Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"A first step towards the detection of damage processes in endodontic Ni-Ti alloy files, using acoustic emission","authors":"Jeanne Davril ,&nbsp;Romain Hocquel ,&nbsp;Marin Vincent ,&nbsp;Rémy Balthazard ,&nbsp;Stéphane Claude ,&nbsp;Eric Mortier ,&nbsp;Adrien Baldit ,&nbsp;Rachid Rahouadj","doi":"10.1016/j.jmbbm.2024.106743","DOIUrl":"10.1016/j.jmbbm.2024.106743","url":null,"abstract":"<div><p>Despite major instrumental developments over the last decade, endodontic files are still not infallible. It is well known that NiTi rotary files can break without any visible sign of deformation. Instrument breakage under combined flexion-torsion loading is still common in clinical practice. Unfortunately, breakage of this type of instrument mainly occurs in narrow canals, through pinching in the apical region. When such an incident occurs, the endodontist must adopt a debris retrieval strategy that is both stressful and not guaranteed success. This study proposes a new method for experimental damage detection leading to the fracture of Ni-Ti shape memory alloy endodontic files. It is based on the acoustic emission (AE) technique and mechanical parameters measured in real-time and image analysis. It has been shown that the AE results correlate with the damage observations and torque and force measurements recorded during the tests.</p><p>Having carried out numerous root canal treatment on resin blocks, it appears that this new detection and analysis technique can be used to analyze and anticipate the first signs of damage leading to endodontic file failure. The technological development of such a method, at the level of the engine itself, associated with the act in service procedure, would constitute a revolution in the field of endodontics.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106743"},"PeriodicalIF":3.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific surrogate model to predict pelvic floor dynamics during vaginal delivery","authors":"Rita Moura ,&nbsp;Dulce A. Oliveira ,&nbsp;Marco P.L. Parente ,&nbsp;Nina Kimmich ,&nbsp;Luděk Hynčík ,&nbsp;Lucie H. Hympánová ,&nbsp;Renato M. Natal Jorge","doi":"10.1016/j.jmbbm.2024.106736","DOIUrl":"10.1016/j.jmbbm.2024.106736","url":null,"abstract":"<div><p>Childbirth is a challenging event that can lead to long-term consequences such as prolapse or incontinence. While computational models are widely used to mimic vaginal delivery, their integration into clinical practice is hindered by time constraints. The primary goal of this study is to introduce an artificial intelligence pipeline that leverages patient-specific surrogate modeling to predict pelvic floor injuries during vaginal delivery. A finite element-based machine learning approach was implemented to generate a dataset with information from finite element simulations. Thousands of childbirth simulations were conducted, varying the dimensions of the pelvic floor muscles and the mechanical properties used for their characterization. Additionally, a mesh morphing algorithm was developed to obtain patient-specific models. Machine learning models, specifically tree-based algorithms such as Random Forest (RF) and Extreme Gradient Boosting, as well as Artificial Neural Networks, were trained to predict the nodal coordinates of nodes within the pelvic floor, aiming to predict the muscle stretch during a critical interval. The results indicate that the RF model performs best, with a mean absolute error (MAE) of 0.086 mm and a mean absolute percentage error of 0.38%. Overall, more than 80% of the nodes have an error smaller than 0.1 mm. The MAE for the calculated stretch is equal to 0.0011. The implemented pipeline allows loading the trained model and making predictions in less than 11 s. This work demonstrates the feasibility of implementing a machine learning framework in clinical practice to predict potential maternal injuries and assist in medical-decision making.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106736"},"PeriodicalIF":3.