Revista de Senologia y Patologia Mamaria最新文献

{"title":"Hamartoma gigante de mama: reporte de caso","authors":"Guillermo Peralta-Castillo,&nbsp;Juan José Delgado-Reynoso,&nbsp;Ana Cecilia Santiago-Prieto","doi":"10.1016/j.senol.2024.100601","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100601","url":null,"abstract":"<div><p>Breast hamartoma is a rare and benign tumor, made up of different breast tissues. It represents no more than 4.8% of breast tumors and it rarely reaches a significant size to be categorized as a Giant Hamartoma. We present a case of a 31-year-old woman, who presented an asymmetrical breast growth. At physical examination with left macromastia, tumor of 20 x 10 cm. Resection and reconstruction with Wise pattern is performed in the breast without complications. As far as we know, it is one of the largest reported cases in the literature.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100601"},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abordaje fisioterapéutico de la mastitis y el dolor mamario durante la lactancia materna","authors":"Izaskun Montori Rodrigo ,&nbsp;Ana María Insausti Serrano ,&nbsp;Paula Camelia Trandafir","doi":"10.1016/j.senol.2024.100602","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100602","url":null,"abstract":"<div><h3>Objectives</h3><p>Mastitis and breast pain are common issues that affect the breastfeeding experience of many women. In this study, the physiotherapeutic approach undertaken in the baby, promoting proper breast drainage for managing mastitis and breast pain during lactation, is described.</p></div><div><h3>Materials and methods</h3><p>A pilot study was conducted with a sample of breastfeeding women who presented mastitis and breast pain. An assessment and treatment were carried out through physiotherapy in the baby at the musculoskeletal level of the cervical, cranial, oral, and temporomandibular joint regions. Specific physiotherapeutic techniques were applied to the baby to improve breastfeeding biomechanics and thereby promote proper milk drainage.</p></div><div><h3>Results</h3><p>Improvements in mastitis symptoms and breast pain were observed after physiotherapeutic intervention. Out of the total sample (30 cases), 17 (56.7%) reported pain during breastfeeding at the time of assessment. Additionally, in these cases of pain, mastitis was present in 35.3%. After physiotherapy treatment, these symptoms disappeared in the mother, being significant with a p-value &lt;<!--> <!-->0.001.</p></div><div><h3>Discussion</h3><p>This study examines how physiotherapy, by improving biomechanics and baby function during breastfeeding, can facilitate proper breast drainage and effectively help resolve mastitis and breast pain. Further studies are needed to evaluate the resolution time of mastitis with physiotherapeutic therapy combined with other treatments.</p></div><div><h3>Conclusions</h3><p>The results of this study could support the integration of physiotherapy into the multidisciplinary approach to breastfeeding women's care, in managing mastitis and breast pain during lactation, thus improving their breastfeeding experience and overall well-being.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100602"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor phyllodes en tejido ectópico de la glándula mamaria: caso reporte y revisión de la literatura","authors":"Marcelo Chávez Díaz ,&nbsp;Daniel Enrique Castro Vela ,&nbsp;María del Rosario Cueva Pérez","doi":"10.1016/j.senol.2024.100599","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100599","url":null,"abstract":"<div><p>Ectopic tissue of the mammary gland presents as an embryological alteration, in the involution of the mammary line, with an incidence of 0.2-6% in the population. Axillary polymastia is the most common form of presentation (71%) and can be affected by diseases of the breast tissue: benign and malignant diseases. Phyllodes tumors are unusual fibroepithelial tumors in the mammary gland (1% of neoplasms). Their presentation in ectopic tissue is extremely rare, with only 10 cases having been reported in the literature. We present the case of a patient with unilateral axillary polymastia, in which a borderline phyllodes tumor was developed, showing the process of diagnosis, treatment and follow-up, as well as the review of the literature.