IJC Heart and Vasculature最新文献

{"title":"Diagnostic performance and risk assessment of combined copeptin and high-sensitivity cardiac troponin I in Chinese emergency department","authors":"Juan Sun ,&nbsp;Xingtong Chen ,&nbsp;Yitong Huang ,&nbsp;Yongcai Tang ,&nbsp;Yan Du ,&nbsp;Xiaofan Gu ,&nbsp;Jun Liao","doi":"10.1016/j.ijcha.2025.101793","DOIUrl":"10.1016/j.ijcha.2025.101793","url":null,"abstract":"<div><h3>Background</h3><div>Rapid and early identification of acute myocardial infarction (AMI) is crucial for initiating timely treatment and assessing post-discharge risks. Copeptin’s unique release profile may help detect early myocardial damage, particularly when high-sensitivity cardiac troponin I (hs-cTnI) is undetectable. However, there is a limited understanding of copeptin’s application in the Chinese population, highlighting the need for further research.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted, enrolling 414 consecutive patients presenting to the emergency department (ED) within 6 h of chest pain onset. Baseline clinical characteristics were recorded, and copeptin and hs-cTnI levels were measured from the initial blood draw. Patients were followed for 180 days to determine the occurrence of major adverse cardiovascular events (MACE). The final diagnosis was independently adjudicated by a panel of cardiologists blinded to copeptin results.</div></div><div><h3>Results</h3><div>Of 414 Chinese patients, 112 (27.05 %) had AMI. In hs-cTnI-undetectable patients, median copeptin was 290 pmol/L (IQR: 211–547) in STEMI and 130 pmol/L (IQR: 47.8–184) in NSTEMI. DBRS (copeptin/hs-cTnI dual-negative biomarker rule-out strategy) had higher AUC than single biomarkers (<em>P</em> &lt; 0.05), with 100 % NPV (95 % CI: 95.86–100) for chest pain (3/6 h). Elevated copeptin (Hazard Ratio (HR) 3.65, 95 % CI: 2.35–5.67) and hs-cTnI (HR 1.69, 95 % CI: 1.36–2.10) independently predicted 180-day MACE (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In Chinese patients, DBRS provided a safe and effective strategy for ruling out AMI. In addition, Combined negative results predicted safer 180-day post-discharge outcomes.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101793"},"PeriodicalIF":2.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between baseline right ventricular systolic function and left ventricular recovery at six-months of follow up among women with peripartum cardiomyopathy in Uganda","authors":"Juliet Nabbaale ,&nbsp;Emmy Okello ,&nbsp;Annettee Nakimuli ,&nbsp;Graham Chakafana ,&nbsp;Karen Sliwa","doi":"10.1016/j.ijcha.2025.101788","DOIUrl":"10.1016/j.ijcha.2025.101788","url":null,"abstract":"<div><h3>Background</h3><div>LV recovery in Peripartum Cardiomyopathy (PPCM) depends on several baseline factors including left ventricular ejection fraction (LVEF), LV end-diastolic diameter (LVEDD), duration of symptoms. The role baseline RV function in LV recovery remains poorly described. This study sought to determine the relationship between baseline RV systolic function and LV recovery at six-months follow up among women with PPCM in Uganda.</div></div><div><h3>Methods</h3><div>Prospective cohort study of 80 PPCM cases and 80 healthy matched controls observed over a 6-month period while on goal-directed medical therapy (GDMT). All enrolled participants had a 12-lead electrocardiography, echocardiography at baseline and at 6-months follow-up for assessment of LV systolic function using LV global longitudinal strain (LV GLS) and LV EF whereas RV systolic function was assessed using; fractional area change (FAC), tricuspid annular plane excursion (TAPSE), RV lateral wall S’ (RV S’), fractional wall strain (FWS) and RV global longitudinal strain (RV GLS).</div></div><div><h3>Results</h3><div>The mean data of cases included age of 33.6 ± 6.6 years, LVEF 35.7 ± 11.0 %, LV GLS −11.9 ± 4.7 % and RV GLS −14.7 ± 10.9 %, RV FAC 32.9 ± 13.5 %, Lat S’ 10.6 ± 3.0 cm/s and RV FWS −17.1 ± 7.2 %. LV recovery occurred among 46.3 % cases. Factors which predicted LV recovery included heart rate and LVEDD.