Revista de Senologia y Patologia Mamaria最新文献_第8页

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.senol.2024.100655

Xavier Bargalló , Lledó Cabedo , Esther Sanfeliu , Sergi Ganau , Belén Úbeda , Carla Sitges , Dominika Gasior , Isaac Cebrecos , Eduard Mensión

{"title":"Adenomioepitelioma de la mama","authors":"Xavier Bargalló , Lledó Cabedo , Esther Sanfeliu , Sergi Ganau , Belén Úbeda , Carla Sitges , Dominika Gasior , Isaac Cebrecos , Eduard Mensión","doi":"10.1016/j.senol.2024.100655","DOIUrl":"10.1016/j.senol.2024.100655","url":null,"abstract":"<div><h3>Objectives</h3><div>To perform a descriptive analysis of the clinical information and radiological findings, emphasizing those provided by magnetic resonance imaging of a single-center series of cases of adenomyoepithelioma of the breast.</div></div><div><h3>Material and methods</h3><div>Our series consists of 11 patients, most of them were diagnosed by ultrasound-guided core needle biopsy. In three cases, the initial diagnosis was papilloma, and adenomyoepithelioma was diagnosed by surgical excision or vacuum aspiration biopsy. In five cases, breast magnetic resonance was performed.</div></div><div><h3>Results</h3><div>Most of our cases were diagnosed by mammography from the population-based breast cancer screening program, with a mass or focal asymmetry being the most frequent presentations. Ultrasound show oval and well-defined mass with a tendency to form angles. The two malignant cases showed prominent vessels in the Doppler study. On magnetic resonance imaging, they are predominantly hyperintense on T2 without restriction in diffusion and with intense gadolinium uptake. Three cases (two malignant and one atypical) relapsed.</div></div><div><h3>Conclusion</h3><div>Small adenomyoepitheliomas may mimic fibroadenomas, although they show a certain tendency to show angled edges. Core needle biopsy is usually diagnostic, although it is sometimes difficult to differentiate adenomyoepithelioma from papilloma.</div><div>Magnetic resonance imaging does not help to suspect malignancy since most cases do not show restriction in diffusion. In our series, the presence of vessels in the Doppler study has shown some relation to atypical or malignant adenomyoepithelioma. Wide surgical removal is warranted in atypical or malignant cases.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100655"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triose phosphate isomerase 1 in serum of women with breast cancer 乳腺癌妇女血清中的磷酸三糖异构酶 1

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-11-22 DOI: 10.1016/j.senol.2024.100647

Obaida Adnan Jwameer , Ekhlas Abdallah Hassan , Faiz M. Al-Abady

{"title":"Triose phosphate isomerase 1 in serum of women with breast cancer","authors":"Obaida Adnan Jwameer , Ekhlas Abdallah Hassan , Faiz M. Al-Abady","doi":"10.1016/j.senol.2024.100647","DOIUrl":"10.1016/j.senol.2024.100647","url":null,"abstract":"<div><h3>Introduction</h3><div>Triosephosphate isomerase 1 (TPI1) plays a role in various biological processes, specifically in the development of the metastatic phenotype, and is recognized as a significant enzyme in the glucose metabolism pathway. TPI1 has been proposed as a potential oncogene, with several types of cancer including breast cancer (BC).</div></div><div><h3>Material</h3><div>This research aims to assess activity of TPI1 in serum samples obtained from female subjects with BC. The levels of TPI1 were evaluated in the serum samples of four different BC groups, with 54 women included as the control group.</div></div><div><h3>Results</h3><div>Based on the findings, the average TPI levels were (41.01 ± 7.92) and (11.91 ± 2.68) in BC patients and healthy controls, respectively. The mean level higher in BC patients compared to healthy controls (<em>P</em>  <.0001) compared to groups I, II, and III. Analysis of both univariate and multivariate models indicated that age (odds ratio [OR] = 1.12, 95% confidence interval [CI] = 0.76–8.12, <em>P</em>  =.001) were identified as independent predictors for the presence of malignancy. Furthermore, receiver operating characteristic analysis demonstrated a high diagnostic accuracy for TPI concentrations, with an area under the curve value of 0.999.</div></div><div><h3>Conclusion</h3><div>The levels of serum TPI1 have been observed to increase in patients diagnosed with BC. There is a correlation between the concentration of TPI1 and the presence of breast malignancy.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100647"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological lesions of risk for breast carcinoma. An updated survival guide 乳腺癌风险组织学病变。最新生存指南

