IJC Heart and Vasculature最新文献

{"title":"Assessment of comorbidity awareness in patients with atrial fibrillation: The ACAPAF study","authors":"Rana Önder ,&nbsp;Lien Desteghe ,&nbsp;Johan Vijgen ,&nbsp;Hein Heidbuchel","doi":"10.1016/j.ijcha.2025.101813","DOIUrl":"10.1016/j.ijcha.2025.101813","url":null,"abstract":"<div><h3>Background and aim</h3><div>Systematic and integrated comorbidity management in patients with atrial fibrillation (AF) requires patient involvement, starting with comorbidity awareness. This study evaluates comorbidity awareness in patients with AF before and after a first nurse-led AF clinic visit and after six months. We also measured the time needed for full comorbidity mapping using the EHRA-PATHS software.</div></div><div><h3>Methods</h3><div>This prospective two-centre study included patients diagnosed with AF attending the AF clinic for the first time. The software systematically assessed 23 comorbidities. Patients completed a comorbidity awareness questionnaire, focusing on nine AF-related comorbidities two weeks before their first visit, less than a week after, and six months later. Patients also had a telephone consultation with the AF nurse to discuss their comorbidities 1–3 months post-visit.</div></div><div><h3>Results</h3><div>The study included 76 patients (mean age 68.3 ± 10.3 y). Baseline awareness of comorbidity relevance for AF ranged between 11.1–100.0 %. Awareness about own alcohol consumption was the most ‘underestimated’ comorbidity before first contact (50.0 %), while smoking was most ‘overestimated’ (55.6 %; i.e. admitted in private but not during formal evaluation by nurses). The impact of an AF clinic visit on awareness of personal comorbidities was limited (p = 0.456), and also after an additional phone consultation, awareness was suboptimal after six months (p = 0.099). AF nurses needed 18.4 ± 8.7 min to complete the software.</div></div><div><h3>Conclusions</h3><div>Patients’ comorbidity awareness is moderate, and more educational efforts are needed to improve their awareness. A systematic and complete comorbidity evaluation at the AF clinic using EHRA-PATHS software can be done within a reasonable time frame.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101813"},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in myocardial fibrosis among patients with aortic stenosis: A systematic review and meta-analysis","authors":"Paul C. Onyeji ,&nbsp;Shivank Dani ,&nbsp;Sonise Momplaisir-Onyeji ,&nbsp;Miguel C. Lenzi ,&nbsp;Paweł Łajczak ,&nbsp;Felipe S. Passos ,&nbsp;Leo Consoli ,&nbsp;Hristo Kirov ,&nbsp;Torsten Doenst ,&nbsp;Tulio Caldonazo","doi":"10.1016/j.ijcha.2025.101814","DOIUrl":"10.1016/j.ijcha.2025.101814","url":null,"abstract":"<div><h3>Background</h3><div>Aortic stenosis (AS) leads to pathological myocardial remodeling, particularly fibrosis, which contributes to adverse outcomes including heart failure, arrhythmias, and mortality. Evidence suggests sex-specific differences in fibrotic response, but individual studies are underpowered for definitive conclusions. This <em>meta</em>-analysis aimed to evaluate sex-related differences in myocardial fibrosis using cardiac magnetic resonance (CMR) parameters.</div></div><div><h3>Methods</h3><div>Three databases were searched for studies comparing male and female patients with AS reporting CMR-derived measures. The primary outcomes were late gadolinium enhancement (LGE%), infarct-related and non-infarct-related LGE, extracellular volume (ECV) and Septal E/e′. Effect sizes were expressed as risk ratios (RR) for binary outcomes and mean differences (MD) for continuous outcomes, each with 95% confidence intervals (CI), using random-effects models. Study quality was appraised with the Newcastle–Ottawa Scale, and certainty of evidence was graded using the GRADE framework.