</div></div><div><h3>Conclusion</h3><div>Under half of PPCM cases had LV recovery at six-months on GDMT and Bromocriptine. Baseline heart rate and LVEDD predicted LV recovery.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101788"},"PeriodicalIF":2.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of coronary artery calcium in a large European all-comer population referred for cardiac imaging","authors":"Julia Duelli,&nbsp;Christoph Ryffel,&nbsp;Magdalena Stuetz,&nbsp;Raffael Ghenzi,&nbsp;Marko Gajic,&nbsp;Dimitrios Moysidis,&nbsp;Dominik C. Benz,&nbsp;Aju P. Pazhenkottil,&nbsp;Andreas A. Giannopoulos,&nbsp;Philipp A. Kaufmann,&nbsp;Ronny R. Buechel","doi":"10.1016/j.ijcha.2025.101792","DOIUrl":"10.1016/j.ijcha.2025.101792","url":null,"abstract":"<div><h3>Background and aims</h3><div>The coronary artery calcium score (CACS) is a well-established surrogate marker of atherosclerotic plaque burden and is highly valuable for risk stratification. However, contemporary data on the distribution of CACS across age and sex is lacking, particularly for European countries and quantified by multi-slice CT. We assessed predictors of CACS and provide granular age- and sex-specific reference values derived from a real-world clinical population referred for cardiac imaging.</div></div><div><h3>Methods</h3><div>This single-center, retrospective study examined patients clinically referred for non-invasive cardiac imaging from May 2013 to May 2024. Patients without coronary artery disease, cardiomyopathy, cardiac surgery or intervention, renal or hepatic failure were included. Multiple linear regression was used to identify independent predictors of CACS, and predictor importance was calculated. CACS percentiles were then calculated for both sexes and stratified across nine age groups.</div></div><div><h3>Results</h3><div>The final population consisted of 18′225 individuals (39.6 % women; 60.8 % symptomatic). Age and sex were the most influential predictors of CACS, accounting for 69 % and 18 % relative predictor importance, respectively. Men exhibited a significantly higher median CACS than women (59 [IQR 1–338] vs. 10 [IQR 0–129], <em>p</em> &lt; 0.001) across all age groups.</div></div><div><h3>Conclusions</h3><div>This study provides contemporary age- and sex-based CAC score reference values, as observed in a large European real-world cohort referred for cardiac imaging. Age and sex exhibit the most relevant impact on expected CAC scores, while other conventional risk factors appear to be less important. Our results enable improved classification regarding the coronary calcium burden.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101792"},"PeriodicalIF":2.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen-to-albumin ratio as a novel biomarker for risk assessment in clinically suspected acute myocarditis","authors":"Lihi Levi-Gofman ,&nbsp;Shaul Atar ,&nbsp;Gassan Moady","doi":"10.1016/j.ijcha.2025.101791","DOIUrl":"10.1016/j.ijcha.2025.101791","url":null,"abstract":"<div><h3>Background</h3><div>Acute myocarditis typically follows a benign course, but fatal complications may occur in fulminant cases. Evaluation is based on clinical, laboratory, and imaging parameters. We aimed to assess the prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with clinically suspected myocarditis.</div></div><div><h3>Methods</h3><div>Echocardiographic, laboratory, and clinical parameters were obtained from patients with clinically suspected myocarditis. We assessed the correlations between troponin, albumin, fibrinogen, FAR, left ventricular ejection fraction (LVEF), and complications during the index hospitalization. Repeat echocardiography was performed in patients with reduced LVEF. Several potential factors were tested for their ability to predict LVEF recovery.