbell-shaped samples. Uronic acid (proteoglycan), hydroxyproline (collagen), and water contents were measured from the samples after mechanical testing. No systematic between-region differences were found for any measured biomechanical or biochemical parameter. However, the phase difference between stress and strain decreased as a function of increasing sinusoidal frequency (from 0.1 Hz to 5 Hz), suggesting the human patellar tendon behaves more elastically at higher strain rates. These results indicate the human patellar tendon is a homogenous material at its mid-substance and that other factors, such as geometrical constraints, enthesis properties, and insertion points, may be responsible for any region-specific behaviour <em>in vivo</em>. Additionally, the more elastic behaviour of the human patellar tendon as strain rate increases likely supports improved joint control and enhanced movement economy during fast actions such as sprinting.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106875"},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical behavior of cantilevered 3-unit implant-supported prostheses made of PEKK and monolithic zirconia: A finite element study","authors":"Hatem S. Sadek ,&nbsp;Noha M. Anany ,&nbsp;Mohamed I. El-Anwar ,&nbsp;Abdulaziz Alhotan ,&nbsp;Al-Hassan Diab ,&nbsp;Mostafa Aldesoki ,&nbsp;Tarek M. Elshazly ,&nbsp;Christoph Bourauel","doi":"10.1016/j.jmbbm.2024.106872","DOIUrl":"10.1016/j.jmbbm.2024.106872","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the biomechanical performance of various designs of cantilevered three-unit implant-supported prostheses, using two distinct prosthetic materials and under different loading conditions.</div></div><div><h3>Method</h3><div>Three mandibular models were created with varying implant positions to support a 3-unit prosthesis using two materials (Zirconia and PEKK), resulting in three different designs: distal cantilever (M1), fixed-fixed (M2), and mesial cantilever (M3). The geometric model was created by segmenting a CBCT scan of an edentulous mandible using Mimics software, followed by refinement in 3-Matic to generate a trabecular bone core encased by a 2 mm-thick cortical shell and a 1 mm-thick mucosal layer. Implant CAD files were integrated, and the models were processed in SolidWorks to finalize solid geometries. These were then imported into ANSYS for mesh generation and finite element analysis, with materials assumed to be isotropic and elastic. Models underwent 3 different static loading protocols (Vertical 100 N, 30° Oblique 50 N, 45° Oblique 50 N). Von Mises stress and total deformation were calculated.</div></div><div><h3>Results</h3><div>Model 2 demonstrated the best performance. Under vertical loading, PEKK prostheses showed lower stress than zirconia in the prosthetic body (10–45 %) and the cortical bone (3–40 %), but higher stresses in the implant (4–10 %). Compared to vertical loading, oblique loading generated higher stress but remained within a safe range without compromising function.</div></div><div><h3>Conclusion</h3><div>The fixed-fixed design showed optimal biomechanical performance. The mesial cantilever was more favorable than the distal for stress distribution. Zirconia provided superior stress dissipation, while PEKK showed reduced stress in the prosthetic body but increased stress I the implant and bone.</div></div><div><h3>Clinical significance</h3><div>The study provides prosthodontists with evidence recommending design and materials for 3-unit implant-supported prostheses. Zirconia is ideal for cantilevered designs, resisting high bending forces and minimizing implant stress, while PEKK is more suitable for fixed-fixed designs with lower stress levels.