IJC Heart and Vasculature最新文献

{"title":"Sudden cardiac death associated with fatty liver disease","authors":"Jonathan Vo ,&nbsp;Thien T.T.T. Truyen ,&nbsp;Audrey Uy-Evanado ,&nbsp;Arayik Sargsyan ,&nbsp;Harpriya Chugh ,&nbsp;Christopher Young ,&nbsp;Sean Hurst ,&nbsp;Christina Y. Miyake ,&nbsp;Kyndaron Reinier ,&nbsp;Sumeet S. Chugh","doi":"10.1016/j.ijcha.2025.101602","DOIUrl":"10.1016/j.ijcha.2025.101602","url":null,"abstract":"<div><h3>Background</h3><div>Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD).</div></div><div><h3>Objectives</h3><div>To investigate the relationship between SLD and SCD.</div></div><div><h3>Methods</h3><div>A post-mortem case-case study was conducted in victims of SCD from an ongoing community-based study in Southern California (Ventura, CA, 2015–2023). Diagnosis of SLD was determined from post-mortem liver histopathology reports. For each patient, demographic variables, laboratory values, and presence of co-morbidities were ascertained from medical records and were compared between patients with and without SLD.</div></div><div><h3>Results</h3><div>Of 162 individuals with SCD, there were 101 SLD cases and 61 without SLD. Individuals with SLD were found to have higher BMI (31.6 ± 7.6 vs. 26.7 ± 5.7, p &lt; 0.001), higher prevalence of heavy drinking (28 % vs. 12 %, p = 0.008), heavier liver weights (2433.6 g ± 940.6 vs 1934.7 g ± 505.3, p &lt; 0.001), and were more often Hispanic (37 vs. 18 %, p = 0.01). Patients with SLD had lower prevalence of coronary artery disease (CAD) (49 % vs. 70 %). Multivariable logistic regression analysis showed that CAD was a negative predictor of SCD with SLD (OR = 0.35, 95 % CI 0.14 – 0.83).</div></div><div><h3>Conclusion</h3><div>Among adults with SCD, SLD was associated with higher prevalence of Hispanic ethnicity and lower prevalence of CAD. Given the major rise in SLD burden, these ethnicity-based differences as well as the specific nature of non-ischemic SCD etiologies warrant urgent further investigation.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101602"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of left atrial stiffness in patients undergoing transcatheter aortic valve implantation","authors":"Hiroki Usuku ,&nbsp;Eiichiro Yamamoto ,&nbsp;Ryudai Higashi ,&nbsp;Atsushi Nozuhara ,&nbsp;Yuichiro Shirahama ,&nbsp;Fumi Oike ,&nbsp;Noriaki Tabata ,&nbsp;Masanobu Ishii ,&nbsp;Shinsuke Hanatani ,&nbsp;Tadashi Hoshiyama ,&nbsp;Hisanori Kanazawa ,&nbsp;Yuichiro Arima ,&nbsp;Hiroaki Kawano ,&nbsp;Yasuhiro Izumiya ,&nbsp;Yasuhito Tanaka ,&nbsp;Kenichi Tsujita","doi":"10.1016/j.ijcha.2024.101559","DOIUrl":"10.1016/j.ijcha.2024.101559","url":null,"abstract":"<div><h3>Aim</h3><div>This study was performed to evaluate the association between left atrial (LA) stiffness and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI).</div></div><div><h3>Methods and Results</h3><div>This study involved 279 patients with aortic stenosis (AS) who underwent TAVI at Kumamoto University Hospital between 2015 and 2023. During a median follow-up of 468 days (interquartile range: 258–825 days), 42 deaths occurred. Pre-TAVI echocardiography showed that the LA stiffness index (E/e′ ratio/LA strain during the reservoir phase [LASr]) was significantly higher in the all-cause death group than in the survival group (2.80 ± 2.56 vs. 1.70 ± 1.23, p &lt; 0.01). Multivariate Cox proportional hazard analysis identified LA stiffness as significantly and independently associated with all-cause death after adjusting for body mass index, <em>trans</em>-aortic valve velocity, atrial fibrillation, log-transformed high-sensitivity cardiac troponin T (hazard ratio [HR]: 1.31, 95 % confidence interval [CI]: 1.14–1.51, p &lt; 0.01), tricuspid regurgitation, left ventricular global longitudinal strain (HR: 1.24, 95 % CI: 1.06–1.44, p &lt; 0.05), and LASr (HR: 1.27, 95 % CI: 1.05–1.60, p &lt; 0.05). Receiver operating characteristic analysis showed that the optimal cutoff value of the LA stiffness index for predicting all-cause mortality was 1.69 (sensitivity: 60 %, specificity: 62 %, area under the curve: 0.64). Kaplan–Meier analysis demonstrated that patients with a high LA stiffness index (≥1.69) had a significantly higher probability of all-cause death (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Estimation of LA stiffness provides significant prognostic value in patients with AS undergoing TAVI, even after adjusting for multiple predictive factors.