Journal of the Mechanical Behavior of Biomedical Materials最新文献

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Fatigue strength of bilayer yttria-stabilized zirconia after low-temperature degradation 双层钇稳定氧化锆低温降解后的疲劳强度
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-06 DOI: 10.1016/j.jmbbm.2024.106725
Raíssa Monteiro Pereira , Renan Belli , Ulrich Lohbauer , Katrin Hurle , Tiago Moreira Bastos Campos , Gilmar Patrocínio Thim
{"title":"Fatigue strength of bilayer yttria-stabilized zirconia after low-temperature degradation","authors":"Raíssa Monteiro Pereira ,&nbsp;Renan Belli ,&nbsp;Ulrich Lohbauer ,&nbsp;Katrin Hurle ,&nbsp;Tiago Moreira Bastos Campos ,&nbsp;Gilmar Patrocínio Thim","doi":"10.1016/j.jmbbm.2024.106725","DOIUrl":"10.1016/j.jmbbm.2024.106725","url":null,"abstract":"<div><p>This study examined the impact of interfacial interactions on bilayer yttria-stabilized zirconia (YSZ) used in dental restorations. In-house bilayer structures of 3YSZ and 5YSZ composition underwent hydrothermal degradation to compare the properties of control and low-temperature degradation (LTD) treated groups. Biaxial flexural strength via piston-on-three-balls, staircase fatigue strength over 10<sup>6</sup> cycles at 15 Hz, phase characterization and quantification through XRD and Rietveld refinement, and fractography were conducted. Weibull analysis was employed to determine the Weibull modulus and characteristic strength. Results demonstrated an enhancement in the mechanical performance of 3YSZ composition after LTD treatment, whereas the mechanical properties of 5YSZ remained largely unaffected post-degradation. Fractographic analysis revealed that failure originated at the surface tensile location across all specimen groups. These findings offer insights into the mechanical behavior of bilayer zirconia structures and reinforce the significance of hydrothermal treatment in enhancing their performance, particularly in the case of 3Y compositions.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106725"},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanical simulation of segmented intrusion of a mandibular canine using Robot Orthodontic Measurement & Simulation System (ROSS) 使用机器人正畸测量和模拟系统(ROSS)对下颌犬牙分段侵入进行生物力学模拟
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-06 DOI: 10.1016/j.jmbbm.2024.106720
Hisham Sabbagh, Benedikt Dotzer, Uwe Baumert, Linus Hötzel, Corinna Lesley Seidel, Andrea Wichelhaus
{"title":"Biomechanical simulation of segmented intrusion of a mandibular canine using Robot Orthodontic Measurement & Simulation System (ROSS)","authors":"Hisham Sabbagh,&nbsp;Benedikt Dotzer,&nbsp;Uwe Baumert,&nbsp;Linus Hötzel,&nbsp;Corinna Lesley Seidel,&nbsp;Andrea Wichelhaus","doi":"10.1016/j.jmbbm.2024.106720","DOIUrl":"10.1016/j.jmbbm.2024.106720","url":null,"abstract":"<div><h3>Objective</h3><p>Aim of this study was to investigate the forces and moments during segmented intrusion of a mandibular canine using Cantilever-Intrusion-Springs (CIS).</p></div><div><h3>Methods</h3><p>Three different CIS modifications were investigated using a robotic biomechanical simulation system: unmodified CIS (#1, control), CIS with a lingual directed 6° toe-in bend (#2), and CIS with an additional 20° twist bend (#3). Tooth movement was simulated by the apparative robotic stand, controlled by a force-control algorithm, recording the acting forces and moments with a force-torque sensor. Statistical analysis was performed using Shapiro-Wilk, Kolmogorov-Smirnov, Kruskal-Wallis ANOVA and post hoc tests with Bonferroni correction (α = 0.05).</p></div><div><h3>Results</h3><p>The initial intrusive force, which was uniformly generated by a 35° Tip-Back bend, decreased significantly (p &lt; 0.05) from 0.31 N in group (#1) to 0.28 N in group (#3). Vestibular crown tipping reduced significantly (p &lt; 0.05) from 2.11° in group (#1) and 1.72° in group (#2) to 0.05° in group (#3). Matching to that the direction of orovestibular force significantly (p &lt; 0.05) shifted from 0.15 N to vestibular in group (#1) to 0.51 N to oral in group (#3) and the orovestibular tipping moment decreased also significantly (p &lt; 0.05) from 4.63 Nmm to vestibular in group (#1) to 3.56 Nmm in group (#2) and reversed to 1.20 Nmm to oral in group (#3). Apart from that the orovestibular displacement changed significantly (p &lt; 0.05) from 0.66 mm in buccal direction in group (#1) to 0.29 mm orally in group (#2) and 1.49 mm in oral direction as well in group (#3).