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106872"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and age differentially affect stiffness, injury susceptibility, and composition of murine uterosacral ligaments","authors":"Catalina S. Bastías ,&nbsp;Lea M. Savard ,&nbsp;Kathryn R. Jacobson ,&nbsp;Kathleen A. Connell ,&nbsp;Sarah Calve ,&nbsp;Virginia L. Ferguson ,&nbsp;Callan M. Luetkemeyer","doi":"10.1016/j.jmbbm.2024.106874","DOIUrl":"10.1016/j.jmbbm.2024.106874","url":null,"abstract":"<div><div>Pelvic organ prolapse is a debilitating condition that diminishes quality of life, and it has been linked to pregnancy and aging. Injury of the uterosacral ligaments (USLs), which provide apical support to the pelvic organs, is a major cause of uterine prolapse. In this study, we examined the effect of pregnancy and age on the apparent elastic modulus, susceptibility to collagen damage, and extracellular matrix (ECM) composition of the murine USL. USLs from mice at three different stages of pregnancy and across two age groups were mechanically tested and evaluated for collagen microdamage. Raman spectroscopy was used to evaluate changes in ECM composition. Our findings reveal that (1) all USLs subjected to mechanical stretch sustained collagen microdamage, (2) both pregnancy and age significantly affected USL stiffness and injury susceptibility, and (3) pregnancy, but not age, altered ECM composition. Overall, this work represents a major step toward understanding the role of tissue microstructure and mechanical function in USL injury, which should guide novel ECM-targeted treatment and prevention strategies for uterine prolapse.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106874"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed suction clamps for tensile testing of brain tissue","authors":"J. Zwirner ,&nbsp;J.N. Waddell ,&nbsp;B. Ondruschka ,&nbsp;K.C. Li","doi":"10.1016/j.jmbbm.2024.106873","DOIUrl":"10.1016/j.jmbbm.2024.106873","url":null,"abstract":"<div><div>The conventional mounting of ultra-soft biological tissues often involves gluing it between two plates or manually tightening grips. Both methods demand delicate handling skills and are time-consuming. This study outlines the design and practical application of 3D-printed suction clamps for uniaxial tension tests on brain samples. Successful testing was defined by the absence of relevant slippage or the sample being drawn into the clamp. A total of 112 deer brain samples underwent testing using a universal testing machine after one freeze-thaw cycle. These samples were obtained from eight different brain regions. During sample preparation, 7 out of all samples failed. Among the 105 tests, 89 (85%) were successful. Of the 16 unsuccessful tests, 15 samples (14%) slipped, while only one sample (1%) was drawn into the clamp to an extent that testing became impossible. Medulla oblongata samples exhibited exceptionally high slippage at 38%, whereas samples from the temporal cortex, external capsule, and putamen had the lowest slippage in only one single case. In conclusion, suction clamps facilitate high-throughput testing through user-friendly and rapid sample mounting. Testing success is contingent on the specific brain site, with sample slippage being the primary reason for testing failures, while sample inspiration into the clamp is negligible.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106873"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cutting forces and microdamage during indentation cutting of bone","authors":"Ger Reilly ,&nbsp;David Taylor","doi":"10.1016/j.jmbbm.2024.106870","DOIUrl":"10.1016/j.jmbbm.2024.106870","url":null,"abstract":"<div><div>In surgery, bone can be cut by applying force to a wedge-shaped blade. The published literature is relatively sparse regarding the biomechanics of this type of indentation cutting, especially regarding the relationships between blade geometry, bone quality, cutting force and microdamage. Microdamage created near the cut surfaces can be beneficial, as a trigger for bone remodelling, but it is known that excessive fracture damage can prolong the healing time. In this research, specimens of compact bovine bone were tested by cutting using wedge blades of different geometries. We labelled and measured microdamage occurring during bone cutting for the first time. We found that there were statistically significant effects arising from the variation in wedge angle, edge radius and blade orientation (with respect to bone's anisotropic structure) on both the magnitude of the cutting force and the extent of the microdamage. Interestingly, we found that the amount of damage occurring during cutting is directly correlated to the cutting force which causes the damage, independent of other factors. This work contributes to a better understanding of the biomechanics of this important surgical cutting process.