Revista de Senologia y Patologia Mamaria最新文献_第2页

Ética y filosofía de la inteligencia artificial aplicada a la enfermedad mamaria

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-12-31 DOI: 10.1016/j.senol.2024.100656

David Casacuberta

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Adenomioepitelioma de la mama

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-12-17 DOI: 10.1016/j.senol.2024.100655

Xavier Bargalló , Lledó Cabedo , Esther Sanfeliu , Sergi Ganau , Belén Úbeda , Carla Sitges , Dominika Gasior , Isaac Cebrecos , Eduard Mensión

{"title":"Adenomioepitelioma de la mama","authors":"Xavier Bargalló , Lledó Cabedo , Esther Sanfeliu , Sergi Ganau , Belén Úbeda , Carla Sitges , Dominika Gasior , Isaac Cebrecos , Eduard Mensión","doi":"10.1016/j.senol.2024.100655","DOIUrl":"10.1016/j.senol.2024.100655","url":null,"abstract":"<div><h3>Objectives</h3><div>To perform a descriptive analysis of the clinical information and radiological findings, emphasizing those provided by magnetic resonance imaging of a single-center series of cases of adenomyoepithelioma of the breast.</div></div><div><h3>Material and methods</h3><div>Our series consists of 11 patients, most of them were diagnosed by ultrasound-guided core needle biopsy. In three cases, the initial diagnosis was papilloma, and adenomyoepithelioma was diagnosed by surgical excision or vacuum aspiration biopsy. In five cases, breast magnetic resonance was performed.</div></div><div><h3>Results</h3><div>Most of our cases were diagnosed by mammography from the population-based breast cancer screening program, with a mass or focal asymmetry being the most frequent presentations. Ultrasound show oval and well-defined mass with a tendency to form angles. The two malignant cases showed prominent vessels in the Doppler study. On magnetic resonance imaging, they are predominantly hyperintense on T2 without restriction in diffusion and with intense gadolinium uptake. Three cases (two malignant and one atypical) relapsed.</div></div><div><h3>Conclusion</h3><div>Small adenomyoepitheliomas may mimic fibroadenomas, although they show a certain tendency to show angled edges. Core needle biopsy is usually diagnostic, although it is sometimes difficult to differentiate adenomyoepithelioma from papilloma.</div><div>Magnetic resonance imaging does not help to suspect malignancy since most cases do not show restriction in diffusion. In our series, the presence of vessels in the Doppler study has shown some relation to atypical or malignant adenomyoepithelioma. Wide surgical removal is warranted in atypical or malignant cases.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100655"},"PeriodicalIF":0.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Blockchain aplicado en afecciones mamarias: desafíos y consideraciones éticas

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-12-04 DOI: 10.1016/j.senol.2024.100652

Víctor Gómez-Bocanegra , Guadalupe Silvia García-de la Torre , Carlos Alberto Pantoja Meléndez , Bernardo Loose-Rojo

{"title":"Blockchain aplicado en afecciones mamarias: desafíos y consideraciones éticas","authors":"Víctor Gómez-Bocanegra , Guadalupe Silvia García-de la Torre , Carlos Alberto Pantoja Meléndez , Bernardo Loose-Rojo","doi":"10.1016/j.senol.2024.100652","DOIUrl":"10.1016/j.senol.2024.100652","url":null,"abstract":"<div><div>The Fourth Industrial Revolution, driven by the Internet, has generated significant technological advances, transforming various aspects of daily life, including the healthcare industry. Blockchain technology emerges as an innovative solution to address problems related to breast pathology. Being a decentralized network that records ‘data’ events in chained blocks, it offers security and transparency when storing information. Initially, blockchain was applied to cryptocurrencies and has spread to various industries, including healthcare in senology, where it facilitates the management of electronic medical records, such as mammograms interpreted using machine learning technology, biopsy results, scan interpretation, and the use or consumption. of medications, thus facilitating the exchange of data for prevention, diagnosis, management of medical or pharmaceutical supplies and research. Blockchain adoption presents ethical and practical challenges, especially in information confidentiality. Furthermore, the digital divide and unequal access to the Internet represent obstacles to its equitable implementation. Similarly, the use of blockchain raises questions about truth and trust in data, as it theoretically offers integrity and security, necessitating full epistemological validation of its usefulness in generating knowledge. In short, blockchain has the potential to revolutionize the healthcare industry; However, it is crucial that its implementation faces ethical, legal and technological challenges to ensure genuine social benefit and avoid exacerbating inequalities. Constant evaluation of its impact and integration with current systems are essential to maximize its potential while mitigating its risks.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100652"},"PeriodicalIF":0.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Angiomatosis of the breast: A rare lesion in a young patient. A case report and review of the literature