</div></div><div><h3>Results</h3><div>Seven studies (n = 2,105; 1,246 males) were included. No significant difference was observed in LGE% (MD 0.13; 95 %CI −0.93 to 1.18; p = 0.770), and risks of infarct-related LGE between sexes (RR 1.61; 95 %CI 0.90 to 2.89; p = 0.080). Males had higher risk of non-infarct LGE (RR 1.51; 95 %CI 1.34 to 1.70; p = 0.002). There were no significant differences in ECV (MD −0.45; 95 %CI −2.34 to 1.44; p = 0.506) and Septal E/e′ between sexes (MD −1.87; 95 %CI −4.05 to 0.32; p = 0.072).</div></div><div><h3>Conclusion</h3><div>This <em>meta</em>-analysis shows sex-related differences in myocardial fibrosis in AS, with men exhibiting more focal replacement fibrosis and women a tendency toward diffuse interstitial fibrosis. These patterns highlight the relevance of incorporating sex-specific factors into diagnosis and management.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101814"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative videodensitometric assessment of aortic regurgitation in Myval, Sapien, and Evolut THV series: Results from the LANDMARK trial","authors":"Elfatih A. Hasabo ,&nbsp;Niels van Royen ,&nbsp;Ignacio J Amat-Santos ,&nbsp;Martin Hudec ,&nbsp;Matjaz Bunc ,&nbsp;Alexander IJsselmuiden ,&nbsp;Peep Laanmets ,&nbsp;Daniel Unic ,&nbsp;Bela Merkely ,&nbsp;Renicus S Hermanides ,&nbsp;Vlasis Ninios ,&nbsp;Marcin Protasiewicz ,&nbsp;Benno J W M Rensing ,&nbsp;Pedro L Martin ,&nbsp;Fausto Feres ,&nbsp;Manuel De Sousa Almeida ,&nbsp;Eric van Belle ,&nbsp;Axel Linke ,&nbsp;Alfonso Ielasi ,&nbsp;Matteo Montorfano ,&nbsp;Osama Soliman","doi":"10.1016/j.ijcha.2025.101804","DOIUrl":"10.1016/j.ijcha.2025.101804","url":null,"abstract":"<div><h3>Background</h3><div>The quantitative videodensitometric aortography (QVDA) has reliably quantified post-TAVI aortic regurgitation (AR). However, this method has not yet been evaluated in randomized trials comparing various transcatheter heart valve (THV) systems. Here, we investigated the QVDA of AR following TAVI for severe aortic stenosis among Myval, Sapien, and Evolut THV series as part of the LANDMARK trial.</div></div><div><h3>Methods</h3><div>The final aortograms, either without or after balloon post-dilatation (BPD) were analyzed using the advanced CAAS-A-Valve 2.1.2 software. The regurgitant fraction (RF) was computed and categorized into none/trace AR (RF &lt; 86 %), mild AR (6 % ≤ 8RF ≤ 817 %), and moderate/severe AR (RF &gt; 17 %).</div></div><div><h3>Results</h3><div>Five hundred ninety-six final analyzable aortograms and 97 aortograms following BPD were included in the analysis. The BPD resulted in a significant reduction of RF in the Myval [12.0(6.0–18.5) vs 2.0(1.0, 5.5);p = 0.0002], Sapien[18.0(1.0–19.0) vs. 2.0(1.0–3.0); p = 0.04206] and Evolut [10.5 (6.0–15.0) vs 5.0 (1.0–8.0); p = 0.0009]. The rate of final RF &gt; 17 % was lower in the Myval(2.0 %) compared to Evolut(8.00 %), but similar to the Sapien series (4.0 %)(P_Myval-Sapien = 0.2333, P_Myval-Evolut = 0.0057). In the as-treated population, the Myval series demonstrated a comparable RF to the Sapien series, but a significantly lower RF compared to the Evolut [Myval: 3.0 %(1.0–7.0), Sapien:3.0 %(1.0–7.0), Evolut:5.0 %(1.0–10.0)], P_Myval-Sapien = 0.8997,P_Myval-Evolut = 0.0010].</div></div><div><h3>Conclusion</h3><div>The QVDA highlights the superior performance of the Myval THV series compared to the Evolut THV series, with the lowest rate of moderate/severe RF among the three THV series, and could be used with echocardiography to help in detecting cases with none/trace AR.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101804"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the coronary paradox of obesity: not all fat is equal!","authors":"Gaetano Santulli ,&nbsp;Shivangi Pande ,&nbsp;Pasquale Mone ,&nbsp;Fahimeh Varzideh","doi":"10.1016/j.ijcha.2025.101807","DOIUrl":"10.1016/j.ijcha.2025.101807","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101807"},"PeriodicalIF":2.