</p></div><div><h3>Significance</h3><p>None of the modifications studied achieved pure mandibular canine intrusion without collateral effects. The significant lingual displacement caused by modification (#3) is, not least from an aesthetic perspective, considered much more severe than a slight tipping of the canine. Consequently, modification (#2) can be recommended for clinical application based on the biomechanical findings.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106720"},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003527/pdfft?md5=8d0bc472c53040c750365948fa501677&pid=1-s2.0-S1751616124003527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of damage mechanisms in cortical bone: Quantification of fracture resistance, critical strains, and crack tortuosity 表征皮质骨的损伤机制:断裂抗力、临界应变和裂纹迂回的量化
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-05 DOI: 10.1016/j.jmbbm.2024.106721
Anna Gustafsson , Giulia Galteri , Arthur Barakat , Jonas Engqvist , Lorenzo Grassi , Luca Cristofolini , Hector Dejea , Hanna Isaksson
{"title":"Characterization of damage mechanisms in cortical bone: Quantification of fracture resistance, critical strains, and crack tortuosity","authors":"Anna Gustafsson ,&nbsp;Giulia Galteri ,&nbsp;Arthur Barakat ,&nbsp;Jonas Engqvist ,&nbsp;Lorenzo Grassi ,&nbsp;Luca Cristofolini ,&nbsp;Hector Dejea ,&nbsp;Hanna Isaksson","doi":"10.1016/j.jmbbm.2024.106721","DOIUrl":"10.1016/j.jmbbm.2024.106721","url":null,"abstract":"<div><p>One step towards understanding bone fragility and degenerative diseases is to unravel the links between fracture resistance and the compositional and structural characteristics of cortical bone. In this study, we explore an optical method for automatic crack detection to generate full fracture resistance curves of cortical bone. We quantify fracture toughness, critical failure strains at the crack tip, and crack tortuosity in three directions and analyze how they relate to cortical bone microstructure.</p><p>A three-point bending fracture test of single-edge notched beam specimens in three directions (cracks propagating transverse, radial and longitudinal to the microstructure) from bovine cortical bone was combined with 2D-digital image correlation. Crack growth was automatically monitored by analyzing discontinuities in the displacement field using phase congruency analysis. Fracture resistance was analyzed using J-R-curves and strains were quantified at the crack tip. Post-testing, a subset of specimens was scanned using micro-tomography to visualize cracks and to quantify their tortuosity.</p><p>Both fracture toughness and crack tortuosity were significantly higher in the transverse direction compared to the other directions. Similar fracture toughness was found for radial and longitudinal directions, albeit 20% higher crack tortuosity in the radial specimens. This suggests that radial crack deflections are not as efficient toughening mechanisms. Strains at crack initiation were ∼0.4% for all tissue orientations, while at fully developed damage process zones failure strains were significantly higher in the transverse direction (∼1.5%). Altogether, we present unique quantitative data including different aspects of bone damage in three directions, illustrating the importance of cortical bone microstructure.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106721"},"PeriodicalIF":3.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003539/pdfft?md5=ac71da9fba2f69664daf41b38f570386&pid=1-s2.0-S1751616124003539-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of different cutting instruments and rotational speeds on heat generation and cutting efficiency when sectioning different types of zirconia 切割不同类型氧化锆时,不同切割工具和转速对发热量和切割效率的影响
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-05 DOI: 10.1016/j.jmbbm.2024.106715
Lisa Türp, Frank Lehmann, Sebastian Wille, Matthias Kern
