Journal of the Mechanical Behavior of Biomedical Materials最新文献

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Corrigendum to “Elastic constants of biogenic calcium carbonate” (155), 106570 更正 "生物碳酸钙的弹性常数"(155),106570。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-01-01 DOI: 10.1016/j.jmbbm.2024.106831
Richard Johannes Best , Andrei Sotnikov , Hagen Schmidt , Igor Zlotnikov
{"title":"Corrigendum to “Elastic constants of biogenic calcium carbonate” (155), 106570","authors":"Richard Johannes Best , Andrei Sotnikov , Hagen Schmidt , Igor Zlotnikov","doi":"10.1016/j.jmbbm.2024.106831","DOIUrl":"10.1016/j.jmbbm.2024.106831","url":null,"abstract":"","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106831"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaffold geometries designed to promote bone ingrowth by enhancing mechanobiological stimulation and biotransportation - A multiobjective optimisation approach
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-31 DOI: 10.1016/j.jmbbm.2024.106883
Ben M. Ferguson , Jonathan R. Clark , Qing Li
{"title":"Scaffold geometries designed to promote bone ingrowth by enhancing mechanobiological stimulation and biotransportation - A multiobjective optimisation approach","authors":"Ben M. Ferguson ,&nbsp;Jonathan R. Clark ,&nbsp;Qing Li","doi":"10.1016/j.jmbbm.2024.106883","DOIUrl":"10.1016/j.jmbbm.2024.106883","url":null,"abstract":"<div><div>In a tissue-engineered bone scaffold implant, the process of neo-tissue ingrowth and remodelling into hard lamellar bone occurs slowly; it typically requires a period of several months to a year (or more) to complete. This research considers the design optimisation of a scaffold's unit cell geometry for the purpose of accelerating the rate at which neo-tissue forms in the porous network of the scaffold (ingrowth), and hence, reduce the length of time to complete the bone ingrowth process. In this study, the basic structure of the scaffold is the Schwarz Primitive (P) surface unit cell, selected for its compelling biomechanical and permeability characteristics. The geometry of the scaffold is varied using two parameters (namely iso-value, <em>k</em>, and spatial period, <em>a</em>) within the surface equation defining the Schwarz P-surface unit cell. In total, sixteen different unit cell geometries are considered here with the porosity ranging from 50% to 82%.</div><div>The design objectives for the scaffold are to (i) enhance mechanobiological stimulus conditions conducive to bone apposition and (ii) enhance permeability to improve the transport of nutrients/oxygen and metabolities to and from the sites of neo-tissue formation throughout the porous scaffold. The independent design variables (<span><math><mrow><mi>k</mi></mrow></math></span> and <span><math><mrow><mi>a</mi></mrow></math></span>) of the periodic unit cell geometry are optimised to best satisfy the design objectives of appositional mechanobiological stimulus and biotransporting permeability. First, a reconstructed sheep mandible computed tomographic (CT)-based finite element (FE) analysis model is used to relate the strain energy density and mechanobiological stimulus to the design variables. Next, a computational fluid dynamics (CFD) model of a 5 × 5 × 5 unit cell scaffold is developed to relate the distributions of pressure and fluid velocity to the design variables. Then, surrogate modelling is undertaken in which bivariate cubic polynomial response surfaces are fitted to the FE and CFD analysis output data to form mathematical functions of each objective with respect to the two design variables. Finally, a multiobjective optimisation algorithm is invoked to determine the best trade-off between the competing design objectives of mechanobiological stimulus and biofluidic permeability. The novel design of the scaffold structure is anticipated to provide a better biomechanical and biotransport environment for tissue regeneration.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"164 ","pages":"Article 106883"},"PeriodicalIF":3.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143328667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning the mechanical properties of alginate dialdehyde–gelatin (ADA–GEL) bioinks for bioprinting approaches by varying the degree of oxidation
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-28 DOI: 10.1016/j.jmbbm.2024.106871
Jessica Faber , Jan Hinrichsen , Anahita Ahmadi Soufivand , Hsuan-Heng Lu , Tanja Rosenberger , Emine Karakaya , Rainer Detsch , Aldo R. Boccaccini , Silvia Budday
