Obesity Medicine最新文献

{"title":"Association of glucose-6-phosphate dehydrogenase (G6PD) expression and obesity: A systematized review","authors":"Esphie Grace Fojas ,&nbsp;Nader Lessan ,&nbsp;Mary Anne Chiong ,&nbsp;Roozbeh Naemi","doi":"10.1016/j.obmed.2024.100546","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100546","url":null,"abstract":"<div><p>Several studies have associated glucose-6-phosphate dehydrogenase (G6PD) overexpression with obesity due to its roles in proinflammatory signalling. However, a systematic review has not been reported to synthesize and evaluate the findings. This is a systematized, scoping review on the recent 10-year publications for all species, and all-time studies in humans on the associations of G6PD with obesity. Systematized electronic searches on Pubmed and Medline for all studies from April 2011 to April 2021 were performed; Pubmed was searched for all human studies. The eighteen human studies since the 1960s to date reported ambiguous, conflicting outcomes on the association of G6PD expression and weight regulation. Over the last ten years, however, the ten included reports for all species, which were primarily mice studies, all suggested that G6PD activity or level is increased in the obese. In the same way, G6PD deficiency has been linked with insulin resistance amelioration and weight gain reduction due to opposing mechanisms. In line with this, four of the included studies were diet inclusion or pharmacotherapeutic interventions to suppress G6PD activity, hence weight gain and obesity. Further investigations, particularly on pharmacotherapeutic applications on the roles of G6PD on obesity are needed.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"48 ","pages":"Article 100546"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of liraglutide in pediatric obesity: A review of clinical trial data","authors":"Marcello Agosta ,&nbsp;Maria Sofia ,&nbsp;Salvatore Pezzino ,&nbsp;Sara D'Amato ,&nbsp;Giorgia Litrico ,&nbsp;Chiara Mazzone ,&nbsp;Gaetano La Greca ,&nbsp;Saverio Latteri","doi":"10.1016/j.obmed.2024.100545","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100545","url":null,"abstract":"<div><p>Pediatric obesity is steadily increasing, and reaching alarming levels; for this reason, effective interventions are necessary to fight this global health challenge. First-line treatments based on diet and exercise may be ineffective, resulting in common weight regain. Therefore, second and third-line alternatives are necessary in current therapies to address even the most difficult cases. Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, used in the past only in the treatment of diabetes, has shown promising results also in the treatment of obesity in adults. This review aims to explore the potential of liraglutide as a therapeutic option for pediatric obesity, focusing on its mechanism of action, safety profile, and efficacy in clinical trials. Additionally, this review discusses the challenges and opportunities associated with liraglutide's use in the pediatric population, such as bariatric surgery.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"48 ","pages":"Article 100545"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451847624000150/pdfft?md5=85a3927809097fb3425e3fe0869f2de9&pid=1-s2.0-S2451847624000150-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methanolic extract of Merremia emarginata (Burm. f.) Hallier f. attenuates renal damage in streptozotocin-induced diabetic nephropathy in rats","authors":"Reema Mitra ,&nbsp;Payal Mittal ,&nbsp;Pradeep Goyal","doi":"10.1016/j.obmed.2024.100544","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100544","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Merremia emarginata</em> (syn: <em>Ipomoea reniformis</em>) is used by the traditional healers of the Tirunelveli district of Tamil Nadu and Nelliampathy hills of Kerala for the treatment of diabetes. It contains important phytoconstituents like scopoletin, quercetin, and kaempferol and is reported to have pharmacological activities like antidiabetic antioxidant, antihyperlipidemic, ACE inhibitory, and hypotensive. Diabetic kidney disease is a common microvascular complication seen in patients with long-term diabetes. This study aimed to investigate the efficacy of <em>Merremia emarginata</em> in attenuating diabetic kidney disease.</p></div><div><h3>Materials and methods</h3><p>Diabetes was induced by a single i.p. injection of 55 mg/kg streptozotocin (STZ). The animals were divided into seven groups with six rats in the control group and seven each in the STZ, STZ + Standard drug Ramipril (STD), STZ + Low dose (LD) methanolic extract of <em>Merremia emarginata</em> (MEME), STZ + High dose (HD) MEME, STZ + STD + LD, and STZ + STD + HD groups. The renal function was assessed by estimating various parameters viz, blood glucose, serum and urine creatinine, urine albumin, blood urea nitrogen (BUN), glycosylated haemoglobin (HbA1c) levels, oxidative stress, and kidney hypertrophy.