Efecto de la cirugía bariátrica en el riesgo de cáncer de mama. Evaluación de la calidad de los metaanálisis

Abstract

Introduction

Obesity is considered a risk factor for breast cancer in postmenopausal women. Some meta-analyses report the reversal of this risk with bariatric surgery. However, the methodological quality of these studies is unknown. To evaluate systematic reviews that include non-randomized studies, the AMSTAR 2 tool is used.

Objective

To evaluate the quality of meta-analyses examining the effects of bariatric surgery on breast cancer risk.

Materials and methods

A systematic review of meta-analysis studies was performed using the search terms “Obesity surgical procedures and Breast Neoplasms” in the PubMed, Embase, Scopus and Cochrane Database of Systematic Reviews databases. The finally selected meta-analyses were scored with the AMSTAR 2 assessment tool.

Results

The database searches found 87 articles, of which, after selection and complete reading of the articles, six were finally extracted for qualitative analysis. Meta-analyses reviewed using the AMSTAR 2 assessment tool found that overall confidence in the results was critically low.

Conclusions

Meta-analyses showed an association between bariatric surgery and a lower risk of developing breast cancer. However, all of them have important limitations. Evaluation using the AMSTAR-2 assessment tool showed that overall confidence in the results of the studies evaluated was critically low.