{"title":"Tuning the mechanical properties of alginate dialdehyde–gelatin (ADA–GEL) bioinks for bioprinting approaches by varying the degree of oxidation","authors":"Jessica Faber ,&nbsp;Jan Hinrichsen ,&nbsp;Anahita Ahmadi Soufivand ,&nbsp;Hsuan-Heng Lu ,&nbsp;Tanja Rosenberger ,&nbsp;Emine Karakaya ,&nbsp;Rainer Detsch ,&nbsp;Aldo R. Boccaccini ,&nbsp;Silvia Budday","doi":"10.1016/j.jmbbm.2024.106871","DOIUrl":"10.1016/j.jmbbm.2024.106871","url":null,"abstract":"<div><div>Extrusion-based 3D bioprinting is one of the most promising and widely used technologies in bioprinting. However, the development of bioprintable, biocompatible bioinks with tailored mechanical and biological properties remains a major challenge in this field. Alginate dialdehyde–gelatin (ADA–GEL) hydrogels face these difficulties and enable to tune the mechanical properties depending on the degree of oxidation (<span><math><mtext>%</mtext></math></span> DO) of ADA. Here, we present a holistic approach for characterizing the influence of the <span><math><mtext>%</mtext></math></span> DO on the mechanical properties of ADA–GEL hydrogels under multiple loading modes, compression, tension, and torsional shear in the large-strain regime. We evaluate complex mechanical characteristics including nonlinearity, hysteresis, conditioning, and stress relaxation. We calibrate hyperelastic material models to determine the corresponding material parameters inversely. Our results confirm that decreasing the <span><math><mtext>%</mtext></math></span> DO of ionically crosslinked ADA–GEL hydrogels leads to an increase in stiffness, more distinct nonlinearity, more pronounced hysteresis, and minor preconditioning effects, while the relaxation behavior is slightly affected. The fabrication technique – molding or printing – does only slightly affect the complex mechanical properties and stress relaxation behavior. Ionically and enzymatically dual-crosslinked ADA–GEL hydrogels showed higher stresses during cyclic loading and less viscous effects during stress relaxation in all three loading modes. We conclude that the <span><math><mtext>%</mtext></math></span> DO and the crosslinking procedure are crucial parameters to tune the mechanical behavior of ADA–GEL hydrogels. Careful choice of these parameters might facilitate the fabrication of biomaterials that closely mimic the properties of native tissues for advanced tissue engineering applications.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106871"},"PeriodicalIF":3.3,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic valve leaflet assessment to inform novel bioinspired materials: Understanding the impact of collagen fibres on the tissue's mechanical behaviour 主动脉瓣小叶评估为新型生物启发材料提供信息:了解胶原纤维对组织力学行为的影响。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-27 DOI: 10.1016/j.jmbbm.2024.106881
Celia Hughes , Alix Whelan , David O'Reilly , Evelyn M. Campbell , Caitríona Lally
{"title":"Aortic valve leaflet assessment to inform novel bioinspired materials: Understanding the impact of collagen fibres on the tissue's mechanical behaviour","authors":"Celia Hughes ,&nbsp;Alix Whelan ,&nbsp;David O'Reilly ,&nbsp;Evelyn M. Campbell ,&nbsp;Caitríona Lally","doi":"10.1016/j.jmbbm.2024.106881","DOIUrl":"10.1016/j.jmbbm.2024.106881","url":null,"abstract":"<div><div>Aortic stenosis is a prevalent disease that is treated with either mechanical or bioprosthetic valve replacement devices. However, these implants can experience problems with either functionality in the case of mechanical valves or long-term durability in the case of bioprosthetic valves. To enhance next generation prosthetic valves, such as biomimetic polymeric valves, an improved understanding of the native aortic valve leaflet structure and mechanical response is required to provide much needed benchmarks for future device development. This study aims to provide such information through imaging and mechanical testing of porcine aortic valve leaflet tissue. Using second harmonic generation imaging on cleared tissue it is shown that the fibre orientations are dependent on the leaflet type (left coronary, right coronary, non-coronary), while fibre crimp is not solely dependent on either of these factors. Uniaxial tensile testing of the leaflets and their layers showed that the ventricularis layer is stiffer than the fibrosa but the fibrosa dominates the mechanical response of the whole leaflet due to its higher thickness. Overall, this work provides a detailed assessment of the native porcine aortic valve leaflets’ microstructure and mechanical response, delivering key information to aid the design and manufacture of future bioinspired valve implant devices.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106881"},"PeriodicalIF":3.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions 三尖瓣边缘到边缘修复模拟对环空边界条件高度敏感。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-22 DOI: 10.1016/j.jmbbm.2024.106879
