IJC Heart and Vasculature最新文献

{"title":"Fibrinogen-to-albumin ratio as a novel biomarker for risk assessment in clinically suspected acute myocarditis","authors":"Lihi Levi-Gofman ,&nbsp;Shaul Atar ,&nbsp;Gassan Moady","doi":"10.1016/j.ijcha.2025.101791","DOIUrl":"10.1016/j.ijcha.2025.101791","url":null,"abstract":"<div><h3>Background</h3><div>Acute myocarditis typically follows a benign course, but fatal complications may occur in fulminant cases. Evaluation is based on clinical, laboratory, and imaging parameters. We aimed to assess the prognostic value of the fibrinogen-to-albumin ratio (FAR) in patients with clinically suspected myocarditis.</div></div><div><h3>Methods</h3><div>Echocardiographic, laboratory, and clinical parameters were obtained from patients with clinically suspected myocarditis. We assessed the correlations between troponin, albumin, fibrinogen, FAR, left ventricular ejection fraction (LVEF), and complications during the index hospitalization. Repeat echocardiography was performed in patients with reduced LVEF. Several potential factors were tested for their ability to predict LVEF recovery.</div></div><div><h3>Results</h3><div>A total of 118 patients were included (80 % male; median age, 35 years; mean LVEF, 55 %). Median troponin level was 2558 ng/L, and the median fibrinogen-to-albumin ratio (FAR) was 120. In 38 patients (32 %), LVEF was reduced; among them, 15 (39 %) had persistently reduced LVEF on repeat echocardiography. Troponin levels and FAR were inversely correlated with reduced LVEF (r = –0.28, p = 0.002 and r = –0.31, p = 0.001, respectively). FAR remained an independent factor after adjustment for age and sex. Neither troponin nor FAR was associated with persistently reduced LVEF on follow-up echocardiography. In addition, high FAR was not correlated with longer length of stay (LOS) (p = 0.07), readmissions (p = 0.29), or complications during hospitalization (p = 0.22).</div></div><div><h3>Conclusion</h3><div>FAR is associated with reduced LVEF and may reflect disease severity in clinically suspected myocarditis; however, it does not appear to be useful for long-term prediction.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101791"},"PeriodicalIF":2.5,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated balloon angioplasty for chronic total coronary occlusions. Blended strategies: the best of two worlds","authors":"Fernando Alfonso ,&nbsp;Bernardo Cortese ,&nbsp;Emmanouil S. Brilakis","doi":"10.1016/j.ijcha.2025.101789","DOIUrl":"10.1016/j.ijcha.2025.101789","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101789"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating artificial intelligence-enabled medical tests in cardiology: Best practice","authors":"Jonas L. Isaksen ,&nbsp;Malene Nørregaard ,&nbsp;Martin Manninger ,&nbsp;Dobromir Dobrev ,&nbsp;Thomas Jespersen ,&nbsp;Ben Hermans ,&nbsp;Jordi Heijman ,&nbsp;Gernot Plank ,&nbsp;Daniel Scherr ,&nbsp;Thomas Pock ,&nbsp;Vajira Thambawita ,&nbsp;Michael A. Riegler ,&nbsp;Jørgen K. Kanters ,&nbsp;Dominik Linz","doi":"10.1016/j.ijcha.2025.101783","DOIUrl":"10.1016/j.ijcha.2025.101783","url":null,"abstract":"<div><div>Machine learning methods are increasingly used in cardiovascular research. In order to highlight opportunities and challenges of the evaluation of studies applying machine learning, we use examples from cardiac electrophysiology, a field characterized by large and often imbalanced amounts of data. We provide recommendations and guidance on evaluating and presenting supervised machine learning studies. We recommend proper cohort selection, keeping training and testing data strictly separate, and comparing results to a reference model without machine learning as basic principles to ensure the quality of studies using machine learning methods. We furthermore recommend specific metrics and plots when reporting on machine learning including on models for multi-channel time series or images. This Best Practice paper represents a possible blueprint to help evaluate machine learning-based medical tests in cardiac electrophysiology and beyond.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101783"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in cardiac sarcoidosis","authors":"Katrina A. Williamson ,&nbsp;Jenna M. Davison ,&nbsp;Andrew N. Rosenbaum ,&nbsp;Panithaya Chareonthaitawee ,&nbsp;Nikhil Kolluri ,&nbsp;John P. Bois ,&nbsp;Omar F Abou Ezzeddine ,&nbsp;John A. Schirger ,&nbsp;Suraj Kapa ,&nbsp;Konstantinos C. Siontis ,&nbsp;Leslie T. Cooper ,&nbsp;Courtney A. Arment","doi":"10.1016/j.ijcha.2025.101777","DOIUrl":"10.1016/j.ijcha.2025.101777","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac sarcoidosis (CS) is an inflammatory cardiomyopathy for which sex differences outcomes are not well described.</div></div><div><h3>Objectives</h3><div>This study aimed to understand differences in CS presentation, complications, and outcomes between females and males.