Revista de Senologia y Patologia Mamaria最新文献

{"title":"Sarcoma pleomórfico indiferenciado de alto grado como tumor primario de mama en una paciente de 12 años: reporte de caso","authors":"Daniela María Cuadrado Franco,&nbsp;Sandra Milena Pantoja Burbano,&nbsp;Natalia Restrepo Abisambra","doi":"10.1016/j.senol.2025.100709","DOIUrl":"10.1016/j.senol.2025.100709","url":null,"abstract":"<div><div>High-grade undifferentiated pleomorphic sarcoma (UPS) of the breast is an extremely rare entity in children, representing less than 1% of malignant breast tumors. It poses a challenge in diagnosis and treatment due to the lack of specific guidelines. We describe the case of a 12-year-old patient with no significant medical history who presented to a tertiary care hospital with a rapidly growing, painful breast mass with cutaneous changes. Imaging studies showed a complex BIRADS 4C mass with no sign of metastasis. The case was submitted to a multidisciplinary board, which indicated primary surgical management. The postoperative pathology report indicated UPS. Adjuvant intensity-modulated radiation therapy (IMRT) and chemotherapy with ifosfamide and doxorubicin were indicated according to the protocol for pediatric non-rhabdomyosarcoma. The patient showed a favorable postoperative outcome, with complete graft healing and no signs of relapse to date. This case highlights the importance of aggressive surgical management and personalized adjuvant treatment in pediatric breast sarcomas, emphasizing the need for additional studies to establish specific management guidelines and optimize outcomes in this population.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100709"},"PeriodicalIF":0.3,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic implications of antiangiogenic agents and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors in breast cancer: Current status and future perspectives","authors":"Muhammad Adil ,&nbsp;Ghazanfar Abbas ,&nbsp;Mavara Iqbal ,&nbsp;Sarmad Rasheed ,&nbsp;Shamsa Kanwal","doi":"10.1016/j.senol.2024.100658","DOIUrl":"10.1016/j.senol.2024.100658","url":null,"abstract":"<div><div>Angiogenesis exhibits an integral role in cancer development and metastasis, therefore, antiangiogenic therapy forms the basis of several promising treatment strategies for breast cancer. Moreover, DNA damage has long been exploited in cancer chemotherapy and poly-adenosine diphosphate ribose polymerase (PARP) inhibitors constitute a novel group of drugs for the targeted disruption of DNA repair phenomenon attributed to breast cancer. Several antiangiogenic drugs and PARP inhibitors are effectively used as sole agents for the therapeutic management of early breast cancer and breast cancer gene mutation–induced breast cancer, respectively. Whereas, other antiangiogenic agents are employed for the ancillary therapy of metastatic breast cancer in conjunction with chemotherapeutic drugs. Likewise, some PARP inhibitors are recommended as adjuncts to chemotherapy against the triple-negative form of breast cancer. Combinations of PARP inhibitors with immunotherapy have also demonstrated favorable outcomes and offer an efficient treatment strategy for breast cancer. Currently, the combinations of antiangiogenic agents and PARP inhibitors are under investigation for prospective synergistic or additive effects in breast cancer. Despite being suggested for high-risk patients, the prophylactic use of PARP inhibitors has not been supported by means of preclinical or clinical studies. Finally, the identification of patient cohorts, determination of predictive biomarkers, optimization of dosing strategies, validation of long-term safety, and containment of resistance issues, necessitate proper attention for improving the clinical efficacy of potentially useful antiangiogenic agents and PARP inhibitors against breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100658"},"PeriodicalIF":0.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of vitamin D3 and 5-aza-2′-deoxycytidine on VDR methylation and breast cancer progression","authors":"Anjali K. Ravi ,&nbsp;Saradhadevi Muthukrishnan ,&nbsp;S. Abirami ,&nbsp;Gayathiri Gunasangkaran ,&nbsp;Vijaya Anand Arumugam ,&nbsp;Velayuthaprabhu Shanmugam ,&nbsp;Marie Arockianathan Pushpam ,&nbsp;Ashokkumar Kaliyaperumal","doi":"10.1016/j.senol.2025.100708","DOIUrl":"10.1016/j.senol.2025.100708","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast cancer (BC) is a highly aggressive disease with limited treatment options. Calcitriol, the active form of vitamin D3, exerts anticancer effects via the vitamin D receptor (VDR), but its efficacy is often reduced by VDR promoter hypermethylation. This study investigates the role of VDR promoter hypermethylation in breast cancer and evaluates the potential of 5-Aza-2dC and vitamin D3 to restore VDR function and enhance therapeutic efficacy.