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003680/pdfft?md5=18db24375ec240fe21dbc2ce80d7caa1&pid=1-s2.0-S1751616124003680-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anisotropic swelling due to hydration constrains anisotropic elasticity in biomaterial fibers","authors":"Xander A. Gouws,&nbsp;Ana Mastnak,&nbsp;Laurent Kreplak,&nbsp;Andrew D. Rutenberg","doi":"10.1016/j.jmbbm.2024.106749","DOIUrl":"10.1016/j.jmbbm.2024.106749","url":null,"abstract":"<div><div>Naturally occurring protein fibers often undergo anisotropic swelling when hydrated. Within a tendon, a hydrated collagen fibril’s radius expands by 40% but its length only increases by 5%. The same effect, with a similar relative magnitude, is observed for single hair shafts. Fiber hydration is known to affect elastic properties. Here we show that <em>anisotropic</em> swelling constrains the anisotropic linear elastic properties of fibers. First we show, using data from disparate previously reported studies, that anisotropic swelling can be described as an approximately linear function of water content. Then, under the observation that the elastic energy of swelling can be minimized by the anisotropic shape, we relate swelling anisotropy to elastic anisotropy — assuming radial (transverse) symmetry within a cylindrical geometry. We find an upper bound for the commonly measured axial Poisson ratio <span><math><mrow><msub><mrow><mi>ν</mi></mrow><mrow><mi>z</mi><mi>x</mi></mrow></msub><mo>&lt;</mo><mn>1</mn><mo>/</mo><mn>2</mn></mrow></math></span>. This is significantly below recently estimated values for collagen fibrils extracted from tissue-level measurements, but is consistent with both single hair shaft and single collagen fibril mechanical and hydration studies. Using <span><math><msub><mrow><mi>ν</mi></mrow><mrow><mi>z</mi><mi>x</mi></mrow></msub></math></span>, we can then constrain the product <span><math><mrow><mi>γ</mi><mo>≡</mo><mrow><mo>(</mo><mn>1</mn><mo>−</mo><msub><mrow><mi>ν</mi></mrow><mrow><mi>x</mi><mi>y</mi></mrow></msub><mo>)</mo></mrow><msub><mrow><mi>E</mi></mrow><mrow><mi>z</mi></mrow></msub><mo>/</mo><msub><mrow><mi>E</mi></mrow><mrow><mi>x</mi></mrow></msub></mrow></math></span> — where <span><math><msub><mrow><mi>ν</mi></mrow><mrow><mi>x</mi><mi>y</mi></mrow></msub></math></span> is the seldom measured transverse Poisson ratio and <span><math><mrow><msub><mrow><mi>E</mi></mrow><mrow><mi>z</mi></mrow></msub><mo>/</mo><msub><mrow><mi>E</mi></mrow><mrow><mi>x</mi></mrow></msub></mrow></math></span> is the ratio of axial to radial Young’s moduli.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106749"},"PeriodicalIF":3.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003813/pdfft?md5=fa50c981380fde36cc4147a2c773261a&pid=1-s2.0-S1751616124003813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dedifferentiation- and aging-induced loss of mechanical contractility and polarity in vascular smooth muscle cells: Heterogeneous changes in macroscopic and microscopic behavior of cells in serial passage culture","authors":"Kazuaki Nagayama,&nbsp;Kenzo Nogami,&nbsp;Shunta Sugano,&nbsp;Miku Nakazawa","doi":"10.1016/j.jmbbm.2024.106744","DOIUrl":"10.1016/j.jmbbm.2024.106744","url":null,"abstract":"<div><p>Dedifferentiation and aging of vascular smooth muscle cells (VSMCs) are associated with serious vascular diseases, such as arteriosclerosis and aneurysm. However, how cell dedifferentiation and aging affect cellular mechanical behaviors at the single-cell and intracellular structure levels remains unclear. An in-depth understanding of these interactions is extremely important for understanding the mechanism underlying VSMC mechanical integrity and homeostatic regulation of vascular walls. Herein, we systematically investigated changes in VSMC morphology, structure, contractility, and motility during dedifferentiation and aging induced by serial passage culture using traction force microscopy with elastic micropillar substrates, laser nanodissection of cytoskeletons, confocal fluorescence microscopy, and atomic force microscopy. We found that VSMC dedifferentiation started in the middle stage of serial passage culture, accompanied by a transient cell spreading in the cell width and decrease in contractile protein expression. Dedifferentiated VSMCs showed a significant decrease in the contraction and stiffness of individual actin stress fibers; however, their overall cell traction forces were maintained. Simultaneously, a significant increase in cell motility and the number of actin fibers was observed in dedifferentiated VSMCs, which may be associated with the enhancement of cell migration and disruption of cell/tissue integrity during the early stage of vascular diseases. As cell senescence progressed in the later stage of serial passage culture, VSMCs displayed reduced cell spreading and migration with decrease in the overall cell traction forces and drastic reduction in mechanical polarity of cell structures and forces. These results suggested that cell senescence causes loss of mechanical contractility and polarity in VSMCs, which may be an important factor in vascular disease progression. The experimental systems established in this study can be powerful tools for understanding the mechanisms underlying cellular dedifferentiation and aging from a biomechanical perspective.