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association between sleep duration, daytime napping, sleep disorders and ischemic heart disease: A systematic review and meta‑analysis of Mendelian randomization studies","authors":"Yi-Neng Shen ,&nbsp;Zi-Ling Cai ,&nbsp;Rui-Ting Jia ,&nbsp;Ai-Song Zhu","doi":"10.1016/j.ijcha.2025.101811","DOIUrl":"10.1016/j.ijcha.2025.101811","url":null,"abstract":"<div><div>Ischemic heart disease (IHD) is a disease with high mortality and disability. Numerous studies have established a significant correlation between IHD and sleep. This study aims to evaluate the quality of existing Mendelian randomization (MR) studies and integrate the results to provide an overview of the latest evidence on the causal relationship between sleep patterns and IHD. We conducted a comprehensive search of PubMed, Embase and Web of Science to identify MR studies related to IHD and sleep. Studies from database inception to September 9, 2024 were included. Following data extraction, we performed a rigorous quality evaluation and <em>meta</em>-analysis. Quality assessment was conducted through the Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR) guidelines. Finally, we included 13 articles in the study. According to the quality assessment, the overall quality of the included literature was moderate. Meta-analysis showed that short sleep duration (≤6h, OR:1.22[1.16,1.28]; <em>P</em> &lt; 0.001, I² = 46.7 %), daytime napping (OR:1.63[1.26,2.12]; <em>P</em> &lt; 0.001, I² = 0.0 %), and sleep disorders (OR:1.44[1.29–1.60]; <em>P</em> &lt; 0.001, I² = 85.4 %) were positively associated with IHD, while extending sleep duration had a protective effect on IHD (OR:0.77[0.71,0.83]; <em>P</em> &lt; 0.001, I² = 0.0 %). These findings show the effect of sleep on IHD. Short sleep duration, daytime napping and sleep disorders increase the risk of IHD, and whereas extending sleep duration is beneficial for reducing the risk of IHD.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101811"},"PeriodicalIF":2.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of ruxolitinib in preventing cardiac arrhythmias: A pooled analysis of clinical studies in hematology","authors":"Silvia Zaoli ,&nbsp;Manish Khatri ,&nbsp;Bjoern Holzhauer ,&nbsp;Severine Peyrard ,&nbsp;AnaRita Ferreira ,&nbsp;Tommaso Stefanelli","doi":"10.1016/j.ijcha.2025.101810","DOIUrl":"10.1016/j.ijcha.2025.101810","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101810"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-onset anemia and its association with ventricular arrhythmias and sudden cardiac death in patients with heart failure with preserved ejection fraction","authors":"Tomohiro Ito ,&nbsp;Kotaro Nochioka ,&nbsp;Takashi Noda ,&nbsp;Takashi Shiroto ,&nbsp;Shinichi Yamanaka ,&nbsp;Nobuhiko Yamamoto ,&nbsp;Hiroyuki Sato ,&nbsp;Takahiko Chiba ,&nbsp;Makoto Nakano ,&nbsp;Takumi Inoue ,&nbsp;Kai Susukita ,&nbsp;Hiroyuki Takahama ,&nbsp;Jun Takahashi ,&nbsp;Satoshi Miyata ,&nbsp;Hiroaki Shimokawa ,&nbsp;Satoshi Yasuda","doi":"10.1016/j.ijcha.2025.101812","DOIUrl":"10.1016/j.ijcha.2025.101812","url":null,"abstract":"<div><h3>Background</h3><div>Anemia is a common comorbidity associated with adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF). However, the clinical relevance of new-onset anemia to sudden cardiac death (SCD) in patients with HFpEF remains unclear. This study investigated the association between new-onset anemia with ventricular arrhythmias (VAs) and SCD.</div></div><div><h3>Methods</h3><div>Anemia was defined as a hemoglobin (Hb) level of &lt;13 g/dL in men and &lt;12 g/dL in women. Patients with Hb levels above these thresholds were categorized as without anemia. We analyzed data of 686 patients with symptomatic HFpEF (ejection fraction ≥ 50 %, New York Heart Association class II–IV) without anemia at baseline from a multicenter prospective observational CHART-2 study. The primary endpoint was a composite of ventricular tachycardia, ventricular fibrillation, and SCD.