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-10-28 DOI: 10.1016/j.senol.2024.100636

Vicente Marco Molina, Felip García Hernández

{"title":"Histological lesions of risk for breast carcinoma. An updated survival guide","authors":"Vicente Marco Molina, Felip García Hernández","doi":"10.1016/j.senol.2024.100636","DOIUrl":"10.1016/j.senol.2024.100636","url":null,"abstract":"<div><div>Histological lesions of risk of breast cancer are proliferative epithelial lesions associated with a higher incidence of breast cancer. The magnitude of the risk is related to the presence of epithelial atypia. Lesions with atypical hyperplasia have a relative risk of cancer 4 times higher than the control population. Proliferative epithelial lesions present diverse histological characteristics and must be appropriately classified. They include usual ductal hyperplasia, radial scar and complex sclerosing lesions, sclerosing adenosis, apocrine adenosis, microglandular adenosis, papillary lesions, atypical ductal hyperplasia, flat epithelial atypia, lobular neoplasia. They propose the differential diagnosis with ductal carcinoma in situ and invasive carcinoma. When risk lesions type B3 are diagnosed in needle-core and vacuum-assisted biopsies, the underestimation rates for invasive carcinoma should be below 5% and below 10% for ductal carcinoma in situ. In this review, we describe the clinical and histological aspects of the different entities and discuss the possible management options depending on the diagnostic category and the lesion size. Correct management requires close collaboration between surgeons, radiologists, and pathologists.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100636"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlación entre la carga tumoral total de los ganglios linfáticos analizada mediante One Step Nucleic Acid Amplification (OSNA) y la decisión de realizar una linfadenectomía axilar en el cáncer de mama temprano 采用一步核酸扩增法（OSNA）检测的淋巴结总肿瘤负担与早期乳腺癌中进行腋下淋巴结切除术的决定之间的相关性

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1016/j.senol.2025.100667

Paula Chamocho Lloro , María Dolores Rodríguez Garnica , Beatriz Sánchez Jimenez , Sergio Rodriguez Lobalzo , Angel Calvo Tudela , Alejandro J. Rohde Calleja , Francisco Rivas Ruiz , José C. Maañón di Leo

{"title":"Correlación entre la carga tumoral total de los ganglios linfáticos analizada mediante One Step Nucleic Acid Amplification (OSNA) y la decisión de realizar una linfadenectomía axilar en el cáncer de mama temprano","authors":"Paula Chamocho Lloro , María Dolores Rodríguez Garnica , Beatriz Sánchez Jimenez , Sergio Rodriguez Lobalzo , Angel Calvo Tudela , Alejandro J. Rohde Calleja , Francisco Rivas Ruiz , José C. Maañón di Leo","doi":"10.1016/j.senol.2025.100667","DOIUrl":"10.1016/j.senol.2025.100667","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to determine the correlation between total lymph load (TLL) analyzed by one step nucleic acid amplification (OSNA) and the results obtained in our clinical practice, and whether TTL is a useful tool for selecting patients who should undergo axillary lymph node dissection.</div></div><div><h3>Material and methods</h3><div>The study has a retrospective cohort design, conducted at the Hospital Costa de Sol on 92 patients with (GC+) analyzed by OSNA, between 2012 and 2017.</div></div><div><h3>Results</h3><div>Disease-free survival was analyzed classifying patients into micro-metastatic, macro-metastatic with less than 25,000 copies of mRNA-CK19/ul, and macro-metastatic with more than 25,000 copies of mRNA-CK19/ul, with no statistical significance found between groups (log-rank test 0.266266).</div></div><div><h3>Discussion</h3><div>The recommendation of axillary lymph node dissection (ALND) in conservatively operated patients with clinically (or radiologically) negative axilla and high tumor load as determined by OSNA is not related to local disease control.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100667"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143341654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ética y filosofía de la inteligencia artificial aplicada a la enfermedad mamaria 人工智能应用于乳腺疾病的伦理和哲学