{"title":"Influence of different cutting instruments and rotational speeds on heat generation and cutting efficiency when sectioning different types of zirconia","authors":"Lisa Türp,&nbsp;Frank Lehmann,&nbsp;Sebastian Wille,&nbsp;Matthias Kern","doi":"10.1016/j.jmbbm.2024.106715","DOIUrl":"10.1016/j.jmbbm.2024.106715","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to evaluate the temperature generated on the intaglio surface and efficiency when cutting different types of zirconia with different rotary instruments and rotational speeds.</p></div><div><h3>Methods</h3><p>A conventional diamond rotary instrument (Brasseler, grit size 107 μm) and special diamond rotary instrument marketed to cut zirconia (4 ZR, Brasseler, grit size 126 μm) were tested on 3Y-TZP and 4Y-TZP zirconia with a rotation speed of 100,000 rpm and 200,000 rpm. Zirconia specimens were cut under water cooling (110 mL/min) in a custom-made holder attached to a universal testing machine. The temperature was recorded with infrared sensors pointing at the intaglio surface of the zirconia specimens.</p></div><div><h3>Results</h3><p>A rotation speed of 200,000 rpm resulted in significantly shorter cutting times, but also in significantly higher temperatures at the intaglio surface of the zirconia specimens compared with a rotation speed of 100,000 rpm. Significantly shorter cutting times were observed for the conventional diamond rotary instrument than for the special rotary instrument marketed to cut zirconia. Using the special rotary instrument, significantly longer cutting times were recorded for 3Y-TZP than for 4Y-TZP.</p></div><div><h3>Conclusions</h3><p>A conventional diamond rotary instrument was more efficient than a special rotary instrument. However, to avoid high temperatures when cutting zirconia clinically, a rotation speed of 100,000 rpm is recommended.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106715"},"PeriodicalIF":3.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003473/pdfft?md5=78e1619198ee9525b027fbaf138a077f&pid=1-s2.0-S1751616124003473-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of connection design and material properties on stress distribution and fatigue lifetime of zygomatic implants: A finite element analysis 连接设计和材料特性对颧骨植入体应力分布和疲劳寿命的影响有限元分析
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-05 DOI: 10.1016/j.jmbbm.2024.106723
Laura H.J. Alberto , Saadman Alamgir , Jason A. Griggs , Michael D. Roach , Randal S. Williamson , Ravi Chandran , Matthew W. Priddy , Yuefeng J. Lu , Patrick F. Bergin , Yuanyuan Duan
{"title":"Influence of connection design and material properties on stress distribution and fatigue lifetime of zygomatic implants: A finite element analysis","authors":"Laura H.J. Alberto ,&nbsp;Saadman Alamgir ,&nbsp;Jason A. Griggs ,&nbsp;Michael D. Roach ,&nbsp;Randal S. Williamson ,&nbsp;Ravi Chandran ,&nbsp;Matthew W. Priddy ,&nbsp;Yuefeng J. Lu ,&nbsp;Patrick F. Bergin ,&nbsp;Yuanyuan Duan","doi":"10.1016/j.jmbbm.2024.106723","DOIUrl":"10.1016/j.jmbbm.2024.106723","url":null,"abstract":"<div><p>Zygomatic implants (ZIs) were developed as a graftless alternative to rehabilitate severely reabsorbed maxillae. This study aims to employ three-dimensional finite element analysis (FEA) to simulate the impact of external hexagonal implant connection (EHC) and internal hexagonal implant connection (IHC) on the stress distribution and fatigue lifetime within the ZI systems using parameters defined in ISO 14801:2016. Two ZI assemblies (Nobel Biocare and Noris Medical) were scanned in a micro-CT scanner and reconstructed using Nrecon software. Three-dimensional models were generated by Simpleware ScanIP Medical software. All models were exported to FEA software (ABAQUS) and subsequently to a fatigue analysis software (Fe-safe). A compressive 150 N load was applied at a 40° angle on the cap surface. A 15 Hz frequency was applied in the in silico cyclic test. The implant components had material properties of commercially pure grade 4 titanium (CPTi) and Titanium-6Aluminum-4Vanadium alloy (Ti64). Von Mises stress data, contour plots, and fatigue limits were collected and analyzed. EHC models exhibited higher peak stresses in implant components for both materials compared to IHC models. However, simulated bone support results showed the opposite trend, with higher stresses on IHCthan EHC models. The fatigue analysis revealed that assemblies with both designs exceeded ISO 14801:2016 number of cycles limits using Ti64, while CPTi groups exhibited comparatively lower worst life-repeats. In conclusion, ZIs with IHC were found to have a more homogeneous and advantageous stress distribution within both materials tested. Ti64 demonstrates a prolonged service life for both design connections.