Obesity Medicine最新文献_第8页

Expansive research on obesity findings regarding weight-related symptoms 关于肥胖症的大量研究发现与体重有关的症状

Obesity Medicine Pub Date : 2024-02-04 DOI: 10.1016/j.obmed.2024.100534

Ahmed Ghani

引用次数: 0

Revolutionizing diabetic wound healing: Targeted therapeutic strategies based on growth factors 糖尿病伤口愈合的革命：基于生长因子的靶向治疗策略

Obesity Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.obmed.2024.100535

Jagat Pal Yadav, Dinesh Kumar Patel, Amita Verma, Prateek Pathak

引用次数: 0

The effects of HCMV seropositivity and BMI degree on T cell immunophenotype in adults 成人 HCMV 血清阳性率和体重指数对 T 细胞免疫表型的影响

Obesity Medicine Pub Date : 2024-01-11 DOI: 10.1016/j.obmed.2024.100531

Diego Del Duca Lima , Gilson Pires Dorneles , Joane Severo Ribeiro , Alisson Felipe Haubert , Pedro Roosevelt Torres Romão , Alessandra Peres , Luiz Carlos Rodrigues Junior

{"title":"The effects of HCMV seropositivity and BMI degree on T cell immunophenotype in adults","authors":"Diego Del Duca Lima , Gilson Pires Dorneles , Joane Severo Ribeiro , Alisson Felipe Haubert , Pedro Roosevelt Torres Romão , Alessandra Peres , Luiz Carlos Rodrigues Junior","doi":"10.1016/j.obmed.2024.100531","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100531","url":null,"abstract":"<div><h3>Aim</h3><p>Human Cytomegalovirus<span> (HCMV) is a latent virus<span> widely spread in the human population. Obesity and HCMV infection are associated with immunological changes in T lymphocytes. This study aimed to evaluate if the association between overweight/obesity and HCMV infection would influence populations of peripheral blood T lymphocytes.</span></span></p></div><div><h3>Methods</h3><p>Plasma and peripheral mononuclear cells<span><span><span><span> were isolated from 111 individuals. The biochemical markers and anti-HCMV IgG were quantified in the plasma. The individuals were classified as eutrophic, overweight or obese, based on their </span>body mass index. The </span>lymphocyte populations </span>helper T cells<span><span>, cytotoxic T cells, memory </span>T regulatory cells<span>, memory effector T cells, early differentiated effector memory cytotoxic T cells, and terminally differentiated effector memory cytotoxic T cells were quantified by flow cytometry.</span></span></span></p></div><div><h3>Results</h3><p>Approximately half of the individuals studied (46.5%) were seropositive for HCMV, of which 14.1% were eutrophic, 8.1% overweight, and 24.32% were obese. The results showed a substantial reduction in the CD4:CD8 ratio in patients with overweight or obesity, and an increase in the circulating terminally differentiated effector memory cytotoxic T cells, both associated with HCMV positive serology.</p></div><div><h3>Conclusions</h3><p>HCMV infection, when associated with weight gain contributes to the profile of immunological senescence mediated by an increase in the number of circulating terminally differentiated cytotoxic T cells.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"46 ","pages":"Article 100531"},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide-1 receptor agonists for post-bariatric surgery weight regain and insufficient weight loss: A systematic review 胰高血糖素样肽-1 受体激动剂用于治疗减肥手术后体重反弹和体重减轻不足：系统综述

Obesity Medicine Pub Date : 2024-01-09 DOI: 10.1016/j.obmed.2024.100533

Kevin Gracia Pratama , Heri Nugroho , Antoninus Hengky , Malvin Tandry , Pauliana Pauliana

{"title":"Glucagon-like peptide-1 receptor agonists for post-bariatric surgery weight regain and insufficient weight loss: A systematic review","authors":"Kevin Gracia Pratama , Heri Nugroho , Antoninus Hengky , Malvin Tandry , Pauliana Pauliana","doi":"10.1016/j.obmed.2024.100533","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100533","url":null,"abstract":"<div><h3>Aim</h3><p>The rising prevalence of obesity has elevated it to a significant public health<span> concern. Bariatric surgery<span> (BS) has emerged as a promising solution for severe obesity and associated complications, surpassing traditional approaches. Nonetheless, the escalating utilization of BS has given rise to novel challenges, namely weight regain (WR) and insufficient weight loss (IWL). Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have surfaced as a promising therapeutic avenue. Recognizing the potential of GLP-1 RAs in addressing relapse among individuals who have undergone BS is imperative for enhancing patient outcomes.</span></span></p></div><div><h3>Materials and methods</h3><p>A comprehensive systematic review was undertaken by searching through databases including PUBMED, EBSCO, ProQuest, and manual exploration, following the PRISMA 2020 guideline. Included were studies that examined the application of GLP-1RAs in individuals who had undergone BS and encountered WR and IWL.</p></div><div><h3>Results</h3><p><span>This review encompassed 10 studies, all of which demonstrated consistent findings. Irrespective of the diversity in surgical methods, a range of total weight loss (TWL) outcomes were observed. Both primary and revisional surgeries exhibited reductions in </span>body mass index (BMI); emphasizing the overall efficacy of GLP-1 RAs. The collective evidence consistently highlighted the effectiveness and safety of GLP-1RAs in managing post-bariatric weight concerns.</p></div><div><h3>Conclusions</h3><p><span>Based on current evidence, GLP-1 RA is a safe and effective treatment for post-BS WR and IWL. However, comparison studies using cohort or </span>randomized controlled trials are needed to confirm its effect.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"46 ","pages":"Article 100533"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139435769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological impact of obesity: A comprehensive analysis of health-related quality of life and weight-related symptoms 肥胖的心理影响：对健康相关生活质量和体重相关症状的综合分析