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-12-04 DOI: 10.1016/j.senol.2024.100654

Maria Cristina Barcellos Anselmi , Cinthya Apolo Carrión , João Pattusi Bertinatti

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Mastitis granulomatosa con buena respuesta a baricitinib 对巴利替尼反应良好的肉芽肿性乳腺炎

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-11-26 DOI: 10.1016/j.senol.2024.100651

Rafael Rubén Pimentel León, Rosa Martha Núñez Rodríguez, María Del Sol Rebollar Vega

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Descripción de un caso: Gigantomastia gestacional tras un tratamiento de hiperplasia virginal mamaria previo 病例报告：曾接受过处女膜乳腺增生治疗的妊娠巨乳症。

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-11-25 DOI: 10.1016/j.senol.2024.100648

Ana Tello Delsors , Ana Gómez Alarcón , Rosa Angélica Barbella Aponte

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Triose phosphate isomerase 1 in serum of women with breast cancer 乳腺癌妇女血清中的磷酸三糖异构酶 1

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-11-22 DOI: 10.1016/j.senol.2024.100647

Obaida Adnan Jwameer , Ekhlas Abdallah Hassan , Faiz M. Al-Abady

{"title":"Triose phosphate isomerase 1 in serum of women with breast cancer","authors":"Obaida Adnan Jwameer , Ekhlas Abdallah Hassan , Faiz M. Al-Abady","doi":"10.1016/j.senol.2024.100647","DOIUrl":"10.1016/j.senol.2024.100647","url":null,"abstract":"<div><h3>Introduction</h3><div>Triosephosphate isomerase 1 (TPI1) plays a role in various biological processes, specifically in the development of the metastatic phenotype, and is recognized as a significant enzyme in the glucose metabolism pathway. TPI1 has been proposed as a potential oncogene, with several types of cancer including breast cancer (BC).</div></div><div><h3>Material</h3><div>This research aims to assess activity of TPI1 in serum samples obtained from female subjects with BC. The levels of TPI1 were evaluated in the serum samples of four different BC groups, with 54 women included as the control group.</div></div><div><h3>Results</h3><div>Based on the findings, the average TPI levels were (41.01 ± 7.92) and (11.91 ± 2.68) in BC patients and healthy controls, respectively. The mean level higher in BC patients compared to healthy controls (<em>P</em>  <.0001) compared to groups I, II, and III. Analysis of both univariate and multivariate models indicated that age (odds ratio [OR] = 1.12, 95% confidence interval [CI] = 0.76–8.12, <em>P</em>  =.001) were identified as independent predictors for the presence of malignancy. Furthermore, receiver operating characteristic analysis demonstrated a high diagnostic accuracy for TPI concentrations, with an area under the curve value of 0.999.</div></div><div><h3>Conclusion</h3><div>The levels of serum TPI1 have been observed to increase in patients diagnosed with BC. There is a correlation between the concentration of TPI1 and the presence of breast malignancy.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100647"},"PeriodicalIF":0.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of action for FDA-approved drugs targeting breast cancer FDA 批准的乳腺癌靶向药物的作用机制

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-10-31 DOI: 10.1016/j.senol.2024.100632

Francis Dhilna , R.N. Binitha , Nissar Riswina , Sebatain Divya , Joseph Rima , P.A. Janish , Balachandran Subin