</div></div><div><h3>Methods</h3><div>Patients meeting Japanese Circulation Society or Heart Rhythm Society criteria for CS were evaluated at a single institution from January 1, 1999, to December 31, 2023 (n = 455). Presenting characteristics including demographics, symptoms, conduction abnormalities, arrhythmias and left ventricular ejection fraction (LVEF) between females and males were compared. Sex-based differences in hospitalizations, LVAD implantation, transplantation and death were analyzed.</div></div><div><h3>Results</h3><div>The cohort was mostly male (60.7 %). Females presented at an older age (58.5, IQR 51–65 in females, vs 54, IQR 45–61 in males, <em>p</em> = 0.001), and more females experienced palpitations (46.4 %, <em>p</em> = 0.04), chest pain (34.6 % <em>p</em> = 0.02), and fatigue (53.6 % <em>p</em> = 0.01) at presentation. Females had higher New York Heart Association (NYHA) class (III or IV) (31.5 % vs 21.8 %; <em>p</em> = 0.05), and higher NT-proBNP (467 in females vs 257.5 in males, <em>p</em> = 0.03) at presentation. Cardiovascular hospitalization–free survival, LVAD/transplant-free survival, and overall survival were not significantly different.</div></div><div><h3>Conclusions</h3><div>Females presented at an older age and were more symptomatic with higher NYHA class symptoms than males, suggesting that females are presenting or being diagnosed with CS later than males. LVEF, rates of heart block, and ventricular arrhythmias were similar between sexes, suggesting greater heart failure severity in females with CS may be related to greater left ventricular stiffening or worse valvular disease. Differences in survival outcomes were not significant.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101777"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking early risk stratification in heart failure-related cardiogenic shock","authors":"Ibrahim Akin","doi":"10.1016/j.ijcha.2025.101786","DOIUrl":"10.1016/j.ijcha.2025.101786","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101786"},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of segmental native T1 mapping for diagnosis and risk-stratification in cardiac sarcoidosis","authors":"Hidehiro Iwakawa ,&nbsp;Nobuhiro Suzuki ,&nbsp;Hirokazu Yoshida ,&nbsp;Yohei Sasaki ,&nbsp;Ryosuke Kato ,&nbsp;Ryota Kaimori ,&nbsp;Hiroyuki Watanabe","doi":"10.1016/j.ijcha.2025.101787","DOIUrl":"10.1016/j.ijcha.2025.101787","url":null,"abstract":"<div><h3>Background</h3><div>The clinical utility and optimal analytical approach for native T1 mapping in cardiac sarcoidosis (CS) remain unclear. This study investigated the clinical value of segmental native T1 assessment in patients with CS.</div></div><div><h3>Methods</h3><div>We recruited 55 participants, including 41 patients undergoing diagnostic evaluation of CS and 14 healthy controls. Of the 41 patients, 29 were diagnosed with CS and 12 were classified as non-CS. Segmental cardiac magnetic resonance findings of the left ventricle were evaluated using a 1.5-T scanner. The primary endpoint was a composite of all-cause death, fatal ventricular arrhythmia, bradycardia, or hospitalization for cardiovascular events.</div></div><div><h3>Results</h3><div>Maximum and global native T1 values were significantly higher in CS patients than in healthy controls and non-CS patients. Maximum and global T1 values demonstrated comparable predictive performance in differentiating CS from the other groups, with areas under the curve (AUCs) of 0.92 and 0.90, respectively. The AUC for predicting segments with late gadolinium enhancement (LGE) was highest for extracellular volume, followed by native T1 and T2 (<em>P</em> &lt; 0.05 for all). Patients with six or more segments showing native T1 ≥ 1091 ms had a significantly worse prognosis than those without (55.6 % vs. 18.2 %, <em>P</em> = 0.028).</div></div><div><h3>Conclusions</h3><div>Maximum and global native T1 values were highly predictive for differentiating CS. The high segmental native T1 values in patients with CS may reflect the regional presence of LGE. Segmental native T1 assessment can aid in estimating long-term outcomes.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"61 ","pages":"Article 101787"},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent highlights from the International Journal of Cardiology Heart & Vasculature: cardiometabolic disease","authors":"Florian Bruns ,&nbsp;Hannah Märte ,&nbsp;Dobromir Dobrev ,&nbsp;Anke Fender","doi":"10.1016/j.ijcha.2025.101779","DOIUrl":"10.1016/j.ijcha.2025.101779","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101779"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of surgical repair versus replacement for tricuspid valve endocarditis − A meta-analysis of reconstructed time-to-event data","authors":"Eric Katsuyama ,&nbsp;Christian Fukunaga ,&nbsp;Felipe S. Passos ,&nbsp;Nicole Lee ,&nbsp;Ana Carolina Ventura de Santana de Jesus ,&nbsp;Camila M. Ydy ,&nbsp;Sofia Junqueira Franco Massuda ,&nbsp;Hristo Kirov ,&nbsp;Torsten Doenst ,&nbsp;Tulio Caldonazo","doi":"10.1016/j.ijcha.2025.101782","DOIUrl":"10.1016/j.ijcha.2025.101782","url":null,"abstract":"<div><h3>Introduction</h3><div>Tricuspid valve infective endocarditis (TVIE) is surgically managed by tricuspid valve repair (TVr) or replacement (TVR). However, the differences in long-term endpoints and perioperative complications between the two strategies remain unclear. Therefore, this updated <em>meta</em>-analysis aimed to evaluate the efficacy and safety of TVr compared with TVR.