Revista de Senologia y Patologia Mamaria最新文献_第2页

Silent complications: Liquid silicone granuloma in a patient after unregulated cosmetic mamary augmentation 无症状的并发症：液体硅肉芽肿患者后，不规范的美容乳房增大

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-05-10 DOI: 10.1016/j.senol.2025.100701

Guillermo Lillo-Albert , Ernesto Muñoz-Sornosa , Marcos Adrianzén-Vargas , Vicente López-Flor , Elvira Buch-Villa

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Radioterapia adyuvante en el cáncer de mama: análisis comparativo de la toxicidad de 2 esquemas de hipofraccionamiento 辅助放射治疗乳腺癌：2种低分馏方案的毒性比较分析

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-05-09 DOI: 10.1016/j.senol.2025.100697

Laura Vaya González, Clara Iglesias Melero, María Soledad Quesada Muñoz, María Domínguez Rodríguez, José Manuel Rico Pérez, Nuria Azahara Linares Mesa

{"title":"Radioterapia adyuvante en el cáncer de mama: análisis comparativo de la toxicidad de 2 esquemas de hipofraccionamiento","authors":"Laura Vaya González, Clara Iglesias Melero, María Soledad Quesada Muñoz, María Domínguez Rodríguez, José Manuel Rico Pérez, Nuria Azahara Linares Mesa","doi":"10.1016/j.senol.2025.100697","DOIUrl":"10.1016/j.senol.2025.100697","url":null,"abstract":"<div><h3>Objective</h3><div>Adjuvant radiotherapy (RT) for breast cancer has been given in 1.8–2 Gy daily fractions for decades. Protracted schemes have proven as effective and safe as conventional. Schemes involving 5 fractions once a week are as safe as those involving one daily fraction for three weeks. We compared acute and late toxicity of two hypofractionated regimes.</div></div><div><h3>Material and methods</h3><div>Retrospective single-center observational study involving 100 unselected patients, treated with adjuvant radiotherapy for breast cancer with either 40 Gy/15 fr/3 weeks or 28,5 Gy/5 fr/5 weeks (1:1 ratio). Statistical tests used: Mann–Whitney U and Chi-square (χ<sup>2</sup>). Toxicity (assessed by physicians/nurses using RTOG/CTCAE Score at end of treatment, one month and six months later) was retrieved from patients notes.</div></div><div><h3>Results</h3><div>Median follow-up: 16.6 months. Average age: 59 years. The comparison between the 15-session and 5-session groups revealed the following results: boost: 24% vs. 2%; lumpectomy: 62% vs. 92%; mastectomy 38% vs. 14%; lymphadenectomy 36% vs. 14%; RT to SCF + level III: 54% vs. 8%; acute skin toxicity 70% vs. 60%; acute odynophagia: 16% vs. 2%; late toxicity (induration, edema, deformity-distortion, telangiectasias, hyperpigmentation) 30% vs. 52%.</div></div><div><h3>Conclusion</h3><div>Odynophagia was more frequent in weekly treatments. Prophylactic nodal irradiation rates could be a confounding factor. A modest excess of G1 breast induration in 5 fractions schemes was detected. To summarize, both schemes are similar concerning acute and late toxicity.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100697"},"PeriodicalIF":0.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Subutilización de los colgajos perforantes en cirugía oncoplástica: análisis clínico y barreras terminológicas 肿瘤成形术中穿刺垫使用不足：临床分析和术语障碍

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-05-07 DOI: 10.1016/j.senol.2025.100698

Pablo Sciuto , Maite Campos , Daniel Gonzalez

{"title":"Subutilización de los colgajos perforantes en cirugía oncoplástica: análisis clínico y barreras terminológicas","authors":"Pablo Sciuto , Maite Campos , Daniel Gonzalez","doi":"10.1016/j.senol.2025.100698","DOIUrl":"10.1016/j.senol.2025.100698","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the safety, efficacy, and esthetic outcomes of chest wall perforator flaps in breast-conserving surgery and to analyze the terminological barriers affecting their adoption.</div></div><div><h3>Materials and methods</h3><div>A retrospective observational study was conducted on 27 patients treated between 2020 and 2024 with breast-conserving surgery and partial breast reconstruction using perforator flaps of the lateral intercostal artery (LICAP, Lateral Intercostal Artery Perforator), lateral thoracic artery (LTAP, Lateral Thoracic Artery Perforator), and medial intercostal artery (MICAP, Medial Intercostal Artery Perforator). Clinical variables, flap selection, complications, and esthetic outcomes were analyzed using the Harvard Scale. Follow-up included immediate postoperative assessment and evaluation at one year.</div></div><div><h3>Results</h3><div>A total of 85.2% of patients achieved good or excellent esthetic outcomes, with no changes in Harvard Scale scores at one year. No patient requested symmetry surgery. Eight complications were reported (29.6%), mostly minor (seromas, hematomas, partial fat necrosis), all managed conservatively. One case of flap necrosis required mastectomy. No surgical site infections or wound dehiscence were documented. The complication rate and esthetic success were comparable to international series.</div></div><div><h3>Conclusion</h3><div>Chest wall perforator flaps represent a safe and effective option in breast-conserving surgery, with low morbidity and excellent esthetic acceptance. The lack of consensus in nomenclature remains a barrier to widespread adoption. Standardization and structured training programs are essential to optimize their clinical application.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100698"},"PeriodicalIF":0.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue reaction of the hydrogel marker HydroMARK© 水凝胶标记物HydroMARK©的组织反应