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106744"},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion effect of proanthocyanidin on dentin remineralization via the polymer induced liquid precursor process","authors":"Chaoqun Chen ,&nbsp;Haiyan Lai ,&nbsp;Pingping Song ,&nbsp;Xinhua Gu","doi":"10.1016/j.jmbbm.2024.106750","DOIUrl":"10.1016/j.jmbbm.2024.106750","url":null,"abstract":"<div><p>Proanthocyanidin (PA) has demonstrated promise as a dental biomodifier for maintaining dentin collagen integrity, yet there is limited evidence regarding its efficacy in dentin repair. The aim of this study was to investigate the effect of PA on dentin remineralization through the polymer induced liquid precursor (PILP) process, as well as to assess the mechanical properties of the restored dentin. Demineralized dentin was treated with a PA-contained remineralization medium, resulting in the formation of PA-amorphous calcium phosphate (ACP) nanoparticles via the PILP process. The kinetics and microstructure of remineralized dentin were examined through the use of Fourier transform infrared spectroscopy(FTIR), attenuated total reflectance-FTIR, scanning electron microscopy, transmission electron microscopy. The results showed that the application of PA facilitated the process of dentin remineralization, achieving completion within 48 h, demonstrating a notable reduction in time required. Following remineralization, the mechanical properties of the dentin exhibited an elastic modulus of 15.89 ± 1.70 GPa and a hardness of 0.47 ± 0.08 GPa, which were similar to those of natural dentin. These findings suggest that combining PA with the PILP process can promote dentin remineralization and improve its mechanical properties, offering a promising new approach for dentin repair in clinical practice.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106750"},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid wideband characterization of viscoelastic material properties by Bessel function-based time harmonic ultrasound elastography (B-THE)","authors":"Tom Meyer ,&nbsp;Matthias Anders ,&nbsp;Anton Z. Pietzcker ,&nbsp;Marvin Doyley ,&nbsp;Steffen Görner ,&nbsp;Oliver Böhm ,&nbsp;Pascal Engl ,&nbsp;Yasmine Safraou ,&nbsp;Jürgen Braun ,&nbsp;Ingolf Sack ,&nbsp;Heiko Tzschätzsch","doi":"10.1016/j.jmbbm.2024.106746","DOIUrl":"10.1016/j.jmbbm.2024.106746","url":null,"abstract":"<div><p>Elastography is an emerging diagnostic technique that uses conventional imaging modalities such as sonography or magnetic resonance imaging to quantify tissue stiffness. However, different elastography methods provide different stiffness values, which require calibration using well-characterized phantoms or tissue samples. A comprehensive, fast, and cost-effective elastography technique for phantoms or tissue samples is still lacking.</p><p>Therefore, we propose ultrasound Bessel-fit-based time harmonic elastography (B-THE) as a novel tool to provide rapid feedback on stiffness-related shear wave speed (SWS) and viscosity-related wave penetration rate (PR) over a wide range of harmonic vibration frequencies. The method relies on external induction and B-mode capture of cylindrical shear waves that satisfy the Bessel wave equation for efficient fit-based parameter recovery. B-THE was demonstrated in polyacrylamide phantoms in the frequency range of 20–200 Hz and was cross-validated by magnetic resonance elastography (MRE) using clinical 3-T MRI and compact 0.5-T tabletop MRI scanners. Frequency-independent material parameters were derived from rheological models and validated by numerical simulations.</p><p>B-THE quantified frequency-resolved SWS and PR 13 to 176 times faster than more expensive clinical MRE and tabletop MRE and have a good accuracy (relative deviation to reference: 6 %, 10 % and 4 % respectively). Simulations of liver-mimicking material phantoms showed that a simultaneous fit of SWS and PR based on the fractional Maxwell rheological model outperformed a fit on PR solely.</p><p>B-THE provides a comprehensive and fast elastography technique for the quantitative characterization of the viscoelastic behavior of soft tissue mimicking materials.