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100599"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in systemic oxidative stress correlate to chemoresistance and poor prognosis features in women with breast cancer","authors":"Fernanda Mara Alves ,&nbsp;Hellen dos Santos Jaques ,&nbsp;Julia Fernandes Gois Orrutéa ,&nbsp;Ana Gabriela de Oliveira Silva ,&nbsp;Murilo Galvani Machado ,&nbsp;Lucca L. Smaniotto ,&nbsp;Ana Carolina Lopes Federige ,&nbsp;Matheus Iago Oliveira Colleto ,&nbsp;Janoario Athanazio Oliveira de Souza ,&nbsp;Daniel Rech ,&nbsp;Janaína Carla da Silva ,&nbsp;Carolina Panis","doi":"10.1016/j.senol.2024.100598","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100598","url":null,"abstract":"<div><h3>Objectives</h3><p>Breast cancer is a malignant neoplasm that affects women worldwide, and cytotoxic chemotherapy remains a primary treatment modality. In breast cancer, many women experience therapeutic failure and unfavorable clinical outcomes due to mechanisms related to chemoresistance acquisition, which may include oxidative stress. In this study, we investigated the systemic oxidative stress profile of women diagnosed with chemoresistant breast cancer and evaluated the correlation of this profile with clinicopathological features.</p></div><div><h3>Methods</h3><p>The oxidative stress levels were determined based on lipid peroxidation and nitric oxide metabolite (NOx) measurements. Chemoresistance was determined based on the Response Evaluation Criteria in Solid Tumors guidelines, and patients were categorized as responsive (complete response) or chemoresistant (partial or no response).</p></div><div><h3>Results</h3><p>Reduced lipid peroxide levels were observed independent of the pattern of chemotherapy response, without NOx variation. The type of drug schedule did not interfere with oxidative stress levels in the responsive patients. However, lipid peroxide levels were reduced in patients in the chemoresistant group receiving the combination of adryamicin<!--> <!-->+<!--> <!-->ciclofosfamide<!--> <!-->+<!--> <!-->Taxol. Additionally, lipid peroxidation strongly correlated with high histological grade and obesity in chemoresistant patients, while NOx correlated with disease stage, risk of death and recurrence, and menopausal status.</p></div><div><h3>Conclusion</h3><p>These findings highlight lipid peroxidation and NOx concentrations as putative markers of chemotherapy response in human breast cancer patients.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100598"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140901552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma de células altas con polaridad invertida","authors":"Laia Bernet ,&nbsp;Carlos Prada Puentes ,&nbsp;Magda Palka","doi":"10.1016/j.senol.2024.100597","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100597","url":null,"abstract":"<div><p>Tall cell carcinoma with reversed polarity is a type of breast carcinoma recognized as an independent entity for the first time in the WHO 2018 classification. It is a rare entity, not yet fully characterized in terms of its clinical behavior and evolution.</p><p>Its differential diagnosis includes papillary thyroid carcinoma as well as other types of papillary carcinomas of the breast.</p><p>We review the literature and present a case with three years of follow-up and with special attention to its clinical, morphologic, immunohistochemical, genetic and follow-up features. We discuss the main differential diagnoses of the entity and review the literature.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100597"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cáncer de mama triple negativo, receptor de andrógeno y otros marcadores. Estrategias terapéuticas","authors":"Marta Eguía-Larrea ,&nbsp;Carmen Parra-Pérez ,&nbsp;Teresa Cabero-Morán ,&nbsp;Raquel Jiménez Rosellón ,&nbsp;Luis Muñoz-Bellvís","doi":"10.1016/j.senol.2024.100595","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100595","url":null,"abstract":"<div><h3>Introduction</h3><p>Triple Negative Breast Cancer (TNBC) has dreadful prognosis. Surgery, radiotherapy and chemotherapy are the only effective therapies, since it has no target treatments. In TNBC, AR modulation has been demonstrated to inhibit cell development and increase apoptosis in vitro and in vivo.</p></div><div><h3>Objective</h3><p>To assess whether AR in TNBC is associated with a better prognosis.