</p></div><div><h3>Results</h3><p>Treatment with Ramipril and HD MEME showed a decrease in blood glucose levels, urine albumin, a decrease in serum creatinine, an increase in urine creatinine, a decrease in BUN, HbA1c, kidney hypertrophy, and oxidative stress. The combination treatment of Ramipril and HD MEME showed a synergistic effect.</p></div><div><h3>Conclusion</h3><p>The study revealed that MEME attenuates diabetic nephropathy and has the potential to be used in diabetic nephropathy either alone or as an adjuvant.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"48 ","pages":"Article 100544"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific association of physical activity on visceral obesity: Cross-sectional study","authors":"Hana Moon,&nbsp;Yoon Jeong Cho,&nbsp;Yun-A Kim,&nbsp;Min Jeong Ju","doi":"10.1016/j.obmed.2024.100542","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100542","url":null,"abstract":"<div><h3>Aims</h3><p>Obesity is a chronic disease that needs to be managed worldwide. High-intensity physical activity has a positive effect on the improvement and prevention of metabolic diseases. The purpose of this study was to investigate the age-specific association of physical activity on abdominal and visceral obesity.</p></div><div><h3>Methods</h3><p>The study involved 456 health check-up participants who underwent abdominal computed tomography scans for the assessment of visceral fat area from January 2017 to December 2017. Physical activity levels were categorized as none-to-low-intensity or moderate-to-vigorous-intensity based on the International Physical Activity Questionnaire. Logistic regression analysis, adjusted for covariates, assessed the association of physical activity with abdominal and visceral obesity across 10-year age intervals.</p></div><div><h3>Results</h3><p>The moderate-to-vigorous physical activity group showed 56.5% visceral obesity, while the none-to-low-intensity physical activity group had 63.2%. Most age groups exhibited no significant differences in abdominal or visceral obesity according to physical activity. However, the 50 to 59 age group demonstrated a noteworthy association between visceral obesity and none-to-low-intensity physical activity (odds ratio 3.79, 95% confidence interval 1.12–12.84).</p></div><div><h3>Conclusions</h3><p>This study highlights a distinct age-related response to physical activity, emphasizing the 50 to 59 age group's significant association between visceral obesity and none-to-low-intensity physical activity.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"48 ","pages":"Article 100542"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in therapeutic interventions of polycystic ovarian syndrome","authors":"Sakshi Upendra Lad,&nbsp;Ganesh Sunil Vyas,&nbsp;Sharfuddin Mohd,&nbsp;Vijay Mishra,&nbsp;Sheetu Wadhwa,&nbsp;Saurabh Singh,&nbsp;Vancha Harish","doi":"10.1016/j.obmed.2024.100543","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100543","url":null,"abstract":"<div><p>Polycystic Ovarian Syndrome (PCOS) is a severe infertility-causing disorder rapidly affecting females of reproductive age. It is a multifaceted disorder related to the endocrine system and manifests indicators such as hyperandrogenism, anovulation, and polycystic ovaries. Other prominent characteristics include obesity, metabolic syndrome, irregular menstrual cycles, diabetes mellitus, infertility, hirsutism, acne, endometrial cancer, and cardiovascular disease. The etiopathogenesis of PCOS is not fully understood, but non-Mendelian inheritance is considered a major cause due to genetic complexity. Conventional treatments typically target individual symptoms, sometimes leading to contraindications and numerous side effects, often resulting in less effective outcomes. However, effective surgical methods recommended by professionals include Bariatric Surgery, as well as Complementary and Alternative Medicine based approaches like Moxibustion, acupuncture utilized in clinical practice, aiding patients in regaining a healthy lifestyle. Emerging approaches, such as nanotechnology-based therapies, hold promise for addressing PCOS and its related conditions simultaneously. Nanotechnology-based delivery systems possess unique properties that may enhance bioavailability and therapeutic responses. Phytochemicals represent potential futuristic candidates with multifaceted effects in managing the disease, particularly when effectively delivered through nanoparticles. In this review different aspects of therapeutic interventions are discussed thoroughly and it also highlights the challenges associated with treating PCOS, discussing various treatment options available alongside future directions.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"48 ","pages":"Article 100543"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140534952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between television viewing frequency and anthropometric indices among Peruvian women: Evidence from the 2019 demographic health survey","authors":"Raysa M. Benito-Vargas ,&nbsp;Abraham De-Los-Rios-Pinto ,&nbsp;Brenda Caira-Chuquineyra ,&nbsp;Daniel Fernandez-Guzman ,&nbsp;Carlos J. Toro-Huamanchumo","doi":"10.1016/j.obmed.2024.100541","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100541","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to evaluate the association between television viewing frequency and anthropometric indices in Peruvian women aged 15–49 years.