</div></div><div><h3>Methods</h3><div>BALB/c mice were treated with DMBA to induce VDR promoter hypermethylation. The effects of 5-Aza-2dC and Vitamin D3 on VDR, CYP27B1, and CYP24A1 expression were evaluated to assess their impact on calcitriol signaling and BC proliferation.</div></div><div><h3>Results</h3><div>DMBA-treated mice exhibited VDR hypermethylation, increased CYP24A1, and decreased VDR and CYP27B1 expression, with significantly enhanced tumor growth. Treatment with 5-Aza-2dC reversed VDR hypermethylation, restored VDR and CYP27B1 expression, and suppressed CYP24A1, leading to reduced tumor size and higher vitamin D3 levels. Vitamin D3 pre-treatment preserved VDR and CYP27B1 expression, reduced CYP24A1, and protected against VDR methylation, decreasing tumor proliferation. Combined treatment with 5-Aza-2dC and vitamin D3 synergistically enhanced VDR demethylation, reduced CYP24A1, increased vitamin D3 levels, and significantly inhibited BC proliferation, reducing tumor size.</div></div><div><h3>Conclusion</h3><div>Reversing VDR hypermethylation with 5-Aza-2dC and vitamin D3 offers a promising strategy to overcome calcitriol resistance and improve therapeutic outcomes in BC. This combination may enhance the efficacy of vitamin D3-based therapies in BC treatment.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100708"},"PeriodicalIF":0.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of MammaTyper® versus immunohistochemistry in the molecular subtyping of breast cancer: The SUBMARIN study","authors":"Laia Bernet-Vegué ,&nbsp;Stella Peláez Malagón ,&nbsp;Marina Berna Rubio","doi":"10.1016/j.senol.2025.100706","DOIUrl":"10.1016/j.senol.2025.100706","url":null,"abstract":"<div><h3>Introduction</h3><div>Immunohistochemical study for oestrogen receptor (ER/<em>ESR1</em>), progesterone receptor (PR/<em>PGR</em>), human epidermal growth factor receptor 2 (HER2/<em>ERBB2</em>), and proliferation marker Ki-67/<em>MKI67</em>PR is the standard technique for diagnosing the molecular subtype in clinical practice. However, less subjective techniques, such as the mRNA-quantifying MammaTyper® (MMT), are needed.</div></div><div><h3>Materials and methods</h3><div>Observational, retrospective, single-centre study carried out at the Vinalopó University Hospital, Alacant, Spain, with 109 consecutive formalin-fixed paraffin-embedded samples coming from infiltrating breast carcinoma diagnosed between 2022 and 2023.</div></div><div><h3>Results</h3><div>The global concordance of MMT with IHC was 76.15%. MMT results were concordant with IHC in all HER2-positive (4, 100%) or HER2-Luminal B samples (11, 100%), in 45 (95.7%) classified as Luminal B-like (HER2–) and in 11 (84.6%) Triple negative. MMT disagreed on 22 (64.7%) Luminal A-like samples, mainly because MMT detected Ki-67 expression. High values of positive agreement for ER (96.3%, 95% CI: 90.9; 98.6%), PR (89.9%, 95% CI: 82.8; 94.3%), and HER2 (87.0%, 95% CI: 67.9; 95.5%) were obtained. MMT detected more positives than IHC for Ki-67 (52.6%, 95% CI: 43.2; 62.0%) and HER2-low (74.3%, 95% CI: 66.1; 82.5%).</div></div><div><h3>Conclusion</h3><div>The concordance between both techniques was high for ER, PR, and HER2. Notably, MMT standardises the identification of Luminal A-B-like and HER2-low thanks to its higher sensitivity towards HER2 and Ki-67.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100706"},"PeriodicalIF":0.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into breast cancer education concerning knowledge, awareness, and perceptions: A cross-sectional study among young adult girls","authors":"Anmar Al-Taie ,&nbsp;Ali N. Hussein ,&nbsp;Asma K. Allah","doi":"10.1016/j.senol.2025.100707","DOIUrl":"10.1016/j.senol.2025.100707","url":null,"abstract":"<div><h3>Introduction</h3><div>In developing countries, mortality from breast cancer (BC) is higher due to changes in lifestyle that produce a rise in incidence, with over half of patients receiving advanced-stage diagnoses. Young girls have a significant impact on women's knowledge and awareness of BC in their communities and their motivation needs to be evaluated.