</div></div><div><h3>Results</h3><div>At the 1-year follow-up, 109 patients developed new-onset anemia (median Hb, 11.9 g/dL), whereas 577 remained without anemia (median Hb, 14.0 g/dL). Over a median follow-up of 9.2 years, patients with new-onset anemia had a significantly higher incidence of composite outcomes (12.8 % vs. 5.2 %, P = 0.008). After adjusting for potential confounders, new-onset anemia was associated with an elevated risk of the composite outcome (adjusted hazard ratio 2.20, 95 % confidence interval 1.10–4.42, P = 0.027). The association between new-onset anemia and lethal arrhythmias was independent of heart failure hospitalization or myocardial infarction occurring before the primary endpoint.</div></div><div><h3>Conclusions</h3><div>New-onset anemia was significantly associated with an increased risk of VAs and SCD in patients with HFpEF, underscoring the importance of monitoring Hb levels for risk stratification.</div><div><strong>Registration:</strong> URL: <span><span>https://www.clinicaltrials.gov</span><svg><path></path></svg></span>; Unique identifier: NCT00418041.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101812"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short‑term effects of ambient air pollution exposure on hospital emergency room visits for atrial fibrillation: a nationwide cohort study","authors":"Yu-Shan Huang ,&nbsp;Li-Wei Lo ,&nbsp;Tsung-Ying Tsai ,&nbsp;Hsin-Bang Leu ,&nbsp;Shih-Ann Chen","doi":"10.1016/j.ijcha.2025.101805","DOIUrl":"10.1016/j.ijcha.2025.101805","url":null,"abstract":"<div><h3>Background</h3><div>Although air pollutants are linked to cardiopulmonary mortality, their impact on cardiac arrhythmias is not well understood. This study examines the short-term effects of air pollution on emergency admissions for acute atrial fibrillation (AF) in Taiwan.</div></div><div><h3>Methods</h3><div>This study used Taiwan’s National Health Insurance Research Database, including 16,778,374 participants aged 20 and older, residing in the same districts during 10-year follow-ups from 2008 to 2017. Hourly air pollutant exposure data were obtained from the Taiwan Environmental Protection Administration Database. Records of patients with ICD-9 code 427.31 (AF) as the primary diagnosis from emergency departments were extracted. Emergency visits for AF were compared across exposures to pollutants such as particulate matter PM_2.5, PM₁₀, Nitrogen Dioxide (NO₂), Nitrogen Oxide (NO), Nitrogen Oxides (NO_X), Sulphur Dioxide (SO₂), Carbon monoxide (CO) and Ozone (O₃).</div></div><div><h3>Results</h3><div>In our study cohort of 16,778,374 patients, 129,595 (0.77 %) were admitted to emergency departments for initial AF episodes. Significant associations were found between AF visits and PM_2.5 (1.01 %; CI: 1.00–1.02 %; P = 0.003), PM₁₀ (1.01 %; CI: 1.00–1.01 %; P = 0.001), NO₂ (1.02 %; CI: 1.00–1.03 %; P = 0.001), NO (1.02 %; CI: 1.00–1.04 %; P = 0.016), NO_x (1.01 %; CI: 1.00–1.01 %; P = 0.002), CO (1.05 %; CI: 1.00–1.11 %; P &lt; 0.0001), with exposure levels on the event day compared to the previous 5 days. Except for O₃, patients without comorbidities like coronary artery disease, heart failure, chronic kidney disease, and thyroid disease were more susceptible to air pollution.</div></div><div><h3>Conclusions</h3><div>High concentrations of ambient air pollutants with short-term exposure are linked to an increased number of emergency room visits for acute AF attacks.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101805"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care pathway in patients after myocardial infarction in Denmark − healthcare and drug utilization","authors":"Marius Mølsted Flege ,&nbsp;Theresa Kleinschmidt ,&nbsp;Susanne Hansen ,&nbsp;Kristoffer Jarlov Jensen ,&nbsp;Henrik Kjærulf Jensen ,&nbsp;Morten Krogh Christiansen ,&nbsp;Charlotte Ottar Merland ,&nbsp;Janne Petersen","doi":"10.1016/j.ijcha.2025.101809","DOIUrl":"10.1016/j.ijcha.2025.101809","url":null,"abstract":"<div><h3>Background</h3><div>Following myocardial infarction (MI), patients are recommended to lower their low-density lipid cholesterol (LDL-C) levels and undergo cardiac rehabilitation to prevent recurrent events. Although lowering LDL-C is vital post-MI, many patients fail reaching sufficient levels, resulting in recurrent cardiovascular events. The aim of the study was therefore to investigate the follow-up and the utilisation of lipid lowering therapy one year after MI.