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106870"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrosion fatigue of as-extruded Mg-xGa alloys in simulated bodily fluids with various glucose contents","authors":"Jiebin Zou ,&nbsp;Jia Ma ,&nbsp;Ziyue Zhang ,&nbsp;Lingxiong Sun ,&nbsp;Mohammed R.I. Abueida ,&nbsp;Song Zhang ,&nbsp;Xiaopeng Lu ,&nbsp;Yan Li ,&nbsp;Hongyan Tang ,&nbsp;Qiang Wang","doi":"10.1016/j.jmbbm.2024.106866","DOIUrl":"10.1016/j.jmbbm.2024.106866","url":null,"abstract":"<div><div>The medical devices are subjected to dynamic loads and surrounding physiological condition of the bodily fluids, which will impact the degradation behavior of magnesium (Mg) alloy implants. In this work, the corrosion fatigue (CF) and corrosion behaviors of Mg-<em>x</em>Ga (<em>x</em> = 1, 1.5, and 2 wt%) alloys in Hank's balanced salt solutions (HBSS) with 1 g/L and 3 g/L glucose are thoroughly studied. It is concluded that Mg-2Ga alloy exhibits excellent mechanical and fatigue behaviors. Its ultimate tensile strength (UTS) is 234 MPa, yield strength (YS) is 145 MPa, elongation (EL) is 15%, fatigue limits (<em>σ</em>_<em>f</em>) is 111 MPa in air, 48 MPa in HBSS with 1 g/L glucose, and 66 MPa in HBSS with 3 g/L glucose. The high glucose content in simulated bodily fluids has the function of inhibiting the corrosion reaction of alloy which is favorable to CF.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106866"},"PeriodicalIF":3.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradability, biocompatibility, and mechanical behavior of additively manufactured zinc scaffolds","authors":"Mahdi Kaveh ,&nbsp;Mohsen Badrossamay ,&nbsp;Ehsan Foroozmehr ,&nbsp;Mahshid Kharaziha","doi":"10.1016/j.jmbbm.2024.106868","DOIUrl":"10.1016/j.jmbbm.2024.106868","url":null,"abstract":"<div><div>Zinc is a promising material for biodegradable scaffolds due to its biocompatible nature and suitable degradation rate. However, its low mechanical strength limits its use in load-bearing applications. This study aims to address this challenge by optimizing the process parameters of pure zinc using laser-based powder bed fusion and designing zinc scaffolds with tailored structures. Scaffolds based on five different unit cell types (Diamond, gyroid, primitive, Fischer-Kock S, and I-WP) were designed and fabricated using the optimized process parameters. The resulting scaffolds were evaluated for mechanical properties, degradation behavior, and cytocompatibility evaluation. Results show that I-WP and primitive scaffolds exhibited superior mechanical properties with compressive yield strength of 36.1 ± 1.2 MPa and 33.5 ± 1.4 MPa, respectively. While all scaffolds displayed a degradation rate within the range of 0.14–0.15 mm/year, the I-WP and primitive design exhibited a slightly higher degradation rate (0.15 mm/year) compared to the gyroid, diamond, and Fischer Koch S scaffolds (0.14 mm/year). Zinc itself demonstrated excellent cytocompatibility, as evidenced by in vitro MTT assay and cell morphology studies. Unit cell morphology also could accelerate proliferation, where MG-63 cells formed bridges between the unit cell walls in Fischer Koch S scaffolds. Considering the targeted application (mandible or jawbone healing) and evaluating all findings, scaffolds with I-WP and primitive designs and wall thicknesses of 500 μm (S01) emerged as the most promising candidates in mandible healing injuries.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106868"},"PeriodicalIF":3.3,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Margin quality, homogeneity, and internal porosity assessment of experimental short fiber-reinforced CAD/CAM composite","authors":"Enas Mangoush ,&nbsp;Sufyan Garoushi ,&nbsp;Jorma Määttä ,&nbsp;Pekka K. Vallittu ,&nbsp;Lippo Lassila ,&nbsp;Eija Säilynoja","doi":"10.1016/j.jmbbm.2024.106867","DOIUrl":"10.1016/j.jmbbm.2024.106867","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to evaluate the margin quality of anterior crowns made of experimental short fiber-reinforced CAD/CAM composite (SFRC CAD) block before and after cyclic fatigue aging. Moreover, to investigate the microstructure, homogeneity, and porosity of the SFRC CAD compared with other commercial CAD/CAM materials.