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2024-12-31 DOI: 10.1016/j.senol.2024.100656

David Casacuberta

引用次数: 0

¿Es posible realizar la biopsia selectiva de ganglio centinela (BSGC) en una paciente con mastectomía preservadora de piel y pezón? Descripción de un caso 是否有可能对进行皮肤和乳头保守性乳房切除术的患者进行选择性前哨神经节活检（BSGC）？案例描述

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-04-01 Epub Date: 2025-01-30 DOI: 10.1016/j.senol.2025.100665

Miriam Alcaide Lucena , Carlos José Rodríguez González , Rafael Nieto Serrano , Jesús García Rubio , Benito Mirón Pozo

{"title":"¿Es posible realizar la biopsia selectiva de ganglio centinela (BSGC) en una paciente con mastectomía preservadora de piel y pezón? Descripción de un caso","authors":"Miriam Alcaide Lucena , Carlos José Rodríguez González , Rafael Nieto Serrano , Jesús García Rubio , Benito Mirón Pozo","doi":"10.1016/j.senol.2025.100665","DOIUrl":"10.1016/j.senol.2025.100665","url":null,"abstract":"<div><div>BRCA mutation carriers have an increased risk of breast cancer. Among the risk-reducing measures is prophylactic bilateral mastectomy. In less than 1%  of BRCA patients undergoing this surgery, previously undetected breast cancer is found. Routine sentinel lymph node biopsy has not shown benefit because few patients have occult cancer, and it is a technique that also involves morbidity. If a carcinoma is found in the specimen, axillary staging should be done in a second procedure, which has traditionally been performed with lymphadenectomy due to the absence of breast tissue and the belief that sentinel lymph node biopsy (SLNB) is not feasible. We present the case of a patient diagnosed with an infiltrating tumor in the left mastectomy specimen, and successful SLNB performed in a second procedure. Four nodes were sent for intraoperative analysis with negative results. Axillary lymphadenectomy was avoided, achieving proper axillary staging. It is technically feasible to perform SLNB after a skin- and nipple-sparing mastectomy, avoiding systematic axillary lymphadenectomy for staging in these patients, thus avoiding the morbidity associated with this technique.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 2","pages":"Article 100665"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descripción de un caso: Gigantomastia gestacional tras un tratamiento de hiperplasia virginal mamaria previo 病例报告：曾接受过处女膜乳腺增生治疗的妊娠巨乳症。

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1016/j.senol.2024.100648

Ana Tello Delsors , Ana Gómez Alarcón , Rosa Angélica Barbella Aponte

引用次数: 0

Mechanisms of action for FDA-approved drugs targeting breast cancer FDA 批准的乳腺癌靶向药物的作用机制

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1016/j.senol.2024.100632

Francis Dhilna , R.N. Binitha , Nissar Riswina , Sebatain Divya , Joseph Rima , P.A. Janish , Balachandran Subin