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101559"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational study of sudden cardiac arrest risk (OSCAR): Rationale and design of an electronic health records cohort","authors":"Kyndaron Reinier ,&nbsp;Harpriya S. Chugh ,&nbsp;Audrey Uy-Evanado ,&nbsp;Elizabeth Heckard ,&nbsp;Marco Mathias ,&nbsp;Nichole Bosson ,&nbsp;Vinicius F. Calsavara ,&nbsp;Piotr J. Slomka ,&nbsp;David A. Elashoff ,&nbsp;Alex A.T. Bui ,&nbsp;Sumeet S Chugh","doi":"10.1016/j.ijcha.2025.101614","DOIUrl":"10.1016/j.ijcha.2025.101614","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital sudden cardiac arrest (SCA) is a major cause of mortality and improved risk prediction is needed. The Observational Study of Sudden Cardiac Arrest Risk (OSCAR) is an electronic health records (EHR)-based cohort study of patients receiving routine medical care in the Cedars-Sinai Health System (CSHS) in Los Angeles County, CA designed to evaluate predictors of SCA. This paper describes the rationale, objectives, and study design for the OSCAR cohort.</div></div><div><h3>Methods and Results</h3><div>The OSCAR cohort includes 379,833 Los Angeles County residents with at least one patient encounter at CSHS in each of two consecutive calendar years from 2016 to 2020. We obtained baseline cohort characteristics from the EHR from 2012 until the start of follow-up, including demographics, vital signs, clinical diagnoses, cardiac tests and imaging, procedures, laboratory results, and medications. Follow-up will continue until Dec. 31, 2025, with an expected median follow-up time of ∼ 7 years. The primary outcome is out-of-hospital SCA of likely cardiac etiology attended by Los Angeles County Emergency Medical Services (LAC-EMS). The secondary outcome is total mortality identified using California Department of Public Health – Vital Records death certificates. We will use conventional approaches (diagnosis code algorithms) and artificial intelligence (natural language processing, deep learning) to define patient phenotypes and biostatistical and machine learning approaches for analysis.</div></div><div><h3>Conclusions</h3><div>The OSCAR cohort will provide a large, diverse dataset and adjudicated SCA outcomes to facilitate the derivation and testing of risk prediction models for incident SCA.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101614"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction evaluated by new angiography-derived index of microvascular resistance","authors":"Benoit Caullery ,&nbsp;Laurent Riou ,&nbsp;Stephanie Marliere ,&nbsp;Estelle Vautrin ,&nbsp;Nicolas Piliero ,&nbsp;Olivier Ormerzzano ,&nbsp;Helene Bouvaist ,&nbsp;Gerald Vanzetto ,&nbsp;Gilles Barone-Rochette","doi":"10.1016/j.ijcha.2024.101575","DOIUrl":"10.1016/j.ijcha.2024.101575","url":null,"abstract":"<div><h3>Background</h3><div>Several methods for measuring IMR derived from angiography have been developed. AngioIMR is a novel method for the assessment of angiography-derived IMR with no requirement for a wire and hyperemia. The prognostic value of AngioIMR is unknown in STEMI patients. We aimed to provide the prognostic value of AngioIMR in patients with ST-elevation myocardial infarction (STEMI).</div></div><div><h3>Methods</h3><div>This study included patients with STEMI who underwent invasive coronary angiography and primary percutaneous coronary intervention (PPCI). AngioIMR was calculated using computational flow and pressure simulation immediately after PPCI. The presence of significant coronary microvascular dysfunction was defined as AngioIMR &gt; 40. The primary outcome was a composite of all cause death or hospitalization for heart failure (MACE).