Relationship between baseline right ventricular systolic function and left ventricular recovery at six-months of follow up among women with peripartum cardiomyopathy in Uganda

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2025-09-07 DOI:10.1016/j.ijcha.2025.101788

Juliet Nabbaale , Emmy Okello , Annettee Nakimuli , Graham Chakafana , Karen Sliwa

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引用次数: 0

Abstract

Background

LV recovery in Peripartum Cardiomyopathy (PPCM) depends on several baseline factors including left ventricular ejection fraction (LVEF), LV end-diastolic diameter (LVEDD), duration of symptoms. The role baseline RV function in LV recovery remains poorly described. This study sought to determine the relationship between baseline RV systolic function and LV recovery at six-months follow up among women with PPCM in Uganda.

Methods

Prospective cohort study of 80 PPCM cases and 80 healthy matched controls observed over a 6-month period while on goal-directed medical therapy (GDMT). All enrolled participants had a 12-lead electrocardiography, echocardiography at baseline and at 6-months follow-up for assessment of LV systolic function using LV global longitudinal strain (LV GLS) and LV EF whereas RV systolic function was assessed using; fractional area change (FAC), tricuspid annular plane excursion (TAPSE), RV lateral wall S’ (RV S’), fractional wall strain (FWS) and RV global longitudinal strain (RV GLS).

Results

The mean data of cases included age of 33.6 ± 6.6 years, LVEF 35.7 ± 11.0 %, LV GLS −11.9 ± 4.7 % and RV GLS −14.7 ± 10.9 %, RV FAC 32.9 ± 13.5 %, Lat S’ 10.6 ± 3.0 cm/s and RV FWS −17.1 ± 7.2 %. LV recovery occurred among 46.3 % cases. Factors which predicted LV recovery included heart rate and LVEDD.

Conclusion

Under half of PPCM cases had LV recovery at six-months on GDMT and Bromocriptine. Baseline heart rate and LVEDD predicted LV recovery.

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乌干达围产期心肌病妇女随访6个月时基线右心室收缩功能与左心室恢复的关系

背景围产期心肌病（PPCM）的左室恢复取决于几个基线因素，包括左室射血分数（LVEF）、左室舒张末期内径（LVEDD）、症状持续时间。基线RV功能在左室恢复中的作用仍然描述不清。本研究旨在确定基线左室收缩功能与6个月随访时乌干达PPCM妇女左室恢复之间的关系。方法对80例PPCM病例和80例健康对照进行前瞻性队列研究，观察了6个月的目标导向药物治疗（GDMT）。所有入组的参与者在基线和随访6个月时进行12导联心电图、超声心动图检查，使用左室总纵应变（LV GLS）和左室EF评估左室收缩功能，而左室收缩功能评估使用；分数面积变化（FAC）、三尖瓣环形平面偏移（TAPSE）、RV侧壁S′（RV S′）、分数壁应变（FWS）和RV整体纵向应变（RV GLS）。结果患者平均年龄为33.6±6.6岁，LVEF为35.7±11.0%，lgls为- 11.9±4.7%，lgls为- 14.7±10.9%，lfac为32.9±13.5%，Lat S为10.6±3.0 cm/ S， rvfws为- 17.1±7.2%。46.3%的患者出现左室恢复。预测左室恢复的因素包括心率和LVEDD。结论经GDMT和溴隐亭治疗6个月后，不到一半的PPCM患者左室恢复。基线心率和LVEDD预测左室恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.