</div></div><div><h3>Objective</h3><div>The aim of this study was to assess the level of knowledge of BC regarding potential risk factors, awareness about the most common warning signs, diagnostic and screening, and perceptions towards BC treatment outcomes among young adult girls in Northern Cyprus.</div></div><div><h3>Methods</h3><div>A cross-sectional, observational study was conducted among young adult girls in three major provinces of Northern Cyprus: Nicosia, Kyrenia, and Famagusta, using a structured, validated questionnaire with five parts.</div></div><div><h3>Results</h3><div>A total of 300 young adult girls were enrolled in this study, with a mean age of 22.37 years. There was a significant lack of knowledge about BC risk factors and diagnosis (score = 8.4, <em>P</em> &lt; 0.0001); (score = 5.7, <em>P</em> &lt; 0.0001, respectively). There was also a significant lack of awareness of the BC signs (score = 6.6, <em>P</em> &lt; 0.0001), and perceptions towards treatment (score = 5.3, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>This study found that most young adult girls in Northern Cyprus had lower than expected knowledge of BC risk factors, warning signs, and early cancer diagnosis and screening. The study population, on the other hand, had fairly positive perceptions of BC management.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100707"},"PeriodicalIF":0.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision paradigm in breast cancer management: A mini review","authors":"Suman Bhadra ,&nbsp;Sohini Kulavi ,&nbsp;Jaya Bandyopadhyay","doi":"10.1016/j.senol.2025.100703","DOIUrl":"10.1016/j.senol.2025.100703","url":null,"abstract":"<div><div>“One-size-fits-all” is a conventional medical approach to treating patients with similar symptoms with similar types of drugs. The effectiveness of various targeted therapies in such diverse tumors has entered an era in which treatment is determined based on the tumor's molecular abnormality profile, or “characteristics,” rather than on the type of tumor tissue or the site of anatomical origin. It improves the prognosis of patients and determines their quality of life. The evolving field of personalized medicinal drugs has significant potential in cancer prevention, diagnosis, and therapeutics. Identifying cancer susceptibility genes, such as the BRCA gene in breast cancer, helps screening programs identify patients at risk for developing cancer and make decisions about individual risk-modifying behaviors. Precision medicine plays a vital role in breast cancer management, e.g., using intracellular agents (Vemurafenib and Olaparib) and monoclonal antibodies (Cetuximab and Trastuzumab) in HER2-positive breast cancer. This review mainly focuses on the role of precision medicine in preventing and treating breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100703"},"PeriodicalIF":0.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal of Senology and Breast Disease. Why Transition to English?","authors":"David Martínez Ramos","doi":"10.1016/j.senol.2025.100705","DOIUrl":"10.1016/j.senol.2025.100705","url":null,"abstract":"","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100705"},"PeriodicalIF":0.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linfedema secundario a cáncer de mama: una revisión narrativa del papel del ejercicio físico","authors":"Ana Belén Puentes Gutiérrez ,&nbsp;Elena Vaquero Ramiro ,&nbsp;María García Bascones","doi":"10.1016/j.senol.2025.100681","DOIUrl":"10.1016/j.senol.2025.100681","url":null,"abstract":"<div><div>The role of exercise in breast cancer-related lymphedema (BCRL) is not clearly defined. The main target of this review is to describe the effects of the different types of exercises on this kind of patient. Bibliographic research was done through the databases of PubMed and PEDro. Controlled trials published between 2017 and 2023 in both Spanish and English, were included. Article selection was carried out separately by 2 researchers using the PICO strategy. Forty-three articles were selected and, after the authors´ review, 19 were included, the majority focused on strength exercises. Strength physical exercise in women with BCRL or at risk of developing it, proved to be safe, even with heavy loads and even during taxanes treatment. Furthermore, it has a beneficial effect on the patients quality of life, in lymphedema symptoms, extremities functionality, and strength gain, although it could not prove its positive role in the prevention or treatment of BCRL. There are no specific protocols for the strength exercise. Other types of exercises such as water sports, pilates, and yoga are considered adequate for these patients.