</div></div><div><h3>Results</h3><div>A total of 178 patients were included (65.0 ± 12.8 years on average, 74 % male gender). An AngioIMR &gt; 40 was found in 72 patients. During a median follow-up of 2.9 (2.3–6.9) years, a primary endpoint was observed in 56 patients. By Kaplan-Meier analysis, the risk of MACE was significantly higher in patients with AngioIMR &gt; 40 (log-rank P &lt; 0.01). An Angio IMR &gt; 40 was significantly associated with the occurrence of the primary endpoint in univariate (70 % vs 27 %; hazard ratio 4.519; 95 % CI: 2.550–8.009; p &lt; 0.0001) and multivariate analysis (Hazard ratio 4.282; 95 % CI: 2.325–7.886; p &lt; 0.0001). AngioIMR model showed incremental prognostic value compared to a model with clinical and imaging risk predictors (C-index 0.84 vs 0.79; p = 0.04).</div></div><div><h3>Conlusion</h3><div>Elevated AngioIMR showed a independent prognostic significance in STEMI patients. In addition to well-known risk factors, assessment of coronary microvascular dysfunction can be a feasible approach for early prevention and a therapeutic target in STEMI patients.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101575"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher cardiorespiratory fitness levels attenuate but do not negate the heightened risk of sudden cardiac death due to obesity: A prospective cohort study","authors":"Jari A. Laukkanen ,&nbsp;Sudhir Kurl ,&nbsp;Kai Savonen ,&nbsp;Setor K. Kunutsor","doi":"10.1016/j.ijcha.2024.101588","DOIUrl":"10.1016/j.ijcha.2024.101588","url":null,"abstract":"<div><h3>Background</h3><div>Higher levels of CRF have been demonstrated to attenuate or negate the adverse cardiovascular impacts of other risk factors. We aimed to assess the interplay between body mass index (BMI), CRF and sudden cardiac death (SCD) risk.</div></div><div><h3>Methods</h3><div>Body mass index was calculated based on guideline recommendations and CRF assessed using a respiratory gas exchange analyzer during clinical exercise testing at baseline in 2308 men aged 42–61 years of age. Cox regression analysis was used to estimate hazard ratios (HRs) with 95 % confidence intervals (CIs) for SCD.</div></div><div><h3>Results</h3><div>During a median follow-up of 28.1 years, 264 SCDs occurred. Comparing obese vs normal weight category, the multivariable-adjusted HR (95 % CI) for SCD was 1.86 (1.28–2.71). Comparing low vs high CRF levels, the corresponding adjusted HR (95 % CI) for SCD was 1.99 (1.38–2.87). The HRs persisted on mutual adjustment for each exposure. Compared with non-obese and medium–high CRF, obese individuals with low CRF levels had the greatest risk of SCD (HR = 2.90, 95 % CI, 1.98–4.25), which was attenuated but persisted in obese individuals with medium–high CRF levels (HR = 2.02, 95 % CI, 1.08–3.78).</div></div><div><h3>Conclusions</h3><div>There is an interplay between BMI, CRF and SCD risk. Higher CRF levels may attenuate the risk associated with obesity.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101588"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in infective endocarditis: A systematic review and meta-analysis of clinical profiles and management outcomes","authors":"Heba T. Salim ,&nbsp;Yousef A. Hamad ,&nbsp;Huda Alwadiya ,&nbsp;Woroud Siriya ,&nbsp;Baraa Mansour ,&nbsp;Haya Alhadad ,&nbsp;Walid Marouf ,&nbsp;Mohammed Ayyad ,&nbsp;Ragavendar Saravanabavanandan ,&nbsp;Saif Almaghrabi ,&nbsp;Mohammed Al-Tawil ,&nbsp;Assad Haneya","doi":"10.1016/j.ijcha.2025.101607","DOIUrl":"10.1016/j.ijcha.2025.101607","url":null,"abstract":"<div><h3>Background</h3><div>Infective endocarditis (IE) presents significant morbidity and mortality, with potential sex differences in clinical profile and outcomes. This is the first meta-analysis that aims to compare the clinical profile and outcomes of IE between males and females.</div></div><div><h3>Methods</h3><div>We conducted a meta-analysis of nine studies evaluating the clinical profile and outcomes of IE in males versus females extracted from PubMed, EMBASE, SCOPUS, and Cochrane databases up to 1st of Jan 2024.