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106723"},"PeriodicalIF":3.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence of time dependent degradation of polypropylene surgical mesh explanted from the abdomen and vagina of sheep 从绵羊腹部和阴道取出的聚丙烯手术网片随时间发生降解的证据
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-05 DOI: 10.1016/j.jmbbm.2024.106722
Nicholas T.H. Farr , David A. Gregory , Victoria L. Workman , Cassandra Rauert , Sabiniano Roman , Alexander J. Knight , Anthony J. Bullock , Alexander I. Tartakovskii , Kevin V. Thomas , Christopher R. Chapple , Jan Deprest , Sheila MacNeil , Cornelia Rodenburg
{"title":"Evidence of time dependent degradation of polypropylene surgical mesh explanted from the abdomen and vagina of sheep","authors":"Nicholas T.H. Farr ,&nbsp;David A. Gregory ,&nbsp;Victoria L. Workman ,&nbsp;Cassandra Rauert ,&nbsp;Sabiniano Roman ,&nbsp;Alexander J. Knight ,&nbsp;Anthony J. Bullock ,&nbsp;Alexander I. Tartakovskii ,&nbsp;Kevin V. Thomas ,&nbsp;Christopher R. Chapple ,&nbsp;Jan Deprest ,&nbsp;Sheila MacNeil ,&nbsp;Cornelia Rodenburg","doi":"10.1016/j.jmbbm.2024.106722","DOIUrl":"10.1016/j.jmbbm.2024.106722","url":null,"abstract":"<div><div>The failure of polypropylene mesh is marked by significant side effects and debilitation, arising from a complex interplay of factors. One key contributor is the pronounced physico-mechanical mismatch between the polypropylene (PP) fibres and surrounding tissues, resulting in substantial physical damage, inflammation, and persistent pain. However, the primary cause of sustained inflammation due to polypropylene itself remains incompletely understood. This study comprises a comprehensive, multi-pronged investigation to unravel the effects of implantation on a presumed inert PP mesh in sheep. Employing both advanced and conventional techniques to discern the physical and chemical transformations of the implanted PP. Our analyses reveal a surface degradation and oxidation of polypropylene fibres after 60 days implantation, persisting and intensifying at the 180-day mark. The emergence and accumulation of PP debris in the tissue surrounding the implant also increased with implantation time. We demonstrate observable physical and mechanical alterations in the fibre surface and stiffness. Our study shows surface alterations which indicate that PP is evidently less chemically inert than was initially presumed. These findings underscore the need for a re-evaluation of the biocompatibility and long-term consequences of using PP mesh implants.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106722"},"PeriodicalIF":3.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003540/pdfft?md5=bb13941f8c591ec434cb88d20f40c404&pid=1-s2.0-S1751616124003540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
4D printing and optimization of biocompatible poly lactic acid/poly methyl methacrylate blends for enhanced shape memory and mechanical properties 4D 打印和优化生物相容性聚乳酸/聚甲基丙烯酸甲酯共混物,增强形状记忆和机械性能
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-04 DOI: 10.1016/j.jmbbm.2024.106719
Hossein Doostmohammadi , Kamyab Kashmarizad , Majid Baniassadi , Mahdi Bodaghi , Mostafa Baghani