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106746"},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003783/pdfft?md5=3574ff5bbf490b6c72c67808783a4233&pid=1-s2.0-S1751616124003783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanofilament organization in highly tough fibers based on lamin proteins","authors":"Yael Tzror ,&nbsp;Mark Bezner ,&nbsp;Shani Deri ,&nbsp;Tom Trigano ,&nbsp;Kfir Ben-Harush","doi":"10.1016/j.jmbbm.2024.106748","DOIUrl":"10.1016/j.jmbbm.2024.106748","url":null,"abstract":"<div><div>The escalating plastic pollution crisis necessitates sustainable alternatives, and one promising solution involves replacing petroleum-based polymers with fibrous proteins. This study focused on the recombinant production of intracellular fibrous proteins, specifically <em>Caenorhabditis elegans</em> lamin (Ce-lamin). Ce-lamins spontaneously organize within the cell nucleus, forming a network of nanofilaments. This intricate structure serves as an active layer that responds dynamically to mechanical strain and stress. Herein, we investigated the arrangement of nanofilaments into nanofibrils within wet-spun Ce-lamin fibers using alcoholic solutions as coagulants. Our goal was to understand their structural and mechanical properties, particularly in comparison with those produced with solutions containing Ca⁺² ions, which typically result in the formation of nanofibrils with a collagen-like pattern. The introduction of ethanol solutions significantly altered this pattern, likely through rearrangement of the nanofilaments. Nevertheless, the resulting fibers exhibited superior toughness and strain, outperforming various synthetic fibers. The significance of the nanofilament structure in enhancing fiber toughness was emphasized through both the secondary structure transition during stretching and the influence of the Q159K point mutation. This study improves our understanding of the structural and mechanical aspects of Ce-lamin fibers, paving the way for the development of eco-friendly and high-quality fibers suitable for various applications, including medical implants and composite materials.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106748"},"PeriodicalIF":3.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of micro-scale bone adaptation of human trabecular bone under different implanted conditions","authors":"Masud Rana ,&nbsp;Santanu Kumar Karmakar ,&nbsp;Nico Verdonschot ,&nbsp;Amit Roychowdhury","doi":"10.1016/j.jmbbm.2024.106747","DOIUrl":"10.1016/j.jmbbm.2024.106747","url":null,"abstract":"<div><h3>Background and objective</h3><p>Different bone remodeling algorithms are used to predict bone adaptation and to understand how bones respond to the mechanical stimuli altered by implants. This paper introduces a novel micro-scale bone remodeling algorithm, which deviates from conventional methods by focusing on structure-based bone adaptation instead of density-based approaches.</p></div><div><h3>Methods</h3><p>The proposed model simulated cellular activities such as bone resorption, new bone formation, and maturation of newly formed bone. These activities were assumed to be triggered by mechanical stimuli. Model parameters were evaluated for the 3D geometries of trabecular bone from intact femur developed from micro computed tomography (CT) scan data. Two different hip implants, solid and porous were used, and two different bone remodeling methods were performed using the proposed and conventional methods.</p></div><div><h3>Results</h3><p>Results showed that micro CT scan-based finite element (FE) models accurately captured the microarchitecture and anisotropy of trabecular bone. The predicted bone resorption rate at the peri-prosthetic regions for the solid and porous implants was in the range of 17–27% and 4.5–7.3%, respectively, for a simulated period of four years.</p></div><div><h3>Conclusions</h3><p>The results obtained from FE analysis strongly align with clinical findings, confirming the effectiveness of the proposed algorithm. By emphasizing the structural aspect of bone adaptation, the proposed algorithm brings a fresh perspective on bone adaptation at the peri-prosthetic bone. This method can help researchers and clinicians to improve implant designs for better clinical outcomes.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106747"},"PeriodicalIF":3.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanical properties of chimeric silk are improved by expressing the full-length Trichonephila clavipes major ampullate spidroin gene in the silkworm Bombyx mori via recombinant AcMNPV","authors":"Xinyu Tong ,&nbsp;Min Zhu ,&nbsp;Jijie Li ,&nbsp;Qunnan Qiu ,&nbsp;Yongjie Feng ,&nbsp;Xiaolong Hu ,&nbsp;Chengliang Gong","doi":"10.1016/j.jmbbm.2024.106742","DOIUrl":"10.1016/j.jmbbm.2024.106742","url":null,"abstract":"<div><p>Spider silk is a type of natural protein fiber with excellent toughness and tensile strength. The mechanical properties of chimeric silk have been improved by integrating the spider silk protein gene into the silkworm (<em>Bombyx mori)</em> genome, but this strategy requires a long time to produce genetically modified silkworms. In this study, to rapidly produce chimeric silkworms/spider silk with improved toughness and tensile strength, recombinant <em>Autographa californica</em> multiple