</p></div><div><h3>Material and methods</h3><p>This study is a retrospective description of a cohort of 163 TNBC patients, who underwent treatment from 2003 to 2017. Immunohistochemical determinations were examined in the surgical specimen for AR, E-cadherina and GATA3.</p></div><div><h3>Results</h3><p>AR positive TNBC are more differentiated and less proliferative tumors than AR negative (p &lt; 0.05). However, this fact has not been significantly associated with better overall survival nor disease free survival. Loss of expression of GATA3 and E-cadherina has not been related to worse overall survival in our paper.</p></div><div><h3>Conclusions</h3><p>Although no difference in TNBC survival related to AR expression has been observed, determination of AR may be useful in TNBC due to possibility of modulating AR as a target therapy. Future treatment options in TNBC may be the combined use of selective androgen receptor and other drugs such as Pi3K inhibitors or immunomodulators, due to the frequent pi3K mutations of AR positive TNBC and the usefulness of immunotherapy in TNBC.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100595"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of do-not-do practice recommendations in metastatic breast cancer in Spain","authors":"Iranzo González-Cruz Vega ,&nbsp;Mª. Ángeles García Rescalvo ,&nbsp;Fernando Moreno ,&nbsp;Pura Ballester ,&nbsp;Antonia Martínez Guisado ,&nbsp;Christian Sisó ,&nbsp;Alejandra Peña ,&nbsp;José Joaquín Mira ,&nbsp;DNDs Metastatic Breast Cancer Group","doi":"10.1016/j.senol.2024.100593","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100593","url":null,"abstract":"<div><h3>Introduction</h3><p>34 722 incident cases of breast cancer were diagnosed in Spain in 2022. At the time of initial diagnosis, 5%–6% already presented metastasis. In 2007, The National Institute for Health and Care Excellence published a set of recommendations about low-value practices commonly known as “do-not-do” (DND), which lead to initiatives to decrease the overuse of health resources. The aim of our study was to collect, based on an expert consensus, DND recommendations for metastatic breast cancer and assess frequency of adherence in the real world.</p></div><div><h3>Methods</h3><p>Mixed analysis based on a literature review that combined a qualitative analysis (a panel of 10 experts reached an agreement on a list of criteria by consensus building) and a quantitative analysis (observational retrospective study assessing codified clinical information from electronic health records [EHRs] about the DND recommendations in 4 Spanish university hospitals).</p></div><div><h3>Results</h3><p>Consensus was reached on 12 recommendations based on the review of 826 EHR from the participating hospitals. The review revealed a 1.3%–28.1% range for improvement in the adherence to the recommendations. The DND recommendation with the higher non-adherence rate was do not start the locoregional metastatic treatment of the primary tumor, except in those with stable systemic disease.</p></div><div><h3>Conclusions</h3><p>DND recommendations for metastatic breast cancer provide an opportunity to reduce costs and unnecessary procedures, increasing patient safety and the sustainability of the healthcare system.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordancia entre ganglio centinela y ganglio marcado en la disección axilar dirigida. Revisión sistemática de la literatura","authors":"Faustino Bastidas ,&nbsp;Vanesa Ziade ,&nbsp;Lilian Torregrosa ,&nbsp;Nathalie Tamayo Martinez","doi":"10.1016/j.senol.2024.100590","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100590","url":null,"abstract":"<div><p>Patients with breast cancer and nodal involvement are routinely referred for axillary emptying. In cases where positive nodes are negative after chemotherapy, patients may be selected for targeted axillary dissection. This technique consists of marking the positive node and then administering neoadjuvant systemic management. If a complete clinical and imaging response is achieved, patients are taken to resection of the marked node and sentinel nodes. This procedure allows good locoregional control of the disease, avoids futile axillary emptying and reduces the percentage of post-surgical complications such as lymphedema. The objective of our review was to describe the agreement between the sentinel node and the clipped node; for this we followed the PRISMA guide and performed a literature search in Pubmed, Embase, LILACS and WoS databases. We found that the agreement between the sentinel node and the clipped node is 70.9%. Performing Targeted Axillary Dissection, even in patients where the clipped node is not found after neoadjuvant treatment, as well as in centers where axillary node marking is not available, is a feasible option taking into account the high concordance between the clipped node and the sentinel nodes. The procedure under these circumstances reduces surgical morbidity of axillary emptying while maintaining oncologic safety.