Collin E. Haese , Vijay Dubey , Mrudang Mathur , Alison M. Pouch , Tomasz A. Timek , Manuel K. Rausch
{"title":"Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions","authors":"Collin E. Haese ,&nbsp;Vijay Dubey ,&nbsp;Mrudang Mathur ,&nbsp;Alison M. Pouch ,&nbsp;Tomasz A. Timek ,&nbsp;Manuel K. Rausch","doi":"10.1016/j.jmbbm.2024.106879","DOIUrl":"10.1016/j.jmbbm.2024.106879","url":null,"abstract":"<div><div>Transcatheter edge-to-edge repair (TEER) simulations may provide insight into this novel therapeutic technology and help optimize its use. However, because of the relatively short history and technical complexity of TEER simulations, important questions remain unanswered. For example, there is no consensus on how to handle the annular boundary conditions in these simulations. In this short communication, we tested the sensitivity of such simulations to the choice of annular boundary conditions using a high-fidelity finite element model of a human tricuspid valve. Therein, we embedded the annulus among elastic springs to simulate the compliance of the perivalvular myocardium. Next, we varied the spring stiffness parametrically and explored the impact on two key measures of valve function: coaptation area and leaflet stress. Additionally, we compared our results to simulations with a pinned annulus. We found that a compliant annular boundary condition led to a TEER-induced “annuloplasty effect,” i.e., annular remodeling, as observed clinically. Moreover, softer springs led to a larger coaptation area and smaller leaflet stresses. On the other hand, pinned annular boundary conditions led to unrealistically high stresses and no “annuloplasty effect.” Furthermore, we found that the impact of the boundary conditions depended on the clip position. Our findings in this case study emphasize the importance of the annular boundary condition in tricuspid TEER simulations. Thus, we recommend that care be taken when choosing annular boundary conditions and that results from simulations using pinned boundaries should be interpreted with caution.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106879"},"PeriodicalIF":3.3,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical properties of the bicipital aponeurosis 肱二头肌腱膜的力学特性。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-20 DOI: 10.1016/j.jmbbm.2024.106876
Emmanuel Ocran , Michele Oliver , Anne Agur , Amr Elmaraghy , Karen Gordon
{"title":"Mechanical properties of the bicipital aponeurosis","authors":"Emmanuel Ocran ,&nbsp;Michele Oliver ,&nbsp;Anne Agur ,&nbsp;Amr Elmaraghy ,&nbsp;Karen Gordon","doi":"10.1016/j.jmbbm.2024.106876","DOIUrl":"10.1016/j.jmbbm.2024.106876","url":null,"abstract":"<div><div>As a biarticular muscle, the biceps brachii both supinates the forearm and flexes the elbow and shoulder, thus allowing the upper limb to perform a variety of activities of daily living (ADL). The biceps brachii originates on the coracoid apex as well as the supraglenoid tubercle and inserts on the radial tuberosity. At the distal end, the bicipital aponeurosis (BA) provides a transition of the biceps tendon into the antebrachial fascia. Previous work has reported the importance of the bicipital aponeurosis in stabilizing distal tendons. Other studies have reported the supination effect that the BA has on the forearm at the radioulnar joint, where it also protects the brachial artery and median nerve (neurovascular bundle). In addition, it has been speculated to have a proprioceptive function. However, despite the important functions fulfilled by this structure, the mechanical properties of the BA are yet to be quantified.</div><div>Mechanical properties for eight fresh frozen BA specimens (82 ± 12 years, 5 females, 5 right) were quantified using a Cellscale Biaxial (Waterloo, ON) testing machine. Three samples (approximately 7 × 7mm each) were harvested from the proximal, middle and distal regions along the length of the BA. Samples were tested on a biaxial testing machine while maintaining the alignment of the longitudinal collagen fiber orientation with the X-axis of the tester. The testing protocol included 10 preconditioning sinusoidal cycles at 9% strain, at a strain rate of 1%/s, followed by biaxial testing to a maximum strain of 12% at a strain rate of 1%/s. Young's modulus was quantified for all biaxial tests from the linear portion of the resulting stress-strain relation. Results showed that elastic modulus values were significantly greater in the longitudinal direction aligned with the collagen fibers. The outcomes of this study will provide input values for future models of distal biceps repair, thus aiding surgical planning by providing insight into the potential load sharing contributions of the BA.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106876"},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automatic adjustment of dental crowns using Laplacian mesh editing 利用拉普拉斯网格编辑技术自动调整牙冠