</div></div><div><h3>Methods</h3><div>40 anterior crowns were milled from five CAD/CAM blocks divided into five groups (n = 8/group). The first group was made of lithium disilicate ceramic blocks (EM), the second of zirconia-reinforced lithium disilicate blocks (CD), the third of hybrid polymer-infiltrated ceramic network blocks (VE), the fourth of hybrid nanoparticle-filled resin blocks (CS), and the last of SFRC CAD blocks (SFRC). Crowns were inspected with stereomicroscope and margins irregularities were measured using FIJI software. Specimens were scanned using micro-CT to investigate porosity and homogeneity. Crowns were then subjected to cyclic fatigue aging (120,000 cycles, Fmax = 220 N) and margin irregularities were measured again. SEM/EDS and XPS analyses were employed.</div></div><div><h3>Results</h3><div>SFRC CAD group resulted in the least margin irregularity values compared to other groups before and after cyclic fatigue aging, and lithium disilicate group resulted in the highest margin irregularity values (p &lt; 0.05). Micro-CT scanning revealed a homogenous distribution of fillers of tested materials with low internal porosity.</div></div><div><h3>Significance</h3><div>Material type and fatigue aging significantly affect crown margin irregularities. Hybrid and resin-based groups resulted in less margins irregularities than ceramic-based ones. All tested materials have homogenous structures with low internal porosity within the range of imaging resolution.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106867"},"PeriodicalIF":3.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing magnesium-based materials for biomedical applications using an innovative strategy of combined single point incremental forming and bioactive coating","authors":"Roberta Ruggiero ,&nbsp;Rosa Maria Marano ,&nbsp;Benedetta Marrelli ,&nbsp;Anastasia Facente ,&nbsp;Elisabetta Aiello ,&nbsp;Romina Conte ,&nbsp;Giuseppe Serratore ,&nbsp;Giuseppina Ambrogio ,&nbsp;Francesco Paduano ,&nbsp;Marco Tatullo","doi":"10.1016/j.jmbbm.2024.106858","DOIUrl":"10.1016/j.jmbbm.2024.106858","url":null,"abstract":"<div><h3>Background</h3><div>Magnesium (Mg) and its alloys are promising candidates for biodegradable materials in next-generation bone implants due to their favourable mechanical properties and biodegradability. However, their rapid degradation and corrosion, potentially leading to toxic byproducts, pose significant challenges for widespread use.</div></div><div><h3>Objectives</h3><div>This study aimed to address the challenges associated with Mg-based materials by thoroughly evaluating the biocompatibility, genotoxicity, and mechanical properties of Mg-based devices manufactured via Single Point Incremental Forming (SPIF). Additionally, the study explored the efficacy of a bioactive coating in enhancing the biocompatibility of these devices.</div></div><div><h3>Methods</h3><div>The biocompatibility of six different Mg-SPIF substrates was assessed using an indirect cytotoxicity assay while genotoxicity was evaluated using the Ames test. Mg-based implants were subjected to roughness and thickness tests, as well as metallographic observations. To enhance biocompatibility, a coating comprising sodium hydroxide (NaOH), ascorbic acid (AA), and bovine serum albumin (BSA) was applied to the most promising Mg-SPIF devices.</div></div><div><h3>Results</h3><div>None of the Mg-SPIF devices demonstrated genotoxicity. Out of the six devices evaluated, only two, which had lower surface roughness, exhibited the most favourable biocompatibility responses. Additionally, the surface functionalization strategy significantly enhanced the biocompatibility of these Mg-SPIF devices, demonstrating up to 70% improvement in cell viability compared to unmodified substrates, indicating substantial enhancement in biological performance.</div></div><div><h3>Conclusions</h3><div>These results underscore the potential of SPIF Mg-based materials, particularly when enhanced with a bioactive OH-AA-BSA coating, to revolutionize medical implant technology by providing a safer and more effective option for a wide range of biomedical applications. While these <em>in vitro</em> findings are very promising, translation to clinical applications requires comprehensive <em>in vivo</em> validation, focusing on degradation kinetics, local tissue response, and mechanical integrity under physiological conditions.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106858"},"PeriodicalIF":3.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}