Softening of elastic and viscoelastic properties is independent of overstretch rate in cerebral arteries

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-02-20 DOI:10.1016/j.jmbbm.2025.106957

Noah Pearson , Gregory M. Boiczyk , William J. Anderl , Michele Marino , S. Michael Yu , Kenneth L. Monson

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引用次数: 0

Abstract

Collagenous soft tissues are frequently injured by supraphysiologic mechanical deformation, leading to measurable changes in both extra-cellular matrix (ECM) structure and mechanical properties. While each of these alterations has been well studied following quasi-static deformation, little is known about the influence of high strain rate. Previous investigations of high-rate ECM alterations found tropocollagen denaturation and fibrillar kinking to be rate dependent. Given these observations of rate dependence in microstructure alterations, the present work evaluated if the rate and magnitude of overstretch affect the baseline viscoelastic properties of porcine middle cerebral arteries (MCAs). Changes in tissue response were assessed using a series of harmonic oscillations before and after sub-failure overstretches across a large range of rates and magnitudes. We used collagen-hybridizing peptide (CHP) to evaluate the role of tropocollagen denaturation in mechanical softening. Experiments show that softening is dependent on overstretch magnitude but is independent of overstretch rate. We also note that softening progresses at the same rate for both equilibrium (quasi-static) and non-equilibrium (high-rate) properties. Finally, results suggest that tropocollagen denaturation is not the source of the observed sub-yield softening behavior. This study expands fundamental knowledge on the form-function relationship of constituents in collagen fibrils and clarifies material behavior following sub-failure overstretch across a range of strain rates.

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脑动脉的弹性和粘弹性软化与过伸率无关

胶原软组织经常受到超生理机械变形的损伤，导致细胞外基质（ECM）结构和力学性能的可测量变化。虽然这些变化在准静态变形后已经得到了很好的研究，但对高应变率的影响知之甚少。先前对高速率ECM改变的研究发现，胶原变性和纤维扭结是速率依赖的。考虑到微观结构变化的速率依赖性，本研究评估了过度拉伸的速率和幅度是否会影响猪大脑中动脉（MCAs）的基线粘弹性特性。在大范围的速率和幅度的亚失效过度拉伸之前和之后，使用一系列谐波振荡来评估组织反应的变化。我们用胶原杂交肽（CHP）评价对胶原变性在机械软化中的作用。实验表明，软化与过伸幅度有关，而与过伸率无关。我们还注意到，对于平衡（准静态）和非平衡（高速率）性质，软化以相同的速率进行。最后，结果表明，原胶原变性不是观察到的亚屈服软化行为的来源。本研究扩展了胶原原纤维成分的形式-功能关系的基础知识，并阐明了在应变速率范围内亚失效过拉伸后的材料行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.