Obesity Medicine Pub Date : 2023-12-14 DOI: 10.1016/j.obmed.2023.100530

Iren Jaison K , Hiba Asharaf , Gitty Thimothy , Shreya George , Jeswin Jose , Rekha Paily , Jilbi Josey , S.J. Sajna , Rahul Radhakrishnan

{"title":"Psychological impact of obesity: A comprehensive analysis of health-related quality of life and weight-related symptoms","authors":"Iren Jaison K , Hiba Asharaf , Gitty Thimothy , Shreya George , Jeswin Jose , Rekha Paily , Jilbi Josey , S.J. Sajna , Rahul Radhakrishnan","doi":"10.1016/j.obmed.2023.100530","DOIUrl":"https://doi.org/10.1016/j.obmed.2023.100530","url":null,"abstract":"<div><h3>Background</h3><p>Obesity has devastating impacts on both physical and mental health and has emerged as a major global health concern. This cross-sectional study aimed to assess the impact of obesity on various health outcomes and to measure the health-related quality of life (HRQoL) of obese population.</p></div><div><h3>Methods</h3><p>For the study, 207 adult individuals who had a body mass index<span> (BMI) of 30 kg/m2 or greater were chosen from a tertiary care hospital. The Weight-Related Symptom Measure (WRSM), the Depression, Anxiety, and Stress Scale 21 (DASS21), and the Obesity Weight Loss-Quality of Life (OWL-QOL) questionnaires were given to the study participants. The correlation between obesity and the relevant factors was evaluated using Pearson correlation coefficients.</span></p></div><div><h3>Results</h3><p>The findings showed a strong correlation between obesity and weight-related symptoms such fatigue, joint pain<span>, back pain, shortness of breath, overeating behaviours, and irritability. Furthermore, obesity and HRQoL showed a strong inverse connection, suggesting individuals with higher BMI experienced a lower level of quality of life. The assessment of psychological factors revealed a strong correlation between obesity and a higher prevalence of stress, anxiety, and depressive symptoms.</span></p></div><div><h3>Conclusion</h3><p>The study emphasises the intricate interactions between obesity, weight related symptoms, HRQoL, and mental health. The physical and psychological effects of obesity should be addressed by healthcare professionals using a comprehensive strategy. Tailored interventions, early prevention, and targeted management strategies for vulnerable subgroups are essential to enhance the overall well-being and mental health of obese individuals.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"45 ","pages":"Article 100530"},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight regain after bariatric surgery: A systematic review and meta-analysis of observational studies 减肥手术后体重反弹：观察性研究的系统回顾和荟萃分析

Obesity Medicine Pub Date : 2023-12-06 DOI: 10.1016/j.obmed.2023.100528

Marcela Gomes Reis , Luíz Felipe Guimarães G. Moreira , Luiza Siqueira Veloso de Andrade Carvalho , Caroline Tianeze de Castro , Renata Adrielle Lima Vieira , Nathalia Sernizon Guimarães