</div></div><div><h3>Results</h3><div>Our meta-analysis revealed notable sex differences in the incidence and complications of IE. Males exhibited a higher incidence of aortic valve IE (RR 1.57, 95 % CI [1.31, 1.88]), surgical indications for IE (RR 1.38, [1.12, 1.70]), Streptococci infection (RR 1.36, [1.04, 1.77]), intracardiac abscess (RR 1.22, [1.05, 1.42]), and Enterococci IE (RR 1.44, [1.28, 1.61]). In contrast, females had a higher incidence of mitral valve IE (RR 0.79, [0.67, 0.94]) and a higher in-hospital mortality rate (RR 0.84, [0.74, 0.96]). No significant sex differences were found in the incidence of valve vegetations, tricuspid valve IE, embolization, and Staphylococcus IE. In-hospital stay was longer in male patients, however, with borderline significance (RR 3.15, [-0.16, 6.45], p = 0.06). In patients who underwent surgery for IE, mortality rates were significantly lower in male patients (RR: 0.67 [0.59, 0.76], p &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Compared to females, males exhibit higher rates of aortic valve IE, intracardiac abscess, streptococci IE, enterococci IE and IE-related surgery indication. In contrast, females have higher rates of mitral valve IE and in-hospital mortality.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101607"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter or surgical treatment of paravalvular leaks: A meta-analysis of 13 studies and 2003 patients","authors":"Riccardo Improta ,&nbsp;Gianluca Di Pietro ,&nbsp;Yasser Odeh ,&nbsp;Arianna Morena ,&nbsp;Wael Saade ,&nbsp;Fabrizio D’Ascenzo ,&nbsp;Massimo Mancone ,&nbsp;Fabio Miraldi","doi":"10.1016/j.ijcha.2024.101583","DOIUrl":"10.1016/j.ijcha.2024.101583","url":null,"abstract":"<div><h3>Background</h3><div>Significant paravalvular leak is a rare but serious complication of heart valve replacement, leading to symptomatic heart failure and hemolysis. Due to the paucity of comparative data between surgical and transcatheter paravalvular leak correction, we performed a systematic review and meta-analysis of available studies.</div></div><div><h3>Methods</h3><div>Studies comparing transcatheter and surgical treatment of paravalvular leak were systematically identified. Short-term all-cause mortality was the primary outcome. Technical and procedural success, 30-day persistence of significant paravalvular leak, length of hospital stay and long-term mortality, persistence of symptoms and paravalvular leak were the main secondary endpoints.</div></div><div><h3>Results</h3><div>Thirteen studies with 2003 patients were included, treating in most of the cases a mitral prothesis. Transcatheter closure was associated with lower short-term mortality rate (30 days OR 0.28, 95 % CI 0.18–0.42, p &lt; 0.001) compared to surgical treatment. Technical and procedural success did not differ among the two groups. 30-day and long-term rates of persistence of moderate or severe paravalvular leak were higher in the transcatheter group (OR 3.56, 95 % CI 1.49–8.49, p = 0.004 and OR 2.20, 95 % CI 1.27–3.81, p = 0.005 respectively). Long-term death and re-hospitalization events did not differ among the two treatment modalities. The mean difference in days of length of stay was significantly lower in the transcatheter group (mean difference −9.66, 95 % CI −12.37 to −6.94, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Transcatheter closure of paravalvular leaks is associated with lower short-term mortality rates but higher persistence of moderate-severe paravalvular leak and heart failure symptoms at short and long-term follow-up compared to surgical treatment.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101583"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct oral anticoagulants in deep vein thrombosis associated with inferior vena cava agenesis: A report of three cases and a systematic review","authors":"Nicola Osti ,&nbsp;Vito Racanelli ,&nbsp;Nicola Susca ,&nbsp;Nicola Martinelli ,&nbsp;Alberto Maino","doi":"10.1016/j.ijcha.2024.101565","DOIUrl":"10.1016/j.ijcha.2024.101565","url":null,"abstract":"<div><h3>Background</h3><div>Inferior vena cava agenesis (IVCA) is a rare vascular abnormality characterised by the absence of one or more segments of the inferior vena cava and represents an underestimated cause of deep vein thrombosis (DVT). Given the very low prevalence of this condition and the lack of clinical trials, there is no consensus about the optimal anticoagulation strategy in IVCA-associated DVT.