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-05-05 DOI: 10.1016/j.senol.2025.100699

Francesc Tresserra, Jorge Perez-Fuentes, Carmen Ara

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Systemic cortisol correlates with poor prognosis parameters in women with breast cancer and excessive body fat 全身皮质醇与乳腺癌和体脂过多的妇女预后参数差相关

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-05-03 DOI: 10.1016/j.senol.2025.100700

Aedra Carla Bufalo Kawassaki , Carolina Coradi , Elaine Minatti , Janaina Carla da Silva , Daniel Rech , Thalita Basso Scandolara , Fernanda Tomiotto-Pelissier , Carolina Panis , Wander Rogerio Pavanelli

{"title":"Systemic cortisol correlates with poor prognosis parameters in women with breast cancer and excessive body fat","authors":"Aedra Carla Bufalo Kawassaki , Carolina Coradi , Elaine Minatti , Janaina Carla da Silva , Daniel Rech , Thalita Basso Scandolara , Fernanda Tomiotto-Pelissier , Carolina Panis , Wander Rogerio Pavanelli","doi":"10.1016/j.senol.2025.100700","DOIUrl":"10.1016/j.senol.2025.100700","url":null,"abstract":"<div><h3>Introduction</h3><div>Excessive body fat can lead to systemic hormonal deregulation associated with poor cancer prognosis. This study analyzed the relationship between systemic cortisol levels and clinicopathological parameters in breast cancer patients categorized by body mass index (BMI).</div></div><div><h3>Material and methods</h3><div>Peripheral blood samples were collected from 223 women with or without breast cancer to investigate daytime cortisol levels. Circulating cortisol was measured using an enzyme immunoassay kit and correlated with clinicopathological data. The Cancer Genome Atlas (TCGA) data were collected to visualize cortisol axis-related gene expression in breast tumors (<em>n</em> = 1215).</div></div><div><h3>Results</h3><div>No significant difference in cortisol levels was found concerning breast cancer diagnosis. However, when breast cancer patients were stratified by BMI, cortisol levels were significantly higher in obese patients compared to eutrophics. Eutrophic patients exhibited lower cortisol levels when they had Luminal A tumors compared to those with HER2-amplified tumors. Obese patients with Luminal B tumors had higher cortisol levels than those carrying Luminal A, HER2, or triple-negative tumors. Additionally, lymph node metastasis correlated with high cortisol levels and obesity, as did the presence of blood clots.</div></div><div><h3>Conclusions</h3><div>These findings suggest that obesity and systemic cortisol levels in breast cancer patients should be further explored to understand their relationship with clinicopathological parameters.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100700"},"PeriodicalIF":0.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inteligencia artificial en el diagnóstico por imagen de patología mamaria 乳腺病理成像中的人工智能

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-21 DOI: 10.1016/j.senol.2025.100684

Marina Álvarez-Benito, Esperanza Elías-Cabot, Sara Romero-Martín

引用次数: 0

Fundamentals of artificial intelligence 人工智能基础

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-08 DOI: 10.1016/j.senol.2025.100685

Rafael Guzmán Robles

引用次数: 0

Predicción de la sobrevida global y libre de recaída en pacientes con cáncer de mama triple negativo a través de agrupaciones basadas en el aprendizaje automático sobre datos clínicos 通过基于临床数据的机器学习分组预测三阴性乳腺癌患者的整体无复发生存

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-04 DOI: 10.1016/j.senol.2025.100686