{"title":"Mechanisms of action for FDA-approved drugs targeting breast cancer","authors":"Francis Dhilna , R.N. Binitha , Nissar Riswina , Sebatain Divya , Joseph Rima , P.A. Janish , Balachandran Subin","doi":"10.1016/j.senol.2024.100632","DOIUrl":"10.1016/j.senol.2024.100632","url":null,"abstract":"<div><div>Breast cancer treatment encompasses a diverse range of therapeutic strategies targeting specific molecular pathways crucial for tumor growth and progression. Several exciting advancements are likely to shape the future of breast cancer treatment. Understanding the mechanisms by which FDA-approved drugs exert their effects is crucial for optimizing treatment strategies and improving patient outcomes. In this review, we aim to categorize FDA-approved drugs for breast cancer treatment based on their distinct modes of action or mechanisms These mechanisms cover several activities, such as blocking particular enzymes that are essential for the synthesis of hormones, interfering with cellular functions that are necessary for the growth and spread of tumors, altering signaling pathways that are critical for the survival of cancer cells, and taking advantage of weaknesses in DNA repair mechanisms that are specific to them. In order to effectively battle this heterogeneous disease, a customized and all-encompassing therapeutic approach is required. This multifaceted approach highlights the crucial role of therapeutic approaches and synergistic treatment modalities in maximizing efficacy and improving prognosis for individuals with breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 1","pages":"Article 100632"},"PeriodicalIF":0.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anomalías vasculares de la mama 乳房血管异常

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-10-30 DOI: 10.1016/j.senol.2024.100638

Pedro Marín-Rodríguez , Florentina Guzmán-Aroca , María Eulalia García-Solano , Caridad Marín-Hernández , Pedro Galindo-Fernández , Antonio Piñero-Madrona

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Caracterización del cáncer de mama en hombres en el caribe colombiano en el periodo 2015–2023 2015-2023 年期间哥伦比亚加勒比地区男性乳腺癌的特点。

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Revista de Senologia y Patologia Mamaria Pub Date : 2024-10-30 DOI: 10.1016/j.senol.2024.100635

Emily Johanna Hernández Aguilar , Mauricio Bermúdez Sagre , Gustavo Martínez , Jorge Romero , Mileidys Correa

{"title":"Caracterización del cáncer de mama en hombres en el caribe colombiano en el periodo 2015–2023","authors":"Emily Johanna Hernández Aguilar , Mauricio Bermúdez Sagre , Gustavo Martínez , Jorge Romero , Mileidys Correa","doi":"10.1016/j.senol.2024.100635","DOIUrl":"10.1016/j.senol.2024.100635","url":null,"abstract":"<div><h3>Introduction</h3><div>Male breast cancer is little studied and represents 1% of the total and there is no screening strategy or specific treatment guidelines. Generally diagnosed at advanced ages and stages. Its management involves breast and/or armpit surgery and/or chemo-radio or hormone therapy.</div></div><div><h3>Objective</h3><div>To characterize the sociodemographic and clinicopathological aspects of male patients with breast cancer diagnosed in health care providers institutions in the Colombian Caribbean in the period 2015–2023.</div></div><div><h3>Methods</h3><div>Observational, descriptive, cross-sectional, multicenter study. Absolute frequencies and percentages were used for qualitative variables and medians and ranges for quantitative variables.</div></div><div><h3>Results</h3><div>23 cases were analyzed, with a median age of 71 years. The most common symptoms were retroareolar breast mass (91.3%) and axillary lymphadenopathy (39.1%). The majority were advanced tumors (43.5% T4, 60.9% with lymph node involvement and 13% with metastasis). Of the 5 cases with a genetic panel, two had a mutation, one in PMS2 and another in SDM4. 52.2% received neoadjuvant treatment, mainly with the AC-T regimen. 78.3% underwent surgery (n = 18), predominantly mastectomy (95%) and lymph node dissection (81%) depending on the area operated on. A total of 60.9% received adjuvant treatment, 85% radiotherapy and 66% chemotherapy. The most common histology was Infiltrating ductal carcinoma (78.3%), grade 2 (73.9%), and luminal molecular subtype (91.3%).</div></div><div><h3>Conclusion</h3><div>This series is the only one on the Colombian Caribbean coast. The increase in cases since the 1920s is evident, probably due to greater awareness and accessibility. It is recommended to perform a routine genetic panel when diagnosing.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100635"},"PeriodicalIF":0.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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