</div></div><div><h3>Objectives</h3><div>To investigate efficacy and safety of direct oral anticoagulants (DOACs) in IVCA-associated DVT.</div></div><div><h3>Methods</h3><div>We described three patients with IVCA-associated DVT followed at our Institution and treated with DOACs. Then, we performed a systematic review of the literature for ICVA-associated DVT treated with DOACs.</div></div><div><h3>Results</h3><div>In addition to our 3 cases, we found data from 19 publications for a total of 30 patients with IVCA-associated DVT treated with DOACs (24 subjects treated with rivaroxaban, 8 with apixaban, and one with dabigatran). Most patients were males (72.7 %) with a median age at DVT onset of 26.0 years (min–max range 13–64 years). The majority of DVT events were unprovoked (76.0 %). The standard thrombophilia tests were mainly negative. The median follow-up period during DOAC therapy was 1.0 years (min–max range 0–10 years), with one recurrent splanchnic vein thrombosis reported and no haemorrhagic events.</div></div><div><h3>Conclusions</h3><div>IVCA is a rare cause of DVT, which should be suspected in young adults with unprovoked DVT. Although future studies are needed, available data may support the use of DOACs in IVCA-associated DVT, with a reassuring profile of both efficacy and safety.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101565"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the landscape of tricuspid regurgitation with transcatheter tricuspid valve replacement","authors":"Muhammad Adnan Zaman","doi":"10.1016/j.ijcha.2024.101577","DOIUrl":"10.1016/j.ijcha.2024.101577","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101577"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of pulmonary hypertension in patients with hypertrophic cardiomyopathy: A multicenter propensity score matching study","authors":"Huihui Ma ,&nbsp;Fengcheng Xu ,&nbsp;Lei Liu ,&nbsp;Hong Kong ,&nbsp;Rong Luo ,&nbsp;Mingjiang Liu ,&nbsp;Tianhu Liu ,&nbsp;Xiaoping Li","doi":"10.1016/j.ijcha.2025.101605","DOIUrl":"10.1016/j.ijcha.2025.101605","url":null,"abstract":"<div><h3>Objectives</h3><div>Pulmonary hypertension (PH) is known to be associated with increased mortality in patients suffering from left ventricular disease. The aim of this study was to assess the incidence of PH among patients diagnosed with hypertrophic cardiomyopath (HCM) and to evaluate its prognostic significance.</div></div><div><h3>Methods</h3><div>The study cohort consisted of 2781 patients with HCM. Among them, 226 patients had PH (8.1%), and 2555 patients did not have PH (91.8%). The fourteen demographic and clinical variables were matched between the two groups using a 1:3 propensity score matching (PSM) method. Kaplan–Meier survival curves and Cox proportional hazard regression models were used to evaluate the correlation between PH and mortality. Moreover, a competing risk regression analysis was conducted to assess the competing risk.</div></div><div><h3>Results</h3><div>Before matching, there were 519 (18.7 %) patients with all-cause mortality, including 292 (10.5 %) patients who experienced cardiovascular mortality and 128 (4.6 %) patients who experienced SCD. There was a significant difference in the Kaplan–Meier survival curves for all-cause mortality (log-rank <em>P</em> &lt; 0.0001), cardiovascular mortality (log-rank <em>P</em> &lt; 0.0001) and SCD (log-rank <em>P</em> = 0.0005). After matching, there were also significant differences in cardiovascular mortality (log-rank <em>P</em> = 0.011) and SCD (log-rank <em>P</em> = 0.042), but only a similar trend was observed for all-cause mortality (log-rank <em>P</em> = 0.052). Cox regression analyses suggested that PH was an independent risk predictor for cardiovascular mortality [HR: 1.666; 95 % CI: 1.145–2.424; <em>P</em> = 0.008].</div></div><div><h3>Conclusion</h3><div>HCM patients with PH characterized by increased cardiovascular mortality and SCD, as well as a similar trend in all-cause mortality. Moreover, PH is an independent risk factor for cardiovascular mortality.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"56 ","pages":"Article 101605"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}