nucleopolyhedrovirus (AcMNPV), AcMNPV-FHP-MaSp-G, harboring a full-length <em>Trichonephila clavipes</em> major ampullate spidroin G (MaSp-G) gene driven by the silkworm fibroin heavy chain (<em>Fib</em>-H) promoter, was constructed, in which the signal peptide sequence of the MaSp-G gene was replaced by the signal peptide sequence of the <em>Fib</em>-H gene. Western blot and LC–MS/MS results showed that MaSp-G was successfully expressed in the posterior silk gland of silkworm larvae infected with AcMNPV-FHP-MaSp-G and secreted into the cocoon. Mechanical property tests revealed that the average maximum breaking stress and the average maximum elastic strain of chimeric silkworms/spider silk were 497.867 MPa and 14.824%, respectively, which were 36.53% and 23.55% greater than those of silk produced by normal silkworms. Fourier transform infrared (FTIR) spectroscopy revealed that the proportions of β-sheets, α-helices, and β-turns in the chimeric silk increased by 18.22%, 16.92%, and 18.72%, respectively. These results indicate that the mechanical properties of the chimeric silk produced by silkworms infected with AcMNPV-FHP-MaSp-G were significantly improved, which provides a new method for rapid production of chimeric silk in a genetically modified/genome-edited silkworm-independent manner.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106742"},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of porous titanium-based jaw implant structure on osseointegration mechanisms","authors":"Polina Kilina ,&nbsp;Alex G. Kuchumov ,&nbsp;Lyudmila Sirotenko ,&nbsp;Vladimir Vassilouk ,&nbsp;Sergey Golovin ,&nbsp;Andrey Drozdov ,&nbsp;Evgeniy V. Sadyrin","doi":"10.1016/j.jmbbm.2024.106724","DOIUrl":"10.1016/j.jmbbm.2024.106724","url":null,"abstract":"<div><p>The reconstruction of maxillofacial defects caused by anomalies, fractures, or cancer is challenging for dentofacial surgeons. To produce efficient, patient-specific implants with long-term performance and biological suitability, numerous methods of manufacturing are utilized. Because additive manufacturing makes it possible to fabricate complex pore structure samples, it is now recognized as an acceptable option to design customized implants. It is well recognized that a porous structure with proper design promotes accelerated cell proliferation, which enhances bone remodeling. Porosity can also be employed to modify the mechanical characteristics of fabricated implants. Thus, design and choice of rational lattice structure is an important task. The influence of the structure of jaw implants made of highly porous titanium-based materials on their mechanical properties and bone tissue growth was studied. Based on a 3D computer model of Wigner-Seitz lattice structure, the model samples were fabricated from Ti6Al4V powder by selective laser melting to characterize the mechanical properties of the samples depending on their macroporosity. Then two types of jaw bone implants were manufactured to conduct studies of bone tissue ingrowth when implanted in laboratory animals. The research was carried out in several stages: design and production of the implants for replacing incomplete defects of the lower jaw; implantation of SLM-printed implants in laboratory animals into an artificially produced defect of the lower jaw; analysis of the degree of fixation of the “implant - bone” connection (for implantation periods from 2 weeks to 9 months). During the research, Ti-alloy structures with cell diameters of 2–3 mm and macroporosity of 90–97% mimicking the spongy structure of trabecular bone tissue, were characterized by a compressive strength of 12.47–37.5 MPa and an elastic modulus of 0.19–1.23 GPa, corresponding to the mechanical properties of bone tissue. Active processes of tissue growth into implant cells were detected 2 weeks after implantation, the significant differences in the volume and types of filling tissue depending on the size of the cell were described. Recommendations for choosing the cell size depending on the type of bone tissue damage were given. When using SLM-printed implants with lattice structure (cell sizes from 1 to 3 mm), an active osteosynthesis processes occurred, which culminated in the formation of bone tissue inside the implant cells 9 months after implantation, with 68% of the samples characterized by the maximum degree of implant fixation. Implants with 3 mm cells with macropores diameters of 850 μm were recommended for replacing cavities after removal of perihilar cysts. To replace complete and partial defects, it was recommended to use implants with a cell size of 2 and 3 mm.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106724"},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}