{"title":"4D printing and optimization of biocompatible poly lactic acid/poly methyl methacrylate blends for enhanced shape memory and mechanical properties","authors":"Hossein Doostmohammadi ,&nbsp;Kamyab Kashmarizad ,&nbsp;Majid Baniassadi ,&nbsp;Mahdi Bodaghi ,&nbsp;Mostafa Baghani","doi":"10.1016/j.jmbbm.2024.106719","DOIUrl":"10.1016/j.jmbbm.2024.106719","url":null,"abstract":"<div><p>This study introduces a novel approach to 4D printing of biocompatible Poly lactic acid (PLA)/poly methyl methacrylate (PMMA) blends using Artificial Neural Network (ANN) and Response Surface Methodology (RSM). The goal is to optimize PMMA content, nozzle temperature, raster angle, and printing speed to enhance shape memory properties and mechanical strength. The materials, PLA and PMMA, are melt-blended and 4D printed using a pellet-based 3D printer. Differential Scanning Calorimetry (DSC) and Dynamic Mechanical Thermal Analysis (DMTA) assess the thermal behavior and compatibility of the blends. The ANN model demonstrates superior prediction accuracy and generalization capability compared to the RSM model. Experimental results show a shape recovery ratio of 100% and an ultimate tensile strength of 65.2 MPa, significantly higher than pure PLA. A bio-screw, 4D printed with optimized parameters, demonstrates excellent mechanical properties and shape memory behavior, suitable for biomedical applications such as orthopaedics and dental implants. This research presents an innovative method for 4D printing PLA/PMMA blends, highlighting their potential in creating advanced, high-performance biocompatible materials for medical use.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106719"},"PeriodicalIF":3.3,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003515/pdfft?md5=3e165c5fc2e65d963927ec1542c78bfa&pid=1-s2.0-S1751616124003515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D printing of strontium-enriched biphasic calcium phosphate scaffolds for bone regeneration 用于骨再生的富锶双相磷酸钙支架的三维打印技术。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-03 DOI: 10.1016/j.jmbbm.2024.106717
Rodrigo L.M.S. Oliveira , Marcos C. Ferraz , Lais Medeiros Cardoso , Zhongrui Li , Ana Paula F. Albers , Marco C. Bottino , Eliandra S. Trichês
{"title":"3D printing of strontium-enriched biphasic calcium phosphate scaffolds for bone regeneration","authors":"Rodrigo L.M.S. Oliveira ,&nbsp;Marcos C. Ferraz ,&nbsp;Lais Medeiros Cardoso ,&nbsp;Zhongrui Li ,&nbsp;Ana Paula F. Albers ,&nbsp;Marco C. Bottino ,&nbsp;Eliandra S. Trichês","doi":"10.1016/j.jmbbm.2024.106717","DOIUrl":"10.1016/j.jmbbm.2024.106717","url":null,"abstract":"<div><p>Calcium phosphate (CaP) scaffolds doping with therapeutic ions are one of the focuses of recent bone tissue engineering research. Among the therapeutic ions, strontium stands out for its role in bone remodeling. This work reports a simple method to produce Sr-doped 3D-printed CaP scaffolds, using Sr-doping to induce partial phase transformation from β-tricalcium phosphate (β-TCP) to hydroxyapatite (HA), resulting in a doped biphasic calcium phosphate (BCP) scaffold. Strontium carbonate (SrCO<sub>3</sub>) was incorporated in the formulation of the 3D-printing ink, studying β-TCP:SrO mass ratios of 100:0, 95:5, and 90:10 (named as β-TCP, β-TCP/5-Sr, and β-TCP/10-Sr, respectively). Adding SrCO<sub>3</sub> in the 3D-printing ink led to a slight increase in viscosity but did not affect its printability, resulting in scaffolds with a high printing fidelity compared to the computational design. Interestingly, Sr was incorporated into the lattice structure of the scaffolds, forming hydroxyapatite (HA). No residual SrO or SrCO<sub>3</sub> were observed in the XRD patterns of any composition, and HA was the majority phase of the β-TCP/10-Sr scaffolds. The addition of Sr increased the compression strength of the scaffolds, with both β-TCP/5-Sr and β-TCP/10-Sr performing better than the β-TCP. Overall, β-TCP/5-Sr presented higher mineralized nodules and mechanical strength, while β-TCP scaffolds presented superior cell viability. The incorporation of SrCO<sub>3</sub> in the ink formulation is a viable method to obtain Sr-BCP scaffolds. Thus, this approach could be explored with other CaP scaffolds aiming to optimize their performance and the addition of alternative therapeutic ions.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106717"},"PeriodicalIF":3.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the mechanics of gastric tissue: A comparison of constitutive models, damage probability and microstructural insights 揭开胃组织力学的神秘面纱:构成模型、损伤概率和微观结构见解的比较
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-03 DOI: 10.1016/j.jmbbm.2024.106712
François Fournier , Thierry Bège , Jean-Philippe Dales , Wei Wei , Catherine Masson