</p></div><div><h3>Methods</h3><p>A secondary analysis of the 2019 Demographic and Family Health Survey of Peru was conducted. Anthropometric measures related to increased cardio-metabolic risk, including body mass index (BMI), waist circumference (WC), Waist to Height Ratio (WHtR), and Conicity Index (CnI), were evaluated as outcomes. Television viewing frequency during a typical week (never [0 times per month]; occasionally [1 to 3 times per month]; and frequently [≥1 time per week]) was the exposure variable. Ordinal logistic regression analysis was performed considering confounding values as age, education level, current employment status, wealth index, residence area, region of residence, and current smoking status.</p></div><div><h3>Results</h3><p>A total of 13,249 women aged 15–49 years were included in the analysis. The prevalence of overweight and obesity was 39.3% and 25.0%, respectively. Watching television frequently increased the odds of being overweight or obese (aOR: 1.51; 95% CI: 1.07 to 2.12; p = 0.019), as well as having higher tertiles for WC (aOR: 1.57; 95% CI: 1.12 to 2.20; p = 0.008), WHtR (aOR: 1.59, 95% CI: 1.12 to 2.26; p = 0.010), and CnI (aOR: 1.47, 95% CI: 1.04 to 2.09; p = 0.031), compared to those who never watched television.</p></div><div><h3>Conclusions</h3><p>A higher television viewing frequency was associated with obesity and increased values of WC, WHtR, and CnI. These insights underscore the potential impact of television habits on weight-related outcomes and provide valuable considerations for public health initiatives.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"47 ","pages":"Article 100541"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and quantification of double-stranded DNA breaks in blood lymphocytes by detection of γ-H2AX foci during a body mass increase","authors":"Yerlan Bazargaliyev ,&nbsp;Khatimya Kudabayeva ,&nbsp;Azhar Zhexenova ,&nbsp;Altyn Almagambetova ,&nbsp;Yuliya Zame","doi":"10.1016/j.obmed.2024.100540","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100540","url":null,"abstract":"<div><p>The research aims to investigate the relationship of body mass index indicators on the appearance and nature of damage to the genetic material of lymphocyte cells in patients with diagnosed obesity without concomitant pathological conditions. The research methods included anthropometry, biochemical blood examination, immunofluorescence analysis, and static data processing. Characterization of nuclear damage was assessed by studying the phosphorylated histone protein γ-H2AX loci in circulating lymphocytes (computational tool – AKLIDES). The study sample comprised 235 adult patients, categorized into four groups based on body mass index, with randomization conducted for age and sex matching between the groups. BMI increased with higher degrees of obesity. DNA damage in lymphocytes showed significant differences among groups, particularly in overweight patients. Correlations between BMI and various DNA damage indices suggest a relationship between body weight and genetic material breakage in circulating lymphocytes. The analysis of the data revealed that the number of deoxyribonucleic acid double-strand breaks per lymphocyte as well as the number of nuclei with break foci and the break diameter itself correlated with the body mass index and in some cases with the waist/hip index as well as the waist/height index. The results of the work can be used to improve treatment protocols for obese patients, as well as implemented in preventive programs to prevent the development of overweight and type 2 diabetes mellitus.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"47 ","pages":"Article 100540"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140069362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermittent fasting on blood pressure, serum lipid profile and glucose – A review of clinical and experimental evidence.","authors":"Siti Qusyasyiah Ahmad Suhaimi ,&nbsp;Siti Safiah Mokhtar ,&nbsp;Aida Hanum G Rasool","doi":"10.1016/j.obmed.2024.100539","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100539","url":null,"abstract":"<div><p>Cardiovascular disease (CVD) is the leading cause of death worldwide. Lifestyle modification is at the forefront of CVD disease prevention. Lifestyle modification includes taking steps to increase physical activity and practising a healthy, balanced diet to lower risk factors for developing CVD. Intermittent fasting (IF) has increasingly become popular among subjects wanting to lose weight and maintain a healthy weight; it has also been reported to be associated with other health benefits as well. IF is an eating plan that alternates between fasting and eating on a regular schedule. Although there are no large, randomised controlled trials directly addressing intermittent fasting and cardiovascular outcomes, existing clinical and animal research suggest that IF may reduce the risk of CVD by improving cardiovascular risk factors. This review aims to introduce the topic of intermittent fasting and examine the effects of IF on CVD risk factors specifically effects on serum lipid profile, blood pressure and blood glucose levels. Results from clinical and animal studies on these risk factors will be reviewed.