{"title":"Weight regain after bariatric surgery: A systematic review and meta-analysis of observational studies","authors":"Marcela Gomes Reis , Luíz Felipe Guimarães G. Moreira , Luiza Siqueira Veloso de Andrade Carvalho , Caroline Tianeze de Castro , Renata Adrielle Lima Vieira , Nathalia Sernizon Guimarães","doi":"10.1016/j.obmed.2023.100528","DOIUrl":"10.1016/j.obmed.2023.100528","url":null,"abstract":"<div><p><span>Due to its significant impact on public health<span><span>, obesity has been studied from a variety of perspectives. All surgical procedures of bariatric and metabolic surgeries (BMS) carry their risks and benefits and have specific characteristics. Considering that weight regain (WR) is considered a surgical failure. This </span>systematic review, registered on PROSPERO under code CRD42023421203, aims to identify physical and behavioral predictors associated with WR post-BMS. Primary outcomes included WR prevalence after BMS (>10% recovery from maximum weight loss or points of BMI >4 or 5 kg/m</span></span><sup>2</sup><span>), while secondary outcomes assessed factors associated with WR. This systematic review with meta-analysis demonstrated that 49% of patients WR after BMS and this prevalence is higher in those who underwent Roux-en-Y Gastric Bypass (RYGB) surgery (42%) and in Europe (64%). Protective factors for WR only included prior BMI and younger age with statistical significance, however other analyzes did not demonstrate statistical significance. Therefore, it is important to note that the use of BMS does not guarantee long-term sustainable weight loss without continuous lifestyle modifications and treatment dietetic. Efforts to maintain weight loss should include ongoing lifestyle modifications to ensure the effectiveness and efficacy of the surgery.</span></p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"45 ","pages":"Article 100528"},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138624612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of Glycyrrhiza Glabra extract in high-fat diet-induced obese male mice: A controlled experimental study 甘草提取物对高脂饮食诱导的肥胖雄性小鼠的作用:一项对照实验研究

Obesity Medicine Pub Date : 2023-12-01 DOI: 10.1016/j.obmed.2023.100525

Tin Hoang Nguyen , Hung Huynh Vinh Ly , Tien Minh Nguyen , Tien Thi Diem Le , Thu Minh Phung , Reza Nejatbakhsh , Kien Trung Nguyen , Tam Thai Thanh Tran

{"title":"The effects of Glycyrrhiza Glabra extract in high-fat diet-induced obese male mice: A controlled experimental study","authors":"Tin Hoang Nguyen , Hung Huynh Vinh Ly , Tien Minh Nguyen , Tien Thi Diem Le , Thu Minh Phung , Reza Nejatbakhsh , Kien Trung Nguyen , Tam Thai Thanh Tran","doi":"10.1016/j.obmed.2023.100525","DOIUrl":"https://doi.org/10.1016/j.obmed.2023.100525","url":null,"abstract":"<div><h3>Aims</h3><p>This study sought to evaluate anti-obesity effects, improved metabolic function, and spermatogenesis<span> of Licorice root extract at doses of 343 mg/kg and 686 mg/kg.</span></p></div><div><h3>Methods</h3><p><span>This was a controlled experimental, descriptive cross-sectional, longitudinal study follow-up over 10 weeks of nourishment. We generated an obesity model in white mice (Swiss albino) in 6 weeks with a high-fat diet (52–53% lipid, 610 Kcal/100g). Besides, the hydroethanolic extract of </span><span><em>Radix Glycyrrhizae</em></span> (RG) was prepared. Then, we divided mice into 4 groups (NFD, HFD, RG343, RG686) with 12 mice/group. We followed morphological indices, metabolic function, and spermatogenesis after 4 weeks of taking this extract.</p></div><div><h3>Results</h3><p>Following the intervention, mice exhibited reduced weight, weight gain, BMI<span><span><span><span>, and waist circumference. However, there was no difference between the 2 doses. Moreover, blood glucose, </span>visceral fat mass, total cholesterol, and LDL-c levels of mice after the intervention were lower. Furthermore, there was a clear difference between the two doses. After the intervention, mice had larger </span>penis<span>, testes, </span></span>epididymis<span>, and seminal vesicle diameters and improved semen parameters, noting the difference between the two doses.</span></span></p></div><div><h3>Conclusion</h3><p>Licorice root extract helps to reduce weight, BMI, and visceral fat and improve metabolic function and spermatogenesis of obese mice. Significantly, the dose of 686 mg/kg was more effective than the dose of 343 mg/kg.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"44 ","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138484265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends of nonalcoholic fatty liver research in Southeast Asia from 2004 to 2022: A bibliometric analysis 2004 至 2022 年东南亚非酒精性脂肪肝研究趋势：文献计量分析

Obesity Medicine Pub Date : 2023-11-28 DOI: 10.1016/j.obmed.2023.100527

Vivien Joyce D. Josol , Paul Benedic U. Salvador , Linnaeus Louisse A. Cruz , Eric David B. Ornos , Ourlad Alzeus G. Tantengco