{"title":"Unravelling the mechanics of gastric tissue: A comparison of constitutive models, damage probability and microstructural insights","authors":"François Fournier ,&nbsp;Thierry Bège ,&nbsp;Jean-Philippe Dales ,&nbsp;Wei Wei ,&nbsp;Catherine Masson","doi":"10.1016/j.jmbbm.2024.106712","DOIUrl":"10.1016/j.jmbbm.2024.106712","url":null,"abstract":"<div><p>With the increasing prevalence of obesity worldwide, bariatric surgery is becoming increasingly common. However, the mechanic of the gastric wall related to bariatric surgery complications remains to be investigated. This study aims to understand mechanical behaviour of stomach by developing advanced material laws for gastric tissue incorporating microstructure. A multi-scale characterisation of the porcine stomach wall was performed in the fundus and corpus anatomical regions and in circumferential and longitudinal orientations The protocol included uniaxial tensile testing until damage, survival analysis to provide damage probability, comparison of phenomenological (Fung and Ogden order 1, 2 and 3) and structural (Holzapfel fibre-reinforced) computational models fitted to the experimental data, and quantitative analysis of elastin and collagen fibre structure from histological slides. All constitutive models fitted the experimental data well (r<sup>2</sup> &gt; 0.988 and RSME&lt;3.8 kPa). Longitudinal and circumferential elastic modulus in quasi linear phase were respectively 1.75 ± 1.2 MPa, 0.76 ± 0.35 MPa for fundus, and 2.30 ± 0.66 MPa, 1.36 ± 0.89 MPa for corpus, highlighting significant differences between orientations in fundus and corpus, with an overall softer fundus in the circumferential direction. Microstructure analysis illustrated collagen and elastin fibre orientation, dispersion and density. As microstructure appears to play an important role in stomach biomechanics, model incorporating fibre structure such as Holzapfel fibre-reinforced model, seem best suited to describe the material behaviour of the stomach wall. Future research should complement these findings with an expanded sample set in human models.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106712"},"PeriodicalIF":3.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124003448/pdfft?md5=026643cbbf376768caf44972a5b329a7&pid=1-s2.0-S1751616124003448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing and additive manufacturing of biomimetic interpenetrating phase zirconia-resin composite dental restorations with TPMS structure 具有 TPMS 结构的仿生互穿相氧化锆-树脂复合牙科修复体的设计与增材制造。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-03 DOI: 10.1016/j.jmbbm.2024.106718
Xingshi Dong, Gaoqi Wang, Shouren Wang, Xuefeng Yang, Daosheng Wen, Longxiao Zhang
{"title":"Designing and additive manufacturing of biomimetic interpenetrating phase zirconia-resin composite dental restorations with TPMS structure","authors":"Xingshi Dong,&nbsp;Gaoqi Wang,&nbsp;Shouren Wang,&nbsp;Xuefeng Yang,&nbsp;Daosheng Wen,&nbsp;Longxiao Zhang","doi":"10.1016/j.jmbbm.2024.106718","DOIUrl":"10.1016/j.jmbbm.2024.106718","url":null,"abstract":"<div><p>Zirconia and resin are the most commonly utilized materials in dental restorations. However, zirconia presents significant wear on opposing teeth, whereas resin materials have low wear resistance and mechanical performances. A zirconia-resin interpenetrating phase composite (IPC) dental restoration was designed and fabricated using 3D printing and vacuum infiltration processes, incorporating zirconia scaffolds with triply periodic minimal surfaces (TPMS) structures. The mechanical and tribological performances of the IPCs were investigated through compressive and tribological experiments and finite element analysis, elucidating the influence of zirconia volumetric fraction. Results showed that IPCs exhibit excellent mechanical and tribological compatibilities, which can reduce the damage and wear of the antagonistic teeth. This designing and manufacturing strategy enables the IPC restorations with promising applications in dentistry.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106718"},"PeriodicalIF":3.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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