Revista de Senologia y Patologia Mamaria最新文献_第7页

Synergistic effects of vitamin D3 and 5-aza-2′-deoxycytidine on VDR methylation and breast cancer progression 维生素D3和5-aza-2 ' -脱氧胞苷对VDR甲基化和乳腺癌进展的协同作用

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1016/j.senol.2025.100708

Anjali K. Ravi , Saradhadevi Muthukrishnan , S. Abirami , Gayathiri Gunasangkaran , Vijaya Anand Arumugam , Velayuthaprabhu Shanmugam , Marie Arockianathan Pushpam , Ashokkumar Kaliyaperumal

{"title":"Synergistic effects of vitamin D3 and 5-aza-2′-deoxycytidine on VDR methylation and breast cancer progression","authors":"Anjali K. Ravi , Saradhadevi Muthukrishnan , S. Abirami , Gayathiri Gunasangkaran , Vijaya Anand Arumugam , Velayuthaprabhu Shanmugam , Marie Arockianathan Pushpam , Ashokkumar Kaliyaperumal","doi":"10.1016/j.senol.2025.100708","DOIUrl":"10.1016/j.senol.2025.100708","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast cancer (BC) is a highly aggressive disease with limited treatment options. Calcitriol, the active form of vitamin D3, exerts anticancer effects via the vitamin D receptor (VDR), but its efficacy is often reduced by VDR promoter hypermethylation. This study investigates the role of VDR promoter hypermethylation in breast cancer and evaluates the potential of 5-Aza-2dC and vitamin D3 to restore VDR function and enhance therapeutic efficacy.</div></div><div><h3>Methods</h3><div>BALB/c mice were treated with DMBA to induce VDR promoter hypermethylation. The effects of 5-Aza-2dC and Vitamin D3 on VDR, CYP27B1, and CYP24A1 expression were evaluated to assess their impact on calcitriol signaling and BC proliferation.</div></div><div><h3>Results</h3><div>DMBA-treated mice exhibited VDR hypermethylation, increased CYP24A1, and decreased VDR and CYP27B1 expression, with significantly enhanced tumor growth. Treatment with 5-Aza-2dC reversed VDR hypermethylation, restored VDR and CYP27B1 expression, and suppressed CYP24A1, leading to reduced tumor size and higher vitamin D3 levels. Vitamin D3 pre-treatment preserved VDR and CYP27B1 expression, reduced CYP24A1, and protected against VDR methylation, decreasing tumor proliferation. Combined treatment with 5-Aza-2dC and vitamin D3 synergistically enhanced VDR demethylation, reduced CYP24A1, increased vitamin D3 levels, and significantly inhibited BC proliferation, reducing tumor size.</div></div><div><h3>Conclusion</h3><div>Reversing VDR hypermethylation with 5-Aza-2dC and vitamin D3 offers a promising strategy to overcome calcitriol resistance and improve therapeutic outcomes in BC. This combination may enhance the efficacy of vitamin D3-based therapies in BC treatment.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100708"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Precision paradigm in breast cancer management: A mini review 乳腺癌管理的精确范式：一个小回顾

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.1016/j.senol.2025.100703

Suman Bhadra , Sohini Kulavi , Jaya Bandyopadhyay

{"title":"Precision paradigm in breast cancer management: A mini review","authors":"Suman Bhadra , Sohini Kulavi , Jaya Bandyopadhyay","doi":"10.1016/j.senol.2025.100703","DOIUrl":"10.1016/j.senol.2025.100703","url":null,"abstract":"<div><div>“One-size-fits-all” is a conventional medical approach to treating patients with similar symptoms with similar types of drugs. The effectiveness of various targeted therapies in such diverse tumors has entered an era in which treatment is determined based on the tumor's molecular abnormality profile, or “characteristics,” rather than on the type of tumor tissue or the site of anatomical origin. It improves the prognosis of patients and determines their quality of life. The evolving field of personalized medicinal drugs has significant potential in cancer prevention, diagnosis, and therapeutics. Identifying cancer susceptibility genes, such as the BRCA gene in breast cancer, helps screening programs identify patients at risk for developing cancer and make decisions about individual risk-modifying behaviors. Precision medicine plays a vital role in breast cancer management, e.g., using intracellular agents (Vemurafenib and Olaparib) and monoclonal antibodies (Cetuximab and Trastuzumab) in HER2-positive breast cancer. This review mainly focuses on the role of precision medicine in preventing and treating breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100703"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Accelerating cancer diagnostics: A novel AI pipeline for efficient histopathological image analysis 加速癌症诊断：高效组织病理图像分析的新型人工智能管道

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-07-01 Epub Date: 2025-01-15 DOI: 10.1016/j.senol.2024.100662

David Anglada-Rotger , Sonia Rabanaque-Rodríguez , Laura Sáez-Parés , Jordi Temprana-Salvador