{"title":"Mechanisms of action for FDA-approved drugs targeting breast cancer","authors":"Francis Dhilna , R.N. Binitha , Nissar Riswina , Sebatain Divya , Joseph Rima , P.A. Janish , Balachandran Subin","doi":"10.1016/j.senol.2024.100632","DOIUrl":"10.1016/j.senol.2024.100632","url":null,"abstract":"<div><div>Breast cancer treatment encompasses a diverse range of therapeutic strategies targeting specific molecular pathways crucial for tumor growth and progression. Several exciting advancements are likely to shape the future of breast cancer treatment. Understanding the mechanisms by which FDA-approved drugs exert their effects is crucial for optimizing treatment strategies and improving patient outcomes. In this review, we aim to categorize FDA-approved drugs for breast cancer treatment based on their distinct modes of action or mechanisms These mechanisms cover several activities, such as blocking particular enzymes that are essential for the synthesis of hormones, interfering with cellular functions that are necessary for the growth and spread of tumors, altering signaling pathways that are critical for the survival of cancer cells, and taking advantage of weaknesses in DNA repair mechanisms that are specific to them. In order to effectively battle this heterogeneous disease, a customized and all-encompassing therapeutic approach is required. This multifaceted approach highlights the crucial role of therapeutic approaches and synergistic treatment modalities in maximizing efficacy and improving prognosis for individuals with breast cancer.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 1","pages":"Article 100632"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anomalías vasculares de la mama 乳房血管异常

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/j.senol.2024.100638

Pedro Marín-Rodríguez , Florentina Guzmán-Aroca , María Eulalia García-Solano , Caridad Marín-Hernández , Pedro Galindo-Fernández , Antonio Piñero-Madrona

引用次数: 0

Técnicas de reconstrucción mamaria con colgajos de perforantes: nuestra experiencia y comparación con otras técnicas quirúrgicas 穿孔器皮瓣乳房重建技术：我们的经验以及与其他手术技术的比较

IF 0.3

Revista de Senologia y Patologia Mamaria Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI: 10.1016/j.senol.2024.100628

María del Rosario Martín-Merino Acera, Esther Colmenarejo García, Carla Ferrero San Román, Adela Valdazo Gómez, Iris Sánchez Egido, Lucía Latorre Marlasca, Gloria Paseiro Crespo

{"title":"Técnicas de reconstrucción mamaria con colgajos de perforantes: nuestra experiencia y comparación con otras técnicas quirúrgicas","authors":"María del Rosario Martín-Merino Acera, Esther Colmenarejo García, Carla Ferrero San Román, Adela Valdazo Gómez, Iris Sánchez Egido, Lucía Latorre Marlasca, Gloria Paseiro Crespo","doi":"10.1016/j.senol.2024.100628","DOIUrl":"10.1016/j.senol.2024.100628","url":null,"abstract":"<div><h3>Introduction</h3><div>Chest wall perforator flaps (CWPF) have started to be used in the last decade in conservative breast cancer surgery in patients who require relatively large volume of excision (20%).</div></div><div><h3>Methods</h3><div>We present a series of 30 cases who have undergone breast conservation surgery plus CWPF reconstruction in our surgery department between 2020 and 2024. A total of 86.6% were diagnosed with breast cancer, 6.6% were diagnosed with a benign pathology, or needed correction of aesthetic defects following radiotherapy (6.6%).</div><div>This retrospective observational study examines data on flap characteristics, need for re-excision to ensure clear margins after a lumpectomy and surgical complications. These data have been compared with those obtained using other breast reconstruction techniques without CWPF.</div></div><div><h3>Results</h3><div>Immediate post-operative complications occurred in 13.3% of patients, the re-excision rate was 15.3% and no recurrences were detected during the follow-up period. These percentages are similar to those described in previous literature and to other types of surgery that do not use CWPF.</div></div><div><h3>Conclusions</h3><div>Although CWPF breast reconstruction techniques are not yet widely accepted in Spain, we consider that they can be very useful in selected patients to avoid mastectomies and their associated complications, as well as improving breast remodelling before or after radiotherapy.</div></div>","PeriodicalId":38058,"journal":{"name":"Revista de Senologia y Patologia Mamaria","volume":"38 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0