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-20 DOI: 10.1016/j.jmbbm.2024.106878
Oliver Roffmann , Meike Stiesch , Christof Hurschler , Andreas Greuling
{"title":"Automatic adjustment of dental crowns using Laplacian mesh editing","authors":"Oliver Roffmann ,&nbsp;Meike Stiesch ,&nbsp;Christof Hurschler ,&nbsp;Andreas Greuling","doi":"10.1016/j.jmbbm.2024.106878","DOIUrl":"10.1016/j.jmbbm.2024.106878","url":null,"abstract":"<div><div>Currently, the restoration of missing teeth by means of dental implants is a common treatment method in dentistry. Ensuring optimal contact between teeth (occlusion) when designing the occlusal surface of an implant-supported crown is crucial for the patient. Although there are various occlusal concepts and guidelines for achieving optimised occlusion, adapting an occlusal surface is challenging. The contact points must be established in certain areas of the occlusal surface without impairing the aesthetics of the teeth and the masticatory function. A computer-aided, automated modelling approach can assist in the design process and can reduce the reliance on manual labour. This study aimed to develop a modelling approach that enables the automatic adaptation of an occlusal surface to specific occlusal concepts while preserving the natural appearance. In this study, the occlusal surface of an implant-supported crown based on a scanned first right mandibular molar was adopted. Nominal contact points were determined based on occlusal concepts by Ramfjord and Ash (RA) and Thomas (T). The shape of the occlusal surface was then adapted concerning the desired contact points using Laplacian mesh editing. The modification results were validated for different forces and crown materials (3Y-TZP and PMMA) using a finite element contact analysis. The contact analysis results showed that locations with high compressive stresses correspond with the locations of the nominal contact points. The reaction forces were more evenly distributed in PMMA crowns, due to the lower Young's modulus of PMMA compared to 3Y-TZP. Furthermore, the occlusal scheme with fewer contact points (RA) showed higher maximum reaction forces per contact area. The presented method enables the automated adaptation of an (implant-supported) crown to specific occlusal schemes, proving to be valuable in dental CAD.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106878"},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical characteristics of spinal cord tissue by indentation 通过压痕分析脊髓组织的机械特性
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-19 DOI: 10.1016/j.jmbbm.2024.106863
Oskar Neumann , Harsh Vardhan Surana , Stephen Melly , Paul Steinmann , Silvia Budday
{"title":"Mechanical characteristics of spinal cord tissue by indentation","authors":"Oskar Neumann ,&nbsp;Harsh Vardhan Surana ,&nbsp;Stephen Melly ,&nbsp;Paul Steinmann ,&nbsp;Silvia Budday","doi":"10.1016/j.jmbbm.2024.106863","DOIUrl":"10.1016/j.jmbbm.2024.106863","url":null,"abstract":"<div><div>The mechanical properties of brain and spinal cord tissue have proven to be extremely complex and difficult to assess. Due to the heterogeneous and ultra-soft nature of the tissue, the available literature shows a large variance in mechanical parameters derived from experiments. In this study, we performed a series of indentation experiments to systematically investigate the mechanical properties of porcine spinal cord tissue in terms of their sensitivity to indentation tip diameter, loading rate, holding time, ambient temperature along with cyclic and oscillatory dynamic loading. Our results show that spinal cord white matter tissue is more compliant than grey matter tissue with apparent moduli of 128.7 and 403.8 Pa, respectively. They show similar viscoelastic behavior with stress relaxation time constants of <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>1</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>.</mo><mn>38</mn><mspace></mspace></mrow></math></span>s and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>2</mn></mrow></msub><mo>=</mo><mn>36</mn><mo>.</mo><mn>29</mn><mspace></mspace></mrow></math></span>s for grey matter and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>1</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>.