</div></div><div><h3>Methods</h3><div>MEDLINE, EMBASE, Cochrane Library, LILACS, and ClinicalTrials<span><span>.gov</span><svg><path></path></svg></span> were searched. The endpoints of interest were long-term all-cause mortality (primary), any reoperation, reinfection, postoperative stroke, and postoperative acute kidney injury (AKI). Data are reported as hazard ratios (HR) and odds ratios (OR) with their respective 95% confidence intervals (CI).</div></div><div><h3>Results</h3><div>We included 19 retrospective cohorts comprising 9,734 patients, of which 59.7 % received TVr and 74.3 % were intravenous drug users. One study was risk-adjusted. The median age and follow-up were 35.9 years and 3.9 years, respectively. Compared with TVR, TVr was associated with lower long-term mortality (HR: 0.77; 95 %CI: 0.60 to 0.98; P = 0.04) and lower odds of any reoperation (OR: 0.73; 95 %CI: 0.60 to 0.89; P &lt; 0.01), reinfection (OR: 0.40; 95 %CI: 0.19 to 0.86; P = 0.02), and postoperative AKI (OR: 0.79; 95 %CI: 0.68 to 0.92; P &lt; 0.01). No differences were found in postoperative stroke (OR: 1.17; 95 %CI: 0.83 to 1.65; P = 0.41).</div></div><div><h3>Conclusion</h3><div>In this <em>meta</em>-analysis, TVr improved overall survival and reduced postoperative complications in patients with TVIE. A possible treatment allocation bias needs to be considered as a potential concern of series with observational nature.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101782"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac biomarkers for the quantification of myocardial damage after cardiac surgery – The RORSCHACH trial","authors":"Tulio Caldonazo ,&nbsp;Marcus Winter ,&nbsp;Michael Kiehntopf ,&nbsp;René Aschenbach ,&nbsp;Stephanie Gräger ,&nbsp;Sebastian Reinartz ,&nbsp;André Scherag ,&nbsp;Ulrike Schumacher ,&nbsp;Hristo Kirov ,&nbsp;Ulf Teichgräber ,&nbsp;Torsten Doenst ,&nbsp;on behalf of the RORSCHACH Investigators and GermaN HeaRTS","doi":"10.1016/j.ijcha.2025.101781","DOIUrl":"10.1016/j.ijcha.2025.101781","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac biomarkers are important components for diagnosing perioperative myocardial infarction (MI). Efforts to detect MI by biomarker-release only faced heavy criticism, because cardiac biomarker-release has also been observed in situations that are not always related to cell death (e.g., renal insufficiency, neurological diseases, and even after endurance exercise). This study correlates release patterns of all three classically used cardiac injury biomarkers (CK/CK-MB, Troponin T and I) with myocardial damage visualized by late gadolinium enhanced cardiac magnetic resonance imaging (LGE-cMRI) and also compares biomarkers among each other.</div></div><div><h3>Methods and analysis</h3><div>The RORSCHACH study is a prospective, multicenter, single-armed, non-blinded, non-controlled study evaluating cardiac biomarker release during elective aortic or mitral valve surgery and their correlation to perioperative myocardial damage as detected by MRI. Enrolled patients undergo routine monitoring including echocardiography, electrocardiography, cardiac biomarker analyses, and clinical symptom assessment preoperatively (within 24 h prior to surgery) and postoperative at predefined timepoints. LGE-cMRI is performed preoperatively and at least 5 days after surgery to clinically quantify any new myocardial damage. In total, 100 patients will be enrolled, whereby a drop-out rate of 15 % subsequently results in 85 patients necessary for final analysis. The primary endpoint is the correlation of the peak value of the respective biomarker with the amount of perioperatively induced myocardial damage quantified by LGE-cMRI.</div></div><div><h3>Discussion</h3><div>The RORSCHACH trial will deliver the first comparative and quantitative information on the predictive value of the three classic cardiac injury markers used for the detection of new perioperative irreversible injury/MI in cardiac surgery.</div></div><div><h3>Study registration</h3><div><span><span>Clinicaltrials.gov</span><svg><path></path></svg></span>. NCT06066970. Registered on September 28th 2023.</div></div>","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101781"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent highlights from the International Journal of Cardiology Heart and Vasculature: cardio-oncology","authors":"Anke Fender ,&nbsp;Florian Bruns ,&nbsp;Dobromir Dobrev","doi":"10.1016/j.ijcha.2025.101780","DOIUrl":"10.1016/j.ijcha.2025.101780","url":null,"abstract":"","PeriodicalId":38026,"journal":{"name":"IJC Heart and Vasculature","volume":"60 ","pages":"Article 101780"},"PeriodicalIF":2.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}