{"title":"Trends of nonalcoholic fatty liver research in Southeast Asia from 2004 to 2022: A bibliometric analysis","authors":"Vivien Joyce D. Josol , Paul Benedic U. Salvador , Linnaeus Louisse A. Cruz , Eric David B. Ornos , Ourlad Alzeus G. Tantengco","doi":"10.1016/j.obmed.2023.100527","DOIUrl":"https://doi.org/10.1016/j.obmed.2023.100527","url":null,"abstract":"<div><p>With a 25–30% prevalence worldwide, the burden of nonalcoholic fatty liver disease<span> (NAFLD) continues to increase. Southeast Asia has the greatest prevalence of NAFLD in Asia, estimated to be 29% overall. This paper aims to determine the characteristics and trends of published NAFLD studies in SEA countries. We systematically reviewed the literature using the Scopus database and obtained pertinent bibliographic and citation information. Visualization of collaboration networks of countries and keywords related to NAFLD was conducted using VOSviewer software. This bibliometric analysis shows that research on NAFLD is increasing in SEA but varies among countries. Singapore is the most productive country in NAFLD research, followed by Malaysia and Thailand. The majority of papers were published in journals based outside Asia. The study's emergent themes include probiotics<span>, epigenetics<span>, cardiovascular disease, diagnostics, treatment, genetics-related risk factors, and comorbidities. Research productivity in NAFLD and collaborations vary within and outside the region among different countries and is influenced by socioeconomic factors.</span></span></span></p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"45 ","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood obesity in Mexico: A constant struggle and reflection for its prevention on the influence of family and social habits 墨西哥儿童肥胖:家庭和社会习惯影响下预防儿童肥胖的持续斗争与反思

Obesity Medicine Pub Date : 2023-11-21 DOI: 10.1016/j.obmed.2023.100521

Gilberto Mercado-Mercado

{"title":"Childhood obesity in Mexico: A constant struggle and reflection for its prevention on the influence of family and social habits","authors":"Gilberto Mercado-Mercado","doi":"10.1016/j.obmed.2023.100521","DOIUrl":"https://doi.org/10.1016/j.obmed.2023.100521","url":null,"abstract":"<div><p><span>The rate of childhood obesity is a </span>public health<span><span> problem and has increased dramatically in recent decades in most Latin American countries, mainly in Mexico. The different causal factors of the disease are an unhealthy diet<span> based on ultra-processed and easily consumed foods, the environment, socioeconomic status, culture, eating patterns, sedentary lifestyles, insufficient sleep, social prejudice, environmental chemical pollutants<span>, reduced physical activity and the media. The latter exert great pressure to consume more and more industrial foods, which is contributing to aggravate the childhood obesity epidemic existing today in our society. This review presents an analysis of the effect of the different factors related to childhood obesity and shows an acceleration in its prevalence, which could reflect the result of the neglect of prevention programs and methodological deficiencies not yet identified by government authorities. This is important from the point of view of the challenges that Mexican </span></span></span>health systems will face in the next generations. In conclusion, Mexico presents alarming obesity rates in children.</span></p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"44 ","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138423632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian dinner timing and BMI among adults in a Brazilian national survey 巴西国家调查中成年人的昼夜晚餐时间和身体质量指数

Obesity Medicine Pub Date : 2023-11-21 DOI: 10.1016/j.obmed.2023.100526

Anny Kariny Pereira Pedrosa , Márcia de Oliveira Lima , Priscilla Márcia Bezerra de Oliveira , Renan Serenini , Risia Cristina Egito de Menezes , Giovana Longo-Silva

{"title":"Circadian dinner timing and BMI among adults in a Brazilian national survey","authors":"Anny Kariny Pereira Pedrosa , Márcia de Oliveira Lima , Priscilla Márcia Bezerra de Oliveira , Renan Serenini , Risia Cristina Egito de Menezes , Giovana Longo-Silva","doi":"10.1016/j.obmed.2023.100526","DOIUrl":"https://doi.org/10.1016/j.obmed.2023.100526","url":null,"abstract":"<div><h3>Aims</h3><p>To examine if the Time elapsed between Dinner and the Midpoint of sleep (TDM) is associated with BMI and obesity.</p></div><div><h3>Methods</h3><p><span>Participants (n = 1303) were part of a virtual exploratory, population-based survey. To evaluate differences in BMI associated with TDM we performed linear and quantile regression analyses. </span>Logistic regression models were fitted to assess ORs (95%CI) of obesity associated with TDM. Restricted cubic splines were also used to study the shape of the association.</p></div><div><h3>Results</h3><p>We found a dose-response association between TDM and BMI, which decreased by 0.22 kg/m<sup>2</sup><span> for each additional hour of TDM, with stronger and higher effects in the highest percentile of BMI. By increasing TDM, the odds of obesity decreased [OR (95%CI):0.87 (0.78,0.97); P = 0.01]. These associations were independent of age, gender, marital status, weekly duration of physical activity, and the largest meal of the day.</span></p></div><div><h3>Conclusions</h3><p><span>Because we found that having dinner farther from the midpoint of sleep was significantly associated with BMI, our data reflect the pertinence of assessing the circadian meal timing, along with the energy intake and the quality of meals, in nutritional recommendations and </span>obesity prevention<span> and treatment.</span></p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"44 ","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138439370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0