</mo><mn>46</mn><mspace></mspace></mrow></math></span>s and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>2</mn></mrow></msub><mo>=</mo><mn>46</mn><mo>.</mo><mn>10</mn><mspace></mspace></mrow></math></span>s for white matter, while the initial peak force decreased by 54 % for grey and 59 % for white matter tissue. An increase of the applied loading rate by two orders of magnitude led to an approximate doubling of the apparent modulus for both tissue types. Thermal variations showed a decrease in apparent modulus of up to 30 % after heating from 20 to 37.0 °C. Our dynamic tests revealed a significant influence of cyclic preload on the stiffness, with a drop of up to 20 % and a relative decrease of up to 60 % after the first cycle compared to the total modulus drop after five cycles for spinal cord grey matter tissue. Oscillatory indentation experiments identified similar loss moduli for spinal cord grey and white matter tissue and a higher storage modulus for white matter tissue. This work provides systematic insights into the mechanical properties of spinal cord tissue under different loading scenarios using nanoindentation.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106863"},"PeriodicalIF":3.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, additive manufacturing, and characterization of an organ-on-chip microfluidic device for oral mucosa analogue growth 用于口腔黏膜模拟物生长的器官芯片微流控装置的设计、增材制造和表征。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-19 DOI: 10.1016/j.jmbbm.2024.106877
Foteini Machla , Paraskevi Kyriaki Monou , Panagiotis Artemiou , Ioannis Angelopoulos , Vasileios Zisis , Emmanuel Panteris , Orestis Katsamenis , Eric Williams , Emmanouil Tzimtzimis , Dimitrios Tzetzis , Dimitrios Andreadis , Alexander Tsouknidas , Dimitrios Fatouros , Athina Bakopoulou
{"title":"Design, additive manufacturing, and characterization of an organ-on-chip microfluidic device for oral mucosa analogue growth","authors":"Foteini Machla ,&nbsp;Paraskevi Kyriaki Monou ,&nbsp;Panagiotis Artemiou ,&nbsp;Ioannis Angelopoulos ,&nbsp;Vasileios Zisis ,&nbsp;Emmanuel Panteris ,&nbsp;Orestis Katsamenis ,&nbsp;Eric Williams ,&nbsp;Emmanouil Tzimtzimis ,&nbsp;Dimitrios Tzetzis ,&nbsp;Dimitrios Andreadis ,&nbsp;Alexander Tsouknidas ,&nbsp;Dimitrios Fatouros ,&nbsp;Athina Bakopoulou","doi":"10.1016/j.jmbbm.2024.106877","DOIUrl":"10.1016/j.jmbbm.2024.106877","url":null,"abstract":"<div><h3>Introduction</h3><div>Α customized organ-on-a-chip microfluidic device was developed for dynamic culture of oral mucosa equivalents (Oral_mucosa_chip-OMC).</div></div><div><h3>Materials and methods</h3><div>Additive Manufacturing (AM) was performed via stereolithography (SLA) printing. The dimensional accuracy was evaluated via microfocus computed tomography (mCT), the surface characteristics via scanning electron microscopy (SEM), while the mechanical properties via nanoindentation and compression tests. Computational fluid dynamics (CFD) optimized net forces towards the culture area. An oral mucosa equivalent comprising a multilayered epithelium derived by culture of TR146 cells at the air-liquid interface (ALI) and a lamina propria-analogue based on a collagen-I/fibrin hydrogel was maintained under ultra-precise flow conditions.</div></div><div><h3>Results</h3><div>An open-type device concept encompassing two interconnected chambers for long-term dynamic culture was developed and characterized for AM parameters, mechanical and biological properties. The split-inlet flow channel architecture allowed even distribution and symmetric flow velocity to the culture area. Cell viability exceeded 90%, while mCT and SEM indicated the 0° building angle as the most accurate SLA condition. CFD further showed that the 0° and 30° building angles most accurately reproduced the channel flow velocity predicted by the initial CAD model.</div></div><div><h3>Conclusion</h3><div>This study developed a customized, easy-to-produce, and cell-friendly OMC device, providing a 3D tool for biocompatibility assessment of biomaterials.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106877"},"PeriodicalIF":3.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive methodology to assess human bone transversal toughness based on macroscopic specimens, the compliance method, and 3D bio-faithful numerical simulations 基于宏观标本、顺应性方法和三维生物忠实数值模拟的评估人骨横向韧性的综合方法。
IF 3.3 2区 医学
Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-12-18 DOI: 10.1016/j.jmbbm.2024.106869
T. Kurtz , Y. Godio-Raboutet , F.L.B. Ribeiro , J.-L. Tailhan
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