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"47 ","pages":"Article 100539"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the significance of adipose tissue in the inflammatory response to COVID-19","authors":"Sevde Nur Emir ,&nbsp;Servet Emir ,&nbsp;Safiye Sanem Dereli Bulut ,&nbsp;Sema Basat","doi":"10.1016/j.obmed.2024.100538","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100538","url":null,"abstract":"<div><h3>Aim</h3><p>Abdominal adipose tissue is closely related to inflammatory parameters. During the Coronavirus disease (COVID-19) pandemic, inflammatory markers determined the prognosis of the patients. The study aims to investigate the prognostic value of abdominal adipose tissue and its compartments, CRP (C-reactive protein), and NLR (neutrophil to lymphocyte ratio) in patients with COVID-19.</p></div><div><h3>Materials and methods</h3><p>A retrospective analysis was conducted on 381 patient records with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Reverse transcription polymerase chain reaction (RT-PCR) results and low-dose chest computerized tomography (CT) scans between January 1, 2021, and May 30, 2021, at a single center. The study included 270 patients after excluding those under 18 years, with contrast-enhanced CT scans, inappropriate CT images, existing lung masses, or a history of abdomen/thorax operations. Patient demographics, chronic diseases, laboratory results, adipose tissue measurements, and the presence and score of findings on chest CT were noted.</p></div><div><h3>Results</h3><p>To evaluate the prognosis of the patient group, the group was divided into two groups, hospitalized and non-hospitalized individuals. The group of hospitalized individuals had significantly higher levels of total severity score (TSS), total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), CRP, and NLR parameters compared to the non-hospitalized group (p &lt; 0.05). In the multivariate logistic regression analysis, age, TSS, SAT, and CRP levels were found to independently have a significant effect (p &lt; 0.05) in discriminating between hospitalized and non-hospitalized patients.</p></div><div><h3>Conclusion</h3><p>Our study shows that abdominal adipose tissue, especially subcutaneous compartment and related comorbidities increase the risk of hospitalization for COVID-19 infection. In the current era of widespread COVID-19 variants, healthcare professionals can use these parameters to assess hospitalized patients and provide a prognostic tool.</p></div><div><h3>Advances in knowledge</h3><p>This study analyzed abdominal adipose tissue and inflammatory parameters associated with COVID-19 infection. The contrast with other studies is that SAT value was determined as a significant independent variable. This indicates that there is a need for more studies on this subject.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"47 ","pages":"Article 100538"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing obesity Kuznets curve for Türkiye","authors":"Muhammed Benli ,&nbsp;Yasin Acar ,&nbsp;Semih Baş","doi":"10.1016/j.obmed.2024.100537","DOIUrl":"https://doi.org/10.1016/j.obmed.2024.100537","url":null,"abstract":"<div><h3>Aim</h3><p>This paper tests for the existence of Obesity Kuznets Curve (OKC); that is, an inverse U-shape pattern between income and obesity (as measured by Body Mass Index).</p></div><div><h3>Methods</h3><p>We employ linear probability model and logistic regression using cross-sectional data obtained from “2019 Türkiye Health Research” provided by the Turkish Statistical Institute (TUIK).</p></div><div><h3>Results</h3><p>Our findings reveal that OKC hypothesis holds for Türkiye such that the likelihood of obesity first increases as income rises and after reaching a maximum point, it starts to decrease. Furthermore, the study reveals that obesity differs according to gender, so women are more likely to be obese than men. Our empirical study also reveals that marriage, education, age, and physical activity are closely associated with the likelihood of being obese in Türkiye.</p></div><div><h3>Conlusions</h3><p>There is a non-linear relationship between income and obesity. The study also reveals that obesity differs according to gender and marriage, education, age, and physical activity are closely associated with the likelihood of being obese in Türkiye.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"47 ","pages":"Article 100537"},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}