{"title":"Accelerating cancer diagnostics: A novel AI pipeline for efficient histopathological image analysis","authors":"David Anglada-Rotger , Sonia Rabanaque-Rodríguez , Laura Sáez-Parés , Jordi Temprana-Salvador","doi":"10.1016/j.senol.2024.100662","DOIUrl":"10.1016/j.senol.2024.100662","url":null,"abstract":"<div><div>The surge in digital pathology and the vast amount of data from whole slide images (WSIs) have made it essential to develop tools that can efficiently analyze and support cancer diagnosis. An innovative artificial intelligence-based pipeline has been developed to tackle this challenge, significantly speeding up and enhancing the accuracy of breast cancer diagnosis. Created within the DigiPatICS project, in partnership with 8 hospitals across Catalonia, Spain, this pipeline begins by identifying tissue areas in WSIs and breaking them down into smaller, manageable tiles. Using smart image processing techniques, it filters out tiles that do not contain relevant information and focuses on the essential ones. Advanced deep learning algorithms then work to identify and classify different types of cells within the tissue. Proven effective on key breast cancer markers like HER2, Ki67, ER, and PR, the system precomputes the results overnight, allowing pathologists to simply load the pre-analyzed data for the areas of interest of the WSI that they select during their workday. Each WSI is analyzed in more or less 1110 s, providing reliable results that are ready when needed. Now, an integral part of routine workflows, this approach is revolutionizing how breast cancer slides are processed, enhancing diagnostic capabilities, and reshaping digital pathology.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100662"},"PeriodicalIF":0.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of AI and virtual environments in the Future Breast Unit 人工智能和虚拟环境在未来乳房单元中的作用

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1016/j.senol.2024.100661

Rogelio Andrés-Luna , Josep Salvador López , Pedro Gouveia

{"title":"The role of AI and virtual environments in the Future Breast Unit","authors":"Rogelio Andrés-Luna , Josep Salvador López , Pedro Gouveia","doi":"10.1016/j.senol.2024.100661","DOIUrl":"10.1016/j.senol.2024.100661","url":null,"abstract":"<div><div>Artificial intelligence (AI) has offered significant advances in medicine from its beginnings, with expert systems that complemented decision-making, to its current use, present in many applications where we are not fully aware. In this article, we are going to review and analyse different real uses of AI, which will enable us to correctly frame the vectors of present and future applications. From those already known in management, assistance in decision-making, radiomics, or pathomics to more recent ones such as virtual and augmented reality, remote monitoring, or the prediction of morphological results after surgery. Over time, the development of machine learning algorithms and the exponential increase of available health data will allow AI to provide more accurate and personalised diagnoses, development of new therapies and drugs, significantly reducing research and testing times. For this to be possible, greater communication and cooperation between healthcare professionals and the world of engineering will be necessary, starting in the educational field where there is a need to train professionals in engineering and biomedicine capable of tackling challenges with a complete vision, thus reducing the wall of technical understanding and deepening the development of useful applications.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100661"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cáncer de mama bilateral sincrónico en el varón. Descripción de un caso y revisión de la bibliografía 男性双侧同步乳腺癌。案例说明和参考书目审查

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1016/j.senol.2024.100664

Noelia Lete Aguirre, Jorge Martínez Medel, Antonio Tomás Güemes Sánchez

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Blockchain aplicado en afecciones mamarias: desafíos y consideraciones éticas 应用于乳腺癌的区块链：挑战和伦理考虑

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1016/j.senol.2024.100652

Víctor Gómez-Bocanegra , Guadalupe Silvia García-de la Torre , Carlos Alberto Pantoja Meléndez , Bernardo Loose-Rojo

{"title":"Blockchain aplicado en afecciones mamarias: desafíos y consideraciones éticas","authors":"Víctor Gómez-Bocanegra , Guadalupe Silvia García-de la Torre , Carlos Alberto Pantoja Meléndez , Bernardo Loose-Rojo","doi":"10.1016/j.senol.2024.100652","DOIUrl":"10.1016/j.senol.2024.100652","url":null,"abstract":"<div><div>The Fourth Industrial Revolution, driven by the Internet, has generated significant technological advances, transforming various aspects of daily life, including the healthcare industry. Blockchain technology emerges as an innovative solution to address problems related to breast pathology. Being a decentralized network that records ‘data’ events in chained blocks, it offers security and transparency when storing information. Initially, blockchain was applied to cryptocurrencies and has spread to various industries, including healthcare in senology, where it facilitates the management of electronic medical records, such as mammograms interpreted using machine learning technology, biopsy results, scan interpretation, and the use or consumption. of medications, thus facilitating the exchange of data for prevention, diagnosis, management of medical or pharmaceutical supplies and research. Blockchain adoption presents ethical and practical challenges, especially in information confidentiality. Furthermore, the digital divide and unequal access to the Internet represent obstacles to its equitable implementation. Similarly, the use of blockchain raises questions about truth and trust in data, as it theoretically offers integrity and security, necessitating full epistemological validation of its usefulness in generating knowledge. In short, blockchain has the potential to revolutionize the healthcare industry; However, it is crucial that its implementation faces ethical, legal and technological challenges to ensure genuine social benefit and avoid exacerbating inequalities. Constant evaluation of its impact and integration with current systems are essential to maximize its potential while mitigating its risks.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100652"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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La nueva edad del hombre, la edad del hombre-máquina, en la enfermedad mamaria 乳腺疾病中的新人类时代，人类机器时代