</div></div><div><h3>Methods</h3><div>This register-based nationwide Danish observational study included all hospitalized patients with an incident MI from 2018 to 2021, discharged alive. Patients were followed for one year after discharge with respect to LDL-C measurements, contacts with different healthcare actors, and lipid lowering therapy.</div></div><div><h3>Results</h3><div>A total of 24,977 patients were included. During follow-up, the incidence of having an LDL-C measured once and twice were 87 % and 67 %, respectively. The incidence of patients visiting a cardiology department, general practitioner with an LDL-C measurement, and having an acute hospital contact were 66 %, 70 %, and 48 %. Statin therapy was redeemed by most patients at least once (87 %) or twice (82 %), while ezetimibe (16 %) and other drugs were prescribed less frequently. Younger, higher educated, less comorbid males with LDL-C ≥ 1.4 mmol/L at hospitalization were more likely to be followed-up with LDL-C measurement or visit to a cardiology department post-MI.</div></div><div><h3>Conclusion</h3><div>These findings show that a large proportion of patients are not receiving lipid lowering therapy or are not monitored according to guidelines one year after an MI. This suggests a further need for monitoring MI patients with LDL-C levels and healthcare visits.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101809"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the novel virtual myectomy in guiding thoracoscopic myectomy for patients with hypertrophic obstructive cardiomyopathy","authors":"Peijian Wei ,&nbsp;Tong Tan ,&nbsp;Shengwen Wang ,&nbsp;Jiexu Ma ,&nbsp;Guanyu Lu ,&nbsp;Haozhong Liu ,&nbsp;Hanxiang Xie ,&nbsp;Wei Zhu ,&nbsp;Jian Zhuang ,&nbsp;Jian Liu ,&nbsp;Huiming Guo","doi":"10.1016/j.ijcha.2025.101795","DOIUrl":"10.1016/j.ijcha.2025.101795","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to evaluate the efficacy of a novel virtual myectomy procedure in guiding thoracoscopic <em>trans</em>-mitral myectomy.</div></div><div><h3>Methods and Results</h3><div>Clinical data from 37 patients who underwent thoracoscopic <em>trans</em>-mitral septal myectomy guided by virtual myectomy between April 2019 and October 2021 were retrospectively analyzed. Enhanced cardiac CT images were imported into Mimics software to perform virtual myectomy. The short-axis two-chamber plane, perpendicular to the interventricular septum (IVS), was marked for each segment from the basal septum to the apex. IVS thickness was continuously measured at each marked segment, and a figurative digital model determined the resection extent. The cohort consisted of 22 women (59.46 %) with a mean age of 53.14 ± 13.62 years. No deaths or permanent pacemaker implantations occurred. Septal thickness decreased significantly from 20.49 ± 3.85 to 11.28 ± 2.53 mm (P &lt; 0.001), resulting in a marked reduction in obstruction (90.84 ± 28.78 to 11.59 ± 11.06 mmHg, P &lt; 0.001). Twelve patients (32.43 %) underwent mitral valve replacement. The virtual resection’s length, width, thickness, and volume showed strong positive correlations with the actual resection (R = 0.76–0.89). The virtual model’s septal thickness was moderately correlated with the actual resection volume (R = 0.51, P &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Virtual myectomy effectively guided septal myectomy, with favorable outcomes in selected patients. This approach, combined with preoperative 3D simulation and printing, enables precise planning for complex cases<strong>.</strong></div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101795"},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}