Juan Pablo Alzate-Granados, Luis Fernando Niño

{"title":"Predicción de la sobrevida global y libre de recaída en pacientes con cáncer de mama triple negativo a través de agrupaciones basadas en el aprendizaje automático sobre datos clínicos","authors":"Juan Pablo Alzate-Granados, Luis Fernando Niño","doi":"10.1016/j.senol.2025.100686","DOIUrl":"10.1016/j.senol.2025.100686","url":null,"abstract":"<div><h3>Introduction</h3><div>Triple-negative breast cancer (TNBC) accounts for 15%–20% of all breast cancers and is characterised by the absence of hormone and HER2 receptors, limiting therapeutic options to cytotoxic chemotherapy. This subtype is highly aggressive, with frequent relapses and a poor prognosis. The integration of clinical and molecular data using machine learning algorithms offers an opportunity to improve the prediction of clinical outcomes and personalise the management of this disease.</div></div><div><h3>Objective</h3><div>To develop predictive models to estimate overall survival (OS) and relapse-free survival (RFS) in patients with TNBC.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted with 4,808 patients diagnosed between 2012 and 2024. Patients were grouped using the k-prototypes algorithm for mixed data. Demographic and clinical variables, biomarkers, and clinical outcomes were analysed. Multivariate analyses and Cox proportional hazards models were used to assess the association between clusters and OS and RFS outcomes.</div></div><div><h3>Results</h3><div>Four clusters of patients were identified. The highest risk group (cluster 3) had the highest mortality (42.3%; HR: 1.94; 95% CI: 1.63–2.30) and relapse (54.25%; HR: 1.68; 95% CI: 1.45–1.95), whereas cluster 0 had the best outcomes (mortality of 22.51%). Factors such as mutations in PIK3CA (HR: 1.535; <em>p</em>  =0.023) were associated with adverse outcomes.</div></div><div><h3>Discussion</h3><div>The results support the utility of cluster-based stratification to predict outcomes and guide personalised interventions in TNBC.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 4","pages":"Article 100686"},"PeriodicalIF":0.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the prospective of gene therapy for the treatment of breast cancer 了解基因疗法治疗乳腺癌的前景

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-03 DOI: 10.1016/j.senol.2025.100683

Ritika , Sonam Rani , Rishabha Malviya , Shivam Rajput , Sathvik Belagodu Sridhar , Dinesh Kaushik

引用次数: 0

Optimal timing of sentinel node detection using [99mTc]Tc-phytate lymphoscintigraphy: A study of 100 breast cancer patients [99mTc] tc -植酸盐淋巴显像检测前哨淋巴结的最佳时机：100例乳腺癌患者的研究

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Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 DOI: 10.1016/j.senol.2025.100682

Masoud Moslehi , Mohammadreza Elhaie , Koozari Abolfazl , Iraj Abedi

{"title":"Optimal timing of sentinel node detection using [99mTc]Tc-phytate lymphoscintigraphy: A study of 100 breast cancer patients","authors":"Masoud Moslehi , Mohammadreza Elhaie , Koozari Abolfazl , Iraj Abedi","doi":"10.1016/j.senol.2025.100682","DOIUrl":"10.1016/j.senol.2025.100682","url":null,"abstract":"<div><h3>Introduction</h3><div>Sentinel lymph node biopsy guided by preoperative lymphoscintigraphy is an established technique for axillary staging in breast cancer. However, the optimal timing for lymphoscintigraphic imaging remains unclear. Earlier acquisition may expedite surgery while later imaging improves detection rates by allowing radiotracer transit. Defining the timeframe maximizing accuracy and minimizing burden is needed.</div></div><div><h3>Objective</h3><div>To evaluate optimal acquisition timings for [99mTc]Tc-Phytate lymphoscintigraphy in sentinel lymph node mapping for breast cancer.</div></div><div><h3>Methods</h3><div>Hundred breast cancer patients underwent periareolar injection of 1–2 mCi [99mTc]Tc-Phytate and lymphoscintigraphy at 5,10, 30, 60 and 120 min post-injection. Lymph node visualization was assessed by experienced nuclear medicine physicians based on retrospective review of scintigraphy images. Descriptive statistics characterized patient demographics and time to sentinel lymph node detection. Correlation analyses evaluated relationships between visualization parameters and factors such as age, sex and surgical history.</div></div><div><h3>Results</h3><div>Lymph nodes were typically visible within 10 min (median). Regression found no significant predictors of prolonged transit time among age, sex, surgical history. Age is not a statistically significant predictor of node visualization (<em>p</em> = 0.129). Also sex and surgery history are not significant predictors of longer time (<em>p</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Sentinel lymph node biopsy guided by lymphoscintigraphy is an important technique for axillary staging in breast cancer. Standardizing acquisition timing could optimize the accuracy and efficiency of lymphoscintigraphy for axillary staging.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 3","pages":"Article 100682"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0