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1016/j.senol.2025.100679

Eduardo Alcobilla-Ferrara

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Caracterización del cáncer de mama en hombres en el caribe colombiano en el periodo 2015–2023 2015-2023 年期间哥伦比亚加勒比地区男性乳腺癌的特点。

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-10-30 DOI: 10.1016/j.senol.2024.100635

Emily Johanna Hernández Aguilar , Mauricio Bermúdez Sagre , Gustavo Martínez , Jorge Romero , Mileidys Correa

{"title":"Caracterización del cáncer de mama en hombres en el caribe colombiano en el periodo 2015–2023","authors":"Emily Johanna Hernández Aguilar , Mauricio Bermúdez Sagre , Gustavo Martínez , Jorge Romero , Mileidys Correa","doi":"10.1016/j.senol.2024.100635","DOIUrl":"10.1016/j.senol.2024.100635","url":null,"abstract":"<div><h3>Introduction</h3><div>Male breast cancer is little studied and represents 1% of the total and there is no screening strategy or specific treatment guidelines. Generally diagnosed at advanced ages and stages. Its management involves breast and/or armpit surgery and/or chemo-radio or hormone therapy.</div></div><div><h3>Objective</h3><div>To characterize the sociodemographic and clinicopathological aspects of male patients with breast cancer diagnosed in health care providers institutions in the Colombian Caribbean in the period 2015–2023.</div></div><div><h3>Methods</h3><div>Observational, descriptive, cross-sectional, multicenter study. Absolute frequencies and percentages were used for qualitative variables and medians and ranges for quantitative variables.</div></div><div><h3>Results</h3><div>23 cases were analyzed, with a median age of 71 years. The most common symptoms were retroareolar breast mass (91.3%) and axillary lymphadenopathy (39.1%). The majority were advanced tumors (43.5% T4, 60.9% with lymph node involvement and 13% with metastasis). Of the 5 cases with a genetic panel, two had a mutation, one in PMS2 and another in SDM4. 52.2% received neoadjuvant treatment, mainly with the AC-T regimen. 78.3% underwent surgery (n = 18), predominantly mastectomy (95%) and lymph node dissection (81%) depending on the area operated on. A total of 60.9% received adjuvant treatment, 85% radiotherapy and 66% chemotherapy. The most common histology was Infiltrating ductal carcinoma (78.3%), grade 2 (73.9%), and luminal molecular subtype (91.3%).</div></div><div><h3>Conclusion</h3><div>This series is the only one on the Colombian Caribbean coast. The increase in cases since the 1920s is evident, probably due to greater awareness and accessibility. It is recommended to perform a routine genetic panel when diagnosing.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100635"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Descripcion de un caso de carcinoma papilar encapsulado apocrino de mama: un dilema diagnóstico 隐窝乳腺乳头状瘤的诊断困境

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-01-03 DOI: 10.1016/j.senol.2024.100653

José Richard Tenazoa-Villalobos , Edgar Fermín Yan-Quiroz , Gladys Llerena-Cobián

{"title":"Descripcion de un caso de carcinoma papilar encapsulado apocrino de mama: un dilema diagnóstico","authors":"José Richard Tenazoa-Villalobos , Edgar Fermín Yan-Quiroz , Gladys Llerena-Cobián","doi":"10.1016/j.senol.2024.100653","DOIUrl":"10.1016/j.senol.2024.100653","url":null,"abstract":"<div><div>Encapsulated papillary carcinoma of the breast with apocrine differentiation is an extremely rare neoplasm that possesses both an encapsulated papillary configuration as well as epithelial cells that differentiated apocrine. It is not included as such in the fifth edition of the World Health Organization (WHO) classification of tumors because there are no research studies on the subject. These neoplasms have cells that are distinguished by having granular cytoplasm, large nuclei with prominent nucleoli, through immunohistochemistry these tumors are negative for estrogen, progesterone and HER2 receptors, but despite the absence of these markers and the nuclear atypia described, they have an overall survival that exceeds 5 years compared even to the other types of triple-negative breast neoplasm. We present the case of an 85-year-old woman who presented a right breast tumor that was classified as apocrine encapsulated papillary carcinoma, underwent right total mastectomy surgery and allowed the control of the disease, thus achieving a favorable outcome.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100653"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Angiomatosis of the breast: A rare lesion in a young patient. A case report and review of the literature 乳腺血管瘤病：年轻患者中一种罕见的病变。病例报告及文献回顾

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1016/j.senol.2024.100654

Maria Cristina Barcellos Anselmi , Cinthya Apolo Carrión , João Pattusi Bertinatti

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