</div></div><div><h3>Results</h3><div>A total of 118 patients were included (80 % male; median age, 35 years; mean LVEF, 55 %). Median troponin level was 2558 ng/L, and the median fibrinogen-to-albumin ratio (FAR) was 120. In 38 patients (32 %), LVEF was reduced; among them, 15 (39 %) had persistently reduced LVEF on repeat echocardiography. Troponin levels and FAR were inversely correlated with reduced LVEF (r = –0.28, p = 0.002 and r = –0.31, p = 0.001, respectively). FAR remained an independent factor after adjustment for age and sex. Neither troponin nor FAR was associated with persistently reduced LVEF on follow-up echocardiography. In addition, high FAR was not correlated with longer length of stay (LOS) (p = 0.07), readmissions (p = 0.29), or complications during hospitalization (p = 0.22).</div></div><div><h3>Conclusion</h3><div>FAR is associated with reduced LVEF and may reflect disease severity in clinically suspected myocarditis; however, it does not appear to be useful for long-term prediction.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101791"},"PeriodicalIF":2.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated balloon angioplasty for chronic total coronary occlusions. Blended strategies: the best of two worlds","authors":"Fernando Alfonso ,&nbsp;Bernardo Cortese ,&nbsp;Emmanouil S. Brilakis","doi":"10.1016/j.ijcha.2025.101789","DOIUrl":"10.1016/j.ijcha.2025.101789","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101789"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating artificial intelligence-enabled medical tests in cardiology: Best practice","authors":"Jonas L. Isaksen ,&nbsp;Malene Nørregaard ,&nbsp;Martin Manninger ,&nbsp;Dobromir Dobrev ,&nbsp;Thomas Jespersen ,&nbsp;Ben Hermans ,&nbsp;Jordi Heijman ,&nbsp;Gernot Plank ,&nbsp;Daniel Scherr ,&nbsp;Thomas Pock ,&nbsp;Vajira Thambawita ,&nbsp;Michael A. Riegler ,&nbsp;Jørgen K. Kanters ,&nbsp;Dominik Linz","doi":"10.1016/j.ijcha.2025.101783","DOIUrl":"10.1016/j.ijcha.2025.101783","url":null,"abstract":"<div><div>Machine learning methods are increasingly used in cardiovascular research. In order to highlight opportunities and challenges of the evaluation of studies applying machine learning, we use examples from cardiac electrophysiology, a field characterized by large and often imbalanced amounts of data. We provide recommendations and guidance on evaluating and presenting supervised machine learning studies. We recommend proper cohort selection, keeping training and testing data strictly separate, and comparing results to a reference model without machine learning as basic principles to ensure the quality of studies using machine learning methods. We furthermore recommend specific metrics and plots when reporting on machine learning including on models for multi-channel time series or images. This Best Practice paper represents a possible blueprint to help evaluate machine learning-based medical tests in cardiac electrophysiology and beyond.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101783"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in cardiac sarcoidosis","authors":"Katrina A. Williamson ,&nbsp;Jenna M. Davison ,&nbsp;Andrew N. Rosenbaum ,&nbsp;Panithaya Chareonthaitawee ,&nbsp;Nikhil Kolluri ,&nbsp;John P. Bois ,&nbsp;Omar F Abou Ezzeddine ,&nbsp;John A. Schirger ,&nbsp;Suraj Kapa ,&nbsp;Konstantinos C. Siontis ,&nbsp;Leslie T. Cooper ,&nbsp;Courtney A. Arment","doi":"10.1016/j.ijcha.2025.101777","DOIUrl":"10.1016/j.ijcha.2025.101777","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac sarcoidosis (CS) is an inflammatory cardiomyopathy for which sex differences outcomes are not well described.</div></div><div><h3>Objectives</h3><div>This study aimed to understand differences in CS presentation, complications, and outcomes between females and males.</div></div><div><h3>Methods</h3><div>Patients meeting Japanese Circulation Society or Heart Rhythm Society criteria for CS were evaluated at a single institution from January 1, 1999, to December 31, 2023 (n = 455). Presenting characteristics including demographics, symptoms, conduction abnormalities, arrhythmias and left ventricular ejection fraction (LVEF) between females and males were compared. Sex-based differences in hospitalizations, LVAD implantation, transplantation and death were analyzed.