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrategias de pesquisa en mujeres de alto riesgo para cáncer de mama: revisión de la literatura","authors":"Caren González Rojas ,&nbsp;Ana Karina Gordillo Ledesma ,&nbsp;Víctor Arturo Acosta Marín","doi":"10.1016/j.senol.2024.100594","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100594","url":null,"abstract":"<div><h3>Introduction</h3><p>Breast cancer is the most common cancer diagnosed in the female population in the world, but not all women have the same absolute lifetime risk of developing it, there being a group called “high risk” with a risk equal to or greater than 20%, in whom the disease begins at an earlier age and tends to be more aggressive.</p></div><div><h3>Materials and methods</h3><p>A review of the literature was carried out in Google Scholar and PubMed databases using keywords such as “breast cancer”, “high risk”, “breast cancer induced by radiotherapy”, “screening”, “protocols”, and “images”. Finally, 53 articles were analyzed, after applying the inclusion and exclusion criteria.</p></div><div><h3>Results</h3><p>All women should undergo a risk assessment starting at 25 years of age. In the high-risk group, the screening strategy should be early, multimodal and annual. Ample evidence in the literature that MRI is the most sensitive imaging method for the diagnostic of breast cancer.</p></div><div><h3>Conclusion</h3><p>Breast MRI will be the method of choice along with mammography to perform annual screening in this risk group. The heterogeneity of the subgroups within this high-risk group and the advent of AI improving the precision of diagnostic methods raises the need to personalize screening strategies.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 3","pages":"Article 100594"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cáncer de mama: valor pronóstico del estado «TN» versus perfil de expresión génica tumoral","authors":"Juan Antonio Mieza Arana ,&nbsp;Ignacio Zabalza Estévez ,&nbsp;José Antonio López Ruiz ,&nbsp;María del Mar Vivanco Ruiz ,&nbsp;Andoni López Maseda","doi":"10.1016/j.senol.2024.100592","DOIUrl":"https://doi.org/10.1016/j.senol.2024.100592","url":null,"abstract":"<div><h3>Objectives</h3><p>To analyze the prognostic value of the “TNM” system, and specifically the “TN” status, compared to the tumor gene expression profile, when evaluating the risk of metastatic disease.</p></div><div><h3>Materials and methods</h3><p>Retrospective review of 224 cases of infiltrating breast cancer. Genomic risk was established using the 70-gene gene expression platform (MammaPrint®). The result obtained with the genomic risk assessment has been considered “gold standard”.</p></div><div><h3>Results</h3><p>126 cases (56.25%) showed a “low” risk genomic profile and 98 cases (43.75%) showed a “high” risk. Among those with low genomic risk, 26.19% of tumors classified “T2”, “T3” and “T4” were observed. On the contrary, among those with “high” risk, 67.35% of tumors classified as “T1” were observed. Regarding the “N” status, among the “low” risk tumors, 26.98% of cases classified as “N1”, “N2” and “N3” were observed. On the other hand, among those with “high” genomic risk, 77.14% of cases classified as “N0” were observed. Among a total of 131 “T1N0” tumors, 57 (43.51%) showed “high” genomic risk. No significant differences have been observed in terms of risk assessment of metastatic disease (high vs. low) between the various “TN” categories studied.</p></div><div><h3>Conclusions</h3><p>The evaluation of the risk of metastatic disease using the “TN” system is not accurate. The detection of early tumors does not necessarily mean a good prognosis. On the contrary, the detection of “T2” or “N1” tumors does not imply a poor prognosis in all cases.</p></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"37 2","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140534891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}