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100681"},"PeriodicalIF":0.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cirugía oncoplástica reconstructiva: reconstrucción prepectoral inmediata y matrices acelulares dérmicas. Revisión sistemática, indicaciones y resultados","authors":"Manuel Nogueira Sixto,&nbsp;Gonzalo de Castro Parga,&nbsp;Vanesa Rodríguez Fernández","doi":"10.1016/j.senol.2025.100702","DOIUrl":"10.1016/j.senol.2025.100702","url":null,"abstract":"<div><div>In the last decade, we have witnessed an exponential increase in the use of acellular dermal matrices (ADMs) as a result of increased rates of immediate prepectoral breast reconstruction (IPBR) after mastectomy. We performed a systematic search on IPBR with ADMs with the aim of understanding the results obtained and identifying which subgroup of patients benefit from the use of ADMs in IPBR. We recorded the anthropometric characteristics and medical history of the patients, the therapy carried out, and the results obtained.</div><div>A total of 159 articles were identified, of which 46 were selected. These describe a reduction in the onset of global complications after IPBR with ADMs from 27.5% to 23.3%, and a reduction in the incidence of capsular contracture from 12.4% to 2.3%, as well as the disappearance of animation deformity. In this review, the following factors were found to be risk factors for morbidity and/or worse aesthetic results: adjuvant radiotherapy, smoking, larger volume mastectomy, and axillary surgery. BMI &gt; 30, diabetes, age &gt;<!--> <!-->50, and prosthetic volume have not been confirmed as risk factors. Mastectomies &gt;<!--> <!-->1000 g have been described as protective factors. Prepectoral breast reconstruction with ADMs is a safe technique with good functional and aesthetic results. At present, it is not possible to determine which ADM provides the best results.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100702"},"PeriodicalIF":0.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic neutrophilic granulomatous mastitis associated with Corynebacterium: A systematic review of clinical, pathological, and therapeutic insights","authors":"André R. Guimarães ,&nbsp;Ana Pereira Marques ,&nbsp;António Sarmento","doi":"10.1016/j.senol.2025.100704","DOIUrl":"10.1016/j.senol.2025.100704","url":null,"abstract":"<div><div>Cystic neutrophilic granulomatous mastitis (CNGM) is a rare and underrecognized subtype of granulomatous mastitis, increasingly associated with <em>Corynebacterium</em> species, particularly <em>Corynebacterium kroppenstedtii</em>. Despite a growing number of reports, its diagnosis remains challenging, and treatment approaches are highly variable.</div><div>This systematic review aimed to consolidate the clinical, microbiological, and therapeutic characteristics of CNGM to better inform clinical management. A structured search of PubMed using MeSH terms identified 13 studies, of which 11 met inclusion criteria.</div><div>These studies, encompassing 387 patients, were analyzed for clinical presentation, diagnostic methods, histopathological findings, bacterial species, antimicrobial susceptibility, treatment strategies, and outcomes. CNGM typically presented as a unilateral painful breast mass, frequently accompanied by abscess, nipple inversion, or fistulae. Diagnosis was established via histopathology and confirmed by microbiological testing, often through MALDI-TOFMS or 16S rRNA sequencing. While <em>C. kroppenstedtii</em> was most frequently isolated, recent studies suggest <em>C. parakroppenstedtii</em> may be more prevalent than previously recognized. Antimicrobial susceptibility data revealed consistent resistance to beta-lactams and variable susceptibility to clindamycin and fluoroquinolones, whereas linezolid and vancomycin demonstrated consistent efficacy. Directed antibiotic therapy, particularly with lipophilic agents, combined with abscess drainage, was associated with improved outcomes and lower recurrence. In contrast, higher recurrence rates were reported with corticosteroids or immunosuppressants used in isolation.</div><div>These findings support a multimodal approach as the most effective strategy for CNGM management. Further prospective studies are needed to establish standardized diagnostic criteria and evidence-based treatment guidelines.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100704"},"PeriodicalIF":0.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}