</div></div><div><h3>Results</h3><div>The cohort was mostly male (60.7 %). Females presented at an older age (58.5, IQR 51–65 in females, vs 54, IQR 45–61 in males, <em>p</em> = 0.001), and more females experienced palpitations (46.4 %, <em>p</em> = 0.04), chest pain (34.6 % <em>p</em> = 0.02), and fatigue (53.6 % <em>p</em> = 0.01) at presentation. Females had higher New York Heart Association (NYHA) class (III or IV) (31.5 % vs 21.8 %; <em>p</em> = 0.05), and higher NT-proBNP (467 in females vs 257.5 in males, <em>p</em> = 0.03) at presentation. Cardiovascular hospitalization–free survival, LVAD/transplant-free survival, and overall survival were not significantly different.</div></div><div><h3>Conclusions</h3><div>Females presented at an older age and were more symptomatic with higher NYHA class symptoms than males, suggesting that females are presenting or being diagnosed with CS later than males. LVEF, rates of heart block, and ventricular arrhythmias were similar between sexes, suggesting greater heart failure severity in females with CS may be related to greater left ventricular stiffening or worse valvular disease. Differences in survival outcomes were not significant.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101777"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking early risk stratification in heart failure-related cardiogenic shock","authors":"Ibrahim Akin","doi":"10.1016/j.ijcha.2025.101786","DOIUrl":"10.1016/j.ijcha.2025.101786","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101786"},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of segmental native T1 mapping for diagnosis and risk-stratification in cardiac sarcoidosis","authors":"Hidehiro Iwakawa ,&nbsp;Nobuhiro Suzuki ,&nbsp;Hirokazu Yoshida ,&nbsp;Yohei Sasaki ,&nbsp;Ryosuke Kato ,&nbsp;Ryota Kaimori ,&nbsp;Hiroyuki Watanabe","doi":"10.1016/j.ijcha.2025.101787","DOIUrl":"10.1016/j.ijcha.2025.101787","url":null,"abstract":"<div><h3>Background</h3><div>The clinical utility and optimal analytical approach for native T1 mapping in cardiac sarcoidosis (CS) remain unclear. This study investigated the clinical value of segmental native T1 assessment in patients with CS.</div></div><div><h3>Methods</h3><div>We recruited 55 participants, including 41 patients undergoing diagnostic evaluation of CS and 14 healthy controls. Of the 41 patients, 29 were diagnosed with CS and 12 were classified as non-CS. Segmental cardiac magnetic resonance findings of the left ventricle were evaluated using a 1.5-T scanner. The primary endpoint was a composite of all-cause death, fatal ventricular arrhythmia, bradycardia, or hospitalization for cardiovascular events.</div></div><div><h3>Results</h3><div>Maximum and global native T1 values were significantly higher in CS patients than in healthy controls and non-CS patients. Maximum and global T1 values demonstrated comparable predictive performance in differentiating CS from the other groups, with areas under the curve (AUCs) of 0.92 and 0.90, respectively. The AUC for predicting segments with late gadolinium enhancement (LGE) was highest for extracellular volume, followed by native T1 and T2 (<em>P</em> &lt; 0.05 for all). Patients with six or more segments showing native T1 ≥ 1091 ms had a significantly worse prognosis than those without (55.6 % vs. 18.2 %, <em>P</em> = 0.028).</div></div><div><h3>Conclusions</h3><div>Maximum and global native T1 values were highly predictive for differentiating CS. The high segmental native T1 values in patients with CS may reflect the regional presence of LGE. Segmental native T1 assessment can aid in estimating long-term outcomes.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101787"},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent highlights from the International Journal of Cardiology Heart & Vasculature: cardiometabolic disease","authors":"Florian Bruns ,&nbsp;Hannah Märte ,&nbsp;Dobromir Dobrev ,&nbsp;Anke Fender","doi":"10.1016/j.ijcha.2025.101779","DOIUrl":"10.1016/j.ijcha.2025.101779","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101779"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}